#GLP1s have transformed #obesity care, but can they compete with surgery? #AMichaelLincoff & #ScottShikora argue the pros and cons of #semaglutide vs #bariatricsurgery for a man with obesity in our @nejm.org Clinical Decisions www.nejm.org/doi/full/10....

Congratulations to Dr Christos Kotanidis who has been awarded the 2025 ESC Young Investigator Award in Preventative Cardiology at the European Society of Cardiology Congress in Madrid. Read more 👇 shorturl.at/KU2Be

#ZakKohane on #AI in #PeerReview: the surge in scientific publication is straining the conventional review system beyond capacity. @ai.nejm.org piloting AI-augmented fast track review: manuscripts w high prior of being good gets assigned to #GPT5 + a human, disposition reviewed by editorial team!

Comparing submitted vs published RCT abstracts eval'd at @nejm.org in 4 domains (design, outcome, AEs, conclusions). published abstracts improved in a mean 0.9 domains. More improvements observed in leading gen med vs 433 other journals (72 % vs 48%) www.acpjournals.org/... @cpkotanidis.bsky.social

Well done @cpkotanidis.bsky.social ! Also check out our manuscript in @annalsofim.bsky.social url.us.m.mimecastprotect.com/s/kNYpCDkAO2...

Excited to present our work tomorrow on a novel #AI #metabolomics score to predict #cardiovascular risk in #psoriasis at the #ESCCongress #WCCardio 2025 Young Investigator Award session in Preventive Cardiology. #PreventiveCardiology #CardioRheumatology #YIA

Four Original Articles were simultaneously published in NEJM and presented earlier today at this year’s #ESCCongress in Spain. @escardio.bsky.social

The #1 cause of death in women is heart disease. A new report makes the case for treating women with statins who have a high inflammation marker (hs-CRP) but no traditional risk factors academic.oup.com/eurheartj/ad...

🎥 Snackable Science from #ESCCongress 2025 in Madrid! Roxana Mehran & Michael Gibson break down the new Focus Update of the 2019 #ESCGuidelines on #dyslipidaemias with the latest recommendations you need to know 👇

For a man with #obesity, would you recommend the initiation of semaglutide therapy or bariatric and metabolic surgery? Read the case vignette and essays on both treatment options and cast your vote: nej.md/3HiAnJz #MedSky #EndoSky

The win ratio method is gaining traction in #RCTs. Is it just a trend or a smarter way to look at composite hierarchical outcomes? We break it down in our latest Stats, STAT!📊 in NEJM Evidence. youtube.com/watch?v=jKtF... #stats @nejm.org @sarahgorey.bsky.social @chardin.bsky.social @ai.nejm.org

1/ 🚨 NEW #BeyondJournalClub w/ @nejm.org: REDUCE-AMI What is the long term benefit of beta blockers in patients with preserved EF following an MI? 🖥️: www.coreimpodcast.com/2025/06/25/b...

In older patients with acute coronary syndrome, an early invasive strategy did not reduce all-cause mortality but decreased recurrent myocardial infarction and repeated revascularization. https://ja.ma/40hDK9G

What is it like to be an NEJM editorial fellow for a year? This year’s fellows discuss what they have learned, how their experience will help their career, and what surprised them. Apply for the 2026–27 NEJM editorial fellowship by August 1. Learn more: nej.md/3cCQajB #MedSky #MedEd

60-Second Journal Club: The SUMMIT trial examined cardiovascular outcomes of treatment with tirzepatide in patients with heart failure with preserved ejection fraction and obesity. Read the full trial results: nej.md/4hRGaTY #MedSky #CardioSky @cpkotanidis.bsky.social‬

A 73-year-old woman presented with severe chest pain. She had undergone multivessel percutaneous coronary intervention 2.5 years earlier. Angiography revealed a large thrombus in an LAD artery stent (shown in videos). Read the full case details: nej.md/4jC2aSa #MedSky #CardioSky

Really enjoying @cpkotanidis.bsky.social’s fascinating presentation on his interesting work at @brighamandwomens.bsky.social on identifying risk markers of CVD in patients with IMIDs 🤩👏👏👏

New research alert: Our latest report highlights a significant reduction in coronary #inflammation and residual inflammatory risk as captured by #CCTA imaging using CaRi-Heart AI in women with #BreastCancer 2 years post-RT #AI #CardioOncology #CardioEd #EHJ @escardio.bsky.social

Presented at #ACC25: In the PROTECT-TAVI trial, the routine use of cerebral embolic protection during TAVI did not reduce the incidence of stroke within 72 hours or before discharge from the hospital (if discharge occurred sooner). Full trial results: nej.md/41RONXi @accintouch.bsky.social

Ever wondered how interim analyses work in #RCTs? 📊 Check out our Stats, STAT! video at NEJM Evidence: @nejm.org @ai.nejm.org @sarahgorey.bsky.social evidence.nejm.org/doi/full/10.... #MedStats #ClinicalTrials

Tirzepatide was previously shown to provide sustained weight reductions in adults with #obesity. Longer-term findings in adults with both obesity and prediabetes are summarized in a new Quick Take video. youtu.be/c9uazgSdDJc #MedSky #EndoSky

🫀New research🫀 Across 6 #RCTs (n=2,257) early invasive management in #female patients with #NSTEACS did not reduce all-cause mortality or MI risk at 6 months vs. delayed management. #AHAJournals @drroxmehran.bsky.social @vijaykunadian.bsky.social www.ahajournals.org/doi/10.1161/...

In the HELIOS-B trial, researchers assessed the efficacy and safety of vutrisiran in patients with transthyretin amyloidosis with cardiomyopathy. NEJM Editorial Fellow Christos Kotanidis, MD, DPhil, summarizes the results. Full trial: nej.md/3X5nl5Q #MedSky #CardioSky @cpkotanidis.bsky.social

In a new editorial, NEJM Editor-in-Chief Eric J. Rubin, MD, PhD, comments on the effects of the raft of executive orders from the current administration on scientific research and public health. Read the full editorial: nej.md/4gXeRFW #MedSky

🤔Recurrent severe abdominal pain with no clear cause? In the latest #NEJMDoubleTake we unpack a perplexing case with a broad differential, key clinical clues, and a surprising diagnosis. 🎥🩺 🏥🔬 nejm.org/doi/full/10.... @nejm.org