It’s really too bad Twitter got rid of 3rd party app API’s. It would’ve free to have an app that has feeds from both BlueSky and Twitter/X

In honor of attendance at #EULAR2025 I watched “Vicky Christina Barcelona” on my flight. Plot is a mess but the locale is 🧑‍🍳 😚 Stop me in the hallway if you see me wandering around!

www.freethink.com/biotech/evo-.... —new Al in medicine term to learn: “Generative Biology”. Evo 2, an Al trained on DNA of more than 100,000 species is able to spot patterns in genes across species, identify disease-causing mutations , and even write brand new genomes up to 1 million base pairs long

"In an unprecedented move, the US National Institutes of Health (NIH) has begun mass terminations of research grants that fund active scientific projects because they no longer meet 'agency priorities'" www.nature.com/articles/d41...

CDC invites back about 180 fired employees, including some who help fight outbreaks The employees were laid off about two weeks ago

Researchers are organizing protests and making their voices heard as Trump officials slash funding and lay off federal scientists https://go.nature.com/4koFGpq

The College notes with sadness the death of legendary gastroenterologist Dr. John Fordtran at age 93 on February 23rd Among his contributions to GI was the development of bowel preparation for colonoscopy #GastroSky issuu.com/amcollegegas...

I’m encouraged by the so-far-so-good results of #CAR-T cells in human clinical trials for autoimmune diseases! Side note: If you’re interested in a clever twist of CAR-T, called “CAART,” that could reduce global immunosuppression, check out Dr. Aimee Payne’s work @columbiauniversity.bsky.social

Sat down with former NIH director Monica Bertagnolli yesterday at #aaasmtg to talk about layoffs set to hit the NIH and other agencies “We’re going to lose the next generation, that is the most difficult loss," she said, adding she got very little sleep Friday 🧪 www.statnews.com/2025/02/16/n...

Ferrari cars are often red. A red car is a Ferrari. Wrong? Then why claim this without functional antigen-specif data: Exhausted T cells often express PD-1. A T cell expressing PD-1 is exhausted. It is similarly incorrect. PD'1 and other markers are also expressed on activated and memory T cells.

If are shocked or outraged by this but you haven’t already found ways to channel that, here’s a small starting place - bsky.app/profile/ucsu... Your first step doesn’t need to be big or perfect, it just has to happen. Take it, and then we can figure out the next one.

Are you interested in analyzing small samples from marginalized communities and aren't sure how? My new commentary in AJE's collection on Methods in Social Epidemiology lays out rec's for researchers, public health practitioners, and data owners. DM your email address if you need access.

Explore this gift article from The New York Times. You can read it for free without a subscription. www.nytimes.com/2025/02/10/h... #medsky

The January issue of the journal #Rheumatology is now online. This month includes: 1️⃣ The BAD-BSR Behcet's living guideline 1️⃣ Star Trek quote 👀 4️⃣ Systematic reviews on FMF, Still's, MAS & ILD 7️⃣ Graphical abstracts Plus, the brand new 2025 cover 😍 academic.oup.com/rheumatology...

Good summary of Lipoprotein(a). The next frontier of ASCVD risk/event reduction. Really interesting to see the intersection of Cardiology, Rheumatology, and Hematology. #CardioMetabolic #RheumSky #CardioSky #HemeSky

⚠️ Cytokine Release Syndrome is a serious side effect of #CAR-T cell therapies. This article examines the pathways driving cytokine production in T cells during #immunotherapy: 🔗 doi.org/10.1093/imma... (6/8)

#CAR-T cell therapies, a timeline #RWCS2025 Dr. A. Postolova

Really promising case series n=6 #SScl pts undergoing CD19 targeting #CAR-T cell therapy.⬇️ mRRS, ⬇️ digital ulcers, ⬇️ Raynaud’s attacks and pain, ⬆️ FVC, ⬇️ Scl70 Ab. Minimal cases of cytokine release syndrome and no reported immune effector cell-associated neurotoxicity syndrome #RheumSky

Good review article on the few studies published using #CAR-T cell therapy in SScl. Quick and free read

🌊 Proud to share our new paper showing how during a historic 2022 drought in n. Kenya chronic #stress (via nail cortisol) & high levels of #waterinsecurity were assoc. with ⬆️ levels of inflammation. Climate change negatively affects human health & biology. onlinelibrary.wiley.com/doi/10.1002/...

A: hs-CRP. Covariable-adjusted hazard ratios for the primary end point in comparison of the top with the bottom quintile were 1.70 (95% confidence interval [CI], 1.52 to 1.90) for high-sensitivity CRP, 1.36 (95% CI, 1.23 to 1.52) for LDL cholesterol, & 1.33 (95% CI, 1.21 to 1.47) for lipoprotein(a).

Finally a minimum of 5 trials of orflorglipron reading out in 2025 with the first trial to readout in April or May. As noted it's an oral GLP-1 non peptide drug. It's easily mass produced, requires no special dosing or refrigeration. Lilly expects worldwide launch January 2026 for obesity & DM2

Very pleased to confirm that my research investigating racism and Islamophobia discourses around cardiometabolic disease will be presented at the World Critical Dietetics Conference on the 14th Feb 💞 Tickets can be found at the WCD website: worldcriticaldietetics.org

Worth reposting this and highlighting the monumental work of @fackelmeister.bsky.social and colleagues. #CardioMetabolic #GastroSky #RheumSky #microbiome #plantbased

A dialogue between Chris Hayes and Nicholas Reville on using GLP1-RA drugs to treat addiction. Another exclusive from @addictionnews.bsky.social.

