Mert Erogul
@erogul1.bsky.social
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Metabolic health, geroscience, emergency medicine. Thanks for leaving twitter
reposted by
Mert Erogul
Dr. Vin Gupta
about 2 months ago
Regardless of the disgraceful nonsense we will likely hear from this administration in the coming days on vaccine ārecommendations,ā Americas healthcare insurers issued a joint statement tonight saying coverage for Covid and flu shots will remain unchanged from prior years. Speaks for itself.
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They brought in a guy from his house, the circumstances weren't clear. He was found on the ground, unk downtime but the body was covered in pressure sores. He was emaciated and breathing rapidly through his mouth.
4 months ago
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Nice write up in the times for the medical storytelling program (
airwaystories.com
)
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Real Doctors of New York Spill Their Guts
https://www.nytimes.com/2025/06/24/well/real-doctors-of-new-york-spill-their-guts.html?unlocked_article_code=1.Rk8.r7yB.6lMrWfFDR7Gg&smid=nytcore-ios-share&referringSource=articleShare
5 months ago
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A pilot of reverse transcriptase inhibitors for the treatment of tau-opathies. Probing the hypothesis that retrotransposons underlie pathophysiology of Alzheimer's. Results are interesting.
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A Phase IIa clinical trial to evaluate the effects of anti-retroviral therapy in Alzheimerās disease (ART-AD) - npj Dementia
npj Dementia - A Phase IIa clinical trial to evaluate the effects of anti-retroviral therapy in Alzheimerās disease (ART-AD)
https://www.nature.com/articles/s44400-024-00001-z
7 months ago
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FDA has ruled that compounded GLP drugs are no longer permitted
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Compound versions of GLP-1 drugs for weight loss halted by FDA
ABC News' Dr. Tara Narula shares what patients need to know.
https://abcnews.go.com/GMA/Wellness/compound-versions-weight-loss-drugs-longer-fda-rules/story?id=119665010
8 months ago
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Poor sleep disrupts the glymphatic system in humans, which hastens dementia. Exercise improves glymphatic functioning (at least in mice).
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Effects of sleep on the glymphatic functioning and multimodal human brain network affecting memory in older adults - Molecular Psychiatry
Molecular Psychiatry - Effects of sleep on the glymphatic functioning and multimodal human brain network affecting memory in older adults
https://www.nature.com/articles/s41380-024-02778-0
8 months ago
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reposted by
Mert Erogul
The Buck Institute for Research on Aging
8 months ago
Study in
@nature.com
(Nature Medicine) āexposes the
#exposome
in
#aging
ā by exploring how 164 exposures relate to mortality and age-related disease. How and where we live matters big time!
www.nature.com/articles/s43...
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Exposing the exposome in aging - Nature Aging
Nature Aging - Exposing the exposome in aging
https://www.nature.com/articles/s43587-025-00845-x
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Here is a theoretical problem with overdriving anabolism with BCAA supplementation in older adults. It paradoxically causes sarcopenia.
add a skeleton here at some point
9 months ago
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reposted by
Mert Erogul
Jen Wang
9 months ago
Update on my life: Last year, I joined my kids' school's PTA, because they needed a treasurer and I'm good enough with numbers. It was a straightforward, self-contained job: balancing the checkbook for an organization that only did a few fundraisers each year.
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My Chinese patient has a tattoo on his arm. It says 7-5-1986. I ask him its meaning and he says that he did it himself. I say, but why did you write that date, what is the significance of the date? He says thatās what day it was when he did the tattoo.
9 months ago
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reposted by
Mert Erogul
Eric Topol
9 months ago
How exercise during pregnancy can improve metabolic health of offspring: a key mediator (Serpina3c) from mother's white adipose tissue gets into fetal circulation, suppresses inflammation, as demonstrated in the mouse model
www.nature.com/articles/s42...
www.nature.com/articles/s42...
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A landmark paper claiming that somatic mutations to DNA (due to replicative errors, toxins, radiation, etc.) are the sought after drivers of epigenetic changes and account for the ticking of the clock. If true, then it seriously complicates ambitions to reverse aging with Yamanake Factors.
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Somatic mutation as an explanation for epigenetic aging - Nature Aging
Koch and colleagues report that epigenetic clocks mirror age predictions based on the accumulation of somatic mutations and show that somatic mutations at CpG sites coincide with extensive remodeling ...
https://www.nature.com/articles/s43587-024-00794-x
10 months ago
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reposted by
Mert Erogul
Ran Blekhman
10 months ago
Today we report a new compendium of human gut microbiomes with >168,000 samples By analyzing this massive dataset, we discovered distinct microbiome patterns across the globe, and show we can predict where a person lives just from their gut bacteria Now out in Cell:
www.cell.com/cell/fulltex...
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Integration of 168,000 samples reveals global patterns of the human gut microbiome
The Human Microbiome Compendium is a unified database of publicly available human gut microbiome 16S samples, built with the integrated data from hundreds of independent projects. The compendium is us...
https://www.cell.com/cell/fulltext/S0092-8674(24)01430-2
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reposted by
Mert Erogul
The Buck Institute for Research on Aging
10 months ago
Reconciling 2 major explanations for
#aging
, study in Nature Aging
@nature.com
finds somatic mutations are fundamental driver of aging and
#epigenetic
changes simply track process. Reversing aging may be harder than previously thought. Time to rethink strategies?
www.nature.com/articles/s43...
