Anna Williams
@annawilliamslab.bsky.social
📤 349
📥 85
📝 20
The Edinburgh participants at dinner at VasCog!
15 days ago
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Ronja gets the top abstract prize at Vascog!!
17 days ago
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The lab is having a good few months for publications with this one as well in case you missed it:
doi.org/10.1016/j.ym...
www.sciencedirect.com/science/arti...
(Thank you Themis and Francesca, and all!)
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The lncRNA MYRACL regulates human oligodendrocyte maturation and myelination
Recent studies have described disease-associated expression patterns of long non-coding RNAs (lncRNAs) associated with neurodevelopment and neurodegen…
https://www.sciencedirect.com/science/article/pii/S1525001625006409
about 1 month ago
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Our new paper on metformin, myelin, mitochondria and metabolism is now out at
rdcu.be/eDbFD
Thanks to Nina and all of the team!
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Metformin alters mitochondria-related metabolism and enhances human oligodendrocyte function
Nature Communications - Metformin is under clinical trial for brain neuroprotection but how it may work is poorly understood. Here, the authors show that metformin helps myelin formation by human...
https://rdcu.be/eDbFD
about 1 month ago
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Anna Williams
Themis Tsarouchas
about 2 months ago
Now out in Molecular Therapy! With Francesca Vacante, we describe MYRACL, a novel candidate lncRNA driving human oligodendroglia differentiation & myelination. Grateful to our amazing co-authors & mentors
@annawilliamslab.bsky.social
& Andrew Baker! Read more👇
www.sciencedirect.com/science/arti...
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Anna Williams
Institute for Regeneration and Repair
5 months ago
On National Receptionist's Day we would like to thank our fantastic reception team for all they bring to our Institute. They are the friendly face of IRR and help make our staff, students and visitors feel so welcome. Thank you!
#NationalReceptionistsDay
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Anna Williams
5 months ago
For those who want a distraction and/ or are interested, here's the latest from the group, led by Phil Braaker
www.nature.com/articles/s41...
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Activity-driven myelin sheath growth is mediated by mGluR5 - Nature Neuroscience
Employing pharmacology, genetics and all-optical approaches in zebrafish, Braaker et al. find that neuronal activity influences the growth of myelin sheaths along axons by signaling through metabotrop...
https://www.nature.com/articles/s41593-025-01956-9
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reposted by
Anna Williams
Sally Lowell
5 months ago
EDINBURGH AXOLOTLS! Super-excited to hear my wonderful colleague
@aidarodrigo.bsky.social
on BBC Radio 4 talking about the axototl colony she has established in our institute
@edinuni-irr.bsky.social
😃 Available on BBC sounds: Aida's section starts at 23.37
www.bbc.co.uk/sounds/play/...
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BBC Inside Science - How vulnerable is our power supply? - BBC Sounds
Massive power cuts brought parts of Spain, Portugal and France to a standstill this week.
https://www.bbc.co.uk/sounds/play/m002bj79
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Anna Williams
#NeuroDegeneration preprints
6 months ago
Genetic subtypes predict multiple sclerosis severity and response to treatment #NeuroDegeneration 🧪🧠
http://medrxiv.org/cgi/content/short/2025.04.15.25325853v1
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Anna Williams
Calton Consort
6 months ago
📣 Open call for early-career composers. 📣 The successful applicant will be invited to collaborate with the choir in a composition, and receive £1000 upon completion of the work. 🔹Deadline: 25th April 2025 🔹Details:
caltonconsort.org.uk/compose/
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reposted by
Anna Williams
Rana Fetit
7 months ago
Today I met
@rodtmitchell.bsky.social
at our Fringe bootcamp. We will be representing the
@edinuni-irr.bsky.social
at the
@edfringe.bsky.social
this year! Super excited. Lot's of thought-provoking talks by amazing academics - stay tuned!
