This is great and also illustrates how frivolous and completely damaging design review is for housing in our city

Explaining #seattle housing politics to a New Yorker is hilarious. nimby position is new buildings only downtown. The far left most yimby position is brownstone height buildings near commercial centers. The notion of brownstone height everywhere or some taller buildings is outside polite discourse.

Having often dealt with the frustration of binder-limited projects, we sought a more accessible source for nanobodies than yeast display or llama. Here we introduce Germinal, computationally designing antibody-like binders with such a hit rate that only tens need to be screened for each target.

Speak up to prevent a major loss for the field. CASP, which helped shaping structural biology including AlphaFold is on the verge of shutting down. NIH funding has lapsed, UC Davis support ends and the core team is being let go. Painfully shortsighted.

“Someone with a 1-hr car commute needs to earn 40% more to be as happy as someone with a short walk to work. On the other hand, if someone shifts from a long commute to a walk, their happiness increases as much as if they’d fallen in love.” #CityMakingMath 50 reasons to want more walkable cities.

Job Garcia’s kidnapping by the Trump administration is the top story on the LA Times website right now. www.latimes.com/california/s...

One of the hardest things about growing up in #nyc and living elsewhere is the utter lack of Chinese Cuban restaurants #iykyk… Trader Joe’s plantains scratch that itch

Excited to announce that Pramila Jayapal will be our featured speaker at the Rally before the JUNE 14th - Seattle NO KINGS MARCH. #nokings #DefendDemocracy #FightAuthoritarians #NoFascism

THE AMERICAN MEDICAL ASSOCIATION CALLS FOR A SENATE INVESTIGATION INTO RFK, JR. "The resolution’s sponsor, Dr. Jason Goldman, urged his colleagues to support the request for an investigation to ensure the AMA is not “on the wrong side of history.” chicago.suntimes.com/health/2025/...

"If there were justice in the world, Musk would never be able to repair his reputation, at least not without devoting the bulk of his fortune to easing the misery he’s engendered." www.nytimes.com/2025/05/30/o...

Temporary, but a clear win for HB1110 legal approach! Little fanfare is ideal really, when tensions run so high

This guy stole $10 million from the employees of his nursing home to buy himself a luxury yacht and Cartier watches. He PLED GUILTY. And because his Mom gave Trump $1 million, he just got a pardon. And this story barely makes the news today. WTF. www.nytimes.com/2025/05/27/u...

'(...) we could end up with completely new treatments for some of these conditions (or for subsets of patients therein), but no matter what we're going to learn a tremendous amount about the role of B cells in their etiologies, from several different angles all at once' @dereklowe.bsky.social

Cyrus's CEO, Lucas Nivon, is the keynote speaker for Nucleate Seattle’s Activator Demo Day! Join us to hear him speak about Life Sciences Commercialization on May 14th at the Allen Institute. #Seattle #Biotech #Innovation lu.ma/18yj2jg3?tk=...

The structure of human sweetness: Cell Sweet receptor bound to two widely used artificial sweeteners: sucralose and aspartame. A single receptor that mediates all our responses to sweet-tasting compounds.

Nature reports that the National Science Foundation has stopped awarding new grants and allotting funds to existing ones. All of them. @colincarlson.bsky.social says that unless the freeze is lifted, it “is going to destroy people's labs.” 2/10 www.nature.com/articles/d41...

Great piece. Often try to explain this to tech people, they train on human data, it is often easily observable. In bio much of data is invisible to us, now we have transcriptomics, spatial bio, etc. Hubble telescope is an example, before that you can’t see so far! We need bio Hubbles

So happy @openfold.io is growing! More exciting announcements coming soon about our new all atom model adding ligand and RNA/DNA

Idea for a hit movie: 3 professors have their research funding cut. They bootstrap a startup on services revenue, using the services to create new niche products. No VC funding. It is called… Ghostbusters (that’s the actual plot!) #scisky #startups #vc #bootstrap

Protein binder design workflows for everyone! #ai #biotech

They’re going to keep pushing until something stops them.

