Jogi Madhuprakash
@jmadhuprakash.bsky.social
📤 179
📥 1263
📝 13
pinned post!
🚨 New @biorxivpreprint alert! 🚨 We are thrilled to share our latest findings—building on our earlier work on suppressors of helper NLRs of the NRC family—a Phytophthora infestans L-shaped effector captures resistosome assembly intermediates of tomato NRC3!
www.biorxiv.org/content/10.1...
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3 months ago
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reposted by
Jogi Madhuprakash
Ben Engel
11 days ago
Time for a thread!🧵 How different is the molecular organization of thylakoids in “higher” plants🌱? To find out, we teamed up with
@profmattjohnson.bsky.social
to dive into spinach chloroplasts with
#CryoET
❄️🔬. Curious? ..Read on!
#TeamTomo
#PlantScience
🧪 🧶🧬 🌾
elifesciences.org/articles/105...
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Jogi Madhuprakash
Caitie McCafferty
13 days ago
I am excited to share our new preprint on the CAGE complex, a mysterious hollow protein complex that I first saw years ago while surveying Tetrahymena ciliary lysate
www.biorxiv.org/content/10.1...
#cilia
#protistsonsky
🧬🧪
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Jogi Madhuprakash
Oli Clarke
about 1 month ago
Was lucky to see this presented at the NYC cryoEM meeting earlier this year - super cool stuff!
add a skeleton here at some point
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Jogi Madhuprakash
Nature Reviews Immunology
2 months ago
NEW Review from
@soreklab.bsky.social
@dinahoch.bsky.social
explains how immune pathways manipulate the availability of nucleotides, chemically modify nucleotides to generate immune signalling molecules, and produce altered nucleotides that poison viral replication
#immunosky
#microsky
#phagesky
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Manipulation of the nucleotide pool in human, bacterial and plant immunity - Nature Reviews Immunology
Modification of the nucleotide pool is emerging as key to innate immunity in animals, plants and bacteria. This Review explains how immune pathways conserved from bacteria to humans manipulate the nuc...
https://www.nature.com/articles/s41577-025-01206-w?utm_source=bluesky&utm_medium=social&utm_campaign=nri
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Jogi Madhuprakash
Gitta Coaker
2 months ago
Excited this paper is finally published! We focused on the inner concave surface of LRR RKs to expand bacterial flagellin perception in plants. Selection indicates expanded perception is more common than previously thought. Experiments led by
@jerrytli.bsky.social
www.nature.com/articles/s41...
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Unlocking expanded flagellin perception through rational receptor engineering - Nature Plants
Receptor kinase FLS2 detects the flg22 epitope of bacterial flagellin. Here the authors identify key residues on FLS2’s concave surface that enable expanded perception of flg22 variants, allowing the ...
https://www.nature.com/articles/s41477-025-02049-y
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🚨 New @biorxivpreprint alert! 🚨 We are thrilled to share our latest findings—building on our earlier work on suppressors of helper NLRs of the NRC family—a Phytophthora infestans L-shaped effector captures resistosome assembly intermediates of tomato NRC3!
www.biorxiv.org/content/10.1...
1/10
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3 months ago
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12
reposted by
Jogi Madhuprakash
Sophien Kamoun
3 months ago
A co-IP masterclass. Courtesy of Madhu
@jmadhuprakash.bsky.social
add a skeleton here at some point
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Jogi Madhuprakash
bioRxiv Plant Bio
3 months ago
A plant pathogen effector blocks stepwise assembly of a helper NLR resistosome
https://www.biorxiv.org/content/10.1101/2025.07.14.664264v1
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