What is the size of the thrombus in a coronary artery that can send one to Heaven or the CCU? Coronary artery lumens are quite small, and a cholesterol-rich plaque rupture or erosion will induce a thrombus. A tiny thrombus will partially block (cause ischemia) or totally block (cause infarction).

On this podcast, I along with an oncologist (speaking about cancer) and I on lipids had the opportunity to educate a very different crowd - the Finance World - I was a guest on Jimmie Lee's The Bull of Wall Street Podcast - My section starts at 21:23 - Enjoy www.youtube.com/watch?v=FPSE...

To further confuse the EPA vs EPA+DHA story. Here is new data from STRENGTH showing EPA + DHA reduced MACE in Asian patients. Authors had no reasons but perhaps due to Asian incidence of IR and TG issues. www.atherosclerosis-journal.com/article/S002...

DHA is crucial for maintaining brain neuron integrity and may inhibit tau phosphorylation. High doses (0.9–1.8 g/d) of DHA/EPA have shown improvements in cognitive function, while low doses (0.3–0.7 g/d) did not. www.sciencedirect.com/science/article/pii/S0002916523463204?via%3Dihub

Learn why specific sterol measurements are tools to evaluate cholesterol synthesis/absorption - then entertain - an at this time a hypothesis why some degree of reducing brain cholesterol synthesis will likely reduce dementia (in those prone to it) pharmacypodcastnetwork.podbean.com/e/desmostero...

What's a better way to kill an hour+ other that viewing @theproof with Simon Hill interviewing Daniel Soffer and Thomas Dayspring, MD FACP, FNLA reviewing Lipid-modulating medications - theproof.com/lowering-cho... @aspcardio.bsky.social @nationallipid.bsky.social @familyheartfdn.bsky.social

"Understanding the Lipid Panel" - next are insights on Non-HDL-C which refers (1) to the mass (weight) in mg of cholesterol within all of the apoB-containing lipoproteins per dL or (2) the number (in mmols) of cholesterol molecules in all the apoB-particles per L.

Review the chaos at CDC - in a real medical journal www.science.org/content/article/attempt-oust-cdc-director-sparks-key-resignations-agency-officials?utm_source=sfmc&utm_medium=email&utm_campaign=ScienceAdviser&utm_content=breaking&et_rid=17091364&et_cid=5718570

Part 2 of my discussion with @_CynthiaThurlow on her Everyday Wellness Podcast where we continue the journey into lipid/lipoprotein issues with an emphasis on women www.youtube.com/watch?v=IoKZvN8BWbg&t=139s @aspcardio.bsky.social @familyheartfdn.bsky.social @nationallipid.bsky.social

Periodically I repost this very useful document (glossary of terms) for those try to master lipids/lipoproteins. Print it out - peterattiamd.com/glossary-lip... @nationallipid.bsky.social @aspcardio.bsky.social @familyheartfdn.bsky.social @escardio.bsky.social

Introducing Vishnu Priya Pulipati, MD, FACE, who is an internist/endocrinologist/lipidologist who also did a preventive cardiology fellowship & now practices in Tulsa, OK. Check out her podcast to help clinicians better understand lipids. Please provide feedback to her. lipidcurious.com

I just discovered that there is a pretty good, animated lecture of mine (Grand Rounds Presentation from September 2020) describing a lot of useful lipid and lipid profile basics. Enjoy - www.youtube.com/watch?v=uYZd... @nationallipid.bsky.social @aspcardio.bsky.social @familyheartfdn.bsky.social

Insights on HDL-C reported as (1) mass (weight in mg) of all of the cholesterol molecules within all of the HDLs per dL of plasma or (2) the NUMBER of all of the cholesterol molecules in HDLs er liter [mmols). HDL-C or HDL-P have no relationship HDL functionality or reverse cholesterol transport

"Understanding the Lipid Panel" - LDL-C reported as (1) the mass (weight in mg) or the # (mmols) of all of the cholesterol molecules within all of the IDLs and LDLs circulating in a dL of plasma LDL-C is calculated, directly measured, or assayed as the gold standard assay termed beta-quantification

Revisiting my series "Understanding the Lipid Panel" - 1 metric at a time starting with Total Cholesterol. The lipid panel reports lipid mass concentrations but not the lipoprotein concentrations. In essence lipid concentrations are simply guesstimates or surrogates of lipoprotein concentrations.

