Happy to end 2025 by sharing a review we wrote on a dichotomy that fascinates me: are cryptic proteins mostly rapidly degraded to generate MHC antigens, or do they give rise to evolutionarily recent proteins testing new functions? The answer: probably both. onlinelibrary.wiley.com/doi/10.1002/...

@biorxivpreprint.bsky.social Endogenous retroelements promote tolerance to dietary antigens @belkaidlab.bsky.social www.biorxiv.org/content/10.1...

🚨🚨🚨 New review article on #microexons from the lab! A comprehensive recap of the current state of the field by @tahneema.bsky.social. www.annualreviews.org/content/jour...

Many transcriptome regions are translated but not known to encode proteins. They remain poorly annotated and thus under studied, partly due to the lack of terminology for these features. In @natmethods.nature.com we propose using "Translon" for any region decoded by the ribosome

🧬🚨PREPRINT🚨- The first placental isoform reference from long-read seq & supporting data! We demonstrate how tissue-specific assembly improves transcript quantification with short-read data from multi-ancestry birth studies & reveals placenta-mediated effects of gestational diabetes on birth weight🫄

Excited to see this out in @science.org today!! www.science.org/doi/10.1126/...

"The main fates after gene duplication are gene loss, redundancy, subfunctionalization and neofunctionalization". In our new review, @fedemantica.bsky.social and I argue we are missing the most prevalent one: specialization. And the same applies to alternative splicing! 1/7 tinyurl.com/45k7kbmp

Excited to share my first post & see the second part of my PhD work published! Our study on mTNBC highlights that baseline clonal expansion of dysfunctional CD8 cells is linked to better response to chemoimmunotherapy. More here: www.sciencedirect.com/science/arti... #CD8 #TCellExhaustion #TNBC

Nuevo número de la Revista de la @sebbm.bsky.social dedicado al “Genoma no codificante” coordinado por Crisanto Gutiérrez @cbm-csic-uam.bsky.social entrevista a Jordi Camí, @prbb.org y presidente del #CEEI con artículos+contenido interesante Editora: @inmayruela.bsky.social sebbm.es/revista/nume...

🌸Happy Women's Day! 💪👩‍🔬 As we wrap up our campaign, we celebrate the incredible contributions of women in science and beyond. 🌟 A big shoutout to the amazing women of the #yefis Task Force! ✨ Let’s keep inspiring and empowering each other. 💜 #WomensDay #WomenInScience #WomenInStem

1/ We saw an update on the PDAC neoantigen vaccine (Sethna et al., 2025). A remarkable effort in showing long-lived T cell protection in PDAC + an exhaustive look at the T cells. One question intrigued me: Were the selected neoantigens different between the 8 responder and 8 non-responder patients?

Merck & Co. digs into 'junk DNA' for cancer clues in new Epitopea deal firstwordpharma.com/story/5936238

I am very happy to share that last week, I had the opportunity to present my research at the Winter Meeting of the Catalan Society of Immunology. But I feel even more honored to have presented in a session chaired by my first mentor in immunology, Dolores Jaraquemada.

Registration is now open for the next ImmunoSchool! This year’s theme: "10 Years of Discovery in Immunotherapy." We’ve put together a stellar lineup of speakers—don’t miss it! Free registration @ bit.ly/3WFj0Hc #ImmunoSchool #Immunotherapy #CancerResearch

Thrilled to introduce our Cell Reports @cellreports.bsky.social article, showing how the iconic 'Hallmarks of Cancer' are located in the space of real human primary tumors. A team effort co-led by Eduard Porta, Matthew H. Bailey, and yours truly #SpatialBiology #Visium www.cell.com/cell-reports...

Top 4 things to know about doing science: 1. You need to have someone you can talk to 2. One-on-one discussions are the best 3. Think about discussions as improvisations and use the ‘yes, and’ rule 4. Create a safe space so both of you feel open to saying seemingly silly things

The last Cell issue of the year is online. This one is a doozy if you like interferons (as I do!) or transposons and ERVs (and who doesn't?!) There's also cool stem cell and dev bio in this issue, immune responses to Zika during pregnancy... cancer, plants... cool stuff! www.cell.com/cell/issue?p...

The final chapter of my PhD thesis is now out! 🎉 We compared the latest gene regulatory network (#GRN) inference methods for #single-cell multimodal datasets and evaluated their performance across various tasks. Hard to believe this journey started in March 2021 and has finally reached this point 😅🥳

MAETi: Mild acid elution in a tip enables quantitative immunopeptidome profiling from 25,000 cells https://www.biorxiv.org/content/10.1101/2024.12.20.628848v1

WeekendRead! @cicacanesso.bsky.social @danmucida.bsky.social @victora.bsky.social &co show @science.org that cDC1s & Rorgt APCs drive peripheral Tregs to dietary antigens, & that helminth infections increase the ratio of inflammatory cDC2 preventing tolerance induction!

🔬 New insights into protein diversity published in @cellpress.bsky.social: researchers led by Dr. Amigorena have identified over 1,000 unannotated protein isoforms derived from transposable element exonization. Read full publication ⤵️ www.cell.com/cell/fulltext/S0092-8674%2824%2901328-X

To generate HLA-restricted, TAA-binding TCRs (normally eliminated by central tolerance), Abdelfattah et al. (1) mutated a TAA peptide of interest by a single amino acid, (2) used the mutant peptide to expand and identify endogenous reactive [...] acir.org/journal-art...  @harvardmed.bsky.social

Al 1990 va néixer l'ACCC (llavors l'Associació Catalana de Periodisme Científic), com anuncia la nota de premsa compartida aquí per @xavierduran.bsky.social, membre de la 1a Junta Directiva. 📖 Descobreix tota la història de l'ACCC a accc.cat/lassociacio/#historia

How does the immune system make "decisions" at mucosal barriers? My new perspective explores how seeing strategic cell interactions through the lens of game theory could reveal fresh insights into mucosal immune homeostasis and disease. 🧵 1/7 www.sciencedirect.com/science/arti...

#NotOnlyParasites! 2 Cell papers by @edchuong.bsky.social lab & Amigorena lab demonstrate that transposable elements #TEs can exonize giving rise to functional (often shorter) proteins with distinct functions: eg a decoy short IFNAR2 that inhibits #interferon signaling! www.cell.com/cell/fulltex...

And more TEs! Exciting to see this field growing! 😊

Not easy to describe the emotions of seeing our work published in @cellpress.bsky.social ! We explored how novel isoforms emerge during evolution through the exonization of Transposable Elements. Exonized TEs modify the functions and structures of host proteins. www.cell.com/cell/fulltex...