A harmonized benchmarking framework for implementation-aware evaluation of 46 polygenic risk score tools across binary and continuous phenotypes www.biorxiv.org/content/10.6... 🧬💻🧪 github.com/MuhammadMune...

Jesse singal

Don’t be evil

😀

We are deeply saddened to share the news of the passing of David Botstein, a towering figure in modern #genetics and a foundational force behind SGD. www.yeastgenome.org/blog/in-memo... #yeast #modelOrganism

Facing Facts, even fraught ones: the quest for proto-Indo-Europeans in 2023 open.substack.com/pub/razib/p/...

More than kin, less than kind: Jews and Palestinians as Canaanite cousins www.razibkhan.com/p/more-than-...

The emergence of the domestic dog lineage occurred soon after the human expansion out of Africa 50,000 years ago. Now we have genetics to trace the evolution of man’s best friend. @razibkhan.bsky.social digs into its past: buff.ly/aF3GBfG

so what's going on here?

Lost Green Saharans: ancient DNA unearths a new race from a verdant North African interlude www.razibkhan.com/p/lost-green...

Vance is a guy who’s decided to use his perceptiveness about the nature of the Trump movement exclusively for own power and gain and so far it’s worked www.richardhanania.com/p/jd-vance-i...

John Hawks and Chris Stringer: Neanderthals, Denisovans and humans, oh my! www.razibkhan.com/p/john-hawks...

To the memory of the good Jim. From the RAF bar of the Eagle which is where they used to drink.

He made a massive impact. Respect.

Am I allowed to say retarded here?

A Nile shadow 4,500 years old www.razibkhan.com/p/a-nile-sha...

jesse singal

Jesse singal

🚨 New preprint out! We reconstructed parental haplotypes in >440k individuals (UK & Estonian biobanks) to estimate assortative mating directly in the parental generation. This reveals intensified assortment in recent generations. www.biorxiv.org/content/10.1...

Fortune favors the fearless: millennia of Austronesian maritime feats www.razibkhan.com/p/fortune-fa...

Intermarriage rates by race/ethnicity.

News in the history of molecular biology. The Science History Institute in Philadelphia has acquired a huge archive of correspondence and other scientific material from the pioneers of molecular biology (Franklin, Klug, Perutz, Delbrück etc, with items from Crick and Watson, too). 1/n

This from @razibkhan.bsky.social is very interesting indeed: "When civilization control-alt-deletes: prehistoric Europe’s false dawn and long reboot: Reflecting on Europe’s lost 5,000-year-old first draft" www.razibkhan.com/p/when-civil...

Trump executive order seeks to centralize control of grantmaking under political appointees www.statnews.com/2025/08/08/t...

Pretty amazing. Potatoes are the outcome of an ~9 million year ago hybridization that led to an explosive radiation. The evolution of storage.

Still no good evidence that inversions dominate evolution.

big names are now putting the stamp of approval on polygenic embryo selection

Hammond et al 2025. 'The behavioural ecology of hominin locomotion' 👌 www.frontiersin.org/journals/eco...

Evolutionary molecular biology paying dividends again - this time in finding new modulators of innate immunity - www.science.org/doi/10.1126/...

I ways forget the 🦠 🐘 🧪

I'm disturbed by tenured faculty on here behaving like high school bullies. I ask them to look up ad hominem and recognize that what Mamdani did was atrocious and newsworthy. Why are we defending an uber-privileged applicant whose father was faculty at the Ivy League university he was applying to?

Here are replicas of crania: Kabwe, La Ferrassie Neanderthal, Harbin and a recent human..

Impressive and risky research testing ancient seafaring in Japan (love the map): Paleolithic seafaring in East Asia: An experimental test of the dugout canoe hypothesis www.science.org/doi/10.1126/...

‪Congratulations to the new leader of the Democratic Party @zohrankmamdani.bsky.social

This is amazing! SSHash is already one of the fastest existing indexes for kmer queries (esp streaming ones). These performance improvements are surprisingly big! We (@noorpratap.bsky.social & I) suggested streaming improvements & Giulio adopts those & more (w/onhurting the negative lookup case).1/2

blueskye fr

I make my first post in a week and the replies include this stuff from someone with 26,000+ followers (yes, blocking and removing them, but who needs to put up with this on every post?) They aren't even reactions to the post, just folks hunting for people to insult and attack.

Khanversation #43: Jane Smith on cargo cults and Curtis Yarvin in the New Yorker www.khanversationpod.com/p/khanversat...

So excited to talk (remotely) at UC Riverside tonight as the student-nominates speaker. It means so much to be selected by the students.

ELON! TRUMP! GO!

there are two sexes!

affirmative action is racist!

ezra klein and derek thompson are brilliant! if you oppose ABUNDANCE you are a very bad person!

what can i do over here to get a massive pile-on on me so i can get new followers?

Nomads to natives: how Bronze-Age Sami newcomers became eternally Nordic www.razibkhan.com/p/nomads-to-...

Tim Lee: 2025 and the driverless car revolution www.razibkhan.com/p/tim-lee-20...

Bonus monologue: Finland as Germania www.razibkhan.com/p/bonus-mono...