Lynn’s Paradox “A phenomenon in which sequential cause-agnostic randomized trials (CARs) testing a treatment for a disease-agnostic syndrome yield opposing conclusions across studies because enrolled participants represent a shifting mixture of diseases with opposing treatment effects.”

Don’t miss the discussion of RCT design and public safety. zenodo.org/records/1851...

@intenscaremed.bsky.social The danger to the public of using syndromic entry criteria for RCT in critical care. doi.org/10.5281/zeno...

@doced.bsky.social The danger to the public of using syndromic entry criteria for RCT in critical care. doi.org/10.5281/zeno...

@esicm.bsky.social The danger to the public of using syndromic entry criteria for RCT in critical care. doi.org/10.5281/zeno...

@scottishics.bsky.social The danger to the public of using syndromic entry criteria for RCT in critical care. doi.org/10.5281/zeno...

@intenscaremed.bsky.social The danger to the public of using syndromic entry criteria for RCT in critical care. doi.org/10.5281/zeno...

@icmexperimental.bsky.social The danger to the public of using syndromic entry criteria for RCT in critical care. doi.org/10.5281/zeno...

@statsmethods.bsky.social The danger to the public of using syndromic entry criteria for RCT in critical care. doi.org/10.5281/zeno...

@berkeleyctml.bsky.social The danger to the public of using syndromic entry criteria for RCT in critical care. doi.org/10.5281/zeno...

@causalscience.org The danger to the public of using syndromic entry criteria for RCT in critical care. doi.org/10.5281/zeno...

@causalab.org The danger to the public of using syndromic entry criteria for RCT in critical care. doi.org/10.5281/zeno...

@causalhuber.bsky.social The danger to the public of using syndromic entry criteria for RCT in critical care. doi.org/10.5281/zeno...

@acmedsci.bsky.social The danger to the public of using syndromic entry criteria for RCT in critical care. doi.org/10.5281/zeno...

@medsci.ox.ac.uk The danger to the public of using syndromic entry criteria for RCT in critical care. doi.org/10.5281/zeno...

@clevelandclinicmls.bsky.social The danger to the public of using syndromic entry criteria for RCT in critical care. doi.org/10.5281/zeno...

@oxfordstatistics.bsky.social The danger to the public of using syndromic entry criteria for RCT in critical care. doi.org/10.5281/zeno...

@scharr-msg.bsky.social The danger to the public of using syndromic entry criteria for RCT in critical care. doi.org/10.5281/zeno...

@southamptonctu.bsky.social The danger to the public of using syndromic entry criteria for RCT in critical care. doi.org/10.5281/zeno...

@imperialctu.bsky.social The danger to the public of using syndromic entry criteria for RCT in critical care. doi.org/10.5281/zeno...

@primarycaretrials.bsky.social The danger to the public of using syndromic entry criteria for RCT in critical care. doi.org/10.5281/zeno...

@cantrain.bsky.social The danger to the public of using syndromic entry criteria for RCT in critical care. doi.org/10.5281/zeno...

@cochrane.org The danger to the public of using syndromic entry criteria for RCT in critical care. doi.org/10.5281/zeno...

@erc.europa.eu The danger to the public of using syndromic entry criteria for RCT in critical care. doi.org/10.5281/zeno...

@jci.org The danger to the public of using syndromic entry criteria for RCT in critical care. doi.org/10.5281/zeno...

@jclinepi.bsky.social The danger to the public of using syndromic entry criteria for RCT in critical care. doi.org/10.5281/zeno...

@sccm-research.bsky.social The danger to the public of using syndromic entry criteria for RCT in critical care. doi.org/10.5281/zeno...

@sccmmw.bsky.social The danger to the public of using syndromic entry criteria for RCT in critical care. doi.org/10.5281/zeno...

@sccm-pediatrics.bsky.social The danger to the public of using syndromic entry criteria for RCT in critical care. doi.org/10.5281/zeno...

@sccm-research.bsky.social The danger to the public of using syndromic entry criteria for RCT in critical care. doi.org/10.5281/zeno...

@critcarescience.bsky.social The danger to the public of using syndromic entry criteria for RCT in critical care. doi.org/10.5281/zeno...

@ics-updates.bsky.social The danger to the public of using syndromic entry criteria for RCT in critical care. doi.org/10.5281/zeno...

@stephen-t-webb.bsky.social The danger to the public of using syndromic entry criteria for RCT in critical care. doi.org/10.5281/zeno...

@dilipj1.bsky.social The danger to the public of using syndromic entry criteria for RCT in critical care. doi.org/10.5281/zeno...

@criticalcare.bsky.social The danger to the public of using syndromic entry criteria for RCT in critical care. doi.org/10.5281/zeno...

Don’t miss this review doi.org/10.5281/zeno...

@basakcoruh.bsky.social Help raise awareness of the patient safety need for critical care clinical trial reform by forwarding this review. pssjournal.biomedcentral.com/articles/10....

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@criticalcare.bsky.social Help raise awareness of the patient safety need for critical care clinical trial reform by forwarding this review. pssjournal.biomedcentral.com/articles/10....

@dilipj1.bsky.social Help raise awareness of the patient safety need for critical care clinical trial reform by forwarding this review. pssjournal.biomedcentral.com/articles/10....

@stephen-t-webb.bsky.social Help raise awareness of the patient safety need for critical care clinical trial reform by forwarding this review. pssjournal.biomedcentral.com/articles/10....

@ics-updates.bsky.social Help raise awareness of the patient safety need for critical care clinical trial reform by forwarding this review. pssjournal.biomedcentral.com/articles/10....

@critcarescience.bsky.social Help raise awareness of the need for critical care clinical trial reform by forwarding this review. pssjournal.biomedcentral.com/articles/10....

@sccm-research.bsky.social Help raise awareness of the need for critical care clinical trial reform by forwarding this review. pssjournal.biomedcentral.com/articles/10....

@sccm-pediatrics.bsky.social Help raise awareness of the need for critical care clinical trial reform by forwarding this review. pssjournal.biomedcentral.com/articles/10....

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@sccm-research.bsky.social Help raise awareness of the need for critical care clinical trial reform by forwarding this review. pssjournal.biomedcentral.com/articles/10....

@jclinepi.bsky.social Help raise awareness of the need for clinical trial reform by forwarding this review. pssjournal.biomedcentral.com/articles/10....

@jci.org Help raise awareness of the need for clinical trial reform by forwarding this review. pssjournal.biomedcentral.com/articles/10....