#eNeuro | Effect of Functionally Selective Dopamine D1 Receptor Agonists on Complex Cognitive Processes in a Rodent Touchscreen Operant Chamber Task https://doi.org/10.1523/ENEURO.0296-25.2026

happy #fluorescencefriday Compare with last week’s post on APOE3 mice now we have the AD APOE4 model with blood vessels in pink, amyloid in blue and microglia in green. Courtesy of the @mind-western.bsky.social @touchscreencog.bsky.social @tridentpct.bsky.social teams

Have you heard about MouseBytes? Our date repository for @timbussey.bsky.social @lisasaksida.bsky.social touchscreen datasets is growing. Daniel Palmer just uploaded a several datasets to reach over 27,000 individual 🐁 💪 mousebytes.ca/home Look out for new features coming soon

Product Citation 🍁 Researchers @westernu.ca utilized StressMarq's #AlphaSynuclein PFFs to create touchscreen cognitive tests that detect early stimulus-response learning deficits in a mouse model of #synucleinopathy. Paper 🛶 https://go.nature.com/3LPaC5K Product 🌲 https://bit.ly/2u9YHV2

#fluorescencedriday First attempt on NeuN labeling (magenta) to quantify the 3D distribution of neurons and interface with blood vessels (yellow) by @shahrzadbahrampour.bsky.social and @nadiahaghbinphd.bsky.social for the @mind-western.bsky.social @neuroak.bsky.social

Incredible interview with one seriously awesome prof! @liisagalea.bsky.social, the world is so much better for the work you do! 😍💜👏 imsmagazine.com/2026/01/26/n...

#fluorescencefriday distribution of microglia in the whole brain

#fluorescencefriday 🧠 from AppNL-G-F mouse model triple stained for amyloid beta (Cyan) IBA1 (microglia magenta) and CD31 (blood vessels yellow) thanks to @shahrzadbahrampour.bsky.social @nadiahaghbinphd.bsky.social and @arashsalah.bsky.social @mind-western.bsky.social

12 episodes coming out! how lucky am I? I got to interview 🤩 experts in psychiatry, gynecology, global health, nephrology, neuroscience, microbiome, FemTech, charitiable giving, & policy...join us for sometimes intense, but always informative conversations, sprinkled with some laughs along the way!

#fluorescencefriday shows the intimate relationship between astrocytes, (cyan) microglia (green) and amyloid plaques (magenta). we find that in APOE4 mice there is much more glia associated with plaques.

New series coming up where we highlight Bussey-Saksida Touchscreen Chamber tasks! First is the 4-Choice Gambling Task! This task is used to investigate decision-making which can be implicated in many neurological and psychiatric disorders. To learn more: https://lnkd.in/dCFcWc3Z

#neuroskyence community: If you're working with touchscreen operant systems, touchscreencognition.org is a fantastic resource to check out. You'll find SOPs, training videos, real data examples, forums, and more. And best of all, you can stay updated and connected with the touchscreen community 🧪

Explore @touchscreencog.bsky.social, a global hub for touchscreen users, researchers & enthusiasts! 🔹 Training Videos 🔹 SOPs 🔹 Webinars 🔹 Discussion Forums Refine your research, stay updated, & join the community! TouchScreenCognition.org #BehavioralResearch #TouchscreenTech #Science

If you are interested in great #fluorescencefriday videos, images and anything microscopy or MRI related follow our new account for the MIND platform @mind-western.bsky.social @neuroak.bsky.social @touchscreencog.bsky.social @tridentpct.bsky.social

It is #fluorescencefriday and the MIND platform @touchscreencog.bsky.social @tridentpct.bsky.social invites you to see brain blood vessels stained with CD31 and imaged by lightsheet. 🐁 🧠 cleared with SHIELD . thanks as always to @shahrzadbahrampour.bsky.social @arashsalah.bsky.social and company.

A blog by Marilene Lopes explaining our latest fidings on STIP1 in early development communities.springernature.com/posts/the-un...

Latest paper is Vlad Novikov’s careful analysis of proteostasis in a TDP-43 mouse model A Longitudinal Study of Sex Differences in a TDP‐43 Mouse Model Reveals STI1 Regulation of TDP‐43 Proteinopathy and Motor Deficits - Journal of Neurochemistry - onlinelibrary.wiley.com/doi/10.1111/...

Ontario’s message to the international world of biotech, medical devices and pharma…we don’t want your money or research partnerships.

Congratulations 🎉 🥳 to @kateonuska.bsky.social for successfully defending her PhD (co-supervised with Taylor Schmitz). No edits so she can rest for few days. Keep an eye out for Kate as she is one of a kind.

Our new interest: blood vessels and amyloid plaque interactions after lecanemab treatment of an ApoE4 AD mouse line #fluorescenceFriday @arashsalah.bsky.social and @shahrzadbahrampour.bsky.social for credits

a second rendering for #fluorescencefriday

Thanks to everyone who took the time to visit our booth at #AAIC25! We had a wonderful time and met some amazing people being part of the CIHR Institute of Aging's Canadian Pavilion. Until next year!

Last day of #AAIC25 for the exhibitors! Energy is still high 😎 come by our booth at the Canadian 🇨🇦 Pavilion @touchscreencog.bsky.social @westernubrainscan.bsky.social @lisasaksida.bsky.social @timbussey.bsky.social @maximoprado.bsky.social @pradobsky.bsky.social

Great to have all our leaders out supporting the team and young talent at #AAIC25! Shout out to @lisasaksida.bsky.social, @timbussey.bsky.social, @maximoprado.bsky.social, and Vania Prado.

