A brilliant explainer from The Lily Foundation on the science behind genetic diagnosis in mitochondrial disease — featuring cake as a metaphor! 🍰 youtu.be/MCx4joZJtFY #Mito #MitochondrialDisease #GeneticTesting #RareDisease #ClinicalResearch #TheLilyFoundation

A chance to come join Gavin Hudson, Oliver Russell and myself at the Mitochondrial Research Group at Newcastle University. MRC DiMeN Doctoral Training Partnership: Fuelling the Fight: The role of Innate Immunity in Mitochondrial Disease at Newcastle University. www.findaphd.com/phds/project...

Exciting study from @frisophagy.bsky.social in @chinnery in the Chinnery lab @mrc-mbu.bsky.social. Congratulations to all authors involved in the study! #mitochondria Ubiquitin-mediated mitophagy regulates the inheritance of mitochondrial DNA mutations | Science www.science.org/doi/10.1126/...

Why would anyone want to be a scientist? "Doing good science requires the utmost exertion of body, mind and spirit, yet is consistently filled with failure and rejection." journals.biologists.com/jcs/article/...

Proud to share an exciting study on the metabolic changes observed in the body before the spread of breast cancer. This seminal work could pave the way for early interventions and more positive outcomes for patients. Congratulations to all involved! www.embopress.org/doi/full/10....

There's a live job ad for a Post-Grad or Post-doc level Bioinformatician position withing the Newcastle Mitohondrial Research Group @mitonewcastle.bsky.social, funded through the LifeArc Centre for Rare Mitochondrial Diseases www.jobs.ac.uk/job/DNW541/r...

8 healthy babies after Mitochondrial Donation treatment - Press Office - Newcastle University share.google/iaZoEyfgHHd9...

A big day for preventing mitochondrial diseases from transmitting to the next generation www.nature.com/articles/d41... www.nejm.org/doi/full/10.... www.nejm.org/doi/full/10.... www.nejm.org/doi/full/10....

Massive congratulations to @lucialugut.bsky.social on receiving the prestigious 2025 CSAR Award! 🎉 Lucia's groundbreaking work in modeling and correcting mtDNA mutations paves the way for innovative future therapies for mitochondrial diseases. @mrc-mbu.bsky.social www.csar.org.uk/student-awar...

📢 Exciting 3-year funded PhD opportunity 🧠 Prof Bobby McFarland and Dr Laura Smith are advertising for a PhD student to join their lab at the Newcastle Mitochondrial Research Group. 📅 Closing date: 16th July 2025 ⏰ Start date: 15th September 2025 To apply: www.findaphd.com/phds/project...

Yesterday, @carlbergstrom.com presented his course "Modern-day Oracles or BS Machines? How to thrive in a ChatGPT world". Neat way to make students aware of the capacities and limitations of LLMs👇🎰 Recording: www.youtube.com/watch?v=TZC0... Course: thebullshitmachines.com @unswbabs.bsky.social

We are excited to join friends and colleagues from @lilyfoundation.bsky.social , @mdukcharity.bsky.social , @uniofcam.bsky.social and @ucl.ac.uk at the House of Lords to launch the new LifeArc Centre for Rare Mitochondrial Disease #mitodisease

Congratulations Rob!!! @taylorlabncl.bsky.social www.ncl.ac.uk/press/articl...

Meet the minds behind the LifeArc Centre for Rare Mitochondrial Diseases Hear the excitement from the project leads as they hope to transform the mitochondrial research landscape, and meet mito patient Harry, who reminds us why this work matters www.thelilyfoundation.org.uk/affected-by-...

Perfect title to this article: “When everything is a master regulator, nothing is”

I was connected by a writer from The Scientist magazine who was interested in some of my work. Here is what they wrote: www.the-scientist.com/mitochondria...

@newcastleuni.bsky.social @nihrnewcastlebrc.bsky.social @medicalsciencesncl.bsky.social @neygenomics.bsky.social

What to find the Bluesky acount for one of our researchers? Here' a handy-dandy starter pack for you. go.bsky.app/98NSnmp

We’re proud that the @lifearc.bsky.social Centre for Rare Mitochondrial Diseases has officially launched at a prestigious House of Lords event – a significant milestone in transforming the UK’s rare disease research landscape Stay tuned to meet the lead minds behind the centre on our Research Zone!

"I think that the word is being misused. Extinction's forever. It's irreversible...I think it's a really dangerous precedent to claim we can fix some of these irreversible problems," @dieterhochuli.bsky.social says on the podcast. The U. of Sydney ecologist unpacks what's wrong with 'de-extinction'

Latest from Jonas Treebak and team @cbmr.science NAD depletion in skeletal muscle does not compromise muscle function o... www.sciencedirect.com/science/arti...

The de-extinction of the dire wolves? "Colossal Baloney"— @stemcells.bsky.social www.latimes.com/business/sto... @latimes.com by @hiltzikm.bsky.social

Check out also our post to see how the @mrcharwell.bsky.social contributed to the work and what we think it will me for #preclinical in vivo studies and better #TranslationalResearch outcomes www.har.mrc.ac.uk/news/new-fra...

Two mtDNA papers of ours in one PNAS issue: #1 on the Y951N patient mutation of PolG, heroically spear-headed by Josefin Forslund #2 revealing surprising dNTP imbalance & subsequent mtDNA depletion in RRM2B-deficient mice, a great collaboration with the Chabes lab www.pnas.org/toc/pnas/122...

🚨 Join us for the @faseborg.bsky.social Meeting on Mechanisms of Mitochondrial DNA Mutation and Repair, June 1 - 5, 2025 | Nashville, Tennessee. 📅 Abstract submission & Early Registration close on April 20, 2025! Don't miss out: events.faseb.org/event/mitoch... Please re-post!

