Giulia Casal, PhD
@giuliacasal.bsky.social
📤 492
📥 391
📝 26
Blood Nerve Barrier & Schwann cells, currently Lloyd Lab UCL, BSc UniFribourg 🇨🇭🇮🇹
pinned post!
Officially PhD! Feeling very lucky to have had such an amazing lab and experience! Thank you to my examiners
@stevewilsonfish.bsky.social
and Giles Hardingham
@ukdri.ac.uk
and obviously Alison!!!
10 months ago
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reposted by
Giulia Casal, PhD
Juan C. Landoni
5 days ago
Our paper is now out in Science! Super excited to share our discovery that
#mitochondria
#pearling
is the elusive mechanism driving the regular distribution and inheritance of
#mtDNA
nucleoids 🧬 [1/6]
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Giulia Casal, PhD
Melanie D. White
6 days ago
I'm so pleased to see this work on neural crest development out in Nature today! This was a truly fantastic collaboration with
@gleesonlab.bsky.social
, Keng loi (Harry) Vong and
@xiaoxuyang.bsky.social
. Huge thanks to everyone involved 👏 🧪🐣
#devbio
www.nature.com/articles/s41...
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reposted by
Giulia Casal, PhD
6 days ago
Latest offering. How myelin ensheathes axons! Born from chat with Dwight Bergles on "weird things" we saw oligodendrocytes do, like making "bridges" between sheaths. Driven forward by Cody Call, Kelly Monk, and myelin folks
@edinburgh-uni.bsky.social
Enjoy!
www.nature.com/articles/s41...
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Flexible ensheathment of axons enables myelination of complex CNS networks - Nature
The rate of axon ensheathment varies within individual myelinating processes, resulting in chains of myelin sheaths connected by bridges consisting of thin cytoplasmic processes that provide ...
https://www.nature.com/articles/s41586-026-10312-1
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reposted by
Giulia Casal, PhD
Christophe 🔬 L
6 days ago
All data in this work are beautiful – look at this 3-day timelapse of in vivo myelination along a zebrafish axon!
www.nature.com/articles/s41...
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Another beautiful Hsu lab paper!
add a skeleton here at some point
17 days ago
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reposted by
Giulia Casal, PhD
UCL Faculty of Life Sciences
about 1 month ago
Interested in joining a dynamic, interdisciplinary research department? A call is open for Group Leaders at the UCL Laboratory for Molecular Cell Biology. Please submit your expression of interest by April 13, 2026. Further details here:
www.ucl.ac.uk/work-at-ucl/...
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reposted by
Giulia Casal, PhD
Crystal Rogers, PhD
about 1 month ago
Excited to share this collaborative work with
@sarathomasy.bsky.social
- spearheaded by Raneesh Ramarapu and William Stoehr- where we visualized the unique spatial localization of tubulin isotopes in neural crest-derived corneal tissues during development. 🤩
add a skeleton here at some point
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reposted by
Giulia Casal, PhD
about 2 months ago
Latest from the lab, led by
@ara-donia.bsky.social
and
@juliavdkorput.bsky.social
Huge team effort, with immense contributions by friends from nearby and around the globe.
www.science.org/doi/10.1126/...
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Myelin sheaths in the central nervous system can withstand damage and dynamically remodel
Myelin damage is a hallmark of several neurological disorders, but how it occurs remains to be fully understood. In this study, we found that early damage in zebrafish and rodent demyelination models ...
https://www.science.org/doi/10.1126/science.adr4661
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reposted by
Giulia Casal, PhD
eLife
3 months ago
A protein called Uninflatable acts as a switch between glial cells growing and glial cells wrapping themselves around axons. 🔗
buff.ly/WRdybO3
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Latest paper from the Lloyd lab is out! Beautiful work by my best PhD (now both postdoc) lab-mate Alex 🥳🥳🥳 Microenvironmental TGF-β is an early driver of NF1-associated tumor formation: Cell Reports
www.cell.com/cell-reports...
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Microenvironmental TGF-β is an early driver of NF1-associated tumor formation
Power et al. identify TGF-β as the injury microenvironment signal required for neurofibroma formation, enabling the expansion of Nf1-KO SCs outside of a repairing nerve by blocking axonal interactions...
https://www.cell.com/cell-reports/fulltext/S2211-1247%2825%2901594-3
3 months ago
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reposted by
Giulia Casal, PhD
Juan C. Landoni
3 months ago
#Mitochondria
or Alien script? 🧪🔬👽
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reposted by
Giulia Casal, PhD
Joey Tidei
4 months ago
I don't always get pretty, isolated, AND transfected primary neurons in culture, but when I do I take advantage.... Rat hippocampal neuron overexpressing ThymosinB4-mScarlet and imaged for 16hr on a
@zeiss-microscopy.bsky.social
LSM880 with Airyscan.
