Amid this week’s huge milestone in #HD treatment, I’m excited to share part of my PhD thesis + our paper published today in @movedisorder.bsky.social on CSF #PENK predicting striatal atrophy decades before clinical motor diagnosis 🔗 movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...

For the first time, we show that baseline CSF PENK predicts longitudinal striatal atrophy and also outperforms NfL in distinguishing HD-ISS 0 vs 1, supporting CSF PENK as a striatum-specific biomarker to enrich early HD trials and inform future preventive trial design.

Huge thanks to @drmichelaleocadi.bsky.social and #HDYO for organising this fantastic event! Donate now and please support young people impacted by Huntington's disease: hdyo.enthuse.com/pf/huntingto...

Hot off the press! Check out the second edition of the @ehdn-news.bsky.social Imaging Working Group (#iWG) newsletter! #HD #neuroimaging @drmichelaleocadi.bsky.social @rachiscahill.bsky.social @nicolahobbs.bsky.social ehdn.org/wp-content/u...

UCL HD Centre @ucl-hd.bsky.social celebrating #HDGratitudeDay. Thanks to all the families and researchers around the world who together are trying to improve lives for people with Huntington’s disease.

Our paper in Nature Medicine is out today! Great working with @drmfarag.bsky.social & the YAS team (researchers and participants) to identify biomarkers that pave the way for preventative trials in Huntington's Disease. Thanks to @wellcometrust.bsky.social and CHDI for funding. tinyurl.com/3fde9mth

Excited to share my joint first-author paper (with @rachiscahill.bsky.social) published today in Nature Medicine (@natmedicine.bsky.social, @nature.com). Our findings are timely as the #HD therapeutic landscape expands toward preventive clinical trials. 🔓 Open access: www.nature.com/articles/s41...