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Anna Williams
Lucy Stirland
7 months ago
The findings from my focus group project on
#dementia
and
#multimorbidity
are now available to download as an infographic Thanks to the Global Brain Health Institute and
@nrs-ndn1.bsky.social
for supporting this work. It was an enjoyable and illuminating process!
www.gbhi.org/projects/exp...
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Exploring the Priorities of People with Dementia and Multiple Conditions | Global Brain Health Institute
Most people with dementia have at least two further health conditions. However, research usually studies dementia on its own. People with several co-existing conditions are often excluded from drug tr
https://www.gbhi.org/projects/exploring-priorities-people-dementia-and-multiple-conditions
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Anna Williams
Rana Fetit
7 months ago
"Neurons are like trees with roots and branches that talk!" was my favourite comment from a 4-year old from my last workshop for
#BrainAwarenessWeek
at the Little Muslims children's group. Thanks
@edinuni-irr.bsky.social
and
@edinunineuro.bsky.social
for the support!
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Anna Williams
Calton Consort
7 months ago
Book now at
www.ticketsource.co.uk/calton-consort
#choral
#whitacre
#tallis
#liveperformance
#edinburgh
#acappella
#sadmusic
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reposted by
Anna Williams
Rana Fetit
7 months ago
"Your brain is your superpower!" was the takehome message of my second workshop for
#BrainAwarenessWeek2025
. So glad to represent
@edinuni-irr.bsky.social
and
@edinunineuro.bsky.social
again at Danderhall Primary School.
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Anna Williams
Rebecca Sherrard Smith, PhD
7 months ago
It’s international woman’s day! Well we have a lot of amazing women in our group to celebrate from our fierce leader
@annawilliamslab.bsky.social
to our PhD students, postdocs, bioinformaticians, and everyone in between💪🏻 Thank you ladies for being amazing scientists, colleagues and friends 💜💙🩵
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reposted by
Anna Williams
Elaine Emmerson
7 months ago
Looking for a
#postdoc
in
#regenerative
#biology
? 🔬🧬Look no further than this amazing opportunity with my super office mate
@aidarodrigo.bsky.social
at
@edinuni-irr.bsky.social
to explore regenerative capacity across species! 🐭 🐁 Closing 📅 01/04/25
add a skeleton here at some point
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Anna Williams
Calton Consort
7 months ago
Book your tickets in advance at
www.ticketsource.co.uk/calton-consort
7:30pm Saturday 22nd March Canongate Kirk
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Anna Williams
UK Dementia Research Institute
8 months ago
Delighted to announce
@rikeshrajani.bsky.social
as the first Group Leader to join our flagship vascular dementia research centre with
@thebhf.bsky.social
🎉👏 The Rajani Lab will investigate how the protective myelin sheath around brain cells is damaged in small vessel disease👉
buff.ly/4hIGaVM
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reposted by
Anna Williams
Lida Zoupi
8 months ago
onlinelibrary.wiley.com/doi/full/10....
Hot off the press! We find changes in oligodendrocytes that lack FMRP! An excellent collaboration supported by
@sidb-edinburgh.bsky.social
.
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The Fragile X Messenger Ribonucleoprotein 1 Regulates the Morphology and Maturation of Human and Rat Oligodendrocytes
Loss of FMRP impairs human and rat oligodendrocyte (OL) morphology in vitro. FMRP-deficient OLs show impaired maturation when engrafted in hypomyelinated mice. Rat Fmr1 knockout OLs show a delay in m...
https://onlinelibrary.wiley.com/doi/full/10.1002/glia.24680
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reposted by
Anna Williams
Garyfallia Gouna, PhD, 🏳️🌈
8 months ago
I was thrilled to receive this news—I’ve been awarded the
#MSCAPostdoctoralFellowship
for my project, PHOS-SVD! Extremely grateful for the support of
@annawilliamslab.bsky.social
,
@nadlerlab.bsky.social
and my colleagues for their feedback. Excited to begin the journey into membrane lipid research!
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reposted by
Anna Williams
Erin Gibson
8 months ago
www.cell.com/neuron/fullt...
