Curious about how we assess grant applications? We’re inviting researchers to observe a Wellcome funding advisory committee in action. Apply by 11 May 2026 ⤵️ wellcome.org/research-fun...

Don't you f**king dare.

🚨 Latest paper out now 🚨 by @mattjowen.bsky.social and me: "Continuation methods as a tool for parameter inference in models of biological oscillations: A case study in electrophysiology modeling" in doi.org/10.1016/j.ph... short tweetorial follows ..... 🧵1/6

New post, on how AI is normalising n=1 experiments: kucharski.substack.com/p/ai-has-an-...

Me writing EU grant applications: Part B1: I can't possibly squeeze everything they need to know in there. Part B2: but I already explained exactly what you need to know precisely and accurately, I can't make it longer now

How can this go on for another 3 years?

Every day is a good day for sharing one of the most useful papers about research data ever written. PLEASE get your people to understand and follow this advice. www.tandfonline.com/doi/full/10....

So, BlueSky, one of my passions is the study of tea in WW2. I need you to watch this oral history from three ex-tea ladies from the Bermondsey WVS. Because you could guess for ONE THOUSAND YEARS and you would not guess where it is going... #skystorians #history #tea

Peak time express train 6.02pm out of St Pancras. In the 12 seats around me there is one other person. Pricing must be significantly higher than optimal for (a) customers, (b) income for train company, (c) the wider economy. On the plus side it's very pleasant.

Explainer: UK government has announced a suspension on student visa applications from nationals of Afghanistan, Cameroon, Myanmar and Sudan. Details here www.gov.uk/guidance/vis...

Data

Pretty convinced that nursery fees being in the basket of goods is solely responsible for keeping inflation above 2%. ...<googled>... Oh look, nursery fee inflation actually is 8% 🤯! www.ons.gov.uk/economy/infl... Not sure whether to be relieved ours isn't an outlier or to start a nursery.

(1) Read, and replace any mention of 'work' or 'papers' in your mind with 'words in order'. (2) Repeat, replace the same with 'new knowledge'. Which makes most sense? If the article is about words-in-order, discard. If it is about new knowledge, read it carefully to see if the author is loopy.

It's never not been crazy-making to me that we'll have hundreds of thousands of words written about a 2% change to income tax either way and the impact it'll have in the economy, but 9% of half the population under 35 is waved away as a private matter, or "only the price of a gym membership".

Abysmal, immoral, cruel, small hearted, tiny minded, ineffective, undemocratic, and just generally utterly indecent. What a bitter godforesaken disappointment these people are. www.bbc.co.uk/news/article...

New Ep now up. Stewart Lee and I discuss swearing at the BAFTA’s, Blair’s legacy and Gerry Adams trampolining naked with a dog. #StrongMessageHere www.bbc.co.uk/sounds/play/...

I'll just repost this today #ByElection #UKPolitics

The government's immigration plans: a dog’s dinner of half-conceived policy, Reform rhetoric, mean-spirited sentiment, and profound intellectual muddle iandunt.substack.com/p/can-we-ext...

‘Is university still worth it?’ is the wrong question - giftarticle.ft.com/giftarticle/... via @FT

Very good for any scientist to see. We're not all our linkedin profile all of the time

NEW: The FDA just shot down Moderna's new flu shot. From me: www.theguardian.com/us-news/2026...

Paradise Bay, Urupukapuka. Not bad!

Die, Dichotomy. www.linkedin.com/pulse/die-di... A brief post encouraging you to read the original paper with @erik-van-zwet.bsky.social and @f2harrell.bsky.social . onlinelibrary.wiley.com/doi/epdf/10....

#TheBomb podcast is excellent. Season 3 about the Cuban Missile Crisis is inspired, narrated by family of the two leaders - Max Kennedy and Nina Khrushcheva - really enlightening about how both sides were thinking: www.bbc.co.uk/programmes/p...

Just tried to unlock my office door with car key fob. Is it only two weeks since Christmas break?

another robot highlight for 2025: man wearing humanoid mocap suit kicks himself in the balls

"more than a dozen ex-[Tory] MPs and one sitting member have defected to Reform since the election (admittedly to the improvement of both parties)." 🔥 from @financialtimes.com ! www.ft.com/content/d79f...

