Over the past 5+ years I've had the honor of working with @wsdewitt.github.io @victora.bsky.social and many others on a project to "replay" affinity maturation evolution from a fixed starting point. matsen.group/general/2025...

Read the latest from us here: www.science.org/doi/10.1126/... #antibody #cryoEM

🚨 New Publication!!! I’m thrilled to share our latest study, “Clonotype-Enriched Somatic Hypermutations Drive Affinity Maturation of a Public Human Antibody Targeting an Occluded Sarbecovirus Epitope”. www.cell.com/cell-reports... [1/4]

Had a great time presenting my PhD work so far in @camilahcoelho.bsky.social’s lab at the Keystone Vaccinology meeting! Grateful for the chance to share and learn alongside such an inspiring community of scientists! #KSVaccines25

Online now: Somatic hypermutation unlocks antibody specificities beyond the primary repertoire

Find me at Poster Board 1012 on May 6th, Tuesday from 13:15 - 14:30 at #AAI !

Thrilled to share our new mini review article on public antibodies against human pathogens, now out in #mBio. @camilahcoelho.bsky.social journals.asm.org/doi/10.1128/...

One of our obsessions in the Crotty lab is to better understand B-cell immunology in the context of vaccines. Rare B cells can have antibody specificities particularly important for protection against some diseases. In our most recent paper… @cp-immunity.bsky.social www.cell.com/immunity/ful...

The labs of Krammer, @wchnicholas.bsky.social, Ellebedy et al. identify a neuraminidase-targeting human monoclonal antibody (mAb-297) induced by seasonal #influenza vaccination that broadly protects against multiple influenza A & B strains, incl. avian #H5N1. rupress.org/jem/article/...

Cool germinal center acrobatics from Juhee Pae et al, check it out! www.nature.com/articles/s41...

Convergent and clonotype-enriched mutations in the light chain drive affinity maturation of a public antibody https://www.biorxiv.org/content/10.1101/2025.03.07.642041v1

Today @natmedicine.bsky.social published our study showing the older individuals born prior to 1968 have more antibodies that cross-react to #H5N1 relative to younger individuals. If H5N1 causes a pandemic, children will likely be the most susceptible. 1/2 www.nature.com/articles/s41...

Glad to share our work from @camilahcoelho.bsky.social’s lab on identifying affinity-enhancing somatic hypermutations in public antibodies based on convergence and clonotype-enrichment! www.biorxiv.org/content/10.1...

Our long-awaited study in collaboration with the Schmidt lab on H5Nx influenza recognition by naive B cells is out! #antibody #bcell #flu #avianflu #cryoEM www.science.org/doi/10.1126/...