Interface paper is now published www.mdpi.com/2075-4426/15...

GOOD NEWS! Researchers have found that getting vaccinated against shingles- a painful and debilitating condition that can flare up years after infection from VZV- not only LOWERS the risk of infection, but can also PROTECT against dementia and REDUCE the risk of cardiovascular disease! 🧪🧵⬇️

did you think that labetalol is a single drug? nope it’s actually a mixture of FOUR different drugs RS, RR, SS, and SR-labetalol and this is clinically relevant! lets discuss why… 🧵 #1/3 #EMIMCC

For many experts, Health. Secretary Kennedy’s promise to find autism’s causes in a few months is jarring — and unrealistic. That’s because it appears to ignore decades of science linking about 200 genes that play a role. apnews.com/article/auti...

tl;dr- egotistical edgelord intoxicatingly enamored with the (false) idea that he's far smarter than everyone else and therefore superior

Texas measles total tops 700 cases amid rises in other states www.cidrap.umn.edu/measles/texa...

20 years after it was approved, cardiologists are recognizing that ezetimibe is a great statin helper www.msn.com/en-us/health/other/cardiologists-say-statin-combination-therapy-can-reduce-cholesterol-related-deaths-by-49/ar-AA1CKN9r?ocid=msedgntp&pc=DCTS&cvid=77de09834e2542b09bdbdbf88b12fbac&ei=11

Most vaccines don’t trigger mucosal IgA—a key airway defense Clever new Nat Comm study from 🇳🇴 solves that by fusing antigens to albumin, which uses FcRn pathway to cross the nasal barrier Result: a potent intranasal vaccine that protects vs. both flu and SARS-CoV-2 www.nature.com/articles/s41...

🆕🔥 State of the art review article @cmicomms.bsky.social Approach to Clostridioides difficile Diarrheal Infection ( CDI) Excellent discussions about the management of CDI #IDsky #mustread www.sciencedirect.com/science/arti...

🪪 𝐖𝐡𝐚𝐭 𝐢𝐬 teamcubancard.com? Team Cuban Card is a free program that brings the same transparent pricing you know from Cost Plus Drugs to local pharmacies across the country. Just download your card, check available medications, and find a participating pharmacy near you.

Also given our HHS Secretary's comments about fetal cells in vaccines... here's a post I made about that: open.substack.com/pub/deplatfo...

Cool table from @bradspellberg.bsky.social of RCTs of vaccines, in case anyone honestly believes there have been no RCTs of today's routine childhood vaccines: www.bradspellberg.com/vaccine-rcts

🆕🔥Case-control study @bradspellberg.bsky.social Just 1/4 blood cultures positive (≥2 sets drawn) or early clearance → low IE probability. Persistent bacteremia or 4/4 bottles ↑ pretest probability Simple bedside clues to sharpen your endocarditis game. #IDSky #EMIMCC jamanetwork.com/journals/jam...

Just found Dr. Hotez here on Bluesky. 20,000 of you already knew he was here. Great follow. bsky.app/profile/pete...

"most areas do not have experts in mycology" #IDSky @msgerc.bsky.social www.idse.net/Fungal-Infec...

This #FINEHEART pooled analysis, published in #JACC, demonstrated that finerenone significantly reduced the risk of new-onset atrial fibrillation/atrial flutter across the CKM spectrum. www.jacc.org/doi/10.1016/... #AFib

'Lipid-related atherosclerotic risk is most accurately reflected by the total count of apoB-P and is largely unaffected by the major particle type (VLDL, LDL) or size. Elevated count of Lp(a) adds additional risk' #apob #lpa apo(b) apolipoprotein b #ldl #cholesterol academic.oup.com/eurheartj/ad...

'Defining and subphenotyping ARDS' www.sciencedirect.com/science/arti...

procedural sedation protocol, versed and ketamine

Updated vaccine RCT table looking amazing! Sorted for vaccine type, now more interactive in table, can click directly on the pubmed links in the table to go to the manuscripts. bradspellberg. www.bradspellberg.com/vaccine-rcts

Yes, actually in one of my responses on Twitter I wrote that I try to keep the tip of the CVC at least 5cm away from the tip of the dialysis catheter

'ensure CVC and, Vascath tips are distanced, to avoid dialysing out meds given via CVC'

🔴New publication in the CCI journal!🔴 Grateful to our mentors Dr. Shariq Shamim (@shariqshamimmd.bsky.social) and Dr. Salman Arain for their constant support. Big thanks to @vaibhavsharmamd.bsky.social, @drthayu.bsky.social, and Dr. Sahai! 📖 Full Text: onlinelibrary.wiley.com/share/author...

'RV dysfunction occurs on VV-ECMO in ARDS despite ECMO mitigating many of the traditional RV dysfunction risk factor' #critcaresky #cccsky #ecmo #vv-ecmo #emimcc

I was interviewed for this excellent report in @Jamanews by Jennifer Abassi on the new discovery on apoB /LDL receptors interaction made by the @nih_nhlbi Lipoprotein lab led by Alan Remaley. [NB -it was not I who used the terms good and bad] jamanetwork.com/journals/jam...

