Guardian link: www.theguardian.com/lifeandstyle...

MASSIVE RCT from Kenya showing that steroids reduce mortality in CAP Mortality benefit easier to demonstrate w/ less resources available to salvage pts Should allay the hype that the negative REMAP-CAP steroid RCT received (despite being woefully underpowered) www.nejm.org/doi/pdf/10.1... #EMIMCC

The BICAR-ICU-2 trial just dropped! RCT involving IV bicarb in metabolic acidosis among patients with mod-severe AKI Bicarb didn't affect mortality but it reduced the need for dialysis & risk of bacteremia VERY similar conclusions to BICAR-ICU-1 🧵 #1/ jamanetwork.com/journals/jam... #EMIMCC

@gradydoctor.bsky.social What an inspiring talk by Dr. Manning at APDIM! #APDIM

AQUATIC: More Than 6 Months After PCI, Don’t Use Aspirin With OAC

HI-PRO: Oral Apixaban for 1 Year Protective, Safe in Provoked VTE Patients

Ticagrelor wasn’t superior to BID clopidogrel at 1 month post-#PCI, with similar bleeding, but reduced #MACE in the first 2 weeks. https://bit.ly/46eOmcU #ESCCongress #WCCardio #JACC #CardioSky #MedSky

Beta-Blockers after Myocardial Infarction without Reduced Ejection Fraction. www.nejm.org/doi/full/10.... @nejm.org @escardio.bsky.social #CardioSky #ESCCongress #WCCardio

In patients undergoing #PCI, a personalized #DAPT duration from 3 to 24 months based on a clinical risk score led to a lowered risk of net adverse clinical events than standard care consisting of 12 months of DAPT. https://bit.ly/47pBB0l #JACC #ESCCongress #WCCardio #CardioSky

10K is popular but this study shows; there may not much more gain beyond 7k. Easier to achieve for some folks. Daily steps and health outcomes in adults: a systematic review and dose-response meta-analysis - The Lancet Public Health www.thelancet.com/journals/lan...

🤔 www.huffpost.com/entry/white-...

In fiscal year 2024, the report found, NIH awarded more than $36.9 billion to researchers, supporting more than 408,000 jobs and generating over $94.5 billion in new economic activity nationwide. news.harvard.edu/gazette/stor...

99% of new medicines developed by the pharmaceutical industry depend on NIH research jamanetwork.com/journals/jam...

Rep John Larson - Connecticut:

IDSA-"There have been no deaths shown to be related to the MMR vaccine in healthy people. There have been rare cases of deaths from vaccine side effects among children who are immune compromised, which is why it is recommended that they don’t get the vaccine."#IDsky www.idsociety.org/public-healt...

Remembering a lot of people saying stuff like “I don’t agree with RFK Jr. on everything but at least he’s going to do something about the food that’s making us sick”

Saw a surprising semi-heated debate,on ✓ing Fe panel in a pt w/ ↑MCV anemia (PMH:↓Thyroid,HFrEF, Congestive hepatopathy). Sm against ✓ing 2° ↑MCV~103.Rest in favor as ↓Fe can be present on an ↑MCV too.Thoughts? @shematologist.medsky.social @hannahrabrams.bsky.social @amarkelkar.bsky.social #Hemesky

Just a reminder for people who say things like; "old days", "natural ways in the past", "previous generations..", etc. www.statista.com/statistics/1...

Vaccines...

It is a full fledge assault on medical research. Turning off funding, canceling grants, and disabling the tools we use. It is a complete dismantling of the infrastructure.

JUDGE COLLEEN KOLLAR-KOTELLY: Is there an administrator of DOGE at the present time? GOVERNMENT COUNSEL: I don’t know the answer to that

Government funds account for more than *half* the R&D budget that US universities spend each year—in 2023, that was $60B out of $109B. The gov also does a lot of its own research at national labs like Oak Ridge & Los Alamos and agencies like NOAA and DoD. What are the returns on that investment? 3/

In a small trial, nearly half of pancreatic cancer patients who received an mRNA vaccine had no signs of relapse after three years. Dr. Vinod Balachandran from @mskcancercenter.bsky.social joins us to discuss the results and what they could mean for cancer treatment.

Just a reminder that the HPV vaccine literally PREVENTS CANCER and the series can be started as early as 9 years of age.

It seems inpatient physicians/Hospitalists should own or at least initiate the discussion on EOS for IE. ↓ LOS, ↓ cost, ↑Pt comfort, ↓ burden on Pt/caregivers after DC (less home IV infusions etc), easier DC disposition; all of which falls in their realm #medsky #IDsky

Think primary aldosteronism means hypertension, hypokalemia and metabolic alkalosis...think again. Can undercover hyperaldosteronism be a key to CKD?🔎 #NephJC chat 2/11/25 at 9pm EST #NephSky www.nephjc.com/news/primary...

For folks who are surprised about, or shocked by, Vance calling on Trump to ignore judges, he’s been saying it for a while but much of our political press wasn’t paying attention:

NIH funding, jobs supported, and economic activity supported, for Texas. #medsky #NIH Can look up any state here: www.unitedformedicalresearch.org/nih-in-your-...

Trying to find the logic behind this and the freezing of PEPFAR. Will make US population more vulnerable to communicable diseases and more. CDC ordered to stop working with WHO immediately, upending expectations of an extended withdrawal search.app/zhhGuLFMPk1U...

Fantastic, path-breaking research with results! Foot note says, "Supported by grants from the National Heart, Lung, and Blood Institute and a grant from the National Center for Advancing Translational Sciences" Both NHLBI and NCATS are part of the NIH. (Just a reminder why NIH funding is crucial)

Great! Sounds like perfect timing, if you see it from TB's POV...*SMH* www.cjonline.com/story/news/p...

We had a suggestive case and a Q came up.How often do we see acute respiratory acidosis post HD,due to HCO3 shifts, in pts w/ pulm issues?Saw only a few case reports. #nephsky #pulmsky @kidneyboy.bsky.social @grahamabra.bsky.social @pulmcrit.bsky.social @hswapnil.bsky.social @emilyfri.bsky.social

www.jacc.org/doi/abs/10.1... #cardiosky #medsky

Good to see it support what many of us had noticed anecdotally.

ICYMI: Alcohol’s Harms Last Beyond Active Binge Drinking: MunichBREW II

The upside of A.I. hallucination gift link www.nytimes.com/2024/12/23/s...

Ahem... Supposedly a genius🤦🏽‍♂️🙄

Shame..

"Stop asking why schools don’t have bullet proof glass & metal detectors at all the doors. Ask why schools HAVE to. That’s the question that needs to be asked”

"financial incentives"

There's one reason why we don't see these kinds of pictures in the news anymore...

!!! 🔩🔩

Huh! Wonder why? 🤔 Sounds reasonable though 🙄 www.reuters.com/business/aut...

Just great..

#CCRdownunder attendees, check out these findings from this year's @criticalcarereviews.com meeting 🧵: In critically ill adults w/ suspected sepsis, antibiotic regimens were reduced when guided by measurement of procalcitonin but not by C-reactive protein. ja.ma/49BSvrC

DOGE leaders Ramaswamy and Musk have proposed eliminating all NIH funding, which among other things supports life-saving cancer research, contributing to a 33% decline in cancer death rates over the last 30 years. @morningjoe-msnbc.bsky.social