Cause mixture paradox explains non-reproducible sepsis,ARDS, and CAP trials which generate the third estimand.

I’m at the point where I think most sepsis (trial level) research is so fundamentally flawed that it is unlikely to show anything other that random noise. I don’t agree with everything Lawrence says, but he makes some extremely good points on this topic.

If you are a young critical care scientist do not miss this critical care review. The landscape of critical care science is about to change. Be sure to stay ahead of the wave. @sccmcriticalcare.bsky.social @criticalcare.bsky.social @criticalcarereviews.com pubmed.ncbi.nlm.nih.gov/41402862/

It’s hard to correctly state the contribution Richard has made to statistical education. He’s made the subject come alive for so many students (myself included) and continues to iterate and improve on what is already wonderful pedagogy: all for free. An inspiration to educators everywhere. 🤩🙏🎓

Preprint in review (third of the RCT structural series). This examines the 3 layer structure of RCT of crit care syndromes. @cochranecompmed.bsky.social @marionkcampbell.bsky.social @criticalcarereviews.com @criticalcare.bsky.social @esicm.bsky.social @sccmentor.bsky.social t.co/e6fcsknvfx

Lynn’s Paradox “A phenomenon in which sequential cause-agnostic randomized trials (CARs) testing a treatment for a disease-agnostic syndrome yield opposing conclusions across studies because enrolled participants represent a shifting mixture of diseases with opposing treatment effects.”

Don’t miss the discussion of RCT design and public safety. zenodo.org/records/1851...

@intenscaremed.bsky.social The danger to the public of using syndromic entry criteria for RCT in critical care. doi.org/10.5281/zeno...

@doced.bsky.social The danger to the public of using syndromic entry criteria for RCT in critical care. doi.org/10.5281/zeno...

@esicm.bsky.social The danger to the public of using syndromic entry criteria for RCT in critical care. doi.org/10.5281/zeno...

@scottishics.bsky.social The danger to the public of using syndromic entry criteria for RCT in critical care. doi.org/10.5281/zeno...

@intenscaremed.bsky.social The danger to the public of using syndromic entry criteria for RCT in critical care. doi.org/10.5281/zeno...

@icmexperimental.bsky.social The danger to the public of using syndromic entry criteria for RCT in critical care. doi.org/10.5281/zeno...

@statsmethods.bsky.social The danger to the public of using syndromic entry criteria for RCT in critical care. doi.org/10.5281/zeno...

@berkeleyctml.bsky.social The danger to the public of using syndromic entry criteria for RCT in critical care. doi.org/10.5281/zeno...

@causalscience.org The danger to the public of using syndromic entry criteria for RCT in critical care. doi.org/10.5281/zeno...

@causalab.org The danger to the public of using syndromic entry criteria for RCT in critical care. doi.org/10.5281/zeno...

@causalhuber.bsky.social The danger to the public of using syndromic entry criteria for RCT in critical care. doi.org/10.5281/zeno...

@acmedsci.bsky.social The danger to the public of using syndromic entry criteria for RCT in critical care. doi.org/10.5281/zeno...

@medsci.ox.ac.uk The danger to the public of using syndromic entry criteria for RCT in critical care. doi.org/10.5281/zeno...

@clevelandclinicmls.bsky.social The danger to the public of using syndromic entry criteria for RCT in critical care. doi.org/10.5281/zeno...

@oxfordstatistics.bsky.social The danger to the public of using syndromic entry criteria for RCT in critical care. doi.org/10.5281/zeno...

@scharr-msg.bsky.social The danger to the public of using syndromic entry criteria for RCT in critical care. doi.org/10.5281/zeno...

@southamptonctu.bsky.social The danger to the public of using syndromic entry criteria for RCT in critical care. doi.org/10.5281/zeno...

@imperialctu.bsky.social The danger to the public of using syndromic entry criteria for RCT in critical care. doi.org/10.5281/zeno...

@primarycaretrials.bsky.social The danger to the public of using syndromic entry criteria for RCT in critical care. doi.org/10.5281/zeno...

@cantrain.bsky.social The danger to the public of using syndromic entry criteria for RCT in critical care. doi.org/10.5281/zeno...

@cochrane.org The danger to the public of using syndromic entry criteria for RCT in critical care. doi.org/10.5281/zeno...

@erc.europa.eu The danger to the public of using syndromic entry criteria for RCT in critical care. doi.org/10.5281/zeno...

@jci.org The danger to the public of using syndromic entry criteria for RCT in critical care. doi.org/10.5281/zeno...

@jclinepi.bsky.social The danger to the public of using syndromic entry criteria for RCT in critical care. doi.org/10.5281/zeno...

@sccm-research.bsky.social The danger to the public of using syndromic entry criteria for RCT in critical care. doi.org/10.5281/zeno...

@sccmmw.bsky.social The danger to the public of using syndromic entry criteria for RCT in critical care. doi.org/10.5281/zeno...

@sccm-pediatrics.bsky.social The danger to the public of using syndromic entry criteria for RCT in critical care. doi.org/10.5281/zeno...

@sccm-research.bsky.social The danger to the public of using syndromic entry criteria for RCT in critical care. doi.org/10.5281/zeno...

@critcarescience.bsky.social The danger to the public of using syndromic entry criteria for RCT in critical care. doi.org/10.5281/zeno...

@ics-updates.bsky.social The danger to the public of using syndromic entry criteria for RCT in critical care. doi.org/10.5281/zeno...

@stephen-t-webb.bsky.social The danger to the public of using syndromic entry criteria for RCT in critical care. doi.org/10.5281/zeno...

@dilipj1.bsky.social The danger to the public of using syndromic entry criteria for RCT in critical care. doi.org/10.5281/zeno...

@criticalcare.bsky.social The danger to the public of using syndromic entry criteria for RCT in critical care. doi.org/10.5281/zeno...

Don’t miss this review doi.org/10.5281/zeno...

@basakcoruh.bsky.social Help raise awareness of the patient safety need for critical care clinical trial reform by forwarding this review. pssjournal.biomedcentral.com/articles/10....

@janhansel.bsky.social Help raise awareness of the patient safety need for critical care clinical trial reform by forwarding this review. pssjournal.biomedcentral.com/articles/10....

@biosepsis.bsky.social Help raise awareness of the patient safety need for critical care clinical trial reform by forwarding this review. pssjournal.biomedcentral.com/articles/10....

@criticalcare.bsky.social Help raise awareness of the patient safety need for critical care clinical trial reform by forwarding this review. pssjournal.biomedcentral.com/articles/10....

@dilipj1.bsky.social Help raise awareness of the patient safety need for critical care clinical trial reform by forwarding this review. pssjournal.biomedcentral.com/articles/10....

@stephen-t-webb.bsky.social Help raise awareness of the patient safety need for critical care clinical trial reform by forwarding this review. pssjournal.biomedcentral.com/articles/10....

@ics-updates.bsky.social Help raise awareness of the patient safety need for critical care clinical trial reform by forwarding this review. pssjournal.biomedcentral.com/articles/10....

@critcarescience.bsky.social Help raise awareness of the need for critical care clinical trial reform by forwarding this review. pssjournal.biomedcentral.com/articles/10....