Analysis of more than 1 million people shows that mental-health disorders fall into five clusters, each of them linked to a specific set of genetic variants go.nature.com/3XM18e7

Super excited to share that my second project in the @rjdlab.bsky.social is now published in Science! Many thanks to all co-authors, especially @ptnguyen.bsky.social for his expertise in structural biology and enzymology! And big thanks to Ralph for his incredible mentorship and support!

Not surprised that @rjdlab.bsky.social and Zheng put this beautiful story together. Congrats guys!

It's not in this article but the government asserts that the sandwich was thrown at "point blank range", which implies subway sandwiches have defined effective weapon ranges of varying lethality, and I would like to see the government's chart of these ranges.

Just caught up on this fascinating paper in Science in August. It reports evidence of strong selective pressure from breeding of horses around 5000-3000 years ago in Central Asia. One reason it's interesting is that the selection is *really* strong... /1 www.science.org/doi/10.1126/...

Earlier this year, ProPublica found that the sepsis rate in second-trimester pregnancy loss hospitalizations increased by more than 50% under Texas’ abortion ban. Here’s how we did our analysis. (Published Feb. 2025)

A clean quad is a good quad

I’ve said it before and I’ll say it again, the Cheers theme song is fitting for really any time in life….including our current timeline “Making your way in the world today Takes everything you've got Taking a break from all your worries Sure would help a lot Wouldn't you like to get away?”

No notes

jesus christ

Never Forget

have to say that i liked this one quite a bit

I look at this man and I see neurological “challenges” what should we do about that…

We have an Open Rank tenure-track faculty position in the Department of Nutrition & Integrative Physiology! Looking for a new colleague interested in making the University of Utah their new home to build a metabolic research program. Please share! @uofunuip.bsky.social

This special session is a sham. #texas

Our lab has derived over 50 trophoblast organoid lines to better understand how chronic conditions like hypertension and obesity influence placental development and metabolism. (Check out this figure made with @biorender.bsky.social)

Happy to share our work on the role of biomechanical PULSATILITY on lung vessels. Following surgery to alleviate overload in kids with single ventricle hearts, lung arteries form AVMs. #DevBio #EndothelialCell #CHD Beautiful work from Steve Spurgin. #DevBio 🫁 🫀 ❤️‍🩹 www.biorxiv.org/content/10.1...

Our work on new paradigm in peroxisome biogenesis and PEX39 (1st human peroxisomal biogenesis protein (peroxin/PEX) found in > 20 yr) is out in @natcellbio.nature.com! Equal collab w/Tony Rodrigues (Jorge Azevedo lab), @dwendscheck.bsky.social (Bettina Warscheid lab) www.nature.com/articles/s41...

1/New paper on peroxisome assembly, reporting the detailed mechanism of PEX39, a new peroxin involved in PTS2 protein transport. Fantastic work by ‪@walterwchen.bsky.social‬ and a dream team of collaborators, as explained below. www.nature.com/articles/s41...

Excited to share our work just published in @natmetabolism.nature.com examining melanoma tumor metabolism in patients and how well this is (and isn’t) conserved in patient-derived xenograft models.

1/Patient-derived xenografts (PDXs) are used in preclinical testing of cancer therapies, including metabolic therapies. We determined which metabolic properties are retained, and which are lost, when melanomas from patients are implanted and passaged as PDXs in mice. www.nature.com/articles/s42...

We have an Open Rank tenure-track faculty position in the Department of Nutrition & Integrative Physiology! Looking for a new colleague interested in making the University of Utah their new home to build a metabolic research program. Please share! @uofunuip.bsky.social

More #Fluorescence Friday from the Mouse Development, Stem Cells & Cancer course @cshlcourses.bsky.social! E9.5 labeled with Shh (magenta), Sox9 (yellow), DAPI (cyan) using @hcrimaging.bsky.social. Image taken by student Roberta Fiorino using Nikon AX R with @oxfordinstruments.bsky.social Imaris.

BREAKING: A federal judge reversed National Institutes of Health's terminations of hundreds of critical research grants that were canceled because of their alleged connection to disfavored topics, including diversity, equity, inclusion, and gender identity. This is a major win for public health.

If thousands of scientists say that political interference with grants assessment is going to destroy the scientific integrity of federal grants, the agency will have to explain why the rule doesn’t do that (which it can’t because this is precisely why the new regulation is being instituted). 11/n

Awesome to know there is a good chance I will soon be a very well educated bartender who is just waiting for a patron to ask her about developmental metabolism. Over a decade work of training to have a lab for less than 5 years. Cool. Cool. Cool.

A service contract for the LCMS

Today I changed the carburetor in the lawnmower I inherited from my father-in-law. Except for the belt, I’ve replaced almost everything on the mower because I think for some reason this would have made him proud. Or, I’m just trying to prove to a deceased man that I’m good enough for his daughter.

It's the entire email list for all DOGE employees. Have fun!

If you haven’t this week, reach out to your pre-tenured faculty. Especially the ones pre-3 year review. It’s a …. It’s been a lot 🥲

NIH money directly pays for >29,000 jobs in Texas, but the overall economic impact is MUCH bigger: >5 BILLION DOLLARS annually in Texas. NIH funding cuts hurt the bottom line for anyone who sells your lab anything. 2/3 Data for Texas are here: www.unitedformedicalresearch.org/nih-in-your-...

"I want to perform their favorite song, but you know they love to sue" - Kendrick Lamar

The mayor said: “Please stay off the light posts…”

23 year-old Utah woman 'who always wanted to be a mom' died of peripartum cardiomyopathy 9 days postpartum from preterm birth of twins after diagnosis of preeclampsia Although PPCM is “rare” & insidious, this young woman had multiple known risk factors. We need better postpartum surveillance!

What is happening in this Texas football game!?!

This is a crappy feeling for a young PI that feels like they won’t have this opportunity after they chose to start their lab at a world class institution. They could easily spread the wealth by limiting the awards given to these top institutions rather than barring applications from them completely.

Steve just popped back from the pub to ask me if its Thanksgiving today? I don't actually know because I don't live in the US. And he doesn't know because he's an otter that's been at the pub most of the afternoon. Um, is it?

Another gene whose role in embryonic development is via its action in the placenta.

Latest lesbian scout badge achieved: installed a new deadbolt. This means I am now 1/4 plumber (garbage disposal), 1/4 electrician (ceiling fan), and 1/4 locksmith. Just building up my resume if Professor doesn’t pan out.

Green Center potluck. Brisket, pork butt, chicken, and smoked cabbage.

Is there a way to bookmark papers that I will never read on here?

People working on #cancermetabolism, #mitochondrialbiology, #metabolism, please reach out! Share this so I can follow who is here! I will share paper on cancer metabolism, but anything else related to mitochondria and metabolism.

Is this Iowa?