Great illustration from this paper on the tissue distribution of #GLP1 and #GIP receptors and biologic actions. You have my permission to roll your eyes or bang your head on the desk every time a financial analyst refers to these as “obesity meds”. #CardioMetabolic pubmed.ncbi.nlm.nih.gov/37195250/

FLOW study in @nejm.org. MOA for renal protection with SEM likely multi factorial but independent of weight/glycemic control. #GLP1 RA’s reduce glomerular inflammation (⬇️ IL6), reduce fibrosis (⬇️ TGFb), & reduce vascular oxidative stress (⬆️NO, ⬇️ RAS). #RheumSky #NephSky #CardioMetabolic

For any other rheumatologists digging through all the #CAR-T papers, AAV in this case is for Adeno-Associated Viral/Virus. Not to be confused with ANCA-Associated Vasculitis. #RheumSky

One of the biggest scientific breakthroughs of 2024. #CAR-T therapy for autoimmune disease. Imagine a world where patients can receive 1 treatment and be cured! Looking forward to trials in #multiplesclerosis, #neuromyelitisoptica and #anti-MOGassociateddisorder! www.nejm.org/doi/full/10....

As part of our article exchange with @immunolcellbiol.bsky.social, this month we're highlighting the article 'Identification of clonally expanded γδ T-cell populations during CAR-T cell therapy' Read the article exploring immune response after anti-CD19 #CAR-T therapy here: doi.org/10.1111/imcb...

Dr. Shan Liu just called out the Western diet as the "Fast Food" diet and she ain't wrong 😂 And look, the Western diet upped tumor volume... I have a good friend who came back from stage 4 lung cancer after a *massive* diet change, so I find this talk on #keto boosting #Car-T interesting #ASH24 🧪

In November we hosted our first Autoimmune CAR T Symposium at @kingscollegelondon.bsky.social 🏥 It was a pleasure to be joined by an international group of speakers & 170+ attendees 💡 Very happy to share our brief Q&A video from the event here #CARTcell #SLE 🎦 youtu.be/fZnuYHugMjA?...

Our new work on optimising CAR-T cell sensitivity is now on bioRxiv! Optimising CAR-T cell sensitivity by engineering matched extracellular sizes between CAR/antigen and CD2/CD58 adhesion complexes biorxiv.org/cgi/content/...

Anyone know how to extrapolate this data in heme malig’s to autoimmune diseases where there are already auto-reactive T and B cells? #RheumSky #OncSky #CAR-T

Any #academics in my network working in or near the field of #CAR-T therapy? Asking for an industry friend organising a conference, looking for speakers. UK or Europe based preferable.

Anti CD-19 Allogenic CAR-T Cell therapy from #CaribouBioscience. GALLOP phase 1 study in SLE. #RheumSky

Phase I of novel CAR-T therapy for SLE nephritis #SLE #CAR-T #rheumsky

Mitochondrial injury and complement dysregulation are drivers of pathological inflammation in viral myocarditis journals.asm.org/doi/10.1128/...

From the paper “it is not a competition between LDLc and inflammation, but instead that they are partners in crime.” IL-1 beta and IL-6 ravage the vasculature. Holistic lowering of the burden of these cytokines should be a primary target in ASCVD prevention #CardioRheumatology

Well said, and very nice! It’s Time to Bench the Medical Exam Benchmark @roxanadaneshjou.bsky.social @emilyalsentzer.bsky.social ai.nejm.org/doi/full/10....

My segment on @cnbc.com on the ensuing cough and cold season, and vaccine policy in the U.S.

Dismantling the #NIH will be incredibly destructive to medical research and discovery to prevent and treat 1000’s of illness. There is just not enough funding in the private sector to meet the needs of patients. #MedSky

If anyone knows how SLE contributes to ferroptosis (outside of APS induced thrombosis) in preeclampsia, please let me know. Very curious about this. 🙏 #RheumSky

free ebook 'Section 1: Introduction to Cardiogenic Shock and Therapies Section 2: Basics of Mechanical Circulatory Support Section 3: In-Depth Review of Devices Section 4: Selecting Devices and Device Combinations Based on Clinical Need' #impella #cardiosky scaipro.scai.org/Listing/Shor...

🧠 Neurology Podcast: Dr. Derek Stitt and Dr. Miranda M. Wan discuss improving training and public awareness to optimize #PalliativeCare for patients with neurologic conditions. Hint: We can do better - listen to find out how! Listen now: hubs.la/Q033py7j0

Several takeaways but this stood out: “Regions like Latin America and Sub-Saharan Africa had the highest proportions of unidentified taxa, linked to reference database biases, suggesting undersampling and the potential for unobserved microbial diversity.” Microbial Diversity = a new fronteir

The USPSTF latest guidelines on screening for #osteoporosis recommends that women 65 years or older and postmenopausal women under 65 who are at increased risk for osteoporotic fractures undergo screening. 🔗 ja.ma/3DZMpWb #MedSky

Most viewed in the last 7 days from JAMA: USPSTF recommends all women undergo routine #breastcancer screening every other year beginning at age 40, an update from the 2016 recommendation to start at age 50. https://ja.ma/4jdQciA#breastcancer