www.nejm.org/doi/full/10.... There’s some trial data on prevention of albuminuria #nephjc

T2l Initiation of 2 first-line agents is still recommended for Stage 2 HTN but there is a new emphasis on using single-pill combinations. One pill goes down easier than two! What’s your favorite combo pill? Not using combo pills – what’s holding you back? #NephJC www.thelancet.com/jo...#NephJC

Check out the insightful VA that makes sense of the updates 🧠 #nephjc VA by @sejalplakhani.bsky.social

Hi everyone! Pallavi from New Delhi. no COI. #NephJc

Finally, the concurrent results of the ALCHEMIST trial (www.sciencedirect.co...) also showed that spironolactone did not reduce major cardiovascular events in older, high-risk hemodialysis patients. #NephJC Infographic by @nephroseeker.medsky.socia

Hi everyone! Pallavi from New Delhi, joining #Nephjc after a long hiatus. lurking today .. No COI.

The #NephJC editorial team knows that plenty of papers deserve attention between our bi-monthly, full-length discussions ✨Enter #NephJCShorts - quick hits with a critical eye 🦅 on high-impact reads www.nephjc.com/news/nephjc-... #MedSky #NephSky

Hi everyone! Good morning from Kerala, God's own country. will be lurking today. COI: flozinator >> RAASblocker

From Rivka Galchen’s article in @newyorker.com: “The kidney, a tremendously under-celebrated organ, basically does four-dimensional sudoku with ions.” And that’s how I’m going to explain it from now on.

Hilarious (and sobering) essay on the use of AI in medical research & manuscript writing Read the whole thing! John Daugirdas has been on the cutting edge of tech in meded before #MedEd was thing onlinelibrary.wiley.com/doi/10.1111/... #MedSky #NephSky

1/10 Last #NephJC we discussed the role of prophylactic DDAVP for preventing post kidney biopsy (KBx) bleed #TenPostNephJC . The articles 👇 @kireports.bsky.social @asnpublications.bsky.social @jeyakumarmeyyappan.bsky.social www.kireports.org/article/S246... pubmed.ncbi.nlm.nih.gov/40067357/

Again in the haemostasiology world, we do not favour the use of bleeding times. The trend is toward viscoelastic methods and thrombin generation assays. These need to be studied in nephrology too. #NephJC

Don´t forget to advocate the resolution led by Guatemala on #WHA78: 🌍 Chronic kidney disease affects over 850M We must shift from silent neglect to strategic action. Awareness, prevention, and equity in care are our next steps. #NephJC @theisn.org #NephSky #MedSky www.thelancet.com/jo...

Hi everyone! Pallavi from New Delhi. No COI. Have used desmopressin for high risk patients #Nephjc

Alright #PedNeph #NephTwitter ⁦‪#NephJC What do you think? Truly a comparative effectiveness trial? Tacrolimus or Mycophenolate Mofetil for Frequently Relapsing or Steroid-Dependent Nephrotic Syndrome: A Randomized Clinical Trial jamanetwork.com/journals/jam...

1/10 We were delighted to discuss the first ever @KDIGO ADPKD guidelines this March! So satisfied with the chat itself that we forgot to post the #TenPostsNephJC 😉 So here we are! Better late than never.#NephJC kdigo.org/guidelines/a...

We are pleased to announce the publication of the KDIGO 2025 Guideline for Nephrotic Syndrome in Children—an update to Chapter 4 of the KDIGO 2021 Glomerular Diseases Guideline. 📄 Read in @kidneyint.bsky.social: kdigo.co/Nephrotic-Sy... 🧵More below ⬇️

Nephro-pharmacists like Wendy St Peter are trying very hard to educate across disciplines with their learning collaborative AKHOMM (dont think theyre on bluesky but will let them know!) www.kidneymedicationmanagement.org pubmed.ncbi.nlm.nih.gov/39552516/

T3c: #nephjc 🔸7% survival boost with continued metformin in CKD4+ challenges current restrictions 🔸Benefit persists despite observational design, bolstered by rigorous target-trial methods 🔸Aligns with prior data showing glycemic deterioration post-discontinuation

T0i: #NephJC Evidence supporting strict metformin discontinuation in CKD is limited. MALA risk it’s the "acid-ental perfect storm" made by pH and low eGFR. It often occurs with acute stressors like heart failure, sepsis, shock, or AKI, which can happen at any GFR

Hi everyone! Late to #NephJC and lurking today despite being really interested in this topic. Recovering from a bad viral 🤕. No COI.

Hey #NephSky & #MedSky 9pm EST 4/15/25, only on #Bluesky Discussion on the use of metformin in advanced CKD. Worried about lactic acidosis 💪?! What's the evidence that an eGFR < 30 ml/min is the ideal cutoff ✂️? Are there benefits to continuing 💊 www.nephjc.com/news/metformin-tte

Hey #NephSky and #MedSky Check out the VA for our discussion 4/15/25 at 9pm EST Metformin-Should I Stay or Should I Go (in patients with advanced CKD) VA by @nephroseeker.medsky.social www.nephjc.com/news/metformin-ckd-va

The @ukkidney.org guidelines are very on point with both MIC and PROPKD when it comes to prognosis—they make clinicians' job easier #nephjc www.ukkidney.org/sites/defaul...

