New in #GENETICS from @hainerlab.bsky.social: The nucleosome remodelers esBAF and INO80 selectively influence subcompartment identity and enhancer–promoter communication at key regulatory loci during higher-order chromatin organization in mice. 🔗 buff.ly/0eU5xg0

Great thread from an @nationalacademies.org award winner highlighting the current cowardice and capitulation of NAS, tech industry and the leaders of both to the demands of Trump that are destroying American science 🧪

Three @biorxivpreprint.bsky.social preprints on acute depletion of FACT in ES cells. First, from my colleague at Pitt Sarah Hainer's lab 1/ www.biorxiv.org/content/10.6...

Incredibly proud to share our new preprint, lead by the Incomparable Rithika Sankar. Here we temporally dissect the role of FACT in mES cells, finding that FACT loss drives progressive deterioration of chromatin architecture, leading to transcriptional collapse. www.biorxiv.org/content/10.6...

Very sad news. Gail Martin (1944-2026) was a figure in developmental biology. She pioneered the field of ES cells. A great colleague, a friend and a lovely person.

Happy Black History Month! I am sharing a permanent and continuously updated list of inspiring Black scientists! Check it out! Huge thank you to the folks who gathered this info. Thank you to @drstarbird.bsky.social and the rest of the Index Committee! www.wiley.com/en-us/resear...

Proud to be Canadian 🇨🇦 www.cbc.ca/news/politic...

* vaccines keep kids from dying * guns cause kids to die these are unassailable conclusions based on mountains of evidence it is a crying shame that politicians pretend otherwise, endangering our kids and everyone else’s

Comment period ends on Monday for a proposed rule change that would terminate student visas after 4 years. It also puts limits on exchange visitors and reps of foreign media, and shortens the length of time at the end of the visa from 60 days to 30 days. www.federalregister.gov/documents/20...

New preprint is up, led by former postdoc Braulio Bonilla. We know these remodelers regulate nucleosome positions and occupancy, but do they have a role in regulating higher order chromatin structure? We take a peek for BAF and INO80C. www.biorxiv.org/content/10.1...

🧬 Transcription elongation by RNA polymerase II relies on a web of elongation factors. Our new work shows how IWS1 acts as a modular scaffold to stabilize & stimulate elongation. Fantastic work by Della Syau! www.biorxiv.org/content/10.1...

Our collaborative paper with the Arndt lab is out today: doi.org/10.1093/nar/... (originally bioRxiv: www.biorxiv.org/content/10.1...). Here we asked the question of how CHD1 localizes to chromatin.

if i were a better person i would do a tweetorial on our recent paper - but, hey, read the paper. its right there, waiting for you. #Giantvirus #histones are cool! their #nucleosomes are cool. check it out.! thats the tweetorial. rdcu.be/exXBX

Tenure track position alert! Assistant Professor of Molecular Therapeutics in MCB @UCBerkeley. Apply and come be our colleague! 🎉 aprecruit.berkeley.edu/JPF05098

We are hiring! The Dept of Microbiology and Molecular Genetics is looking for faculty at the Assistant or Associate professor level (tenure track). Please consider joining our vibrant microbiology and immunology community at the University of Pittsburgh School of medicine

The successful candidate will oversee the management and direction of the OSU Herbarium and establish an independent research program by conducting original research in an area of plant systematics, ecology, and/or evolution.

We built a team to represent a coalition of unions, non-profits, & local governments in the largest lawsuit challenging Trump’s authority to remake the government without congressional approval. Trump's efforts to dismantle the federal government are unconstitutional and we will see him in court.

Interested in synthetic approaches to both understand and manipulate gene expression? We (the Bintu lab) wrote a review that discusses just that - how modern low- and high-throughput approaches can dissect gene regulation at the DNA, RNA, and protein level. www.annualreviews.org/content/jour...

ATTENTION: NSF GRANT RECIPIENTS We received a heads up from a trusted source that you should proactively download/print/screen shot any documentation on research.gov pertaining to your NSF awards, both those that are current and any that have closed in the last 5-6 years. 1/n

Profiling transcriptome composition and dynamics within nuclear compartments using SLAM-RT&Tag Nadiya Khyzha ∙ Kami Ahmad∙ Steven Henikoff www.cell.com/molecular-ce...

Join us at the 2025 Epigenetics Society International Conference in Chicago! Discover the latest in DNA, RNA, and chromatin epigenetics, steps from Navy Pier & Michigan Ave! www.esconference25.com. #Epigenetics2025 #DNA #RNA #Chromatin #ScientificConference #Chicago

New report shows that NIH grants fueled $95 billion in economic activity and 407,782 jobs in 2024. That's not to mention the countless lives that biomedical research has saved. Show me a better investment than that. www.forbes.com/sites/michae...

