No need to wait until September: We’ve identified the causes of autism and even some of the environmental chemicals interacting with autism genes involved early fetal neurodevelopment during pregnancy

New Acute Migraine Management Guidelines: - Triptans combined with NSAIDs (e.g., sumatriptan + naproxen) offer the highest net benefit - Triptan + acetaminophen is also beneficial. - Monotherapies are effective, but less so than combination therapy. www.acpjournals.org/doi/10.7326/...

Great review from JAMA on Iron deficiency in Adults. Great topic with very little CHE on the topic. jamanetwork.com/journals/jam...

#CardiacRehab #ESCPrev2025 #CVprev Smoking Cessation key component but how do we do it correctly? Study used Motivational Intervention had better cessation rates 🆚 control group ✨ NNT=4 ✨ ⬇️ ASCVD events Such an important study of what we can do in CR! @escardio.bsky.social

How do GLP-1 drugs affect cognitive and mental health disorders? A comprehensive review www.nature.com/articles/s44...

New Liver disease review on MetALD. Nice review if you are interested in metabolic and alcohol-related liver disease MetALD: Clinical aspects, pathophysiology and treatment - JHEP Reports www.jhep-reports.eu/article/S258...

Assessment and management of frailty in individuals living with dementia: expert recommendations for clinical practice - The Lancet Healthy Longevity www.thelancet.com/journals/lan... #frailty #dementia

Psoriatic Arthritis and comorbidity management - Quick review of expert care of patients with PsA. academic.oup.com/rheumatology...

New Rheumatology guideline on Sjogren Disease - Wicked condition for affected patients, for my specialty colleagues, worth a quick read. academic.oup.com/rheumatology...

MASLD pharmacotherapy review - If you are interested in learning more about the new treatments for MASLD, MASH and fibrosis, there is a great review at: www.nature.com/articles/s41... #MASLD, #NAFLD, #MASH

Redefining obesity. It is time. 📏BMI is NOT a direct measure of fat 📏BMI does NOT establish the distribution of fat 📏BMI cannot determine with excess fat is a health problem @thelancet.bsky.social Lancet Commission 📎 www.thelancet.com/commissions/...

New diabetes in pregnancy study of oral antihyperglycemic agents vs. insulin. Insulin is still king when looking at large for gestational age measurement. jamanetwork.com/journals/jam...

Physical activity and weight loss - Common question at this time of year. Moderate weight loss for aerobic exercise. Key findings: - Each 30-minute increase in weekly aerobic exercise leads to measurable reductions in weight, waist circumference, and body fat. jamanetwork.com/journals/jam...

COPD Non-Pharm Recommendations - Nice review of infection prevention, nutrition, physical activity and smoking cessation. Commonly missed with these patients. hashtag#COPD journals.lww.com/ijom/fulltex...

New Alzheimer's Disease Guideline - 19 recommendations for clinicians. Includes recommendations for primary care clinicians as well. #Alzheimer's #guideline alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

While immunocompromised individuals had a heterogeneous antibody response to RSV vaccines, those who received the adjuvanted RSVPreF3-AS01 vaccine showed better neutralization. ja.ma/4iVzJzy

E-cigarettes are likely safer than combustible tobacco, but not safe. Increasing evidence of harm. This article reviews the CVD risk with e-cigarettes. #smokingCessation #tobacco www.wjgnet.com/1949-8462/fu...

E-cigarettes and oral health - Although safer than combustible tobacco, there are risks with e-cigarette use. Increased periodontal disease, dental caries, oral mucosal lesions and teeth staining. #e-cigarettes doi.org/10.3390/dj12...

Managing GLP-1 RA GI-related adverse effects - Common question, new review. Some new tips for your patients. #diabetes, #obesity, #GLP-1RA www.dovepress.com/dietary-reco...

Pediatric influenza vaccine effectiveness Study - We know that 6 months to 5 years is a high-risk group of influenza-related complications. The vaccine reduced the risk of ED visits, noncritical and critical influenza by about 50%. Really supports use in this group. jamanetwork.com/journals/jam...

New Long COVID Data - MMWR published today that 1 in 5 Adults experiencing long COVID had major limitations on their ability to perform daily functions. In this survey 6.4% of US adults were reporting they had long COVID when surveyed. www.cdc.gov/mmwr/volumes...

Dysplipidemia manage - "Lower is better for longer and the earlier the better" rdcu.be/d33UT

The Role of Primary Care in Achieving Life’s Essential 8: A Scientific Statement From the American Heart Association www.ahajournals.org/doi/10.1161/...

