In this great new paper, the authors use metagenomic Hi-C to show that #phage with broad host range are fairly common, contrary to the prevailing view on their biology. Cutting edge methods like Hi-C are shedding light on our blind spots in the microbial world.

Join us at the Microbiome Innovation One Health Conference in Oxford on Sept 15! @ivanliachko.bsky.social will present how ProxiMeta™ maps microbes, viruses, plasmids & resistance genes, bringing clarity to complexity across human, animal and environmental health.

🧬 Important Slug News! Researchers assembled a chromosome-scale #genome for Deroceras laeve using Proximo Hi-C and @pacbio.bsky.social - making it a useful model for study of #genomics, #evolution, and slimyness... Congrats to Alfredo Varela-Echavarría & team! 🔗 academic.oup.com/g3journal/ad...

Glad I saw @ivanliachko.bsky.social present on mind-blowing applications of proximity ligation, including metagenomics--linking plasmids, phages and genomes across microbiomes. I see major impact for precision #phagetherapy (and #onehealth) Godspeed @phasegenomics.bsky.social tinyurl.com/yaubcrpt

A fungus among us: Proximo Hi‑C + @pacbio.bsky.social HiFi produced telomere‑to‑telomere genomes for VCG‑01111/01112, uncovering 4 accessory chromosomes, >3.6 My divergence, SIX6 and novel effectors—pinpointing drivers of high virulence. www.mdpi.com/2309-608X/11...

She doesn’t need a hero, she is the hero we need. 🤩

New study uses long-read + @phasegenomics.bsky.social Hi-C to assemble chromosome-scale #genome of Trichomonas vaginalis and bird-infecting relatives, revealing key genes tied to bird-to-human spillover. Congrats to Jane Carlton, ‪@mikeschatz.bsky.social‬ and team!

Structural variants often go undetected by traditional cytogenetics. A new review in Genes shows how Genomic Proximity Mapping™ (GPM) detects complex SVs right from FFPE. Read more Dr. Patrick Gonzales at the University of Kansas Medical Center: www.mdpi.com/2073-4425/16...

When sample quality is low, insight usually is too. Not with Genomic Proximity Mapping™ (GPM). Phase Genomics’ GPM works on #FFPE and mosaic samples. It’s just one assay, no metaphase prep, and no tradeoff in resolution. A new preprint shows how: www.medrxiv.org/content/10.1...

Comprehensive cytogenetics from any sample type—including #FFPE—in just one assay: CytoTerra® delivers genome-wide SV detection with no culture, no HMW DNA, and results in as little as 5 days. Stop by booth 23 & check out our presentations to see it in action at #CGC2025.

This is very cool

🌸 Chromosome-scale genome of Petunia hybrida assembled with Proximo Hi-C, PacBio HiFi, Illumina & Bionano. 7 pseudochromosomes, 99.8% BUSCO with Hi-C being key for resolving repeats. A powerful resource for Solanaceae genetics & breeding. #genome #HiC 📄 hubs.la/Q03ypPmb0

By popular demand by you, #genomics people - this buffer is super useful for Hi-C and we'll give you some if you ask for it, no strings attached.

🌱🧬Researchers released haplotype-resolved, chromosome-level genomes of Eupatorium splendens - a plant known for medicinal properties and ability to thrive in contaminated soils. A powerful resource for studying stress adaptation & secondary metabolism. www.nature.com/articles/s41...

🍓 Meet ‘Yuexin’ - a next-gen #strawberry with smoother texture, better shelf life, and sweeter aroma. Scientists have released its fully phased #genome, revealing the genetic secrets behind these tasty traits. Proximo #HiC + @pacbio.bsky.social for the win! 🧬 🔗 hubs.la/Q03tZvZD0

“It’s not a brute force technology. It’s a clever technology.” — Jon Chee, CEO @ Excedr In the finale of The Biotech Startups Podcast, Jon and @ivanliachko.bsky.social unpack how smart science powers Phase Genomics' impact in cancer research, metagenomics & more👇 youtu.be/fqL6ZvS2sNQ?...

New💩🚰👨‍🔬 study in #EnvMicrobiology uses shotgun & Hi-C metagenomics to reveal rapid shifts in antibiotic resistance genes and their microbial hosts, highlighting the dynamic nature of resistomes. #AMR #Metagenomics 🔗https://hubs.la/Q03tZ1Jf0

TBT: 🧬 Throwing it back to a cool study from Aug 2021! Using proximity ligation, this paper explores the two-compartment genome of R. irregularis, a model arbuscular mycorrhizal symbiont, using Proximo #HiC and @nanoporetech.com sequencing. @Blunt_Microbe 🔗 Full study: hubs.la/Q03tZ6Ch0

“If we don’t commercialize this, it’s going to be a crime against science.” - @ivanliachko.bsky.social, Founder and CEO Hear how a postdoc aha moment became a platform accelerating #microbiome research, tackling #AMR & more on the Biotech Startups Podcast: www.youtube.com/watch?v=U2UG...

Unleashing the wild side of lupins! 🌕🐺🍃 Researchers built #genomes of rough-seeded lupins - L. cosentinii & L. digitatus - revealing unique #gene expansions tied to stress resilience and seed traits. A howling good resource for legume breeding! #HiC 🔗 hubs.la/Q03v1F2c0

Can’t see the full picture with karyotyping or microarrays? New research in @Genes_MDPI shows how Genomic Proximity Mapping (GPM) detects structural variants other tools miss - translocations, insertions & CN-LOH - even from FFPE! hubs.la/Q03v2s2N0 #Cancer #Cytogenetics

#ASMicrobe ❤️ LA // @tallcuppajoe.bsky.social @bielleogy.bsky.social @gfahurbottino.bsky.social @jlgoff.bsky.social @lebetimonas.bsky.social @dportik.bsky.social @jcamthrash.bsky.social @ahoiching.bsky.social @germjuggler.bsky.social @scottnguyen.bsky.social

Phase Genomics is making Hi-C metagenomics simpler than ever with the new ProxiMeta™ Starter and Elite Bundles. These ready-to-run solutions combine sequencing, no-code bioinformatics & expert support into streamlined packages. #microbiome #phage More in @BioSpace: www.biospace.com/press-releas...

