Cerebrospinal Fluid Proenkephalin Predicts Striatal Atrophy Decades before Clinical Motor Diagnosis in Huntington's Disease movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...

Amid this week’s huge milestone in #HD treatment, I’m excited to share part of my PhD thesis + our paper published today in @movedisorder.bsky.social on CSF #PENK predicting striatal atrophy decades before clinical motor diagnosis 🔗 movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...

A major milestone was reached yesterday in neurodegenerative medicine, advancing hope for those affected by Huntington’s disease🧵

Huntington's disease has been successfully treated for the first time, doctors tell BBC

🧵 BREAKING: Gene therapy shows promise in slowing Huntington’s disease progression. A major milestone in neurodegenerative disease research. @uclqsion.bsky.social @ucl-hd.bsky.social www.bbc.co.uk/news/article...

Open Access UCL Research: Bias in HD-ISS staging introduced by the FreeSurfer cross-sectional stream: Insights from the Huntington's Disease Young Adult Study (HD-YAS) discovery.ucl.ac.uk/id/eprint/10...

The oncogenic KRAS mutation has been the subject of intense investigation. In The Lancet, a new phase 3 trial reports on adagrasib versus docetaxel in KRASG12C-mutated non-small-cell lung cancer. This and more in our latest issue 👉 bit.ly/4mi7T1y

In 2015, just out of medical school, I’d never have imagined seeing my name in @thelancet.com! Our review on vesicular monoamine transport (#VMAT) inhibitors is published today. @uclqsion.bsky.social @uclbrainscience.bsky.social 🔗 Read the full article here: www.thelancet.com/journals/lan...

Here's an open access link to full text of our paper shared last week! rdcu.be/evKF9

Important paper on accessible biomarkers from @hob-lab.bsky.social. Well done Annabelle Coleman @drl-bo.bsky.social and all.

I am unbelievably proud to have my first senior author paper published today! It was a long slog through multiple review cycles but we got there! A big thank you to my lab members and all the collaborators and participants who contributed to this work! 🥲

We are delighted to present the first publication out of the lab, available online today, titled ‘Evaluating finger-prick blood collection for remote quantification of neurofilament light in neurological diseases’ link.springer.com/article/10.1...

New paper from the @hob-lab.bsky.social just published in Journal of Neurology. A step toward more accessible biomarker testing 🩸 link.springer.com/article/10.1... @drl-bo.bsky.social @uclbrainscience.bsky.social @uclqsion.bsky.social

Super fun first 5K #RUN4HDYO! 🏃 💨 🏃‍♀️‍ Over £2500 raised for the Olivia (Liv) Martinez Scholarship Fund for HDYO - honouring an amazing ambassador I met at #HDYO Congress in Glasgow in 2023. Liv's kindness and passion touched so many. @ucl-hd.bsky.social @uclqsion.bsky.social

A series of digital tests carried out via a smartphone app could enhance the detection of disease progression in #HuntingtonsDisease and improve the efficiency of clinical trials, finds research led by scientists at @uclqsion.bsky.social @ucl-hd.bsky.social and Roche including @profwild.bsky.social

New paper in BRAIN from Team Wild and Roche: A digital motor score for sensitive detection of progression in Huntington’s disease (open access) doi.org/10.1093/brai...

Check out the March 2025 edition of the #HD Clinical Trials Update, now available online in the Journal of Huntington's Disease @profwild.bsky.social 🔓 Open access link: journals.sagepub.com/doi/10.1177/... @ucl-hd.bsky.social @uclbrainscience.bsky.social @uclqsion.bsky.social

Hot off the press! Check out the second edition of the @ehdn-news.bsky.social Imaging Working Group (#iWG) newsletter! #HD #neuroimaging @drmichelaleocadi.bsky.social @rachiscahill.bsky.social @nicolahobbs.bsky.social ehdn.org/wp-content/u...

Thank you HDYO for the opportunity to talk about HD-YAS at #HDYO Congress 2025! Truly an inspiring community and family — and this absolutely drives all the work we do! @ucl-hd.bsky.social @uclqsion.bsky.social

Neuroimaging Techniques in #Huntington's Disease: A Critical Review 🧠 #Neurology #movedisorder #MedEd movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...

Curious about brain imaging in HD? Our latest review summarises key findings from structural, diffusion and fMRI, plus emerging techniques like 7T MRI, MEG and novel mHTT PET ligands. movementdisorders.onlinelibrary.wiley.com/doi/10.1002/... @rachiscahill.bsky.social @carlosestevezfraga.bsky.social

ICYMI: New online! Degeneration decades before disease onset https://bit.ly/3D6Bt8Y

academic.oup.com/braincomms/a... delighted to finally see this out. We asked the question - could we identify different subtypes of CBS using SuStaIn algorithm applied to a baseline structural MRI scan and if so did these associate with underlying pathology? Read the paper to find out!

Prof Tabrizi: “I want to thank the participants in our young adult study as their dedication and commitment over the last 5 years mean we hope clinical trials aimed at preventing #HD will become a reality in the next few years." @rachiscahill.bsky.social @drmfarag.bsky.social @uclqsion.bsky.social

Open Access UCL Research: Somatic CAG repeat expansion in blood associates with biomarkers of neurodegeneration in Huntington's disease decades before clinical motor diagnosis discovery.ucl.ac.uk/id/eprint/10...

Made a starter pack of the Huntington disease researchers/orgs I can find on Bluesky. If you’re an HD researcher and want to be added, reply or DM. go.bsky.app/UM9WCpA

Somatic CAG repeat expansion in blood associates with biomarkers of neurodegeneration in Huntington’s disease decades before clinical motor diagnosis www.nature.com/articles/s41...

Somatic CAG repeat expansion in blood associates with biomarkers of neurodegeneration in Huntington’s disease decades before clinical motor diagnosis www.nature.com/articles/s41...

Our paper in Nature Medicine is out today! Great working with @drmfarag.bsky.social & the YAS team (researchers and participants) to identify biomarkers that pave the way for preventative trials in Huntington's Disease. Thanks to @wellcometrust.bsky.social and CHDI for funding. tinyurl.com/3fde9mth

Subtle changes in the brain happen around 20 years before a clinical motor diagnosis in people with Huntington’s disease. The new findings from a study led by Prof Sarah Tabrizi @uclqsion.bsky.social @uclbrainscience.bsky.social will guide future prevention trials www.ucl.ac.uk/news/2025/ja...

Excited to share my joint first-author paper (with @rachiscahill.bsky.social) published today in Nature Medicine (@natmedicine.bsky.social, @nature.com). Our findings are timely as the #HD therapeutic landscape expands toward preventive clinical trials. 🔓 Open access: www.nature.com/articles/s41...

Check out the latest edition of the #HD Clinical Trials Update, now available online in the Journal of Huntington's Disease @profwild.bsky.social 🔓 Open access link: journals.sagepub.com/doi/full/10....

We're excited to join BlueSky! Make sure to follow us for the latest news from the UCL Queen Square Institute of Neurology.