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snRNA-seq stratifies multiple sclerosis patients into distinct white matter glial responses
Macnair and Calini et al. analyze 632,000 snRNA-seq profiles from multiple sclerosis and control brain samples, identifying distinct cellular responses in white and gray matter. They stratify MS patie...
https://www.cell.com/neuron/fulltext/S0896-6273%2824%2900873-0
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reposted by
Anna Williams
Calton Consort
8 months ago
Book now at
www.ticketsource.co.uk/calton-consort
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reposted by
Anna Williams
Anne Rowling Regenerative Neurology Clinic
8 months ago
Soon we'll be starting a new research study looking at
#MRI
imaging of spinal cord in people with multiple sclerosis
#MS
Congrats
@rozannameijboom.bsky.social
from our imaging team on being awarded
@mssocietyuk.bsky.social
funding for this important study.
www.annerowlingclinic.org/about/news/n...
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New funding for spinal cord imaging research study
Jan 2025: Congratulations to Dr Rozanna Meijboom and colleagues from the MS imaging group, who have recently been awarded funding for a research study to examine changes in the spinal cord of people w...
https://www.annerowlingclinic.org/about/news/new-funding-for-spinal-cord-imaging-research-study
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Anna Williams
Enrica Boda & team
8 months ago
⚠️Useful!⚠️ Protocol for assessing myelination by human iPSC-derived oligodendrocytes in Shiverer mouse ex vivo brain slice cultures by Themistoklis Tsarouchas,
@erinmgibson.bsky.social
@lidazoupi.bsky.social
@annawilliamslab.bsky.social
#neurosky
www.sciencedirect.com/science/arti...
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Protocol for assessing myelination by human iPSC-derived oligodendrocytes in Shiverer mouse ex vivo brain slice cultures
Human induced pluripotent stem cell (iPSC)-derived oligodendrocytes are a powerful tool for studying aberrant myelination in neurodegenerative and neu…
https://www.sciencedirect.com/science/article/pii/S2666166725000152?via%3Dihub
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reposted by
Anna Williams
Calton Consort
8 months ago
The weather may have been lamentable today here in Edinburgh thanks to
#eowyn
, but the good news is that tickets are now on sale for our next performance: Lamentations - A choral programme of ancient and contemporary perspectives on love, loss, and faith.
www.ticketsource.co.uk/whats-on/edi...
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Lamentations at Canongate Kirk
Tickets are now available for Lamentations at Canongate Kirk, Edinburgh on Sat 22 Mar 2025 at 7:30PM. Click the link for further information and to secure your tickets now!
https://www.ticketsource.co.uk/whats-on/edinburgh/canongate-kirk/lamentations
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reposted by
Anna Williams
8 months ago
This week we met with the researchers from our VIDA Doctoral Training Centre! It was a fantastic opportunity to network, discuss future ideas and collaborations, and enjoy research talks from the students and their supervisors. Learn more about the VIDA DTC:
www.alzheimers.org.uk/research/our...
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Anna Williams
Science Magazine
8 months ago
“The impact of the collective executive orders and directives appears devastating.”
scim.ag/40ureTO
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Trump hits NIH with ‘devastating’ freezes on meetings, travel, communications, and hiring
Researchers facing
https://scim.ag/40ureTO
50
1025
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reposted by
Anna Williams
9 months ago
Couple of opportunities up to join the group! One at postdoc level, but open to senior support path. One research assistant role. Please share, or drop a line if you want to learn more! Or just apply! Thanks!
elxw.fa.em3.oraclecloud.com/hcmUI/Candid...
elxw.fa.em3.oraclecloud.com/hcmUI/Candid...
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Anna Williams
Bowles Lab
9 months ago
More incredible speakers lined up for SCMND2025 - in the first of two sessions focused on 3D models of neurodegeneration! Submit your abstract before 31/01/2025 and register now!
scmnd.com
@cbdresearch.bsky.social
@selinawray.bsky.social
@annawilliamslab.bsky.social
@edinunineuro.bsky.social
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reposted by
Anna Williams
9 months ago
First post at this side. Latest axon diameter action led by Jenea Bin, in collaboration with Nolan, Mobius, Monk, Werner, and Emery labs.
www.biorxiv.org/content/10.1...
