Still feels surreal to say I defended my PhD viva with no corrections. Huge thanks to my examiners and supervisors for their support, and to everyone at @ucl-hd.bsky.social @uclqsion.bsky.social who helped along this journey. As in my thesis dedication: for the #HD community. #PhDone 🥳

The current HD-ISS doesn't incorporate wet biomarkers. Dr. Mena Farag discusses the promising results of proenkephalin and other biomarkers to help monitor the earliest stages of HD before the onset of motor symptoms. https://loom.ly/j3VrGFs

So much @ucl-hd.bsky.social love at my leaving do! Thank you to everyone who made the last three years of my PhD journey such a joy. @uclbrainscience.bsky.social @uclqsion.bsky.social

Signing off from the LWENC with this wonderful team. 3 years of teamwork, learning and shared commitment to our #HD clinical trials @ucl-hd.bsky.social @uclqsion.bsky.social - thank you all for making it so special.

Discovery of disrupted sustained attention and altered functional connectivity in far‐from‐onset Huntington's disease gene‐expanded young adults alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

Congratulations @drmfarag.bsky.social from @ucl-hd.bsky.social! 👏 @ukdri.ac.uk @uclqsion.bsky.social @uclbrainscience.bsky.social @uclnews.bsky.social @ucl.ac.uk 🔗 www.ucl.ac.uk/brain-scienc...

I am incredibly honoured to share that I have been awarded the @ukdri.ac.uk PhD Prize at #Connectome 2025! @ucl-hd.bsky.social @uclqsion.bsky.social @uclbrainscience.bsky.social

Open Access UCL Research: Huntington's disease clinical trials update: October 2025 discovery.ucl.ac.uk/id/eprint/10...

Check out the October 2025 edition of the #HD Clinical Trials Update, now published in the Journal of Huntington's Disease and available online! 🔗 journals.sagepub.com/doi/10.1177/... @profwild.bsky.social @ucl-hd.bsky.social @uclqsion.bsky.social @uclbrainscience.bsky.social

🎉 Congratulations to Prof. Sarah Tabrizi ( @ucl-hd.bsky.social, @uclqsion.bsky.social) who has won the prestigious @britishneuro.bsky.social prize for her outstanding contributions to neuroscience! www.ucl.ac.uk/news/2025/no...

A secondary analysis of the TEMPO-2 RCT found no significant improvement in outcomes for minor ischemic stroke patients treated with intravenous tenecteplase, regardless of the presence of disabling deficits. ja.ma/3WT9IHi

Cerebrospinal Fluid Proenkephalin Predicts Striatal Atrophy Decades before Clinical Motor Diagnosis in Huntington's Disease movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...

Amid this week’s huge milestone in #HD treatment, I’m excited to share part of my PhD thesis + our paper published today in @movedisorder.bsky.social on CSF #PENK predicting striatal atrophy decades before clinical motor diagnosis 🔗 movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...

A major milestone was reached yesterday in neurodegenerative medicine, advancing hope for those affected by Huntington’s disease🧵

🧵 BREAKING: Gene therapy shows promise in slowing Huntington’s disease progression. A major milestone in neurodegenerative disease research. @uclqsion.bsky.social @ucl-hd.bsky.social www.bbc.co.uk/news/article...

Open Access UCL Research: Bias in HD-ISS staging introduced by the FreeSurfer cross-sectional stream: Insights from the Huntington's Disease Young Adult Study (HD-YAS) discovery.ucl.ac.uk/id/eprint/10...

The oncogenic KRAS mutation has been the subject of intense investigation. In The Lancet, a new phase 3 trial reports on adagrasib versus docetaxel in KRASG12C-mutated non-small-cell lung cancer. This and more in our latest issue 👉 bit.ly/4mi7T1y

In 2015, just out of medical school, I’d never have imagined seeing my name in @thelancet.com! Our review on vesicular monoamine transport (#VMAT) inhibitors is published today. @uclqsion.bsky.social @uclbrainscience.bsky.social 🔗 Read the full article here: www.thelancet.com/journals/lan...

Here's an open access link to full text of our paper shared last week! rdcu.be/evKF9

Important paper on accessible biomarkers from @hob-lab.bsky.social. Well done Annabelle Coleman @drl-bo.bsky.social and all.

I am unbelievably proud to have my first senior author paper published today! It was a long slog through multiple review cycles but we got there! A big thank you to my lab members and all the collaborators and participants who contributed to this work! 🥲

We are delighted to present the first publication out of the lab, available online today, titled ‘Evaluating finger-prick blood collection for remote quantification of neurofilament light in neurological diseases’ link.springer.com/article/10.1...