Spatial analysis of mitochondrial gene expression reveals dynamic translation hubs and remodeling in stress | Science Advances www.science.org/doi/10.1126/...

Good science from Josefin Forslund and our team: The POLγ Y951N patient mutation disrupts the switch between DNA synthesis and proofreading, triggering mitochondrial DNA instability | PNAS www.pnas.org/doi/10.1073/...

Such a great day and opportunity to work together as a UK mitochondrial research community going forward! @mitonewcastle.bsky.social @drperscitus.bsky.social @sarahjpickett.bsky.social @mtrost.bsky.social @jim-ca.bsky.social @newcastleuni.bsky.social @medicalsciencesncl.bsky.social

It was a great day and a fantastic #PPIE workshop!! @lifearc.bsky.social @ritahorvath.bsky.social @jellevda.bsky.social @robpitceathly.bsky.social @taylorlabncl.bsky.social @dwong47.bsky.social @mitogene.bsky.social @mrc-mbu.bsky.social @mitonewcastle.bsky.social @uclqsion.bsky.social

Yesterday we were proud to join the launch of the LifeArc Centre for Rare Mitochondrial Diseases - a major step forward in mito research We led a workshop on making complex science clear – because involving patients is key to success #mitochondrialdisease #mitoresearch #patientvoice #raredisease

Very full schedule at our #IMGCglasgow workshop last week, delivered by MitoCluster team @robpitceathly.bsky.social, Carlo Viscomi, @mitogene.bsky.social, and @jim-ca.bsky.social. A pleasure to attend, thanks for the invite @mrcmousenetwork.bsky.social & IMGS! 🧬 #mitochondria #MouseModels #ECR

New paper out from the Falkenberg and Gustafsson labs. Thanks to Pretzel for a successful collaboration. www.nature.com/articles/s41...

Congratulations Maria et al.!!! @mito-at-bsky.social www.nature.com/articles/s41...

Shared from another social media site. Seemed topical given the post-publication peer reviews on the "dire wolf" going on here....

Workshops in full swing with two of them led by us. Robert Pitceathly and Carlo Viscomi of the MitoCluster with Andrew Wood of the Degron Cluster running the Mouse models of mitochondrial DNA disease workshop. Sara Wells and Sonia Bains running the Home cage monitoring one. #IMGCGlasgow #ECRS

The 2025 @bsdb.bsky.social Wolpert Medal goes to Pleasantine Mill @cilialab.bsky.social 🎉 In this interview, Pleasantine talks about why it’s important, now more than ever, for scientists to engage in community work: thenode.biologists.com/an-interview...

Exciting News: Learn about the Speakers of Euromit 2026! We are happy to announce the amazing speakers for Euromit 2026, the leading congress on mitochondrial pathology.🌍✨ 📢 See the full list ! 👇 #euromit2026 #mitochondria #science #innovation #angers

Looking forward to #IMGC2025 Glasgow next month! MitoCluster will be delivering an #ECR Workshop on Mouse Models of #Mitochondrial DNA Disease, featuring cluster lead @robpitceathly.bsky.social and investigators Carlo Viscomi, @jim-ca.bsky.social, and @mitogene.bsky.social🐁

🧪In human evolution circles, it seems that the splitters drove the lumpers to extinction. "...in the history of all modern humans, in which two ancestral populations that diverged ~1.5 million years ago came together in an admixture event ~300 thousand years ago..." www.nature.com/articles/s41...

University College London is seeking a Research Fellow to develop novel nucleic acid therapy approaches for rare disorders, focusing on developing and validating adeno-associated virus (AAV) split vector strategies and possibly additional approaches www.dementiaresearcher.nihr.ac.uk/job/research...

As part of this, Newcastle University is highlighting two women from the Mitochondrial Research Group, who are accelerating action towards equity in their fields, embodying this year’s theme: @joannaelson.bsky.social and @vdileo.bsky.social Congratulations! #WeAreNCL 💜

It requires the addition of two prokaryotic transgenes to facilitate efficient end-joining in mtDNA to engineer mtDNA deletions. First Point – Very cool work Second – Please remember this when someone claims CRISPR transgenesis is success in animal mtDNA. 🧪 www.sciencedirect.com/science/arti...

🌍Euromit 2026 is coming to Angers!🌍 ✨The international congress dedicated to mitochondrial research, will take place in France, at the Centre des Congrès of Angers. from May 31 to June 4, 2026! ✨ 📢 Stay informed by following this page and get ready for an exceptional scientific experience! 🚀🔬

REGISTRATION OPEN for @faseborg.bsky.social Meeting on Mechanisms of Mitochondrial DNA Mutation and Repair | June 1 - 5, 2025 | Nashville, Tennessee. Apply before it is too late: events.faseb.org/event/mitoch... Please re-post!

It is believed that proton conductance by the mitochondrial uncoupling protein (UCP1) is inhibited specifically by purine nucleotides, but we show that pyrimidine nucleotides also inhibit UCP1 with similar affinities in a pH-dependent manner. #mitochondria www.embopress.org/doi/full/10....

🍾Bursting with pride and joy! Watching you grow as a scientist and individual has been incredible. Congrats, Jon, on truly earning your 🎓PhD! Thanks to all the amazing support @taylorlabncl.bsky.social @cgm-newcastle.bsky.social @mitonewcastle.bsky.social and examiners Ray O’Keefe and Tom Nicholls!

A belated congratulations to @imogenf.bsky.social for passing her PhD viva last month. Imogen’s work aims to understand the negative selection of mtDNA variants in blood. Many thanks to @jim-ca.bsky.social and @ryanlab.bsky.social for being great examiners!