‼️Two new PhD positions open! One experimental, one modelling, exploring these beautiful collective dynamics in mitochondria across species. 🇳🇴, good pay, full staff benefits. [Shares much appreciated] Lab: www.jobbnorge.no/en/available... Modelling: www.jobbnorge.no/en/available...

Generative AI is amazing at tasks where I am not qualified to judge the output.

PhD position with John King at University of Nottingham @ University of Nottingham, UK Deadline: 9 Jan 2026 www.nottingham.ac.uk/mathematics/...

At the @uniofnottingham.bsky.social faculty of Science Christmas lecture. Here's a sustainability periodic table showing the abundance of the elements.

Can't help but think the best way to assess a research strategy is to assess the research it produces. Are the people that told #REF2029 they need to assess the strategies the same people who create strategies? www.researchprofessionalnews.com/rr-news-uk-r...

NEW BLOGPOST Abolishing trial by jury: why is the government overlooking the obvious? thesecretbarrister.com/2025/12/02/a...

Quite enjoying #StrongMessageHere podcast @aiannucci.bsky.social : I'm an influencer. No you're not. Get to school 🤣

Friends. Comrades. I have QUESTIONS, especially about item 4 there.

📝 Excited to share our latest work, now out at European Heart Journal! We studied 252 SCN5A variants previously found in patients with Brugada Syndrome, an inherited arrhythmia disorder linked to sudden cardiac death. [1/4]

I hope @teamlabouruk.bsky.social are getting some statistical input. If 84% of your landslide-victory voters have unfavourable view of Farage, adopting policies he likes is not going to be a winning strategy (as you can see from how well Davey and Polanski are polling amongst your core vote).

“Enjoy the result you have found by exploratory subgroup analysis, for you will not find it again.” Sayings of Confuseus

Thanks for the email summary #GMail. The only thing is, it is longer than the actual email was. Can we put in some common sense checks before rolling this AI stuff out?!

Postdoc Position (2y) in Physics-informed Model Discovery for Reaction-Diffusion Equations @ Roskilde, Denmark Deadline: 15 Dec 2025 candidate.hr-manager.net/ApplicationI...

Research aims and objectives aren’t the same thing but are related It helps to understand the differences and connections patthomson.net/2025/11/01/r...

Ozempic, MRI machines and flat screen televisions all emerged out of fundamental research decades earlier — the very types of study being slashed by the US government www.nature.com/articles/d41...

Language models are terrible at counting (part 12381...) It's concerning how many workflows/copilots etc. these tools are now creeping into, despite making small numerical errors all over the place (which a causal eye might not catch). Below from GPT-5 and Sonnet-4.5:

Calling ALL health data folk: Re UK Health Data Research Service. The UK gov & Wellcome have pledged up to £600 million to create a HDRS. Myself & an ace team have been tasked by Wellcome to assess the existing health data ecosystem & identify what is needed to support the HDRS 👇. Get in touch

So I've been reading the Post-16 Education and Skills White Paper. There's some good things in there. But when it comes to universities there's very little to cheer. The situation is very tough and will get worse. The last chance to preserve what we've got has passed. Let me explain why. (1/?)

About 50% of my time interacting with #MacOS is navigating to a folder in a "Save As" pop up window to download attachments etc., then doing exactly the same thing in Finder to open it 10 seconds later. Am I missing some workflow that avoids this bluesky-o-sphere!?

That's a "nuh" [N]. Nuh for... Netflix! #ParentingFail

New blogpost on my concerns about Wellcome LEAP new $50m program on autism/microbiome links. deevybee.blogspot.com/2025/10/a-le... #autism #microbiome #biomarkers #diagnostic

Our ForSys method to infer the mechanical state of a tissue in space and time is published now in @cp-iscience.bsky.social ! www.cell.com/iscience/ful... (1/10)

Ultra-processed food - the eternal enemy of the people. And, apparently, testicles. Or...is it? My new piece. gidmk.substack.com/p/is-ultra-p...