Paul Sheppard 🧠
@paulsheppard.bsky.social
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📥 228
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Behavioural neuroscience, poems, running, weird noises — ALLERGIC TO FUN
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Paul Sheppard 🧠
12 days ago
Don't miss
@paulsheppard.bsky.social
's visually innovative poem "a n y w a y (s)" in Issue 32! Excerpting doesn't do it justice; just click through to the poem:
www.thetemzreview.com/sheppard-32....
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Paul Sheppard 🧠
Possum Every Hour
17 days ago
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It's tragic, but I forgot to post this Good Meme when the touchscreen cognitive judgement bias paper came out. (paper link for context:
www.nature.com/articles/s41...
)
2 months ago
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I ran my first ultra distance race today, an intense and technical 56km
@limberlosttrailrun.bsky.social
. It was HOT and I learned a lot of things that I'll do differently next time, but it was some great Type 2 Fun!
3 months ago
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Possum Every Hour
3 months ago
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Today I ran just shy of a marathon during a race called The Farthest put on by Persistence Racing. Everyone started from the same point and ran in whatever direction they wanted to get the farthest as the crow flies within 2, 4, or 8h. I did the 4h "Half-Farthest".
3 months ago
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From canceled faculty hiring searches to this in <6 months... 👀
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4 months ago
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In case you were wondering (you 100% weren't): the mouse in the graphical abstract is "greyer mouse" because "grey mouse" just wasn't grey enough for certain co-authors who will go unnamed...
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4 months ago
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Paul Sheppard 🧠
Baptiste Lacoste
4 months ago
Happy to share the current version of our latest story, currently under peer review. Cool collab with
@dablab.bsky.social
@manickam-lab.bsky.social
and others. We are not only understanding endothelial deficits in an
#autism
model, but now also capable of rescuing them!
#16p11.2
#treatment
#P2Y2
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Purinergic receptor activation rectifies autism-associated endothelial dysfunction
Early cerebrovascular alterations affect brain maturation by impacting trophic support and energy supply. Recent evidence in a 16p11.2 deletion mouse model of autism spectrum disorder (ASD) revealed b...
https://www.biorxiv.org/content/10.1101/2025.06.02.657522v1
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🚨 NEW PAPER ALERT 🚨 🚨 KLAXON KLAXON 🚨 Impaired Cognitive Flexibility With Preserved Learning in an Amyloid Precursor Protein Knock-In Mouse Model of Amyloidopathy
onlinelibrary.wiley.com/doi/10.1111/...
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Impaired Cognitive Flexibility With Preserved Learning in an Amyloid Precursor Protein Knock‐In Mouse Model of Amyloidopathy
The amyloid precursor protein knock-in mouse model of amyloidopathy (AppNL-G-F/NL-G-F) was assessed on touchscreen-based learning and cognitive flexibility tasks in comparison with both AppNL/NL and ....
https://onlinelibrary.wiley.com/doi/10.1111/gbb.70024
4 months ago
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Paul Sheppard 🧠
Western BrainsCAN
4 months ago
Well done to all of our affiliated presenters at this year's
@canacn.bsky.social
Meeting! Great work!
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Paul Sheppard 🧠
Marco A. Maximo Prado
4 months ago
This is finally out! Great collaboration with Andy Holmes
@timbussey.bsky.social
@lisasaksida.bsky.social
and
@touchscreencog.bsky.social
@westernubrainscan.bsky.social
trainees
www.nature.com/articles/s41...
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Integrating optical neuroscience tools into touchscreen operant systems - Nature Protocols
This protocol extension enables researchers to integrate optically based manipulation and measurement techniques into their touchscreen experimental systems, focusing on optogenetic manipulation, fibe...
https://www.nature.com/articles/s41596-025-01143-x
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Paul Sheppard 🧠
Papouin Lab @ WashU
5 months ago
Thought this would be a nice way to enter the bsky community👇Delighted for Katie (now in Chris Dulla's lab at Tufts). Thank you to our collaborators, to the reviewers and to Cagla Eroglu for the highlight!
www.science.org/doi/10.1126/...
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Norepinephrine signals through astrocytes to modulate synapses
Locus ceruleus (LC)–derived norepinephrine (NE) drives network and behavioral adaptations to environmental saliencies by reconfiguring circuit functional connectivity, but the underlying synapse-level...
https://www.science.org/doi/10.1126/science.adq5480
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Paul Sheppard 🧠
CANGlia
4 months ago
Dr. Adebiyi kicking off our second session with an exciting talk about demyelination and repair!
