1/4 When rules change, dopamine (DA) changes what it calls an “action”. New bioRxiv version: “Dopamine tracks adaptive learning of action representations”. www.biorxiv.org/content/10.1... This project brought together Maxime Come’s PhD work and Arnaud Lespart’s postdoctoral work in our lab.

Congratulations Lauren

⚠️ New paper alert and what a way to end 2025! 🎉 Happy to share our story “Sleep-dependent infraslow rhythms are evolutionarily conserved across reptiles and mammals.” published today in Nature Neuroscience. Sleeping dragons 🦎 and functional ultrasound! Read the full paper here: rdcu.be/eWJHb 1/8

Congrats, well deserve

You just finished your PhD and you are looking for a postdoc to study stress-dependent modulation of learning. We are using the powerful fly model to understand the underlying circuits and mechanisms. You can apply here: emploi.cnrs.fr/Offres/CDD/U...

Big news for @laurenmac.bsky.social ! 2025 is quite a year: CNRS position + ERC Starting Grant Her project DeMARRe will study how adolescent exploration & risk-taking shape neural circuits and resilience in adulthood. @cnrs.fr @espciparispsl.bsky.social www.insb.cnrs.fr/fr/personne/...

1 To predict the behaviour of a primate, would you rather base your guess on a closely related species or one with a similar brain shape? We looked at brains & behaviours of 70 species, you’ll be surprised! 🧵Thread on our new preprint with @r3rt0.bsky.social , doi.org/10.1101/2025...

Alcool et nicotine : un même circuit cérébral à l’origine de la récompense et de l’anxiété 👋 @cnrs-paris.bsky.social @espciparispsl.bsky.social ✍️ @faurelab.bsky.social & Fabio Marti 👉 Lire l'article dans buff.ly/vE1j6LP buff.ly/fD5DOxu

Nicotine doesn’t just “turn on” the brain’s reward circuits — it reshapes them. Our new paper in Nature Communications shows that activating reward-linked dopamine neurons also sets off a feedback loop that drives negative emotional states. www.nature.com/articles/s41...

Our work on the role of the interpeduncular nucleus in nicotine reward ( www.cell.com/neuron/abstr... ) is featured in a Neuron Preview ! Brandon J Henderson highlights how a new regulatory circuit controlling nicotine reinforcement has been uncovered. www.cell.com/neuron/abstr...

Yesss! So happy to see this, totally deserved!

Our work on rubber hand embodiment in mice is out @plosbiology.org! We show that just like in humans, visuo-tactile pairing can lead mice to an embodiment-like behavior with respect to an artificial limb.

Nouvel article avec mes ami-es belges E. Chaves et A. de Kerchove où on décrit l'effet de l'activation de populations de neurones du striatum sur les stratégies de décision. On a essayé de sortir d'une définition "par l'expérimentateur" de la performance des souris. www.science.org/doi/10.1126/...

Hot off the press: The excellent Maheva Andriatsilavo and colleagues show how a temporal sequence of stochastic molecular mechanisms allow the emergence of stereotyped individualised neuronal circuits. Just published in Nature Neuroscience: rdcu.be/ek010

I have an opening in my lab for a postdoctoral fellow to work on projects that relate to the mechanisms of neurotransmitter release by dopamine neurons and/or on how inflammatory signals infuence the functionning of these neurons. Please share.

The interpeduncular nucleus (IPN) dampens nicotine reward via β4* nAChRs and IPN→LDTg projections. Blocking this pathway enhances VTA responses and CPP: A nicotine-specific brake embedded in the mesolimbic system. New paper from the lab out in @cp-neuron.bsky.social www.cell.com/neuron/abstr...

Registrations for the Symposium for the Biology of decision making (SBDM) in Lyon 2025 are finally open! sbdm2025.github.io Please spread the message!

New preprint from the lab and @clementsolie.bsky.social on social organization & neuromodulation! Read the full preprint here: www.biorxiv.org/content/10.1... @espciparispsl.bsky.social @cnrsbiologie.bsky.social

This is one of my favourite papers for a while. Theoretically informed, technically accomplished, well-written and argued, articulates explanation 👏 By @jeremie-n.bsky.social and colleagues. I would love to teach it but it may be a lot... www.nature.com/articles/s41...

Superb study from Thomas Preat's team here @espciparispsl.bsky.social @cnrsbiologie.bsky.social , showing that astrocytes use redox H₂O₂ signaling to support memory in Drosophila. Amyloid-β disrupts this process, linking it to cognitive deficits in Alzheimer’s. www.nature.com/articles/s42...

#RésultatScientifique🔎Comment la dopamine peut-elle orchestrer à la fois l’apprentissage et la motivation ? @jeremie-n.bsky.social propose une réponse à cette question dans @naturecomms.bsky.social ⤵️ 🤝 @cnrsoccitanieest.bsky.social @umontpellier.bsky.social @cnrsinformatics.bsky.social

🚨 !!! Postdoc Position Available !!! 🚨 Join our team at the Neuromodulation Institute (Hôpital St-Anne) in Paris, France. Work on cutting-edge research involving voltammetric recordings in human patients and machine learning. 🧠🟦 / 🧠🤖 / 🧠🩺 #AcademicSky #postdoc

"Dopamine builds and reveals reward-associated latent behavioral attractors". This study combines computational modeling and experimental work to reveal how DA not only teaches, but also motivates, i.e by creating and using pathways toward goals. www.nature.com/articles/s41...

Paper from my PD with @faurelab.bsky.social came out a couple weeks ago #neuroskyence #neuroscience www.nature.com/articles/s41...

Adolescence is a critical period for nicotine addiction. We found that early nicotine exposure "freezes” dopamine circuits in an immature state, leading to lifelong vulnerability. Details can be checked in new Lab preprint www.biorxiv.org/content/10.1... - Congrats @laurenmac.bsky.social