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Developmental axon diameter growth of central nervous system axons does not depend on ensheathment or myelination by oligodendrocytes
Myelination facilitates the rapid conduction of action potentials along axons. In the central nervous system (CNS), myelinated axons vary over 100-fold in diameter, with conduction speed scaling linea...
https://www.biorxiv.org/content/10.1101/2025.01.10.632348v1
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reposted by
Anna Williams
Institute for Regeneration and Repair
9 months ago
Promising new cell therapy for liver disease shows positive results! Results from the MATCH trial, run by Stuart Forbes' lab in the Centre for Regenerative Medicine, were published in
@nature.com
Medicine today
regeneration-repair.ed.ac.uk/promising-ne...
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Anna Williams
Sarah Jäkel
9 months ago
Did you ever wonder about the role of oligodendrocytes in Parkinson's disease? Check out our new unsolved mysteries article in collaboration with the Burbulla lab! It is quite certain that a lot of work moves in this direction.
journals.plos.org/plosbiology/...
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Are oligodendrocytes bystanders or drivers of Parkinson’s disease pathology?
The major pathological feature of Parkinson ‘s disease (PD), the second most common neurodegenerative disease and most common movement disorder, is the predominant degeneration of dopaminergic neurons...
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002977
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Happy new year and happy reading of our new review on cerebral small vessel disease! Joint effort with Ronja Kremer and Joanna Wardlaw!
www.nature.com/articles/s41...
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Endothelial cells as key players in cerebral small vessel disease - Nature Reviews Neuroscience
Cerebral small vessel disease is a common cause of dementia and stroke. In this Perspective, Wardlaw and co-workers describe evidence from human brain imaging and preclinical models that points to dys...
https://www.nature.com/articles/s41583-024-00892-0
9 months ago
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reposted by
Anna Williams
Will Macnair
10 months ago
So happy to see this work published! This is still the biggest single nuclei dataset of MS, and poses some fascinating questions. We found that the proportions of cell types across lesion types varied as expected, e.g. in active lesions we saw fewer oligos and more microglia.
add a skeleton here at some point
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reposted by
Anna Williams
Anne Rowling Regenerative Neurology Clinic
10 months ago
Positive
#MS
research news just before Christmas! A team co-led by
@annawilliamslab.bsky.social
has published gene expression findings from post-mortem samples that separates MS brain samples into 4 groups. Paves the way for personalised treatments. More at
www.annerowlingclinic.org/about/news/m...
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reposted by
Anna Williams
Institute for Regeneration and Repair
10 months ago
9th Day of Research: £9million to support the next generation of dementia researchers🧑🎓 The investment from @alzheimerssoc will help the IRR support and nurture dementia researchers at the start of their career. 📰 Read more:
edin.ac/48KD4g6
#12DaysOfResearch
#CRM
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reposted by
Anna Williams
Institute for Regeneration and Repair
10 months ago
Transcription factors find and activate their target genes by recognising how DNA is packaged inside the nucleus of cells. New research from Dr Abdenour Soufi & colleagues published in Nature.
#RegenerativeMedicine
#CRM
regeneration-repair.ed.ac.uk/news/irr-new...
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reposted by
Anna Williams
Prof Sarah-Jayne Blakemore
10 months ago
I wrote an article about my dad's death, and how it affected my views on assisted dying, published in the Times Free version here
29
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reposted by
Anna Williams
Julia Edgar
10 months ago
The Myelin Network meeting in Kassel was simply terrific! Thanks to the organisers
@myelincentric.bsky.social
@axoglia.bsky.social
@Tanya Kuhlmann. Exciting science and excellent socialising.
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reposted by
Anna Williams
Garyfallia Gouna, PhD, 🏳️🌈
11 months ago
Very excited to present part of my spatial lipidomics project using MALDI-FT/ICR technology today at the CMVM Postdoctoral Symposium, University of Edinburgh. A great opportunity for catching up with colleagues. Special thanks to the organizers, career panelists and sponsors for the invitation.