More fuel to demolish the cholesterol deniers - Combining LDL-C with LDL-Years LDL-C X age (yrs) www.jacc.org/doi/10.1016/j.jacc.2018.06.046 @nationallipid.bsky.social @aspcardio.bsky.social @familyheartfdn.bsky.social

Lipoproteinology Lessons - Some interesting but sobering facts about LDL and HDL particle concentrations @aspcardio.bsky.social @nationallipid.bsky.social @escardio.bsky.social @familyheartfdn.bsky.social

Here is a thorough updated meta-analysis of the lipid-lowering efficacy of Obicetrapib: looking at a comprehensive review of randomized controlled trials. An amazing new drug. Hard to imagine a better novel primary care drug. www.lipidjournal.com/action/showPdf?pii=S1933-2874%2825%2900356-3

Lipidologists: Nice study by my friends at NIH on the importance of HDLs, not LDLs, supplying cholesterol to steroidogenic tissues. HDLs in addition to Reverse Cholesterol Transport also do Forward Cholesterol Transport. Check with author @RZubiranS for reprints pubmed.ncbi.nlm.nih.gov/40767551/

It's never too late! Lifestyle Interventions to Improve Cognition in Later Life: When Is Enough Enough? Used diet, physical activity, cognitive training, and vascular risk management. Many of the measures were directed at metabolic and cerebrovascular disease health jamanetwork.com/journals/jam...

Just a reminder but last year's very successful Legends of Lipidology series by @VindicoMedEd is still available www.healio.com/cme/mededtalks/lipidlegends

Here is an immense treatise on HDLs from @aspcardio.bsky.social which is for advanced students @ASPCardio "The HDL code is yet to be fully deciphered. A polymolecular assembly as complex as mature HDL is not a simple task to study." www.sciencedirect.com/science/article/pii/S2666667725001436

Amazing editorial by Sniderman et al - sadly firewalled - "Incorporating apoB & Lp(a) into routine clinical care will improve assessment of CV risk & will radically simplify RX —and therefore radically improve—the capacity of all caregivers globally to prevent CVD. doi.org/10.1093/eurh...

Important paper puts to rest those jumping on the VLDL/remnant bandwagon at the expense of ignoring LDLs. Please simply order apoB, a one-time Lp(a) & then lower it. The Rx that lower apoB lowers remnant-P & LDL-P (lower aggressively if Lp(a) is present. academic.oup.com/eurheartj/ar...

Clinical Chemistry - Lipoprotein Metrics - also a lot to digest @nationallipid.bsky.social @eassociety.bsky.social @aspcardio.bsky.social @familyheartfdn.bsky.social

Here are some lipid/lipoprotein tutorial slides to help all better master the complexities involved. So much to master! @nationallipid.bsky.social @aspcardio.bsky.social @escardio.bsky.social @familyheartfdn.bsky.social @eassociety.bsky.social

Reposting my recent Lp-IR Score graphic which contained a mistake caught by a vigilant Lipidaholic. @nationallipid.bsky.social @aspcardio.bsky.social @escardio.bsky.social

Here is a useful chart of reference ranges for those using the NMR derived Lipoprotein Insulin Resistance Score (LP-IR Score). These metrics do not apply to such metrics derived by Ion Mobility Transfer separation of lipoproteins (Quest methodology) @nationallipid.bsky.social @aspcardio.bsky.social

Beg, borrow or Steal this paper so you can cruise down BROADWAY - there is a big need for this med 😅🧐- www.nejm.org/doi/pdf/10.1056/NEJMoa2415820 @nationallipid.bsky.social @aspcardio.bsky.social @familyheartfdn.bsky.social @escardio.bsky.social

Important update on Alzheimer's -Need to start prevention much earlier than waiting for symptoms. www.nih.gov/news-events/news-releases/alzheimer-s-disease-may-damage-brain-two-phases @nationallipid.bsky.social @aspcardio.bsky.social @escardio.bsky.social

Quick blog by @BioLayneabout re the scary, and certainly unethical Keto Study - Sponsored Study Showed High LDL-C and apoB Causes RAPID Plaque Progression! | In other words -APOB DOES BEGET PLAQUE www.youtube.com/watch?v=A2hv... @nationallipid.bsky.social @aspcardio.bsky.social

For those who want to view my lecture on Brain and Lipids - here is the link - 1 hour and twenty minutes www.functionalmedicineuniversity.com/Lipids3-Days... @nationallipid.bsky.social @aspcardio.bsky.social @escardio.bsky.social

For those inquisitive about obicetrapib, Archna Bajaj report a kinetic lipoprotein study which provides insight on how the med significantly reduces apoB. x.com/nationallipi... @aspcardio.bsky.social @escardio.bsky.social @familyheartfdn.bsky.social

For those who missed it last night - Here is my Lecture (audio and animated slides) on Lp(a) to the Functional Medicine University - We had > 500 viewers www.functionalmedicineuniversity.com/LipoproteinLittlea.mp4 @familyheartfdn.bsky.social @nationallipid.bsky.social @aspcardio.bsky.social

Repost with correct link: Reminder -- My second lecture for Functional Medicine University is June 17 (tomorrow) - Register for this informative free 1.5-hour lecture on Lipoprotein(a) with my one-of-a-kind graphics at register.gotowebinar.com/register/141...