#FluorescenceFriday
#Microscopy
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reposted by
Giulia Casal, PhD
Denis Wirtz
4 months ago
We mapped the whole human fallopian tube in 3D and at single-cell resolution via our CODA workflow. More about this work here:
biorxiv.org/content/10.1...
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reposted by
Giulia Casal, PhD
Constantin Pape
6 months ago
Are you studying synapses in electron microscopy? Tired of annotating vesicles? We have the tool for you! SynapseNet implements automatic segmentation and analysis of vesicles and other synaptic structures and has now been published:
www.molbiolcell.org/doi/full/10....
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reposted by
Giulia Casal, PhD
Mathieu Preußner
5 months ago
Can't believe it — my first‑author paper is out and my image graces the cover of
@dev-journal.bsky.social
🎉 Here, we reveal how early developmental programs shape and maintain
#zebrafish
gill architecture throughout life 🔗
journals.biologists.com/dev/issue/15...
#FluorescenceFriday
#LifelongDevSI
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reposted by
Giulia Casal, PhD
Ardem Patapoutian
7 months ago
I will give the UCL Prize Lecture in Life and Medical Sciences. If you are in London on December 3, come say hello. Registration is required but free:
www.eventbrite.co.uk/e/ucl-prize-...
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UCL Prize Lecture in Life and Medical Sciences 2025
The UCL Prize Lecture in Life and Medical Sciences is a prize awarded annually since 1997 to individuals who have excelled in these fields.
https://www.eventbrite.co.uk/e/ucl-prize-lecture-in-life-and-medical-sciences-2025-tickets-1570162792179?aff=oddtdtcreator
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reposted by
Giulia Casal, PhD
UCL Faculty of Brain Sciences
7 months ago
🧵 BREAKING: Gene therapy shows promise in slowing Huntington’s disease progression. A major milestone in neurodegenerative disease research.
@uclqsion.bsky.social
@ucl-hd.bsky.social
www.bbc.co.uk/news/article...
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Huntington's disease successfully treated for first time
One of the most devastating diseases finally has a treatment that can slow its progression and transform lives, tearful doctors tell BBC.
https://www.bbc.co.uk/news/articles/cevz13xkxpro
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reposted by
Giulia Casal, PhD
eLife
7 months ago
Dorsal Vagal Complex: A cell atlas to guide research into appetite control
buff.ly/QY7ev03
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This is why I love science
add a skeleton here at some point
7 months ago
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reposted by
Giulia Casal, PhD
Neuron
7 months ago
We are proud to present a Special Issue on Cancer Neuroscience, curated by editors Bennie Babayan & Ted Dobie. This issue offers a snapshot of the field through a collection of Perspectives, Reviews, and NeuroViews:
cell.com/neuron/issue...
. See below for details on the pieces:
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reposted by
Giulia Casal, PhD
Jemima Burden
10 months ago
Yesterday.. our
#CLEM
with Julia Gutjahr and Antal Rot was featured in the main Science webpage....☺️ Nice to see
#correlativemicroscopy
and
#volumeEM
up front and centre.
www.science.org/doi/10.1126/...
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reposted by
Giulia Casal, PhD
8 months ago
www.nature.com/articles/s41...
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FBXW7 regulates MYRF levels to control myelin capacity and homeostasis in the adult central nervous system - Nature Communications
The homeostasis of myelin in the central nervous system is highly regulated, but the underlying mechanisms are unclear. Here, the authors show that the FBXW7 protein has a role in constraining myelin ...
https://www.nature.com/articles/s41467-025-62715-9
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reposted by
Giulia Casal, PhD
International Society for Regenerative Biology
8 months ago
It's a wrap. The Biannual ISRB Meeting has ended. Stay tuned this week as we reflect on exciting science, honour our Lifetime Achievement and Rising Star Awardees and reflect on all we have learnt about regeneration this past week.
