This is huge: “A drug that provides near-perfect protection against H.I.V. with shots just twice a year will be made available at $40 per patient annually in low- and middle-income countries, offering new hope… making lenacapavir a realistic choice in countries with constrained resources.”

Tuning into the jimmy kimmel monologue and realized i forgot that Lou Wilson is the announcer now. i did many, many Story Pirates shows with Lou. wonderful dude and one of the funniest people i have ever met

Sorry to lib out, but seeing a major network TV personality look straight into the camera and say "this is authoritarian bullshit and you should be disgusted and be part of making it stop" has me feelin a certain way.

rapture thighs around my face, girl. i'm ready to meet god

This guy wanted Secret Service to start firing on UN staffers the moment the escalator stopped

A sleeper political issue of the next few years is the rising costs of electricity. AI & data centers are driving up demand & the Trump Administration is making it harder to add clean energy supply. I joined @chrislhayes.bsky.social on #WITHpod to talk about it: open.spotify.com/episode/32ps...

Kimmel is up on YouTube

Jimmy Kimmel gets emotional while talking about Charlie Kirk's killing: "It was never my intention to make light of the murder of a young man"

Jimmy Kimmel returns to TV: "I want to thank the people who don't support my show and what I believe, but support my right to share those beliefs anyway"

Again, I note the huge overlap between 1) cancel culture terror about supposed totalitarian speech rules of the left, and 2) very rich, powerful men being enraged to discover that social media could be used to accuse them of the sex offences that they have in fact committed

Wait but that’s what real Jackass was, no?

I have a lot of thoughts and opinions about baseball, but chief among them is that a sparsely attended minor league baseball game on a warm afternoon that slides into a cool evening is America. Argue with all the people sitting near you, eat ice cream out of a hat, briefly fall asleep.

Welcome to baseball, baby!

They cared even less than we do.

This may have been the most insane and incoherent four days of his presidency. Tylenol, the U.N., I hate my opponents, other countries are going to hell, this escalator's broken, I'm mad at a TV comedian, I like Ukraine now. It really feels as if some minimal tether to reality has snapped.

I absolutely have to give props to CNN for that thumbnail and opening shot.

even for an unhinged presidency this week has been pretty fuckin unhinged tbh

Damn, you have to work extra hard to slip one past the CA DMV

there are more of us than there are of them

[logging on every day] man what

HAHahahahahHHAHAHHahhahahaha!

HAHahahahahahahahahahahahahahahaaaaaaaa.... [inhale] ..haHA!

Gupta: It is safe. That’s what the best-quality research shows. And how irresponsible, using the podium of the WH to put this out there when you’re not even offering an alternative. That is dangerous. An untreated fever is dangerous. Untreated pain in pregnancy is dangerous.

If it can be believed, the details of this story are actually *worse*. The girl apparently has autism, is a US citizen, and ICE had been chasing them on public roads. The father lived in the US for 22 years. Local cops had to intervene and return the girl. He was arrested two days later.

It's 1100. You're a peasant in Harmston, England. Congrats! It's a fine place to live. But at what cost? Eels. That's what. Each spring, the village owes Earl Hugh 75,000 eels in rent. So every fall your life becomes all about the eels.* Welcome to Harmston. Here's your net. 🗃️🧪

DEUTSCHE: NVIDIA "is currently carrying the weight of US economic growth. The bad news is that in order for the tech cycle to continue contributing to GDP growth, capital investment needs to remain parabolic. This is highly unlikely.” @fortune.com fortune.com/2025/09/23/a...

He won’t face time NOW. For good or for bad, every time I see these people flouting laws and sneering at consequences, I think of @mitchellepner.bsky.social and remember the one true fact about the future.

If Dems put up real candidates in strong R districts next year -- both Congress and state legislatures -- I bet they pick up a bunch of surprising seats. This has the potential to be a highly unusual wave election. But we need horses to have a horse race. Better ppl have to run. For everything.

A federal judge has ordered the Trump administration to restore $500 million in federal grant funding that it froze at the University of California, Los Angeles.

It’s Rapture Eve 🙌 Don’t forget to leave your fillings and implants behind for Satan!

I don’t want to dog on any enthusiasm but the first widely-read case on autism in the U.S. was published in 1943 (Kanner et. al), the term introduced in 1911 (Bleuler), and cases described as early as the 1700s (Tos. Fuller, 1710-1790). Acetaminophen was discovered in 1878 (Northrop Morse).

The whole premise for upholding that regime as constitutional was it's this uniquely important and scarce public resource, and now it's basically irrelevant but that's become the tail wagging the dog.

It's really rather dumb that the ownership and market structure for video content almost nobody actually watches over the air is still built around the legacy regulations for restricting vertical integration in over-the-air tune-your-dial-to-the-right-frequency local broadcasting.

It is indeed end times!

Fuck him up Tylenol.

Tylenol about to make them Dominion Voting Machine lawsuit dollars.

perfect song for the 2025 rapture

I don’t know about the new season of The Pitt

A question for the crackpot heroin addict with a worm eating his brain in charge of HHS. If Tylenol causes Autism why was Autism first identified in 1912 and formally named in 1943 But Tylenol was not invented until 1955? Nor was Tylenol widely available until the early 1960’s. #ProudBlue

I had to see this horror and now so do you. I don’t think you’ll die in seven days, and for that, I am truly sorry.

Only from the science reporters! Jesus, this fucking opinion news media culture. If I wanted an opinion, I’d call my mother.

The NYT liveblog on the autism press conference is a fascinating read -- largely because it's written by health reporters and not political reporters. Look at how direct and appropriately shocked these posts are! www.nytimes.com/live/2025/09...

tired: blocked and reported wired: blocked and raptured

I have not expressed (yet) any autistic superpowers but I *did* help my dad organize his baseball cards for several decades so sign me up on the ally side. 💪

I have taken the Tylenol that was in the medicine cabinet and which they think probably is the reason you like trains forgive me but that’s bullshit you got autism from your dad

I just-

BREAKING: A federal judge has ordered Trump to restore $500 million in frozen UCLA NIH grants. The same judge, Rita F. Lin, previously ordered all UCLA NSF grants reinstated. Lin has now nearly entirely reversed Trump's July de-funding of UCLA research: www.latimes.com/california/s...

I mean, there’s absolutely no way this won’t happen. It’s Kenvue, btw, I assume we’ll all know that by this time next month.

your honor we only said tylenol because the president couldn’t pronounce “acetaminophen”