Yago Arribas
@yarribas.bsky.social
📤 117
📥 192
📝 23
Immunologist. Mass spectrometry. Decoding non-coding but coding genome. Català a París.
pinned post!
Not easy to describe the emotions of seeing our work published in
@cellpress.bsky.social
! We explored how novel isoforms emerge during evolution through the exonization of Transposable Elements. Exonized TEs modify the functions and structures of host proteins.
www.cell.com/cell/fulltex...
loading . . .
Transposable element exonization generates a reservoir of evolving and functional protein isoforms
Transposable element exonization by unannotated splicing events produces stable protein isoforms with acquired functions that are subject to evolutionary selection.
https://www.cell.com/cell/fulltext/S0092-8674(24)01328-X
10 months ago
6
33
16
reposted by
Yago Arribas
Waggoner Lab
about 1 month ago
@biorxivpreprint.bsky.social
Endogenous retroelements promote tolerance to dietary antigens
@belkaidlab.bsky.social
www.biorxiv.org/content/10.1...
0
9
2
reposted by
Yago Arribas
Manuel Irimia
about 2 months ago
🚨🚨🚨 New review article on
#microexons
from the lab! A comprehensive recap of the current state of the field by
@tahneema.bsky.social
.
www.annualreviews.org/content/jour...
add a skeleton here at some point
0
15
4
reposted by
Yago Arribas
Jack Tierney
about 2 months ago
Many transcriptome regions are translated but not known to encode proteins. They remain poorly annotated and thus under studied, partly due to the lack of terminology for these features. In
@natmethods.nature.com
we propose using "Translon" for any region decoded by the ribosome
1
9
13
reposted by
Yago Arribas
Sean Bresnahan
4 months ago
🧬🚨PREPRINT🚨- The first placental isoform reference from long-read seq & supporting data! We demonstrate how tissue-specific assembly improves transcript quantification with short-read data from multi-ancestry birth studies & reveals placenta-mediated effects of gestational diabetes on birth weight🫄
loading . . .
Long-read transcriptome assembly reveals vast isoform diversity in the placenta associated with metabolic and endocrine function
The placenta plays a critical role in fetal development and mediates maternal metabolic effects on offspring health outcomes. Despite its importance, the placenta remains understudied in large-scale g...
https://doi.org/10.1101/2025.06.26.661362
1
22
12
reposted by
Yago Arribas
George Burslem
6 months ago
Excited to see this out in
@science.org
today!!
www.science.org/doi/10.1126/...
add a skeleton here at some point
6
135
58
reposted by
Yago Arribas
Manuel Irimia
7 months ago
"The main fates after gene duplication are gene loss, redundancy, subfunctionalization and neofunctionalization". In our new review,
@fedemantica.bsky.social
and I argue we are missing the most prevalent one: specialization. And the same applies to alternative splicing! 1/7
tinyurl.com/45k7kbmp
2
41
17
reposted by
Yago Arribas
Christina Metoikidou
7 months ago
Excited to share my first post & see the second part of my PhD work published! Our study on mTNBC highlights that baseline clonal expansion of dysfunctional CD8 cells is linked to better response to chemoimmunotherapy. More here:
www.sciencedirect.com/science/arti...
#CD8
#TCellExhaustion
#TNBC
loading . . .
Continuous replenishment of the dysfunctional CD8 T cell axis is associated with response to chemoimmunotherapy in advanced breast cancer
Chemotherapy combined with immune checkpoint blockade has shown clinical activity in breast cancer. Response, however, occurs in only a low proportion…
https://www.sciencedirect.com/science/article/pii/S2666379125000461
1
5
2
reposted by
Yago Arribas
Lluis Montoliu
7 months ago
Nuevo número de la Revista de la
@sebbm.bsky.social
dedicado al “Genoma no codificante” coordinado por Crisanto Gutiérrez
@cbm-csic-uam.bsky.social
entrevista a Jordi Camí,
@prbb.org
y presidente del
#CEEI
con artículos+contenido interesante Editora:
@inmayruela.bsky.social
sebbm.es/revista/nume...
loading . . .
El genoma no codificante
https://sebbm.es/revista/numeros/el-genoma-no-codificante/
1
14
8
reposted by
Yago Arribas
yEFIS
7 months ago
🌸Happy Women's Day! 💪👩🔬 As we wrap up our campaign, we celebrate the incredible contributions of women in science and beyond. 🌟 A big shoutout to the amazing women of the
#yefis
Task Force! ✨ Let’s keep inspiring and empowering each other. 💜
#WomensDay
#WomenInScience
#WomenInStem
0
12
10
1/ We saw an update on the PDAC neoantigen vaccine (Sethna et al., 2025). A remarkable effort in showing long-lived T cell protection in PDAC + an exhaustive look at the T cells. One question intrigued me: Were the selected neoantigens different between the 8 responder and 8 non-responder patients?
7 months ago
1
1
0
Merck & Co. digs into 'junk DNA' for cancer clues in new Epitopea deal
firstwordpharma.com/story/5936238
loading . . .
FirstWord
https://firstwordpharma.com/story/5936238
8 months ago
0
1
0
I am very happy to share that last week, I had the opportunity to present my research at the Winter Meeting of the Catalan Society of Immunology. But I feel even more honored to have presented in a session chaired by my first mentor in immunology, Dolores Jaraquemada.