#ISRB2025
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reposted by
Giulia Casal, PhD
Giulia Paci
8 months ago
Courtney
@courtneyl7a7.bsky.social
has written a lovely piece on this wonderful community initiative we’ve been running for 5 years at UCL - have a read! And follow
@biig-ucl.bsky.social
!
add a skeleton here at some point
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reposted by
Giulia Casal, PhD
Baptiste Lacoste
8 months ago
Another beautiful study by the lab of
@andyshihlab.bsky.social
published today in
@natureportfolio.nature.com
👏🏻👏🏻👏🏻
#cerebrovascular
#aging
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Impaired capillary–venous drainage contributes to gliosis and demyelination in mouse white matter during aging - Nature Neuroscience
How reduced blood flow plays a role in progressive white matter loss during aging and associated cognitive decline is unclear. Here the authors show that selective constriction and rarefaction of capi...
https://doi.org/10.1038/s41593-025-02023-z
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@isrbio.bsky.social
#isrb2025
has started and we had a great time at the pre-conference trainee meeting, organised by us, the monthly trainee meeting organisers (Salome Stierli, Grave Schulz, Matt Cherubino, Jackson Griffiths, Carlos Barradas Chacon) - none of them have bsky!
8 months ago
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reposted by
Giulia Casal, PhD
Cells & Development
8 months ago
Maybe it's time we rethink the idea that development is a cell centric process? In this beautiful review, María-del-Carmen and
@stramerlab.bsky.social
discussed how the ECM underlies and influences many morphogenesis processes from wing unfolding to mammary gland development.
doi.org/10.1016/j.cd...
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Some beautiful Remak cells acquired on the new Hitachi TEM 🤩
add a skeleton here at some point
8 months ago
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reposted by
Giulia Casal, PhD
Evangelos Giampazolias
9 months ago
I'm deeply honoured to receive the BACR/AstraZeneca Young Scientist Frank Rose Award in recognition of my cancer research. Grateful to
@thebacr.bsky.social
@astra-zeneca.bsky.social
#Mentors
&
#Colleagues
whose support has shaped this journey. My reflections👇 🔗
www.bacr.org.uk/news/2025-ba...
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reposted by
Giulia Casal, PhD
Nature Cardiovascular Research
9 months ago
❤️Our July issue is out❤️Discover an Angiopoietin-TIE2-dependent circuit promoting venous malformations, complex disease modelling in cardiac organoids, regulation of cardiac homeostasis by methyonil tRNA synthetase, and more!
www.nature.com/natcardiovas...
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Goodbye Alice! Excited for the new one 👀
add a skeleton here at some point
9 months ago
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reposted by
Giulia Casal, PhD
CCP-volumeEM
9 months ago
🚨 SAVE THE DATE 🚨 Inaugural CCP-volumeEM Community Meeting, 3rd November 2025 at
@crick.ac.uk
in London "Towards a collaborative computational community for volume EM" Timings: 12pm - 5.30pm, followed by networking reception
#volumeEM
#BioImageAnalysis
#VEM
#CCPvolumeEM
#CoSeC
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reposted by
Giulia Casal, PhD
Jemima Burden
9 months ago
Exciting next steps in
#volumeEM
data analysis! A way to remove the data bottleneck..🍾👏
#mmc2025
@ccp-volumeem.bsky.social
@martinjones.bsky.social
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reposted by
Giulia Casal, PhD
Jeff Rasmussen
10 months ago
🎉 Our study identifying the direct precursors of Merkel cells is now published in
@dev-journal.bsky.social
Thank you to our reviewers
@reviewcommons.org
and collaborators for helping us improve the manuscript. Check out these cell behaviors we visualized in
#zebrafish
skin.
doi.org/10.1242/dev....
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reposted by
Giulia Casal, PhD
Franck Pichaud
10 months ago
Delighted to share our latest work on the mechanisms of epithelial curvature and 3D morphogenesis ! Amazing work from newly graduated Dr
@courtneyl7a7.bsky.social
🎉
@lmcb-ucl.bsky.social
@uclnews.bsky.social
@ucllifesciences.bsky.social
www.sciencedirect.com/science/arti...
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Integrins coordinate basal surface contraction and oriented cell growth to enable thickening of a curved epithelium
During development, tissues undergo morphogenesis to achieve their final form. This process relies on coordinated cell shape changes, which have predo…
https://www.sciencedirect.com/science/article/pii/S0960982225006645
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Officially PhD! Feeling very lucky to have had such an amazing lab and experience! Thank you to my examiners
@stevewilsonfish.bsky.social
and Giles Hardingham
@ukdri.ac.uk
and obviously Alison!!!