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Somatic mutation as an explanation for epigenetic aging - Nature Aging
Koch and colleagues report that epigenetic clocks mirror age predictions based on the accumulation of somatic mutations and show that somatic mutations at CpG sites coincide with extensive remodeling ...
https://www.nature.com/articles/s43587-024-00794-x
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reposted by
Mert Erogul
Microbiome Virtual International Forum
10 months ago
It's a new year! ...and a new
#MVIF
program is out! 𤩠Registration here:
cassyni.com/s/mvif-35
āļøMicroTalks: Minna Chang
@hariszaf.bsky.social
āļø Keynote:
@chmoei.bsky.social
āļøSelected talks: Pratyay Sengupta
@fatimacpereira.bsky.social
@cladigar.bsky.social
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reposted by
Mert Erogul
Eric Feigl-Ding
10 months ago
Price gouging by the āBig 3 PBMsāāCaremark Rx (CVS), Express Scripts (ESI), and OptumRx āmarked up numerous specialty generic drugs at their pharmacies by **thousands of percent***, and many by hundreds of percentāresulting in š $7.3 billionš in excess revenue.
www.ftc.gov/news-events/...
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Oscillations in gut microbiota composition regulate the diurnal rhythmicity of HPA axis function, which leads to altered stress responsivity across the day.
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https://www.cell.com/action/showPdf?pii=S1550-4131%2824%2900399-1
10 months ago
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reposted by
Mert Erogul
Eric Topol
10 months ago
Redefining obesity, report of a new commission, to override current BMI categories and better define features and pathophysiologic consequences of pre-clinical and clinical obesity
www.thelancet.com/journals/lan...
open-access
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Move over
#Horvath
.
#Histone
specific epigenetic changes highly predictive of aging, rivaling CpG methylation sites. They typically specify genes important to the aging process.
www.science.org/doi/10.1126/...
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Histone mark age of human tissues and cell types
Histone mark age predictors will complement cytosine methylation-based clocks in aging and rejuvenation studies.
https://www.science.org/doi/10.1126/sciadv.adk9373
10 months ago
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reposted by
Mert Erogul
Eric Topol
10 months ago
Our assessment of a person's epigenetic ("biological") age has been centered on DNA methylation. A new report shows that a set of 7 histone markers has comparable accuracy and also uncovers new pathways of aging biology
www.science.org/doi/10.1126/...
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reposted by
Mert Erogul
Christian Frezza
11 months ago
www.cell.com/trends/endoc...
@cp-trendsendomet.bsky.social
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Inter-organ communication is a critical machinery to regulate metabolism and aging
Inter-organ communication (IOC) is a complex mechanism involved in maintaining metabolic homeostasis and healthy aging. Dysregulation of distinct forms of IOC is linked to metabolic derangements and age-related pathologies, implicating these processes as a potential target for therapeutic intervention to promote healthy aging. In this review, we delve into IOC mediated by hormonal signaling, circulating factors, organelle signaling, and neuronal networks and examine their roles in regulating metabolism and aging. Given the role of the hypothalamus as a high-order control center for aging and longevity, we particularly emphasize the importance of its communication with peripheral organs and pave the way for a better understanding of this critical machinery in metabolism and aging.
https://www.cell.com/trends/endocrinology-metabolism/fulltext/S1043-2760(24)00320-5?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1043276024003205%3Fshowall%3Dtrue
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reposted by
Mert Erogul
Ram Chakrabarty
11 months ago
Our lab's latest study, spearheaded by a fantastic colleague, Colleen, reveals that the blood glucose-lowering effect of metformin requires the inhibition of mitochondrial ETC complex I.
www.science.org/doi/10.1126/...
. An insightful focus by Prof. Doug Green:
bit.ly/41Hc4fX
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Metformin targets mitochondrial complex I to lower blood glucose levels
Acute oral metformin administration lowers blood glucose levels by targeting mitochondrial complex I.
https://www.science.org/doi/10.1126/sciadv.ads5466
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reposted by
Mert Erogul
Danielle Beckman
11 months ago
CDC confirms first severe case of
#H5N1
bird flu in the U.S. š£š£š£
www.cdc.gov/media/releas...
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Delightful
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A āSecond Tree of Lifeā Could Wreak Havoc, Scientists Warn
Research on so-called mirror cells, which defy fundamental properties of living organisms, should be prohibited as too dangerous, biologists said.
https://www.nytimes.com/2024/12/12/science/mirror-life-microbes-research.html?smid=nytcore-ios-share&referringSource=articleShare
11 months ago
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Nuclear kappa beta receptor ligand administration (RANKL) regrows thymus and restores immune function in mice. A potential cure for immune senescence.
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RANKL treatment restores thymic function and improves T cellāmediated immune responses in aged mice
RANK ligand administration reversed age-dependent thymic involution and rejuvenated T cell immunity in mice.
https://www.science.org/doi/10.1126/scitranslmed.adp3171
11 months ago
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Ketones, either endogenous or consumed, help clear misfolded protein in the brain through autophagy.
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Ketone Bodies Clear Damaged Proteins in the Brain - Neuroscience News
Ketone bodies, known for their role in energy metabolism during fasting, have been shown to directly interact with damaged proteins in the brain, aiding their clearance through autophagy.
https://neurosciencenews.com/ketone-bodies-autophagy-28154/
11 months ago
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@neurosciencenews.bsky.social
please start posting
11 months ago
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"Our results reveal that whenever handwriting movements are included as a learning strategy, more of the brain gets stimulated, resulting in the formation of more complex neural network connectivity...typewriting do[es] not activate...networks the same way that handwriting doesā
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Handwriting but not typewriting leads to widespread brain connectivity: a high-density EEG study with implications for the classroom
OpenRead Reading & Notes Taking
https://www.openread.academy/paper/reading?corpusId=503252214
11 months ago
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Seems like a big deal
add a skeleton here at some point
12 months ago
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reposted by
Mert Erogul
htw
12 months ago
Association of
#sleep
quality and
#mitochondrial
DNA copy number in healthy middle-aged adults
www.sciencedirect.com/science/arti...
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