New paper from the @hob-lab.bsky.social just published in Journal of Neurology. A step toward more accessible biomarker testing 🩸 link.springer.com/article/10.1... @drl-bo.bsky.social @uclbrainscience.bsky.social @uclqsion.bsky.social

Super fun first 5K #RUN4HDYO! 🏃 💨 🏃‍♀️‍ Over £2500 raised for the Olivia (Liv) Martinez Scholarship Fund for HDYO - honouring an amazing ambassador I met at #HDYO Congress in Glasgow in 2023. Liv's kindness and passion touched so many. @ucl-hd.bsky.social @uclqsion.bsky.social

A series of digital tests carried out via a smartphone app could enhance the detection of disease progression in #HuntingtonsDisease and improve the efficiency of clinical trials, finds research led by scientists at @uclqsion.bsky.social @ucl-hd.bsky.social and Roche including @profwild.bsky.social

New paper in BRAIN from Team Wild and Roche: A digital motor score for sensitive detection of progression in Huntington’s disease (open access) doi.org/10.1093/brai...

Check out the March 2025 edition of the #HD Clinical Trials Update, now available online in the Journal of Huntington's Disease @profwild.bsky.social 🔓 Open access link: journals.sagepub.com/doi/10.1177/... @ucl-hd.bsky.social @uclbrainscience.bsky.social @uclqsion.bsky.social

Hot off the press! Check out the second edition of the @ehdn-news.bsky.social Imaging Working Group (#iWG) newsletter! #HD #neuroimaging @drmichelaleocadi.bsky.social @rachiscahill.bsky.social @nicolahobbs.bsky.social ehdn.org/wp-content/u...

Thank you HDYO for the opportunity to talk about HD-YAS at #HDYO Congress 2025! Truly an inspiring community and family — and this absolutely drives all the work we do! @ucl-hd.bsky.social @uclqsion.bsky.social

Neuroimaging Techniques in #Huntington's Disease: A Critical Review 🧠 #Neurology #movedisorder #MedEd movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...

Curious about brain imaging in HD? Our latest review summarises key findings from structural, diffusion and fMRI, plus emerging techniques like 7T MRI, MEG and novel mHTT PET ligands. movementdisorders.onlinelibrary.wiley.com/doi/10.1002/... @rachiscahill.bsky.social @carlosestevezfraga.bsky.social

ICYMI: New online! Degeneration decades before disease onset https://bit.ly/3D6Bt8Y

academic.oup.com/braincomms/a... delighted to finally see this out. We asked the question - could we identify different subtypes of CBS using SuStaIn algorithm applied to a baseline structural MRI scan and if so did these associate with underlying pathology? Read the paper to find out!

Prof Tabrizi: “I want to thank the participants in our young adult study as their dedication and commitment over the last 5 years mean we hope clinical trials aimed at preventing #HD will become a reality in the next few years." @rachiscahill.bsky.social @drmfarag.bsky.social @uclqsion.bsky.social

Open Access UCL Research: Somatic CAG repeat expansion in blood associates with biomarkers of neurodegeneration in Huntington's disease decades before clinical motor diagnosis discovery.ucl.ac.uk/id/eprint/10...

Made a starter pack of the Huntington disease researchers/orgs I can find on Bluesky. If you’re an HD researcher and want to be added, reply or DM. go.bsky.app/UM9WCpA

Somatic CAG repeat expansion in blood associates with biomarkers of neurodegeneration in Huntington’s disease decades before clinical motor diagnosis www.nature.com/articles/s41...

Somatic CAG repeat expansion in blood associates with biomarkers of neurodegeneration in Huntington’s disease decades before clinical motor diagnosis www.nature.com/articles/s41...

Our paper in Nature Medicine is out today! Great working with @drmfarag.bsky.social & the YAS team (researchers and participants) to identify biomarkers that pave the way for preventative trials in Huntington's Disease. Thanks to @wellcometrust.bsky.social and CHDI for funding. tinyurl.com/3fde9mth

Subtle changes in the brain happen around 20 years before a clinical motor diagnosis in people with Huntington’s disease. The new findings from a study led by Prof Sarah Tabrizi @uclqsion.bsky.social @uclbrainscience.bsky.social will guide future prevention trials www.ucl.ac.uk/news/2025/ja...

Excited to share my joint first-author paper (with @rachiscahill.bsky.social) published today in Nature Medicine (@natmedicine.bsky.social, @nature.com). Our findings are timely as the #HD therapeutic landscape expands toward preventive clinical trials. 🔓 Open access: www.nature.com/articles/s41...

Check out the latest edition of the #HD Clinical Trials Update, now available online in the Journal of Huntington's Disease @profwild.bsky.social 🔓 Open access link: journals.sagepub.com/doi/full/10....

We're excited to join BlueSky! Make sure to follow us for the latest news from the UCL Queen Square Institute of Neurology.