8 months ago
0
3
0
reposted by
Yago Arribas
Nicolas Vabret
9 months ago
Registration is now open for the next ImmunoSchool! This year’s theme: "10 Years of Discovery in Immunotherapy." We’ve put together a stellar lineup of speakers—don’t miss it! Free registration @
bit.ly/3WFj0Hc
#ImmunoSchool
#Immunotherapy
#CancerResearch
0
3
3
reposted by
Yago Arribas
Manel Esteller
9 months ago
Thrilled to introduce our Cell Reports
@cellreports.bsky.social
article, showing how the iconic 'Hallmarks of Cancer' are located in the space of real human primary tumors. A team effort co-led by Eduard Porta, Matthew H. Bailey, and yours truly
#SpatialBiology
#Visium
www.cell.com/cell-reports...
1
8
5
reposted by
Yago Arribas
Itai Yanai
9 months ago
Top 4 things to know about doing science: 1. You need to have someone you can talk to 2. One-on-one discussions are the best 3. Think about discussions as improvisations and use the ‘yes, and’ rule 4. Create a safe space so both of you feel open to saying seemingly silly things
4
122
38
reposted by
Yago Arribas
Cheri Sirois
10 months ago
The last Cell issue of the year is online. This one is a doozy if you like interferons (as I do!) or transposons and ERVs (and who doesn't?!) There's also cool stem cell and dev bio in this issue, immune responses to Zika during pregnancy... cancer, plants... cool stuff!
www.cell.com/cell/issue?p...
0
36
13
reposted by
Yago Arribas
Pau Badia i Mompel
10 months ago
The final chapter of my PhD thesis is now out! 🎉 We compared the latest gene regulatory network (#GRN) inference methods for
#single-cell
multimodal datasets and evaluated their performance across various tasks. Hard to believe this journey started in March 2021 and has finally reached this point 😅🥳
add a skeleton here at some point
0
31
9
reposted by
Yago Arribas
bioRxiv Immunology
10 months ago
MAETi: Mild acid elution in a tip enables quantitative immunopeptidome profiling from 25,000 cells
https://www.biorxiv.org/content/10.1101/2024.12.20.628848v1
0
0
1
reposted by
Yago Arribas
Ivan Zanoni
10 months ago
WeekendRead!
@cicacanesso.bsky.social
@danmucida.bsky.social
@victora.bsky.social
&co show
@science.org
that cDC1s & Rorgt APCs drive peripheral Tregs to dietary antigens, & that helminth infections increase the ratio of inflammatory cDC2 preventing tolerance induction!
loading . . .
Identification of antigen-presenting cell–T cell interactions driving immune responses to food
The intestinal immune system must concomitantly tolerate food and commensals and protect against pathogens. Antigen-presenting cells (APCs) orchestrate these immune responses by presenting luminal ant...
https://www.science.org/doi/10.1126/science.ado5088
2
33
9
reposted by
Yago Arribas
Institut Curie
10 months ago
🔬 New insights into protein diversity published in
@cellpress.bsky.social
: researchers led by Dr. Amigorena have identified over 1,000 unannotated protein isoforms derived from transposable element exonization. Read full publication ⤵️
www.cell.com/cell/fulltext/S0092-8674%2824%2901328-X
0
3
1
reposted by
Yago Arribas
ACIR
10 months ago
To generate HLA-restricted, TAA-binding TCRs (normally eliminated by central tolerance), Abdelfattah et al. (1) mutated a TAA peptide of interest by a single amino acid, (2) used the mutant peptide to expand and identify endogenous reactive [...]
acir.org/journal-art...
@harvardmed.bsky.social
0
1
1
reposted by
Yago Arribas
Associació Catalana de Comunicació Científica (ACCC)
10 months ago
Al 1990 va néixer l'ACCC (llavors l'Associació Catalana de Periodisme Científic), com anuncia la nota de premsa compartida aquí per
@xavierduran.bsky.social
, membre de la 1a Junta Directiva. 📖 Descobreix tota la història de l'ACCC a
accc.cat/lassociacio/#historia
add a skeleton here at some point
0
3
4
reposted by
Yago Arribas
Eduardo Villablanca
10 months ago
How does the immune system make "decisions" at mucosal barriers? My new perspective explores how seeing strategic cell interactions through the lens of game theory could reveal fresh insights into mucosal immune homeostasis and disease. 🧵 1/7
www.sciencedirect.com/science/arti...
loading . . .
Organismal mucosal immunology: A perspective through the eyes of game theory
In complex organisms, functional units must interact cohesively to maintain homeostasis, especially within mucosal barriers that house diverse, specia…
https://www.sciencedirect.com/science/article/pii/S1933021924001260
4
57
22
reposted by
Yago Arribas
Ivan Zanoni
10 months ago
#NotOnlyParasites
! 2 Cell papers by
@edchuong.bsky.social
lab & Amigorena lab demonstrate that transposable elements
#TEs
can exonize giving rise to functional (often shorter) proteins with distinct functions: eg a decoy short IFNAR2 that inhibits
#interferon
signaling!
www.cell.com/cell/fulltex...
loading . . .
Transposable element exonization generates a reservoir of evolving and functional protein isoforms
Transposable element exonization by unannotated splicing events produces stable protein isoforms with acquired functions that are subject to evolutionary selection.
https://www.cell.com/cell/fulltext/S0092-8674(24)01328-X
0
26
16
And more TEs! Exciting to see this field growing! 😊
add a skeleton here at some point
10 months ago
0
4
0
Not easy to describe the emotions of seeing our work published in
@cellpress.bsky.social
! We explored how novel isoforms emerge during evolution through the exonization of Transposable Elements. Exonized TEs modify the functions and structures of host proteins.
www.cell.com/cell/fulltex...
loading . . .
Transposable element exonization generates a reservoir of evolving and functional protein isoforms
Transposable element exonization by unannotated splicing events produces stable protein isoforms with acquired functions that are subject to evolutionary selection.
https://www.cell.com/cell/fulltext/S0092-8674(24)01328-X
10 months ago
6
33
16
you reached the end!!
feeds!
log in