So much talent from @westernu.ca presenting their cognition and Alzheimer's research at #AAIC25! We are very proud of all of their hard work. Read full abstracts here: touchscreencognition.org/aaic-2025/

Touchscreen-based assessments are transforming our understanding of brain regulation in complex behaviors. Piantadosi et al. (2025) published a guide about experimental design and essential hardware modifications for specialized research. Check it out: www.nature.com/articles/s41...

Check out our posters on Tuesday #AAIC. Learn about new mouse models in which we replaced mouse alpha synuclein with human gene, touchscreen testing in AD mice and ApoE4.

If you are interested in learning the limitations of current models of alpha synuclein pathology and why we need new KI humanized mouse models check out Latiyah’s poster #AAIC25 Poster 200 Characterization of mouse of Synucleinopathies @tridentpct.bsky.social @touchscreencog.bsky.social

Hot off the press Huge congrats to Alycia Crook a PhD student from the lab www.nature.com/articles/s41...

the MouseTRAP team will be presenting the following posters at #AAIC25 today. Come say high and learn how we are using translational approaches to better understand proteinopathies. @touchscreencog.bsky.social @tridentpct.bsky.social

Get some swag plus strawberry milkshake at our booths in the Canadian Pavillion @touchscreencog.bsky.social @tridentpct.bsky.social and learn more about translational approaches to cognition, how well 🐁 can perform in touchscreen tasks #AAIC25

Hey #AAIC25 check out Arash’s presentation today at 8 AM and see some cool whole brain videos of the vasculaturs and plaques plus touchscreen testing room 106 Evaluating the Efficacy and Risks of Early Lecanemab Treatment in APOE4 Humanized Alzheimer’s Disease Mouse Models also poster 151

If you you interested in translational research #AAIC25 and improved rigour in cognitive testing check out the 🐁 2 🧍 approaches to test cognition in identical ways in mice and humans. @touchscreencog.bsky.social get some swag at the Canadian Pavilion.

The MouseTRAP team @touchscreencog.bsky.social @tridentpct.bsky.social presentations at #AAIC25 If you are interested in translating results from basic to clinical research come for a chat.

Why does TRIDENT have strawberry milkshakes at its booth at #AAIC2025 ? Listen to Sarah explain the scientific reasons.

Look at this world-class crew! 😍 So excited to see resident TRIDENT experts @maximoprado.bsky.social and Dr. Vania Prado stop by and say hi! #AAIC25 #NFRF

come by @tridentpct.bsky.social and @touchscreencog.bsky.social #AAIC25 and get your free strawberry milkshake (just the ones out mice get when they do their touchscreen tasks). Learn about touchscreen testing in mice and humans and the TRIDENT pipeline.

Great 1st day at #AAIC25! We're here for the rest of the week, stop by our @touchscreencog.bsky.social booth that's located in the Canadian Pavilion. 🎉 @maximoprado.bsky.social @westernubrainscan.bsky.social @lisasaksida.bsky.social @timbussey.bsky.social @tcnlab.bsky.social @pradobsky.bsky.social

#fluorescencefriday blood vessels and amyloid plaques in a 🐭 model of AD. courtesy of @shahrzadbahrampour.bsky.social Luke Smolders and Arash Salahinejad @tridentpct.bsky.social @touchscreencog.bsky.social We will be 🔜 opening up for external services and collaborations via MIND @westernu.ca

We have a Newsletter! Hear about all the cutting-edge research at TRIDENT...direct to your inbox! Check out Synaptozone, the TRIDENT E-Newsletter Spring 2025 edition via the link below! #TRIDENT createsend.com/t/y-E25C42E0... To subscribe see the link here: confirmsubscription.com/h/y/6B03FD42...

@tridentpct.bsky.social was pleased to welcome MP Lianne Rood and her Constituency Assistant Kim Heathcote to tour TRIDENT facilities with @maximoprado.bsky.social (MouseTRAP), @stefan-everling.bsky.social (marmoset), me (@cfmm.bsky.social) and @jackiesullivan.bsky.social (open science). So engaged!

Congratulations to Samina Panjwani on successfully defending her Masters thesis at @westernu.bsky.social today! Amazing work! @timbussey.bsky.social @lisasaksida.bsky.social @maximoprado.bsky.social

Our latest review on perimenopause menopause and hormone therapy. What key issues have we missed and how can we do better from education to research to clinical care. With Laura Gravelsins! www.cambridge.org/core/journal...

For #fluorescencefriday the Mesoscopic Integrated NeuroImaging Data (MIND) platform @westernu.bsky.social presents abeta plaques and blood vessels in the 🧠 of our ApoE4 mouse model of AD. 🧪 #clearing #lightsheet 🔬 Courtesy of Arash Salahinejad, Luke Smolders and @shahrzadbahrampour.bsky.social

🚨 NEW PAPER ALERT 🚨 🚨 KLAXON KLAXON 🚨 Impaired Cognitive Flexibility With Preserved Learning in an Amyloid Precursor Protein Knock-In Mouse Model of Amyloidopathy onlinelibrary.wiley.com/doi/10.1111/...

#fluorescencefriday a 🧠 full of amyloid courtesy of @shahrzadbahrampour.bsky.social

Well done to all of our affiliated presenters at this year's @canacn.bsky.social Meeting! Great work!

#fluorescencefriday we take a look at blood vessels (yellow CD31) and amyloid (blue).

This is finally out! Great collaboration with Andy Holmes @timbussey.bsky.social @lisasaksida.bsky.social and @touchscreencog.bsky.social @westernubrainscan.bsky.social trainees www.nature.com/articles/s41...

We are looking for a #labmanager with technical expertise to oversee operations at the Translational Cognitive Neuroscience Lab at @westernu.bsky.social and related areas in two core facilities. Search ID 39142 at: recruit.uwo.ca