#KeepSmyelin
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Paul Sheppard 🧠
CANGlia
4 months ago
We are back for our 2nd CANGlia meeting in beautiful Toronto for a day of exciting Glial science!
#CANGlia2025
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Paul Sheppard 🧠
Western BrainsCAN
5 months ago
Come and work with the Translational Cognitive Neuroscience Lab! We are looking for a
#labmanager
who wants to understand the circuits and mechanisms underlying cognition. Search ID 39142 at:
recruit.uwo.ca
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Paul Sheppard 🧠
Possum Every Hour
5 months ago
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Ciarán Murphy-Royal
5 months ago
Very nice series of papers showing the effects of noradrenaline on brain circuits and behaviour require astrocytes. Congrats to the three labs on this fantastic work!
www.science.org/doi/10.1126/...
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Astrocytes, hidden puppet masters of the brain
Astrocyte signaling pathways influence neuronal networks and behavioral responses to neuromodulators
https://www.science.org/doi/10.1126/science.adx7102
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FINALLY a mnemonic that is legitimately helpful for this!
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5 months ago
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My poem "I Fix the Door Open with My Bones" appears in the premiere issue of Diceroll. Go show them some love!
diceroll.press
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diceroll press
https://diceroll.press/?fbclid=PAQ0xDSwKMW09leHRuA2FlbQIxMAABp_4N5wF21fZ4PFkIJKUia09XLwdwfLj5rKJQWb-BImDQZUuKkUHBlEaHgMAk_aem_V5YONi2vPX7UdB6B58HZnA
5 months ago
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Many thanks to The Trinity Review for publishing my poem "Before the Grassfires Flew" in issue 137.1. You can check it, and others, out here:
www.thetrinityreview.com/download
5 months ago
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Today I ran my first marathon ❤️
5 months ago
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Stayed up late last night to register for my fall goal race! Running the 50km at The Bad Thing trail race 🤘🏻
5 months ago
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Paul Sheppard 🧠
Possum Every Hour
5 months ago
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This weekend is my first ever crack at
@cv2magazine.bsky.social
's 2 Day Poem Contest! I think I've got a whole fruit bowl of global melancholy cooking right now for my entry; so, yeah, it's a blast!
#2DayPoem2025
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5 months ago
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I'm immensely grateful to have poem "tiny sounds" published in The Spring Issue of
@cv2magazine.bsky.social
❤️ Received my contributor copy last night.
5 months ago
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Paul Sheppard 🧠
drewtoothpaste
5 months ago
good night
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Today at NOON! (...which I should know, as one of the co-hosts, but definitely thought was at 11am. No: NOON)
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5 months ago
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Another
@canglia.bsky.social
Trainee Webinar tomorrow! Won't you join us?
5 months ago
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🎉🎉🎉 NEW PAPER ALERT 🎉🎉🎉 🚨🚨🚨KLAXON KLAXON🚨🚨🚨 "Pharmacological agents and injection stress, but not social isolation, alter cognitive judgement bias in the mouse touchscreen operant chamber" by Hersey et al. out now in
@natureportfolio.nature.com
#ScientificReports
www.nature.com/articles/s41...
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Pharmacological agents and injection stress, but not social isolation, alter cognitive judgement bias in the mouse touchscreen operant chamber - Scientific Reports
Scientific Reports - Pharmacological agents and injection stress, but not social isolation, alter cognitive judgement bias in the mouse touchscreen operant chamber
https://www.nature.com/articles/s41598-025-98303-6
5 months ago
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Paul Sheppard 🧠
Singletrack Podcast
6 months ago
“Want a chair?” a spectator asks. “No..chairs are for finishers,” John replies. In the howling wind and rain, John Kelly completes a “Fun Run” at the 2025 Barkley Marathons in 39 hours and 50 minutes. Afterward, he takes the ceremonial bugle and plays his own taps.
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Paul Sheppard 🧠
Katie Hinde
7 months ago
I escaped poverty because I am a scientist. And I am a scientist because of the National Science Foundation. A 🧵:
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Paul Sheppard 🧠
Matias 🌈
7 months ago
I have accidentally fired the workers that were combating bird flu and which you were probably saving to keep people alive forgive me it was delicious so sweet and so cold
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Paul Sheppard 🧠
Possum Every Hour
7 months ago
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Thanks again to Soliloquies Anthology for publishing "playthings" in their latest issue. Got my copy earlier this week ❤️
8 months ago
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Reminder that there's another spectacular CANGlia trainee webinar this Thursday at noon (Eastern) 🧠
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8 months ago
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Paul Sheppard 🧠
CANGlia
8 months ago
We're back next week with another exciting CANGlia webinar! Join us February 13th at 12pm to hear about some more Canadian glial research - zoom link in bio! 🧠 🧠 🇨🇦 🇨🇦
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Many thanks to Soliloquies Anthology
@concordiau.bsky.social
for publishing my piece "playthings" in their latest issue (29.1). You can find it online here:
soliloquies.org/29-1/
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Past Issues
Past Issues 29.1 In this issue, our prose takes us from the depths of space to the intricacies of family relationships, and grounds us through meditation retreats. Our poetry is equally thoughtful …
https://soliloquies.org/29-1/
8 months ago
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Excited to see this preprint up from Laura Lopez-Cruz and co! Some cool stuff coming up on its heels too... Stay tuned ;)
@timbussey.bsky.social
@lisasaksida.bsky.social
@tcnlab.bsky.social
www.biorxiv.org/content/10.1...