Hypertension in ADPKD starts early & drives progression. 🎯 BP goals? if age 18–49 & eGFR >60: ≤110/75 mmHg #HALT-PKD says: lower is better (maybe). #NephJC

Go as low as possible with BP Before SPRINT was HALT-PKD (NIH funded) which established intensive BP lowering for ADPKD www.nejm.org/doi/full/10.... Lead by the late Bob Schrier #NephJC

This infographic has a past history. Presented a case of ADPKD post transplant with BKVN to a faculty member during my training. I thought i was well prepared with the case but my entire viva was on ADPKD differentials rather than transplant or BKVN 😂 ...and I was Jon Snow..i Knew nothing #NephJC

Genetic testing isn’t always needed but consider it when: 💼 Unclear imaging 👶 Pediatric cases 📊 Risk stratification #NephJC

Hi everyone! Pallavi from New Delhi. no COI #NephJC

🎨 Don't miss the stunning visual abstract by @nephroseeker.medsky.social

Happening this week! The @kdigo.org guidelines in #ADPKD #PKD on #NephJC www.nephjc.com/news/adpkd-k... Summary from @brianrifkin.bsky.social

⚠️ The FDA has approved oral iptacopan to treat proteinuria in adults with C3 glomerulopathy. This is the first FDA-approved treatment for C3G. #fda #c3glomerulopathy #c3g #kidneydisease #nephrology #nephsky

Ugh This is a nephrologist (And an NSMC internship grad) #NephSky #MedSky

Not lastly, #NephSky #MedSky ✨This year we try something new: #nephjc internship If curious, wanna apply, need to be part of our world-wide community, apply 👇

T3d: Here are the trials with cell B blockers (yeah, induction, refractory LN, or whatever). Any notable differences in their design? #nephjc

Two questions #NephJC 1.Do we have data on B cell depletion from Regency 2. Also, pardon my ignorance but do we have a head to head obin vs ritux showing better B cell depletion?

The IgA field is getting overcrowded though Recent local rounds youtu.be/OChs5BcTEGE?... #NephJC

T0l: #NephJC Type II anti-CD20 mAbs (e.g., obinutuzumab) induce stronger B-cell cytotoxicity and enhanced phagocytosis, resulting in deeper and more sustained depletion, including in tissue-resident B-cell niches

T0g: #NephJC A post-hoc LUNAR trial analysis found that better LN remission correlated with complete, sustained B-cell depletion, highlighting response variability based on depletion effectiveness pubmed.ncbi.nlm.nih....#NephJC

Hi everyone! Pallavi from New Delhi #NephJC. COI: My mind is diverted - planning for Holi (festival of colours) celebrations!💙💚💛❤️🤎🤍🧡

Prospective cohort in Alport's syndrome (values are approx) 🧬60% X linked, 20% auto dom /compound heterozygous, rest AR 📉eGFR trend -6 ml/min/y for X linked♂️ VS +0.6 ml/min/y for X linked ♀️ VS -1.6 in autosomal heterozyg 🧪eGFR trend -10 ml/min/y for UPCR >1g/g VS -1ml/min/y for UPCR <1g/g

1/10 Last #NephJC we continued our Aldo streak as we discussed mineralocorticoid antagonist (MRA) withdrawal before ✅aldosterone renin ratio (ARR) & adrenal vein sampling (AVS) #NephSky #MedSky #TenPostNephJC makes this #Endosky oriented topic easy. pubmed.ncbi.nlm.nih.gov/39660429/

I got a link to the new Endocrine Society guideline for primary aldosteronism (draft open for public comments). www.surveymonkey.com/r/endopacpg >Suggests screening all individuals with hypertension >Proposes various strategies re: handling of confounding BP meds during testing #NephJC #Nephsky

The ARMS RCT - unsupported arm ⬆️ SBP by approx 6 mmHg and arm supported in lap ⬆️ SBP by approx 4 mmHg Takeaway : support the patient arm on desk while taking BP and support guidelines ! 😄 #Nephsky #MedSky

Only 33% of dialysis patients were women. Of 658 transplants performed in this patient pool over 15 yrs, most recipients were men. Women made up 73% of living kidney donors. When women needed kidneys, 58% received the organ from another woman. ApexKidneyCare & @iitbombay.bsky.social study @ #ISNWCN

Announcing the #NephJC internship, @nephjc.bsky.social and @kireports.bsky.social joining forces www.nephjc.com/intern-app for details and to apply! #NephSky

While reading for summary, I found this trial, showing that ARBs rather influence hyperaldo dx, compared with canrenone #nephJC pubmed.ncbi.nlm.nih.gov/32067030/

💡 Current guidelines recommend a stepwise approach: 🩺 Case detection on high-risk patients 🧪 Confirmatory tests 📌 Subtype evaluation (imaging + AVS) #NephJC

🚨 PA: A Massively Underdiagnosed Threat! 🤯 📊 <2% of high-risk patients are screened & <1% diagnosed—despite PA’s high prevalence! 📈 PA increases CV risk ⚠️! Are we missing too many cases? 🤔 #NephJC