My second lecture for Functional Medicine University is June 17 (tomorrow) - Register for this free informative 1.5-hour lecture on Lipoprotein(a) with my one-of-a-kind graphics at htts://register.gotowebinar.com/register/1416372629896094814 @nationallipid.bsky.social @aspcardio.bsky.social

Sobering and downright scary stat: Roughly 1.4 billion individuals worldwide are exposed to elevated Lp(a) and the vast majority of them do not know that they are living with this condition and an increased ASCVD risk. Please download this incredibly well-done treatise on Lp(a). t.co/IFXXkIdY6G

For those want to view my spectacular (based on several reviews) one hour forty minute lecture on understanding lipids and its historical past take a watch www.functionalmedicineuniversity.com/Dayspring-Li...

RARE OPPORTUNITY for Lipidaholics - 3 lectures not to be missed Register for (1) at register.gotowebinar.com/register/579... and (2) at register.gotowebinar.com/register/141... and lecture 3 at register.gotowebinar.com/register/537... @nationallipid @ASPCardio @escardio @society_eas @atherosociety

Anytime I get to share a microphone with preventive neurologist Dr Kellyann Niotis, is a great day. Hope all will enjoy this event sponsored by the @familyheartfdn.bsky.social www.youtube.com/watch?v=EoOn... @aspcardio.bsky.social @nationallipid.bsky.social

Graphic of the pathways in cholesterol homeostasis - CETP plays a major role transferring CE from HDLs to apoB-particles. Time for all to comprehend that LDLs as well as the small intestine play major roles in RCT. Expert comments on the disproven notion that HDL-C tells you anything about RCT!

To truly understand CETP, one must understand some HDL complexities and rather confusing is HDL nomenclature - Understanding and mastering the terms requires significant study. Note neither HDL-C nor HDL-P are not nomenclature - they are HDL lab metrics @aspcardio.bsky.social

Continuing the CETP story: Cholesteryl ester, an inactive or neutral lipid, is the storage or transportation form of cholesterol. Triglycerides (glycerol esters) is the storage or transportation form of fatty acids. @nationallipid.bsky.social @aspcardio.bsky.social @escardio.bsky.social

With all of the emerging info on the Cholesteryl Ester Transfer protein inhibitor obicetrapib, it is time for me to start shedding some light on CETP starting in 1964 w early work of Carl Rehnborg & Alexander Nichols & 1975 when Donald Zilversmit described exchange of CE between LDLs & VLDLs

Take a watch and listen of Peter Attia at the NY Times Well Festival -- Peter's part of the video (starts at 6:48:15 and is about 30 minutes): www.youtube.com/watch?v=Nw-t... @nationallipid.bsky.social @familyheartfdn.bsky.social @aspcardio.bsky.social

Nice lipid-oriented interview conducted by Dr Faris Al-Radi (an internist from Dubai) & all of the typical Q/As folks ask are answered. Happy to get exposure to the Arab World. www.youtube.com/watch?v=5MgD86Xxl28 @nationallipid.bsky.social @aspcardio.bsky.social @familyheartfdn.bsky.social

Important paper = New NHANES findings on thyroid testing values should help establish more accurate reference intervals for thyroid diseases and facilitate development of a consensus about how to define and manage those diseases. pubmed.ncbi.nlm.nih.gov/40324200/ @nationallipid.bsky.social

Picture worth a thousand words - As the late-great editor of the American Journal of Cardiology William Roberts once editorialized - "It's the cholesterol stupid!"

20 years after it was approved, cardiologists are recognizing that ezetimibe is a great statin helper www.msn.com/en-us/health/other/cardiologists-say-statin-combination-therapy-can-reduce-cholesterol-related-deaths-by-49/ar-AA1CKN9r?ocid=msedgntp&pc=DCTS&cvid=77de09834e2542b09bdbdbf88b12fbac&ei=11

STEROLOGY LESSON: No stanol esters and sterol esters are not the same thing. Stanols are SATURATED sterols. Once ingested esters [stanols or sterols attached to fatty acids: (stanyl-FA or (steryl-FA)]. they are rapidly de-esterified by pancreatic sterol-esterases to free stanols and sterols.