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Characterisation of a touchscreen-based Go/No Go task for assessing cognitive judgement bias in mice: a new translational tool for affective state disorder drug screening.
A major obstacle in the pre-clinical study of mood-related disorders and novel affective state therapeutic evaluation is the lack of animal models that fully recapitulate human symptomatology. In this...
https://www.biorxiv.org/content/10.1101/2025.01.20.633915v1
8 months ago
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Paul Sheppard 🧠
Baptiste Lacoste
9 months ago
Once again, someone else says it: "Aβ accumulation affecting brain vessel function could be a very early pathology leading to neurodegenerative disease."
doi.org/10.1186/s131...
#cerebrovascular
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The cerebral blood flow response to neuroactivation is reduced in cognitively normal men with β-amyloid accumulation - Alzheimer's Research & Therapy
Background Accumulation of β-amyloid (Aβ) in the brain is a hallmark of Alzheimer’s Disease (AD). Cerebral deposition of Aβ initiates deteriorating pathways which eventually can lead to AD. However, t...
https://doi.org/10.1186/s13195-024-01652-z
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reposted by
Paul Sheppard 🧠
I present to you the third installment of our annual Christmas album! This year is more unhinged, more adult, and more... betterer!
navigatorblackandtheindighost.bandcamp.com/album/yule-l...
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Yule Love It! Volume 3: Big Nick Energy, by The Noisy Electric Christmas Light Orchestra
16 track album
https://navigatorblackandtheindighost.bandcamp.com/album/yule-love-it-volume-3-big-nick-energy
9 months ago
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Paul Sheppard 🧠
Shrew
9 months ago
Putting the picture of this covid test through all the photo filters at once to see if I'm still positive like it's a western blot I'm trying to publish in Nature
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I present to you the third installment of our annual Christmas album! This year is more unhinged, more adult, and more... betterer!
navigatorblackandtheindighost.bandcamp.com/album/yule-l...
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Yule Love It! Volume 3: Big Nick Energy, by The Noisy Electric Christmas Light Orchestra
16 track album
https://navigatorblackandtheindighost.bandcamp.com/album/yule-love-it-volume-3-big-nick-energy
9 months ago
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Paul Sheppard 🧠
drewtoothpaste
9 months ago
i was looking for a job, and then i found a job, and heaven knows i'm miserable now
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Paul Sheppard 🧠
Bethany Brookshire
9 months ago
A friend of mine asked for the source of the protein in his "CORE POWER" protein shake, so I looked. It's milk. Ultra filtered milk. I am deeply amused that companies are selling dudes "protein shakes" that are just like "chocolate milk but let's make it for MEN"
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📜 It's in the pipeline, but we've put up this
@tcnlab.bsky.social
paper, led by first-author-superstars Leila Dzinic and Olivia Ghosh-Swaby, as a preprint so folks can start using this technique for their
#TouchscreenCognition
research!
www.researchsquare.com/article/rs-5...
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Citric acid water as an alternative to food restriction to motivate task performance in mice during touchscreen testing
Rodent behavioural testing paradigms in touchscreen operant chambers have successfully provided insight into the neural mechanisms underlying various cognitive domains in healthy and disease models. T...
https://www.researchsquare.com/article/rs-5575045/v1
9 months ago
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reposted by
Paul Sheppard 🧠
My first 3 pieces of published poetry are available in the latest issue of The /tƐmz/ Review! Check out these playful and experimental works and all the other great work in the issue. https://www.thetemzreview.com/issue-twenty-nine.html
10 months ago
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My first 3 pieces of published poetry are available in the latest issue of The /tƐmz/ Review! Check out these playful and experimental works and all the other great work in the issue. https://www.thetemzreview.com/issue-twenty-nine.html
10 months ago
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Paul Sheppard 🧠
Possum Every Hour
10 months ago
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