Very excited to be at American Society for Microbiology #ASMicrobe meeting. I’m here with a large suitcase of, what could it be? Science swag and also just science. Come talk to us about transforming the future of #metagenomics and #phage research. @phasegenomics.bsky.social (booth 1109)

Just launched at #ASMicrobe 2025: the new ready-to-use ProxiMeta™ Starter and Elite bundles for Hi-C metagenomics. Visit booth #1109 to chat w/ the team about how the new bundles can accelerate your research, or discover more online & book a call here: info.phasegenomics.com/proximeta-bu...

ICYMI: A jam-packed spring edition of Phasebook, available in your inbox and on the web. You’ll find all the latest on our Hi-C tech and updates from the Phase Genomics team here: info.phasegenomics.com/phasebook

Catch Phase Genomics CEO @ivanliachko.bsky.social at NIAMRRE 2025 for an insightful panel discussion on #AMR in today’s shifting landscape on Thurs, May 15. Find the full details and register here: exchange.niamrre.org/2025niamrrea...

Another impressive paper, the authors used Proximo Hi-C data to build a allohexaploid wheatgrass genome.

I hear the first author is defending tomorrow 🐦, so read this paper. Also, this is what happens when leadership learns how to use Canva...

Cool paper on #duckweed #genomes, now with free gratuitous frog 🐸.

Really neat paper out, using measurements of 3D genome folding (with our Proximo Hi-C tech, wink wink) to pinpoint the CA2 gene as a potential target to reverse drug resistance in #breastcancer.

Very cool recent preprint from @chicascientifica.bsky.social and team. #phages in bee poop, what's not to like? #microbiome #bees

2 weeks from today: Catch Phase Genomics’ @IvanLiachko and Steve Eacker at #AACR2025 in Chicago, April 25–30. We’ll present two posters on Genomic Proximity Mapping™ (GPM) for the genome-wide detection of chromosomal abnormalities in HNSCC & sarcoma. Find the full details:

We made a new tool to help people process deep #metagenomics data. If you’re scared of R and prefer to clicky click and draggy drop things instead, while making beautiful figures, check this out. Oh and it’s free, are we crazy?!? #microbiome #phage #AMR

The best things come in 2s—like our purpose-built, user-friendly Proximo™ Hi-C Plant Kit two-packs. Purchase a Proximo Hi-C Plant two-pack by April 30 & we’ll send you #PGShield preservative for long-term sample storage at *without* refrigeration. 🛒 bit.ly/4iLCuCy

I don't know who needs to see this, but we (@PhaseGenomics) are hiring an ops coordinator (Seattle-based, hybrid role)

Tune in to the Talk is Biotech podcast to hear Phase Genomics CEO @ivanliachko.bsky.social share how Hi-C unlocks new DNA discoveries: “It’s a sequence of letters, but it makes shapes, colors—it makes a strawberry look like a strawberry.” Thanks to pod host Guru Singh: bit.ly/4ijpyUy

Today on the International Day of Women & Girls in Science—and every day—we honor the women who drive discovery forward. From the double helix to WiFi, we celebrate their discoveries that define modern life. Because women shape every second of science, every day of the year.

Proximo™ Hi-C helped researchers in 🇦🇺 pinpoint new oat crown rust #plantpathogen. They used our Hi-C tech to pinpoint new somatic hybridization & intercontinental movement of haplotypes, a major step toward a #pangenome & int’l molecular-level monitoring. More: journals.plos.org/plosgenetics...

Take a look at how Genomic Proximity Mapping™ (GPM) accelerates your discovery. We’ll build your new map of the genome to help you build the future of #cancerbiology. GPM pinpoints known & novel chromosomal anomalies in cell lines, blood—and even #FFPE samples. Here’s how:

Peas are packed with protein—but for an unlucky few, one of those proteins is an allergen. Researchers used our Proximo Hi-C protocol to build the genome for future breeding studies. Because the only place peas should pack a punch is in nutrition. More in @jxbotany.bsky.social: bit.ly/3E1g4OD

This made me snort this morning 😂

Using our Hi-C kits and @pacbio.bsky.social, researchers at ICAR assembled a #chromosome -level #genome of a near-threatened freshwater catfish, providing valuable resources for comparative genomics and the enhancement of economic traits in aquaculture. Read here: www.nature.com/articles/s41...

Hey, science folks. Does anyone have experience transforming Lactobacillus plantarum and would be willing to talk to me about it?

A little bit of post-Xmas this.

We did a lot this year. Including starting a Bluesky account :)!

🌿Wielding genomics to understand disease vectors: Study uses Proximo & @pacbio.bsky.social to create #chromosome -level #genome assemblies of psyllids, shedding light on pathogen transmission. Congrats Heaven, @tom-mathers.bsky.social @samtmugford.bsky.social & team! www.biorxiv.org/content/10.1...

Can confirm.

New life goal unlocked! Getting to work on marsupials, including kangaroos, koalas, and my all time faves, wombats. Privileged to help on this great UQ-led study showing differences in hydrogen cycling and electron flow explain low methane emissions in marsupials. www.biorxiv.org/content/10.1...

The native fauna of #ASH24