My first post on BlueSky, I could not access the same handle as my X (someone hacked into that one): So it's @peterhotez for X and @peterhotezmdphd for BlueSky I'm a pediatric-vaccine scientist based in Houston TX at our Texas Medical Center

“Kennedy’s team requested that Marks turn over data on cases of brain swelling and deaths caused by the measles vaccine—data that Marks said doesn’t exist because there have been no such confirmed cases in the U.S.” www.wsj.com/health/healt...

Thinking about printers and #biotech #ai Why are printers so lame? Because the interface from software to real world is complex. Ink on paper is relatively simple but still not robust.

1. Another Friday afternoon massacre of sorts: NIH just rescinded its Scientific Integrity Policy. h/t @lizborkowski.bsky.social

An abundant future is possible & we must work to create it. Supporting the status quo hasn’t worked. We need bold, innovative solutions if we want different results.

Excited to present about OpenFold #ai consortium!

They are cutting cancer research. They are cutting cancer research. They can deny it all they want, but they are cutting cancer research. These are the cuts being made the DoD CDMRP cancer funding mechanism www.fightcancer.org/sites/defaul...

Unidentified men grabbing someone off the street and putting her in a car because she wrote an op-Ed. This as flatly authoritarian as anything we’ve seen in this country in a very long time.

James Malone just flipped a Pennsylvania State Senate district that went for Trump by 15 points last year. This is what building Democratic power looks like. Congratulations, Senator-elect Malone!

#urbanist bluesky. I'm developing an argument that missing middle and upzoning are in fiduciary interest of most big city companies. Supply side housing limits effectively tax younger employees and critically limits corporate growth (most payroll pays people w less housing equity)

Reporter: Are you so are you saying you're okay with the continued use of signal by administration officials? Trump: No, that's not what I said. It seems to be the number one used device or app, whatever you want to call it

Excited to start introducing Cyrus's first clinical directions in dangerous Hematological autoimmune disease! #autoimmune #biotech #pharma #drugdiscovery #ai

Someone literally try to run over @teslatakedown.com protesters today. Terrorism aimed at actual people, not cars. I'm assuming this will get at least as much coverage as the property damage?

So excited to read this. New ideas that are not mercantilism. Grow housing, tech, biotech, and transit! #urbanism @ezraklein.bsky.social is pointing a potent new direction

"On October 8, 1931, a law went into effect requiring every Italian university professor to sign an oath pledging their loyalty to the government of Benito Mussolini. Out of over 1,200 professors in the country, only 12 refused. All of them were immediately fired." www.chronicle.com/article/what...

This thread is amazing — about AI realism and the false hype of DOGE

Where have I seen this before? Oh yeah…

Is America winning yet? www.startribune.com/iron-range-l...

If you have ever authored a scientific paper, the text is now being used by META. So paywalls keep out people but not the META spiders.

It’s not a kitchen-table issue, nevertheless I find myself hoping Democratic leaders pipe up about Trump handing his top campaign donor our contingencies for war against a nuclear power where he makes cars.

A friend drove two hours today for her breast cancer chemotherapy only to learn it was canceled due to NIH cuts. Clinical trial ended midstream. No treatment, no restart, no plan, no information. Her bro-in-law's chemo was also canceled.

This is terrifying. Grabbed on the street and spirited away without any process for “views.”

This is unacceptable

The administration is removing phone support for Soc Security recipients. Making it more difficult for seniors to get their checks. It’s a back door way to cut SS benefits. Horrific. If you know anyone who is impacted, please help them get online to get their benefits approved

In case you, like me, are a high-anxiety human who missed this piece of moderately reassuring news: Despite many broken things, the FDA *did* make a flu shot recommendation for this fall. www.cnn.com/2025/03/13/h...

They want the unreviewable power to grab people and render them to a foreign gulag.