Thrilled to announce our new paper in @natneuro.nature.com! We managed the impossible: precision functional mapping during #DBS, with 11.7h fMRI/patient. Selective DBS-induced deactivations in the SCAN, building on our recent @nature.com paper. nature.com/articles/s41... @ndosenbach.bsky.social

Please support Lead-DBS by buying our Lego Kit. Its also fun!

New preprint: Revisiting the methodological foundation of lesion network mapping. doi.org/10.64898/202... A thread.

A recent paper in @natureportfolio.nature.com raised concerns about the lesion network mapping method. Our team of 16 coauthors analyzed >1000 lesions and 34 symptoms and found that "The methodological foundations of lesion network mapping remain sound" www.biorxiv.org/content/10.6...

A recent @natneuro.nature.com paper analyzed lesion network mapping and raised concerns about the validity of the method. See below 👇 for our response. www.biorxiv.org/content/10.6...

(3/4) PIET includes 45 essential tremor patients, also with 30-minute scans. Download link: doi.org/10.57760/sci...

A recently discovered brain network that links cognition and actions may have an important role in Parkinson’s disease and could improve its treatment, according to a study in Nature. go.nature.com/49VBuKI #Neuroskyence 🧪

More excellent reporting by NPR's Jon Hamilton about a new brain network that explains symptoms of Parkinson's that have befuddled brain researchers for decades. Kudos to @jianxunren.bsky.social and Hesheng Liu for this groundbreaking research in the journal Nature! doi.org/10.1038/s415...

In case this important point gets overlooked: along with our Nature paper, we’ve publicly released two large and scarce datasets—PIPD and PIET. IMHO, these are the best open Parkinson's and Tremor datasets available to date. See threads (1/4) 👇 nature.com/articles/s41...

Good news for Parkinson's sufferers. These researchers should review recent papers on Essential Tremor. ET researchers have identified the back of the brain as the ET problem area, the same area identified as part of the Parkinson's problem. Potential for beneficial cooperation. (I have ET.)

#Medsky🧪 #IDsky #Neurosky #publichealth @nature.com This study has redefined #ParkinsonsDisease (PD) as a disorder of the Somato-Cognitive Action Network (SCAN), a brain system that integrates whole-body movement, cognition, and internal physiological states www.nature.com/articles/s41...

Nature research paper: Parkinson’s disease as a somato-cognitive action network disorder go.nature.com/4aemciV

Targeting the somato-cognitive action network (SCAN) rather than motor regions doubles efficacy of TMS treatments for Parkinson’s disease. Seems that various DBS targets for Parkinson’s are selectively connected to the SCAN rather than effector-specific motor regions.🧪 www.nature.com/articles/s41...

The highlight of my week was the publication of "Parkinson’s disease as a somato-cognitive action network disorder" in @nature.com. It's a great paper that shows how conceptual changes in fundamental neuroscience - the discovery of SCAN - can improve treatment 🧪 www.nature.com/articles/s41...

Breakthrough @nature.com study showcases new non-invasive treatment for Parkinson’s Disease that targets the somato-cognitive action network (SCAN) with personalized neuromodulation, for superior outcomes. www.nature.com/articles/s41...

Game-changer for PD therapy! Our @Nature study shows targeting the SCAN network with non-invasive brain stimulation doubles efficacy—no surgery needed. #Therapy #BrainScience #HealthTech nature.com/articles/s41...

Check out our new work on the relationship between glioma and system-level functional networks! We identify that nearly all gliomas localize within a common brain functional network, Action-Mode Network (AMN) . biorxiv.org/content/10.64898/2026.01.05.697608v1

I’m very excited about this new work describing the specific cortical-striatal circuits that are altered in Parkinson’s Disease and that should be targeted for optimal PD treatment. www.nature.com/articles/s41...

Happy to share a short but super cool video that gives a quick overview of our Nature paper on the somato-cognitive action of netwokr in Parkinson's disease www.nature.com/articles/s41...

Non-invasive brain surface stimulation targeting personalized SCAN alleviated symptoms in patients with Parkinson’s disease. See the videos below.(www.nature.com/articles/s41...)

www.nature.com/articles/s41... the original research article ... no paywall

A recently discovered brain network that links cognition (thinking) and actions may have an important role in Parkinson’s disease and could improve its treatment, according to a study published in Nature: spklr.io/63320DMwOi #Neuroscience #Neuroskyence #Parkinsons 🧠 🧪

Very interesting findings! Gliomas selectively locate within in the Action-mode Network, using glioma network mapping derived from lesion network mapping @foxmdphd.bsky.social

Why are gliomas overwhelmingly found in the action-mode network (AMN)? Could its function be contributing or is it that its function lines up with gene expression & receptor patterns? Either way, it raises the possibility of using inhibitory neuromod of the AMN to treat gliomas. #cancerneuroscience

It’s time to rethink Parkinson’s disease. Our work reframes PD as a disorder of the somato-cognitive action network (SCAN), and shows that normalizing SCAN connectivity represents a shared mechanism across diverse effective therapies. rdcu.be/e2n4t @ndosenbach.bsky.social @gordonneuro.bsky.social

A recently discovered brain network that links cognition and actions may have an important role in Parkinson’s disease and could improve its treatment, according to a study in Nature. go.nature.com/49VBuKI #Neuroskyence 🧪