@kateonuska.bsky.social
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reposted by
Hugo Spiers
7 days ago
Repeated head trauma causes neuron loss and inflammation in young athletes in
@nature.com
www.nature.com/articles/s41...
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Repeated head trauma causes neuron loss and inflammation in young athletes - Nature
Repetitive head impacts from contact sports are associated with brain inflammation, vascular damage and neuron loss that are independent of hyperphosphorylated tau pathology.
https://www.nature.com/articles/s41586-025-09534-6
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reposted by
Marco A. Maximo Prado
about 1 month ago
Latest paper is Vlad Novikovās careful analysis of proteostasis in a TDP-43 mouse model A Longitudinal Study of Sex Differences in a TDPā43 Mouse Model Reveals STI1 Regulation of TDPā43 Proteinopathy and Motor Deficits - Journal of Neurochemistry -
onlinelibrary.wiley.com/doi/10.1111/...
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A Longitudinal Study of Sex Differences in a TDPā43 Mouse Model Reveals STI1 Regulation of TDPā43 Proteinopathy and Motor Deficits
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by abnormal accumulation of the RNA-binding protein TDP-43. Using a mouse model that mildly overexpresses human ...
https://onlinelibrary.wiley.com/doi/10.1111/jnc.70204
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1:00-2:00 PM but same location š
add a skeleton here at some point
about 1 month ago
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reposted by
Marco A. Maximo Prado
2 months ago
Hot off the press Huge congrats to Alycia Crook a PhD student from the lab
www.nature.com/articles/s41...
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Characterization of a novel transgenic mouse model to investigate brain-wide activation of astrocyte Gq signaling - Lab Animal
This study uses a transgenic mouse line expressing Cre-inducible astro-hM3Dq to study astrocytesā role in neuroinflammation and cognition without the use of viral transduction, mitigating the potentia...
https://www.nature.com/articles/s41684-025-01587-4
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reposted by
Marco A. Maximo Prado
3 months ago
Grad student extraordinaire
@kateonuska.bsky.social
dropped this preprint
www.biorxiv.org/content/10.1...
using multimodal imaging, behavior, š and human datasets to show how cholinergic plasticity regulates resilience to Alzheimerās pathology. Led by Taylor Schmitz š§Ŗ
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Cholinergic synaptic plasticity shapes resilience and vulnerability to tau
Synaptic dysfunction is a hallmark of Alzheimerās disease (AD). Yet due to their plasticity, synapses may also adapt to early AD pathology. Using within-subject positron emission tomography scans targ...
https://www.biorxiv.org/content/10.1101/2025.05.27.656174v1
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