🚨 Ever wanted a simple way to control the activity of thousands of neurons? We introduce an all-optical raster photostimulation method to do just that! w/ @computingnature.bsky.social @marius10p.bsky.social #FluorescenceFriday #neuroskyence www.biorxiv.org/content/10.6... 1/n

Thrilled to share our work out in @nature.com today! Linking flexibility modeling, single-cell imaging, and targeted optogenetics allowed us to characterize how some prefrontal neurons, and mPFC-VTA neurons in particular, drive contingency degradation behavior. www.nature.com/articles/s41...

I love this idea so much

Delighted to share our discoveries about one of the brain's neurotransmitter systems: www.biorxiv.org/content/10.6... Together with colleagues at the @alleninstitute.org, we have learned a lot about a tiny cluster of neurons in the brainstem locus coeruleus (LC) that releases norepinephrine (NE). 1

Eager to learn how one shanks a P10 rat with a neuropixels Very cool stuff

1) Why is this the first I’m learning about fish talking to each other by slapping their bellies 2) The actual results in this paper are awesome

how a small (~15) prolific and opinionated set of reviewers could steer a field over time This is great, and even these numbers underestimate the effect. Some fields have <10 qualified reviewers, one loud voice can tank or lift papers on its own

Our perspectives piece on Agentic AI for biomedical research has been published in Nature Biotechnology www.nature.com/articles/s41... #agenticAI #artificialintelligence #agents

Science has now published our eLetter responding to Rajendran et al., titled, “Data show that macaques do not synchronize to a beat” doi.org/10.1126/scie...

For all the energy we use in developing new technologies and fancier data handling, this is an immediate, actionable problem that we need to prioritize Beautifully written!

New lab preprint! Can we study conscious perception of gut sensations in mice to reveal its neuronal basis? Can we train mice to report their gut sensations? Omer Rafael and Stav Shtiglitz in the lab teamed up to discover that…YES! Thread…1/6 www.biorxiv.org/content/10.6...

Almost feels wrong to see suite2p as a paper after all these years, used to it being a more of a silent pillar

What is the computational role of dendritic excitations? Byung Hun Lee and team mapped voltage dynamics throughout the dendritic trees of CA1 pyramidal neurons in mice navigating in virtual reality. www.biorxiv.org/content/10.6...

lab preprint! Interopceptive predictions are central to many brain-body interactions theories, but it's unclear if/how they affect bodily physiology. We (fearless Einav Litvak et al) show that insular cortex predictions are essential for glucose homeostasis-THREAD.. www.biorxiv.org/content/10.6...

We used rabies virus 👾 to map how #psilocybin modifies long-range circuits 🧠, revealing network-specific reorganization that we didn’t expect. The full study is now online at Cell. @cp-cell.bsky.social Paper 👉 www.cell.com/cell/fulltex... Thread for a synopsis 👉 bsky.app/profile/alex...

In @thetransmitter.bsky.social’s Rising Stars of Neuroscience 2025, we recognize 25 early-career researchers who have made outstanding scientific contributions and demonstrated a commitment to mentoring and community-building in neuroscience. #neuroskyence #StateOfNeuroscience bit.ly/4rnFnyQ

Thanks @thetransmitter.bsky.social and to my lab for brightening my week with this rising stars in neuroscience award!! Wish I could be in #sfn to celebrate in the sun. Wonderful list of people: www.thetransmitter.org/early-career...

Woulda guessed 50%, glass half full kinda person

ADD YOUR THOUGHTS ON LIMITING STUDENT VISA TO FOUR YEARS Comment period ends September 29th www.federalregister.gov/documents/20... 1/2

graphical abstract goes hard

Wild! Stephen, Praneel and their team use fluorescence lifetime imaging and various manipulations to show that, in male mice, both mating drive and hypothalamic tonic dopamine release drop after a successful mating and gradually recover over the next week, paralleling the recovery in sperm count.

Featuring 2p FLIM to track DA levels over days, and a demonstration that a neurons molecular identity is pretty labile @stephen-zhang.bsky.social @markandermann.bsky.social P.S: Praneel will be applying to MD PhD and is an absolute beast. Systems neuro labs don’t miss out!!

URGENT! Contact your senators today to advocate to fund science agencies and programs! The Senate Appropriations Committee & its subcommittees are writing appropriation bills for the federal FY26 budget now. Here's how you can help: esa.org/esablog/2025...