Just a reminder that iron deficiency is incredibly common jamanetwork.com/journals/jam... And reference intervals are garbage. Join us at 2pm today #ASH24 in SDCC room 11 #ChoosingFairly to learn how you can work to change that!

Genital herpes is a common sexually transmitted infection caused by herpes simplex virus (HSV). This JAMA Patient Page describes genital herpes and its symptoms, diagnosis, treatment, and prevention measures. ja.ma/498JfLi

Mpox is a self-limited viral infection primarily spread through skin contact, but poses significant risks for the immunocompromised. by Titanji BK, Hazra A and Zucker J in JAMA #MedSky 📖 read the article:

Smoking decreases vaccine immune response - As if we need another reason to quit, smokers have a 48% higher risk of diminished immune response to vaccines (especially COVID-19 and Hep B) www.mdpi.com/2076-393X/12...

New review of Iron Status during pregnancy: They recommend screening during pregnancy www.sciencedirect.com/science/arti...

Alcohol use when using antiobesity medications - almost 50% of participants reduced alcohol. jamanetwork.com/journals/jam...

New International Scabies Guidelines - Topic that is rarely discussed. Detailed review. onlinelibrary.wiley.com/doi/10.1111/...

Man I'm tired of people acting as if Ozempic and GLP-1 medications are just for "vanity" or being used because people don't understand nutrition/exercise

Beautiful 🛟🧪🩺

How well do vaccines protect vs #LongCovid, a systematic review during the Omicron era? —about 20% reduced by primary series (vs no vaccination), and —another 20% reduction by boosters vs primary series www.medrxiv.org/content/10.1...

Quick review of XEC variant. Worth a quick read: jamanetwork.com/journals/jam...

Albuminuria, an established biomarker of the progression of CKD, is also recognized as a biomarker for the risk of CVD (ca. 2024) #Nephpearls #NephSky #Cardiorenal 👉🏼 pubmed.ncbi.nlm.nih.gov/38214258/

Transition from an estimated glomerular filtration rate (eGFR)-based to a risk-based approach to CKD care from KDIGO #Nephpearls #NephSky 👉 kdigo.org/guidelines/c... 💻 kidneyfailurerisk.com

New Innovative review of Glucagon-based Therapies for Obesity Management - Current and future therapies for the management of obesity academic.oup.com/jes/article/...

New Asthma Exacerbation prevention and management review article for Primary Care - International expert review www.nature.com/articles/s41...

300,000 women die from cervical cancer every year. But this is a cancer we can effectively eliminate with the HPV vaccine. This is something very few people know about. Article from my colleague @scientificdiscovery.dev: ourworldindata.org/hpv-vaccinat...

#AHA24 NUDGE FLU #fluvaccine 💉flu vax underused in AMI 💉study looked at impact of a letter nudge to improve flu vax rates in Denmark 🇩🇰 💉2.1 Million randomized 💉Nudge resulted in modest improvement of vax rates 💉sentence including CV sentence ⤴️ vax uptake

FINEARTS-HF trial in JAMA Cardiology: Finerenone was effective in reducing the risk of CV death and heart failure events even in patients with mildly reduced or preserved ejection fraction who experienced elevated potassium levels. #AHA24 https://ja.ma/4euKMwg

New Canadian Diabetes Pharmacotherapy Guidelines in Type 2 diabetes. Updated for 2024. www.canadianjournalofdiabetes.com/article/S149...

Dr. Guang Ning presents on the effect of intensive BP lowering in Diabetes #AHA24 #BPROAD study 🫀intensive 🆚 UC: <120 🆚 <140 SBP🎯 🫀12,821 patients enrolled 🫀45% 💃🏻 mean age 63 💥21% reduction in CV events in intensive tx ! SAE same 📎 www.nejm.org/doi/full/10....

#LBCT #SUMMIT trial #AHA24 💥 Treatment with tirzepatide led to ⤵️risk of a composite of death from cardiovascular 🫀 causes or worsening heart failure 🆚 placebo and improved health status in patients with HFpEF+obesity 📎 @NEJM www.nejm.org/doi/full/10....

@TheLancet session at #AHA24 starting now! #obesity 🫀Malnutrition was a problem but now obesity is taking over worldwide with few exceptions 🫀Severe obesity has also ⤴️ 🫀BMI doesn’t reflect obesity as well as waist-to-height ratio 🫀⤴️ diabetes follows obesity

Another GLP-1 drug success. Tirzepatide in heart failure with preserved ejection fraction (HFpEF) with longer term follow-up than 2 previous trials with semaglutide nejm.org/doi/full/10.... in people with BMI >30; no data yet for HFpEF in people without obesity