F’ those f’ing f’ers and their f’ing f’ery. Episome as rhetorical device.

Thomas Hunt Morgan, born 159 years ago #OTD in 1866. Happy 1.59 centiMorgans. en.m.wikipedia.org/wiki/Thomas_...

Ruin a book with a car: To Have and Have Nova

Ruin a book with a car: Catcher in the Rivian

We are hiring! The Dept of Microbiology and Molecular Genetics is looking for faculty at the Assistant or Associate professor level (tenure track). Please consider joining our vibrant microbiology and immunology community at the University of Pittsburgh School of medicine

We have an open Assistant Professor position in Evolutionary Cell and Molecular Biology in the @weillinstitute.bsky.social at Cornell University. academicjobsonline.org/ajo/jobs/30607

Does #economics or #management have a term for when the cost of gathering information exceeds the value of that information? If not, may I suggest Kualification

I am thrilled to share a joint work with Melissa Gymrek that spans several years to study what is the impact of promoter proximal short tandem repeats (STRs) on expression by using MPRAs. I am sure you'd enjoy! Awesome effort by @xzhangbsky.bsky.social and the team! www.biorxiv.org/content/10.1...

Subtly downgrade a band One Republic, If You Can Keep It

Smith Rock State Park, OR. 2025

Journal-specific formatting does not bother me half as much as all the atomized pedantic nonsense in the submission systems.

New version. New results: Reduced expression from polypyrimidine tract mutations is consistent across tissues. Reduced TULP3 level reduced primary cilium frequency and & length distributions, but not TULP3 or GPR161 localization, prior to kidney cyst formation. www.biorxiv.org/content/10.1...

Timeline cleanse, featuring the majestic sea flap-flaps (aka mobula rays). They're a migratory animal, moving from one part of the ocean to another in large groups called "fevers". They migrate to follow upwellings that enrich for zooplankton food items & to visit their breeding grounds. (📷:OCR)

Political violence is bad. It usually begets more political violence. Celebrating political violence is bad. It usually encourages more political violence, against various targets. Campus shootings are bad. They make everyone on campus less safe. It's bad that what I wrote here is controversial.

This is awesome. @ellecordova.bsky.social

Slightly diminish a book Backup Catcher in the Rye

Nonequivalence of Zfp423 premature termination codons in mice. Formatted version of record #OA at #Genetics academic.oup.com/genetics/adv...

'Early on in her life, Esther defied societal conventions by pursuing biochemistry, against recommendations from her teachers who believed that a career in science was too difficult for women' academic.oup.com/genetics/adv...

New Opinion out today in @chicagotribune.com "The Bio10 is an academic powerhouse." "The health of our society depends on generations of young students equipped to embrace, and succeed in the face of, uncertainty." www.chicagotribune.com/2025/09/02/o...

Every few months the "good lab hands" thing comes up and it misses a key point: you can learn to have good hands. Training matters. Good hands aren't some magic gift from the PCR gods, you have to develop them through directed repetitive practice, like any other skill

Both annoyed with and grateful to reviewer who asked for something that will make an already good paper better. #costbenefit

YOU DON'T SAY

📢We're #hiring Group Leaders! Apply to lead a lab at Janelia & advance biology using theory, computational modeling & machine learning. 🔹5-year renewable appointment 🔹Pioneer new tools & approaches 🔹Collaborate across disciplines Apply by Nov. 4👉 https://janelia.link/groupleader

🅁 evealing 🄴 vidence, 🅂 parking 🄴 xploration, 🄰 dvancing 🅁 eason, 🄲 reating 🄷 ope @ucsandiego.bsky.social @ucsdmedschool.bsky.social @ucsdpharmacy.bsky.social

The Guns of August

If it takes a 26-page document to explain how to upload a form to your site, then you have designed a lousy site. Kuali.

Now with peer review (Thank you @genetics-gsa.bsky.social Genetics, anonymous reviewers and editors). pubmed.ncbi.nlm.nih.gov/40825037/

Make a band food: Stone Tempeh Pilots

slightly diminish a band: Cast iron Dan

Today in great automation: Page proofs that changed capitalization to “open Reading frame” throughout. I have nothing against the town, it just isn’t essential to translating this mRNA.

Small pleasure in a turbulent time. Just going to enjoy this while it last.

This from @tressiemcphd.bsky.social hit me over the head like a mallet of truth. This is the thing. This is what I’ve been trying to warn people about perfectly crystallized. www.nytimes.com/2025/08/12/o...

Gentle reminder: not following the funder’s formatting requirements does make your proposal stand out so much as makes it not fit in.

For those wondering and reaching out: thank you, truly. We are amongst the lucky ones, we are ok - for now. But the reality is that no one is an island. Research is stellar because it is an ecosystem, a fragile one at that, as we are learning. So we won't be fine, if no one else is. We all lose

I don’t have a problem with someone evaluating my science abilities if I have the ability to examine theirs. Let’s do televised qualifying exams for all the political appointees who will be evaluating science grants and proposals. Let’s start with directors of institutes and cabinet secretaries.

Today in great automated correspondence: “Dear Dr. Editorial Office…” (From a respectable place, but not one where I have ever been an editor)

But I mean who are you going to believe, every expert in the field supported by massive amounts of data from loads of clinical trials, or a hyper-confident non-expert with an opinion?

“In not killing one, a brain worm may kill many.” Proverb

Reminder! Tenure track position in Genetics at Trinity College Dublin! Come join us, we're nice... 😊 Please repost! 🙏

Accepted is such a lovely word. And may the universe be kind to those who post it on a weekend.

NIH saves lives. Save NIH.

No, @nytimes.com, making stuff up is not a “version of reality.”

TFW manuscript status changed to “decision in progress” but it’s the weekend.

Thank goodness all that trade uncertainty has been resolved.

Ah, the MLB trade deadline, when every GM thinks, “I’ve built such a great team that all I need to do now is change everything.”

Extra kudos and thanks to all the staff at NIH and NSF and other federal funding agencies for working extra hard in very small windows of opportunity to get grants reviewed and funds released before the attention-addled federal policies change again (on an hourly basis).

To all post-docs: The Genome Biology dept ‪@embl.org has an Independent faculty position. Fantastic place to set up your lab –great package: core funding, fantastic Ph.D. students, cutting edge core facilities & great colleagues. Closing date Sept 19th embl.wd103.myworkdayjobs.com/en-US/EMBL/j...