Senator Chris Van Hollen met with Kilmar Armando Abrego Garcia in San Salvador. 💚

“We no longer have all the mechanisms in place to learn from those situations and prevent the next outbreak from happening,” www.yahoo.com/news/deadly-...

Soon after, DOGE installed a virtual system inside the agency’s servers that operated in secret. This system left no logs, no trace of its activity, and was removed without a record of what had been done.

Very happy to be one of the contributors to this manuscript discussing a patient's failure to respond to PCSK9 inhibitors. Open access at www.jacc.org/doi/epdf/10.1016/j.jaccas.2025.103696 @nationallipid.bsky.social @aspcardio.bsky.social @familyheartfdn.bsky.social @escardio.bsky.social

From 1999-2013, RFK sold his own brand of bottled water (in plastic bottles, and with a horrible carbon footprint) that contained TWO TIMES the upper limit of fluoride recommended for dental health, which is more than the safely allowable amount per US Public Health Service, and IS potentially toxic

If I had elevated Lp(a), pending new therapies, I would be on a PCSK9i + statin (low dose) + ezetimibe. Since patients have high Lp(a) since birth the mantra needs to be "lower (very much) for longer" is better. NO LONGER ARGUABLE. In such patients I desire LDL-C (apoB) well < 50 mg/dL

The most anticipated RCT in ID 🔥SNAP RCT🔥The largest RCT 2 date in SA bactermia N:1341 Cefazolin Vs ASPs ((flu)cloxacillin) for MSSA bacteremia Cefazolin is non-inferior (90d mortality)& less AKI than ASPs A practice-changer RCT that must change the guidelines #ESCMIDGlobal #IDSky

Colleges enthusiastically participating in arresting students. “Several universities in Florida have signed agreements to cooperate with Immigration and Customs Enforcement amid an ongoing push by state leaders to aid the Trump administration’s crackdown on immigration.” www.cnn.com/2025/04/12/u...

Two groups representing Harvard professors sued the Trump administration on Friday, saying that its threat to cut billions in federal funding for the university violates free speech and other First Amendment rights.

Gonna keep repeating this: 1) Fluoride added for dental health (which improves cardiovascular health, neurologic functioning, and more) is NOT toxic. 2) Water with naturally high levels of fluoride (not added, levels are much higher) can be a risk for toxicity. He is going after 1 and ignoring 2.

As we’ve warned before, the Trump administration has subjected around 80 staffers to lie detector tests. America, please understand—this is not normal.

Vaccines save lives. And no, they do not cause autism.

ICU Snapshots: Patient with #COPD exacerbation, on the ventilator. Bad, bad auto-PEEP... #foamed #foamcc #meded #medsky #cccsky #emimcc

Trump's EPA just moved to reverse state and local bans on toxic "forever chemicals" that can lead to birth defects and cancer.  So much for "Make America Healthy Again." https://www.theguardian.com/environment/2025/apr/05/trump-pfas-toxic-forever-chemicals

SNAP trial results reported Cefazolin was the champion for MSSA 🏆 Less nephrotoxicity than flucoxacillin 🏆 Reduced early mortality Not published but I think the answer is clear: Cefazolin now generally 1st line tx for MSSA "Innoculum effect" with nafcillin= debunked Updated IBCC (#1/2) #EMIMCC

When I first became reviews editor at Vaccine, my predecessor Kathy Neuzil very kindly gave me advice that I’ve carried into my role as co-EIC. Last year she received the Jenner Award for her contributions to vaccinology. Kathy’s vaccine research & advocacy saved many lives. This is disgraceful.

you now have to reconsider. A majority of people will not accept paying this cost to being wrong- at least, not in any kind of short-term timeframe. Instead, they will opt for belief perseverance to resolve their cognitive dissonance.

Refresher on Swan-Ganz catheter:

U.S. Military Removes Commander of Greenland Base After Vance Visit www.nytimes.com/2025/04/11/w...

Lipidology Teaching: Ever see an LDLc of 1000 mg/dL? Few have ever heard of Lipoprotein-X. A pathology that mimics but is not FH. What you need to know. If seen, check for hepatobiliary disease. @nationallipid.bsky.social @aspcardio.bsky.social @escardio.bsky.social @familyheartfdn.bsky.social

ICYMI from #ACC25: Dr. Nuccia Morici & colleagues report the results of ALTSHOCK-2, the largest RCT of IABPs in heart failure-related #CardiogenicShock. They found that early IABP implantation did *not* reduce mortality. www.jacc.org/doi/10.1016/... #HeartFailure #CardioSky #ALTSHOCK2

Staphylococcus aureus bacteremia has a case fatality rate of 15% to 30% and causes 300 000 deaths per year worldwide. This Review discusses management of S aureus bacteremia. ➡️ ja.ma/3RF8b50 #MedSky