Big news: we are setting up a new non-profit organization to run bioRxiv and medRxiv. It's called openRxiv [no it's not a new preprint server; it's dedicated organization to oversee the servers] openrxiv.org 1/n

First @fnucleosome.bsky.social talks of the year coming up on Wednesday! Register to join us And, if you're interested in presenting with us this year, you can fill out this survey: docs.google.com/forms/d/e/1F...

In case you missed them, a number of our @fnucleosome.bsky.social talks from 2024 are now up on our youtube channel! Check out the recently uploaded seminars below: Julia Rogers: Notch induces transcription by stimulating release of paused RNA Pol II www.youtube.com/watch?v=GME2...

PhD studentship! Chromatin! Structural Biology! Signaling! Stem Cells! Beautiful Devon! Honestly, what more could you want? APPLY NOW! Deadline Friday 10 Jan! @lsiexeter.bsky.social

Happy New Year from us to you!

Happy to share the latest preprint which is a close collaboration with Karen Arndt with a shared PhD student, Sarah Tripplehorn. Here we show a direct interaction between Chd1 and Paf1C subunit Rtf1 required for nucleosome positioning across genes: t.co/E9FSj2nHv8

Happy to share work with my close colleague Karen Arndt through a joint PhD student. Here we explored how Chd1 localizes across gene bodies, following up from previous Arndt lab studies identifying Rtf1 as require for Chd1 localization.

What an amazing time! Students at #ABRCMS2024 were so impressive! Incredibly proud of all the Pitt Biosci undergrads and grad students

I could not be more proud of these two amazing women: I told you to watch out for Kya Foxx last year: here she goes giving a talk and winning! And then introducing Bryona Jackson who you should be on the lookout for; just won a poster presentation award. #ABRCMS2024

Pitt BIOSC undergrads at #ABRCMS2024

Pitt Biosci grad students at #ABRCMS2024! So many amazing posters last night!

Please see our paper in Nature on read-write mechanisms of H2AK119 ubiquitination by Polycomb repressive complex I. Congrats to the whole team, especially Victoria and huge thanks to our collaborator JP Armache! Also big thanks to Mark Foundation for Cancer Research for the support! rdcu.be/dZ5HZ

Kya Foxx checking her talk for Friday at 11:15am (CC-407) #ABRCMS2024 #proudmentor

We made it! See you at #ABRCMS2024!

I just published: What’s a toxic environment for a PhD student? Being aware of potential red flags when selecting a host lab is crucial. Here are some issues I’ve witnessed over the years. #phdchat #AcademicChatter link.medium.com/O5fd2PQ0GHb

“Integrating cultural relevance into STEM education, promoting culturally responsive mentoring, engaging communities, and showcasing role models are all crucial strategies for empowering NA/AN students in their STEM pursuits.” www.openaccessgovernment.org/article/indi...

reviewing many grants and I will say that three letter acronyms are the WORST. why do I need to learn a new language for every grant? Folks, let me say this loud and clear: the space you gain by using TLAs is proportional to reviewer irritation. Use them sparingly. or NOT AT ALL! You are welcome

Happy New Year from us to you!

Incredibly proud of superstar Kya Foxx. Not only a full travel awardee but also a poster presentation award from #ABRCMS2023 - and this was her first poster presentation and first conference! Watch out science world! #proudmentor

When I struggled to write a fundable grant back in 2020 and 2021, I applied for a JEDI award with LSEF and got it. I received the guidance I needed. If you are in a similar situation- please check it out! lifescienceeditors.org/apply/ youtu.be/lvguQrYgL1A?...

#NIH revises its research grant review process. For applications submitted on or after Jan. 25, 2025. go.nih.gov/9EROYa2

Can’t begin to express my profound gratitude to each and every one of these people for making the first edition of the New Investigators in Chromatin and Epigenetics (NICE) conference so stellar! Particularly big 🙏 to my co-organizers @hainerlab.bsky.social and @4everBiochemist

Heading to the inaugural NICE meeting: www.nicechromatin.com A chromatin&epigenetics mtg for new PIs only (pre-tenure); we are hoping to expand pending how this initial mtg goes! if you are interested in next year, get in touch! We want to build a chromatin community filled nice (get it?!) folks!

Sometimes I forget how insanely horrible my first experience serving on an NIH study section was until I give details to people I haven't told before. But I still stand: if you identify a clear bias in the review process - bring it up. Even if it means the SRO shouts at you. Worth it every time.

y'all this is really not ok

5.5yrs into being an Assistant Prof, and I still feel like I don't know how to do this job: how do I manage being a scientist, mentor, administrator, writer, businesswoman, cheerleader, critic, therapist, analyst, coordinator, colleague, etc all at once?? Oh btw, I'm a mom of two also.