I know it's not very helpful, but I find myself thinking about those who criticized Nature's and Scientific American's Harris endorsement on the grounds that "science should stay out of politics." I think about those people quite a lot.

It’s is practically guaranteed that what is happening to Harvard WILL happen to your favorite R1 institution if we don’t continue to engage our local representatives.

Reminder: Bluesky is an echo chamber. As useful as it is to get informed and feel support on here, it’s time to get uncomfortable and speak up *in real life*. Talk to those who are not here. Be ready to explain these catastrophes. Add YOUR grain of salt to the mobilization process. It matters.

Positional molecular markers guide the regeneration of the correct body parts in axolotls. Go axolotl gang!

Under 65 years old? No Novovax COVID vaccine for you this year. As expected, the Republicans have enabled RFK Jr. and his coterie of antivax grifters to take away your right to make your own medical decisions in consultation with your doctor. Gift Link: www.nytimes.com/2025/05/17/h...

Dozens of responses to my essay summarized. 1. Why aren’t scientists in an uproar? 2. Most Americans don't know that defunding science will make their lives worse. Bluesky, tell your neighbors, science matters. Scientists, roar. 🧪💙📚 #scicomm #science 🌎 🔬 ⚒️ theconversation.com/unprecedente...

TOMORROW 12pm PT/3pm ET, academic workers across the country are organizing to call Senators and Representatives, particularly from historically “red” districts, to sign onto to letters supporting federal research funding. Register here to join the phonebank: form.laborbase.org/251246245216...

Hardest surgery I’ve seen to get the coolest brainstem imaging I’ve seen! Rachel’s paper shows interoceptive information, in particular feeding-related info, is organized across PBN

A thread: NIH Fellows United is committed to showing up, even when leadership won’t. 🧪

Pretty ironic that those who stand to gain the most from a quantitative arm are biologists given the reformatting of the field with new tech.

One of the most inspiring essays I’ve read on resistance. www.vnews.com/Column-A-tim...

I am extremely pleased to share this feature articulating why I have lost my sanity lately. www.science.org/content/arti...

🚀🔬🦠 Releasing 🤖Cellpose-SAM🤖, a cellular segmentation algorithm with superhuman generalization 🦸‍♀️. Try it now on 🤗 huggingface.co/spaces/mouse... paper: www.biorxiv.org/content/10.1... w/ @computingnature.bsky.social 1/n

The scientific community is at a pivotal moment right now. And we are seeing things start to shift. Now is the time for scientists and scientific institutions to step up. No one is coming to save us. 🧵

I 💙 seeing team science makin it happen

www.nytimes.com/2025/04/03/o... Really important piece to share widely. Too many Americans don’t know how severe a threat this Administration poses to our scientific infrastructure, global leadership, and health security

BREAKING: We're suing the National Institutes of Health over their politically-motivated purge of research grants. This is an unlawful attack on scientific progress that puts lives at risk.

Many of us use 2p scopes to image 3D volumes of brain. But then we analyze the data plane by plane, resulting in duplicated neurons, missed neurons, and low s/n. Let's go 3D! Suite3D: Volumetric cell detection for two-photon microscopy by @haydari.bsky.social & team. www.biorxiv.org/content/10.1...

Last year, I was overjoyed to receive an NIH NRSA fellowship to study toddler brains and caregiving effects on memory at Columbia. Last night, my grant was terminated.

The House Continuing Resolution budget “adjustments” for NIH are drastic. Here are some examples:

Another NIH grant rescinded - The Epidemiology of Alzheimers Disease and Related Dementias in Sexual and Gender Minority Older Adults: Identifying Risk and Protective Factors - 1K01AG056669

This is the most relevant article to NIH and research cuts I’ve seen. Imagine if this was today , how many people would be saying “Why are we studying Gila Monsters and their impact on diabetes ? That’s wasted money !” globalnews.ca/news/9793403...

A Sensitive Soma-localized Red Fluorescent Calcium Indicator for Multi-Modality Imaging of Neuronal Populations In Vivo. It works well with wide-field imaging, two-photon microscopy, and fiber photometry biorxiv.org/content/10.1...

🧪🧠 more new red GECIs!🚨 👏🥳 congrats to everyone involved!

There is one True Skill that defines all basic neuroscientists, and that is the ability to copy and paste arrowheads from a lil green picture of cells to their lil red picture of cells

week-long recordings of agrp neurons and circadian fluctuations in hunger (we can all relate), always exciting work from @amdouglass.bsky.social and Hakan! www.cell.com/cell-metabol...