10 months ago
1
7
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reposted by
Giulia Casal, PhD
James Briscoe
11 months ago
New Faraday Fellowships for international applicants moving to the UK Up to £4 million per researcher over 5-10 years Fast-track option for mid-career researchers looking to relocate to the UK
add a skeleton here at some point
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reposted by
Giulia Casal, PhD
Omer Ali Bayraktar
11 months ago
How does tumour heterogeneity arise? How can we predict cancer cell plasticity? In 2 new studies, we trace
#glioblastoma
heterogeneity to a spatial cancer cell trajectory w. multimodal cell atlassing
bit.ly/4mkrWgs
& predict plasticity w. snRNA/ATAC+deep learning
bit.ly/3FbI6Ic
🧵
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reposted by
Giulia Casal, PhD
Matthew Freeman
12 months ago
Pretty amazing graphic to go with the
@financialtimes.com
article about the cost of Trump's attack on US science NIH is HUGE!
www.ft.com/content/67fd...
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reposted by
Giulia Casal, PhD
Nature Neuroscience
11 months ago
Our May issue is now live!
www.nature.com/neuro/volume...
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reposted by
Giulia Casal, PhD
11 months ago
For those who want a distraction and/ or are interested, here's the latest from the group, led by Phil Braaker
www.nature.com/articles/s41...
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Activity-driven myelin sheath growth is mediated by mGluR5 - Nature Neuroscience
Employing pharmacology, genetics and all-optical approaches in zebrafish, Braaker et al. find that neuronal activity influences the growth of myelin sheaths along axons by signaling through metabotrop...
https://www.nature.com/articles/s41593-025-01956-9
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reposted by
Giulia Casal, PhD
Quanta Magazine
11 months ago
The feeling of a hug comes from the pressure and vibration of millions of nerve endings.
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Touch, Our Most Complex Sense, Is a Landscape of Cellular Sensors | Quanta Magazine
Every soft caress of wind, searing burn and seismic rumble is detected by our skin’s tangle of touch sensors. David Ginty has spent his career cataloging the neurons beneath everyday sensations.
https://www.quantamagazine.org/touch-our-most-complex-sense-is-a-landscape-of-cellular-sensors-20250416/
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I’ve submitted but not quite done it yet! The viva is on 3rd of June at the
@lmcb-ucl.bsky.social
😎 thank you so much for the cake 🫶🏻
@stellakouloulia.bsky.social
& Delan who is still not on bluesky
11 months ago
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reposted by
Giulia Casal, PhD
Selin Jessa
11 months ago
Delighted to share our latest work deciphering the landscape of chromatin accessibility and modeling the DNA sequence syntax rules underlying gene regulation during human fetal development!
www.biorxiv.org/content/10.1...
Read on for more: 🧵 1/16
#GeneReg
🧬🖥️
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Dissecting regulatory syntax in human development with scalable multiomics and deep learning
Transcription factors (TFs) establish cell identity during development by binding regulatory DNA in a sequence-specific manner, often promoting local chromatin accessibility, and regulating gene expre...
https://www.biorxiv.org/content/10.1101/2025.04.30.651381v1
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reposted by
Giulia Casal, PhD
eLife
about 1 year ago
🧵 🧪 1/ Female
#ReproductiveBiology
is, unfortunately, notoriously understudied. So maybe it’s no surprise that a supposedly useless ‘developmental leftover’ in the ovaries could turn out to be...not so useless after all. Meet the rete ovarii 👇
buff.ly/VudxQ2U
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reposted by
Giulia Casal, PhD
Barriga Lab
about 1 year ago
REPOSTING this here just to officially leave "the other place" Our work on the role of endogenous electric fields in guiding collective cell migration during
#morphogenesis
is out
@naturematerials.bsky.social
nature.com/articles/s41...
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Stretch-induced endogenous electric fields drive directed collective cell migration in vivo - Nature Materials
Electric fields guide collective cell migration in developing embryos of Xenopus laevis via a voltage-sensitive phosphatase.
https://nature.com/articles/s41563-024-02060-2
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reposted by
Giulia Casal, PhD
WEBKNOSSOS
about 1 year ago
@LukeNoon from CIPF shared insights into his research at the vEM Data Challenges Symposium on mapping liver & peripheral tissues using innovative annotation & collaboration strategies. 🎥 Watch the recorded session here:
youtu.be/1sMQFpRGMLs?...
.
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Luke Noon: Thinking outside the (brain) box - vEM Workflows in Liver
https://youtu.be/1sMQFpRGMLs?feature=shared
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