Out today in @annalsofim.bsky.social doi.org/10.7326/ANNA... Our systematic review of 11 RCTs found bisphosphonates may reduce short-term pain but increase risk for AEs. Results limited by substantial, unexplained heterogeneity, introduced by inclusion of terminated trial data.

www.medrxiv.org/content/10.1... INSPECT-SR: A tool for assessing trustworthiness of randomised controlled trials.

To do no harm, we must first “know harms” Our new perspective piece on the challenge of measuring and reporting adverse events in interventions for pain is now available in @painthejournal.bsky.social dx.doi.org/10.1097/j.pa... @iasp.bsky.social @efic.bsky.social @britishpainsoc.bsky.social

Is medical practice ahead of the evidence?

@efic.bsky.social @britishpainsoc.bsky.social @auspainsoc.bsky.social

Out today 🚨 Our Cochrane review of 67 RCTs finds no clear evidence of benefit for ketamine or other NMDA antagonists for chronic pain. IV ketamine associated with risk of psychotomimetic effects, nausea, and vomiting. doi.org/10.1002/1465...

Despite a large body of new evidence, our best treatments for neuropathic pain continue to provide only modest benefits, write Michael Ferraro and Dr Nadia Soliman buff.ly/F5irUsl

One-Page Patient Fact Sheets for Low Back Pain in Primary Care url:https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2836549?utm_source=bluesky&utm_campaign=content-shareicons&utm_content=article_engagement&utm_medium=social&utm_term=072425

Despite a large body of new evidence, our best treatments for neuropathic pain continue to provide only modest benefits, write Michael Ferraro and Dr Nadia Soliman buff.ly/F5irUsl

🥁 This week, we submitted to BMC medicine our stage 2 registered report "Efficacy and safety of esketamine for ‘treatment-resistant depression’: registered report for a systematic review with an individual patient data meta-analysis of randomized, double-blind, placebo-controlled trials". 🧵

RCT: Among patients with low back pain, a nondirective information sheet listing treatment options improved patient-reported preparedness for decision-making more than a directive advice sheet. https://ja.ma/4nUr96z

One-Page Patient Fact Sheets for Low Back Pain in Primary Care Fact sheets do better than regular advice to support shared decision making! jamanetwork.com/journals/jam...

Delighted that the editors of 15 Pain and Anaesthesiology have chosen to endorse and amplify the ENTRUST-PE framework. More info here: www.linkedin.com/pulse/entrus... @iasp.bsky.social @efic.bsky.social @britishpainsoc.bsky.social @ukrio.bsky.social @coarassessment.bsky.social

#PAIN joins with other editors of pain-related journals to affirm our editorial commitment to trust and integrity in science. Read our joint statement at bit.ly/4lj3b3b

Editorial: The editors-in-chief from @thejournalofpain.bsky.social & other pain/anesthesia journals come together to align and strengthen initiatives to enhance research integrity, trust, and impact across our field. Full: doi.org/10.1016/j.jp...

Editorial commitment to trust and integrity in science: implications for pain and anesthesiology research journals.lww.com/pain/fulltex...

Assessing the feasibility and impact of clinical trial trustworthiness checks via an application to Cochrane Reviews: Stage 2 of the INSPECT-SR project - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

International #ResearchIntegrity conference taking place in beautiful Sydney Australia on 16-18 November 2025 🐨 🌏 Great speakers including @elisabethbik.bsky.social @jdwilko.bsky.social @jasonchin.bsky.social For more info contact @simongandevia.bsky.social 🧪

International Research Integrity Conference. I am arranging this in Sydney in November 16-18th 2025. researchintegrityconf.com Note the excellent speaker list. Contact me!

www.bmj.com/content/389/... "Evidence from 68 systematic reviews with conclusions distorted by retracted trials was used in 157 guideline documents."

Updated @iasp.bsky.social NeuPSIG systematic review & guideline for treatment of neuropathic pain now published in @thelancetneuro.bsky.social. A privilege to contribute to this project, brilliantly led by @nadiasoliman.bsky.social doi.org/10.1016/S147...

Inclusion of Retracted Studies in Systematic Reviews and Meta-Analyses of Interventions jamanetwork.com/journals/jam...