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Anna Williams
11 months ago
My first first author paper is out!
doi.org/10.3390/gene...
Main message: 💸 Less expensive sequencing methods can provide just as good quality single-cell data 📊 With David A. D. Munro, Meryam Beniazza, Josef Priller,
@annawilliamslab.bsky.social
, Andrea Corisnotti
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Anna Williams
Rebecca Sherrard Smith, PhD
11 months ago
The Williams lab is on a roll.
@nadinebc.bsky.social
has her first first author paper reviewing sequencing methods for single-cell data. As said by Nadine 'Less expensive sequencing methods can provide just as good quality single-cell data' Check it out for an interesting read! 📢
add a skeleton here at some point
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Anna Williams
Rebecca Sherrard Smith, PhD
11 months ago
A new News & Views article from our lab
@annawilliamslab.bsky.social
is out today highlighting some major advances in understanding MS using spatial transcriptomics. A great lunchtime read from
@kellie-horan.bsky.social
📖📊
www.nature.com/articles/s41...
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Mapping out multiple sclerosis with spatial transcriptomics - Nature Neuroscience
In this issue, Alsema, Wijering, Miedema, Kotah et al. and Lerma-Martin, Badia-i-Mompel et al. demonstrate the ever-growing possibilities of spatial transcriptomics by applying it to the spatially het...
https://www.nature.com/articles/s41593-024-01798-x
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The directors of the new Alzheimer’s society VIDA PhD programme in vascular and immune interactions in dementia together at the beginning of the adventure! Thank you @alzheimerssoc for the start up meeting!
12 months ago
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Profs Anna Williams and Tilo Kunath are appointed as co-directors of the University of Edinburgh centre for regenerative medicine!
12 months ago
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Our new snRNAseq paper on glia in Huntington’s disease is now out!
eur02.safelinks.protection.outlook.com?url=https%3A...
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Mapping the glial transcriptome in Huntington’s disease using snRNAseq: selective disruption of glial signatures across brain regions
https://eur02.safelinks.protection.outlook.com/?url=https%3A%2F%2Frdcu.be%2FdXyIa&data=05%7C02%7C%7C563a6782ae7f45e3bdfe08dcf1753e31%7C2e9f06b016694589878910a06934dc61%7C0%7C0%7C638650733067589555%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C0%7C%7C%7C&sdata=nqcfFXedOIuRfcYDiartNwu0g7PhIoJGeUhWtSnXG%2BM%3D&reserved=0
12 months ago
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Anna Williams
And our latest paper in full here:
www.nature.com/articles/s41...
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CRISPR-edited human ES-derived oligodendrocyte progenitor cells improve remyelination in rodents - Nature Communications
Increasing age and disease progression negatively impact remyelination in Multiple Sclerosis. Here authors show that genetically edited human oligodendrocyte precursor cells may help overcome remyelin...
https://www.nature.com/articles/s41467-024-52444-w
12 months ago
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And our latest paper in full here:
www.nature.com/articles/s41...
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CRISPR-edited human ES-derived oligodendrocyte progenitor cells improve remyelination in rodents - Nature Communications
Increasing age and disease progression negatively impact remyelination in Multiple Sclerosis. Here authors show that genetically edited human oligodendrocyte precursor cells may help overcome remyelin...
https://www.nature.com/articles/s41467-024-52444-w
12 months ago
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Our latest paper is summarised here:
www.ed.ac.uk/news/2024/ge...
Enjoy!
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Gene-edited cells could halt MS progression
Scientists have used gene-editing techniques to boost the repair of nerve cells damaged in multiple sclerosis, a study shows.
https://www.ed.ac.uk/news/2024/gene-edited-cells-could-halt-ms-progression?utm_source=twitter&utm_medium=organic_post&utm_campaign=cam_research_comms&utm_term=&utm_content=ms_gene_edit
12 months ago
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