A new comparative single-cell multi-omic study of two neurodegenerative disorders, Alzheimer's disease and Pick's disease. A long time in the making and finally published last week!! 🥳

🗞️ Genetic diversity has a profound impact on genomic annotations, and there is currently a massive European bias in widespread annotations like GRCh38 🤯 This paper is the result of the hard work and passion of @pclavell.bsky.social and @fairlie.bsky.social, congrats to the authors!

Long-read transcriptomics of a diverse human cohort reveals widespread ancestry bias in gene annotation https://www.biorxiv.org/content/10.1101/2025.03.14.643250v1

I got laid off today, with the rest of 18F. 18F was an elite federal software shop. We made gov't websites work better, more efficiently for the American people. We saved taxpayers from getting screwed over by contractors. And were fired for it. We made this website to tell our story: 18f.org

“Assume that what you write will be read by malign foreign actors and tailor your response accordingly.”

As a result of Trump’s slashes to research funding, dozens of graduate programs have announced reductions and cancellations of graduate admissions slots. If you are an impacted applicant, please fill out this survey: docs.google.com/forms/d/e/1F... 🧪🧠🧬🔬🥼👩🏼‍🔬🧑‍🔬

🌟Great News: CNAG is now on BlueSky! 🚀From Barcelona to the world, we’re bringing you the latest in genomics! Stay tuned for breaking news, cutting-edge technologies, groundbreaking research, and upcoming events 🔗https://www.cnag.eu #Genomics #Innovation #Research #BlueSky #CNAG

Pretty sad. Just got the email that CZI is canceling the second round of Diversity Leadership Awards. Private industry will definitely not fill the hole that NIH and NSF are leaving. 😢💔

I was just told that I have to remove “climate” from the title of an ongoing grant if I want to keep it. And publications from that grant cannot include “climate” and other forbidden words. I can’t believe I’m writing this from the United States of America. #AcademicSky

The National Institutes of Health plans to severely cut the percentage of its grant money that can be used for overhead costs rather than research.

1. Today the NIH director issued a new directive slashing overhead rates to 15%. I want to provide some context on what that means and why it matters. grants.nih.gov/grants/guide...

Inspired by @charlesgaba.com's Herculean effort to post all Wayback URLs from the CDC website (including pages that have recently been deleted), I built this GitHub repo to share Wayback links to all CDC website pages, and will add more websites when I get a chance github.com/Niema-Lab/Go...

📢 SUPER EXCITED to share our latest preprint: Decoding the immune response in leptomeningeal disease through single-cell sequencing of cerebrospinal fluid Incredible work and collaboration from @jcnietos.bsky.social @piazeiner.bsky.social @hoheyn.bsky.social and others. biorxiv.org/content/10.110…

All NIH study sections canceled indefinitely. This will halt science and devastate research budgets in universities.

Overjoyed to share that I was selected for the EMBO #postdoc fellowship for my proposal titled "Charting immune cell signatures to tackle non-response to immunotherapy in colorectal cancer". Excited to work on this project over the next few years in #Barcelona! #EMBOFellows

3 reviews on planning, execution, & validation of transcriptomic experiments in neuroscience published in @natureportfolio.bsky.social #NatureNeuroscience. A MUST READ if you're doing transcriptomics. 3 reviews, an amazing editorial, a beautiful cover – this is the issue of the year! (mini thread)

So excited that our work on predicting gene expression from histone modifications using deep learning is out in NAR today. Brilliant to work with lead author @al-murphy.bsky.social and collaborators Aydan Askarova, @borislenhard.bsky.social and Nathan Skene 🧬⭐️🙏 academic.oup.com/nar/advance-...

A really nice summary on Alzforum of my recent paper where we used #SingleCell and #spatial #omics to investigate molecular and cellular abnormalities in the brains of individuals with Alzheimer's in Down Syndrome (DSAD). www.alzforum.org/news/researc...

Big day for single cell and neuroscience. Trio of single cell perspective pieces discussing applications, opportunities, challenges, and validation of single cell and spatial genomics in neuroscience are out now in Nature Neuroscience. Links in thread below.👇 1/n

A little piece that's been in the works with former MSc, now PhD student, Jiayi Wang & @markrobinsonca.bsky.social in the multi-sample/-condition/-subpopulation theme: ...

Hi all! I'm a computational biologist studying the impact of variation on the functional genome at @bsc-cns.bsky.social. Consortium alumnus (ENCODE, LRGASP, IGVF @igvfconsortium.bsky.social); @ucirvine.bsky.social PhD; @ucsandiego.bsky.social BS; and recent transplant from California to Barcelona.

News & Views with @irholtman.bsky.social on spatial and single-cell gene expression analyses of Alzheimer's and Down's Sydrome www.nature.com/articles/s41.... This is a commentary on the work by the Swarup lab: www.nature.com/articles/s41....

Our comparative spatial & single-nuc study of Alzheimer's, Down Syndrome in AD, and a genetic mouse model, just published in Nature Genetics. Massive effort of the 2nd half of my PhD, and a pleasure to work with co-first author Emily, my advisor Vivek, & many others at UC Irvine 🧠 🧬

STAMPing single cell like never before…at a ~0.25c/cell single cell-imaging is the new single cell-sequencing. www.biorxiv.org/content/10.1...

👀 Working on a #StarterPack for early career researchers (PhD students & Postdocs) in #genomics & #bioinformatics 🧬🖥️ Please share! Happy to add those working in this area so please suggest. Seeing a lot of PIs on here but would love to see more students 🎓🚀

Amazing new study led by my labmate Inés Sentís, leveraging #SingleCell 🖥️🧬 technologies to study the effects of #immunotherapy in #pediatric #cancer. Emphasis on #Tcell dynamics throughout treatment and comparing circulating vs. tumor-resident immune cells 🩸💪

Has anybody made a starter pack specifically for trainees #phd students & #postdocs in #genomics or #bioinformatics 👀 🖥️ 🧬

"Single-cell atlas of the human immune system reveals sex-specific dynamics of immunosenescence" Interesting pre-print on immune cells dynamics throughout aging, from Marta Mele's group at Bacelona Supercomputing Center. www.biorxiv.org/content/10.1... #singlecell #immunology #aging

Hi BlueSky! I am a computational biologist 🖥️🧬 using -omics to study human diseases like cancer & Alzheimer's 🧠 Originally from southern #California, now in #Barcelona as a postdoc in the #singlecell #genomics group at the Centre Nacional d'Anàlisi Genòmica (CNAG). Happy to connect w/ others on here!