File under “Never take the company’s word for it” www.thelancet.com/journals/lan...

@iasp.bsky.social @efic.bsky.social

What are the benefits and harms of antidepressants for low back pain and spine‐related leg pain? Find out in our Cochrane review, published today: doi.org/10.1002/1465...

Fantastic to make the front cover of @journalofpain with the featured article “Enhancing the trustworthiness of pain research: A call to action” www.jpain.org/article/S152... It’s open access so get downloading!

Great article on the launch of our new Center to End Corporate Harm at @ucsf-prhe.bsky.social by @lizagross.bsky.social Through empirical investigations, our work will aim to prevent the leading risk factor for death and disease globally. bit.ly/434MfqU

Building trust in pain research - a webinar describing the ENTRUST-PE project, March 7th: europeanpainfederation.eu/efic-webinars/

Need help on reporting your factorial trial? Then this new paper in the @bmj.com provides lots of great advice and examples. www.bmj.com/content/388/... #transparency #RCTs

« Incomplete reporting of adverse events in duloxetine trials: a meta-research survey of randomized controlled trials versus placebo » with a great group of colleagues including JC Roy and P Rolland who were great chiefs resident in Rennes Iniversity hospital.. new paper in @jclinepi.bsky.social.

Today we launched The Center to End Corporate Harm, which will illuminate and counteract corporate influence on #science, the regulatory & #policy process leading to improved #health & health equity. Read about the strategic aims of the Center in the blog 👇

New @IASP_MESISIG webinar alert. Join us on January 29, 2025 Wed 2:30 PM EST to learn about Enhancing Equity, Diversity and Inclusivity In Pain Research. We have excellent speakers and it will be a great session. Register here: www.pathlms.com/iasp/webinar...

There has been a lot of discussion around how to assess trustworthiness of research studies (including investigation of fraud). Some thoughts on this below, to appear in @jclinepi.bsky.social - with @davidit.bsky.social : www.sciencedirect.com/science/arti...

Nice write up of our study applying potential trustworthiness checks to RCTs in 50 Cochrane Reviews in Nature by @richvn.bsky.social : www.nature.com/articles/d41...

Our world first systematic review of the health harms of #microplastics was published today. We concluded that microplastics are “suspected” to harm human #reproductive, #digestive, and #respiratory health, with a suggested link to colon and lung #cancer. www.thenewlede.org/2024/12/bewa...

Evidence or Marketing? Check out our comment (no letter to the editor option for JAMA Network Open) about this problematic industry funded review of spinal cord stimulation. With @mcferraro.bsky.social and @adriantraeger jamanetwork.com/journals/jam...

How can we reduce the spread of retracted pain research? Our Journal of Pain commentary proposes a potential solution: doi.org/10.1016/j.jpai… @nadiasoliman.bsky.social

Are you interested in enhancing the trustworthiness of research in pain (or health generally). Our ENTRUST-PE White Paper is a good long read on this osf.io/preprints/os...

How can we reduce the spread of retracted pain research? Our Journal of Pain commentary proposes a potential solution: doi.org/10.1016/j.jpai… @nadiasoliman.bsky.social

Please join my talk tomorrow, 26/11 at 12pm AEST 'Using Internal Industry Documents to Address the 21st Century Vector of Disease; Corporate Influence (#chemicals, #tobacco, #UPFs) on Science, Health & Democracy' at The University of Sydney. uni-sydney.zoom.us/j/89245914291 Meeting ID: 892 4591 4291

Privileged to have contributed to this project—please share widely. Amazing leadership from @neiloconnell.bsky.social

Wonderfully led by @neiloconnell.bsky.social - let's enhance the trustworthiness of pain research: www.sciencedirect.com/science/arti...

Super happy to share HERE our new analysis paper in @bmj.com "Fragile promise of psychedelics in psychiatry" with Cédric Lemarchand,Raphaël Chopin,Morgane Paul, Alain Braillon, Lisa Cosgrove, @ioanaacristea.bsky.social , @eikofried.bsky.social and @eturnermd1.bsky.social. www.bmj.com/content/387/...