@basakcoruh.bsky.social Help raise awareness of the patient safety need for critical care clinical trial reform by forwarding this review. pssjournal.biomedcentral.com/articles/10....

@janhansel.bsky.social Help raise awareness of the patient safety need for critical care clinical trial reform by forwarding this review. pssjournal.biomedcentral.com/articles/10....

@biosepsis.bsky.social Help raise awareness of the patient safety need for critical care clinical trial reform by forwarding this review. pssjournal.biomedcentral.com/articles/10....

@criticalcare.bsky.social Help raise awareness of the patient safety need for critical care clinical trial reform by forwarding this review. pssjournal.biomedcentral.com/articles/10....

@dilipj1.bsky.social Help raise awareness of the patient safety need for critical care clinical trial reform by forwarding this review. pssjournal.biomedcentral.com/articles/10....

@stephen-t-webb.bsky.social Help raise awareness of the patient safety need for critical care clinical trial reform by forwarding this review. pssjournal.biomedcentral.com/articles/10....

@ics-updates.bsky.social Help raise awareness of the patient safety need for critical care clinical trial reform by forwarding this review. pssjournal.biomedcentral.com/articles/10....

@critcarescience.bsky.social Help raise awareness of the need for critical care clinical trial reform by forwarding this review. pssjournal.biomedcentral.com/articles/10....

@sccm-research.bsky.social Help raise awareness of the need for critical care clinical trial reform by forwarding this review. pssjournal.biomedcentral.com/articles/10....

@sccm-pediatrics.bsky.social Help raise awareness of the need for critical care clinical trial reform by forwarding this review. pssjournal.biomedcentral.com/articles/10....

@sccmmw.bsky.social Help raise awareness of the need for critical care clinical trial reform by forwarding this review. pssjournal.biomedcentral.com/articles/10....

@sccm-research.bsky.social Help raise awareness of the need for critical care clinical trial reform by forwarding this review. pssjournal.biomedcentral.com/articles/10....

@jclinepi.bsky.social Help raise awareness of the need for clinical trial reform by forwarding this review. pssjournal.biomedcentral.com/articles/10....

@jci.org Help raise awareness of the need for clinical trial reform by forwarding this review. pssjournal.biomedcentral.com/articles/10....

@erc.europa.eu Help raise awareness of the need for clinical trial reform by forwarding this review. pssjournal.biomedcentral.com/articles/10....

@cochrane.org Help raise awareness of the need for clinical trial reform by forwarding this review. pssjournal.biomedcentral.com/articles/10....

@cantrain.bsky.social Help raise awareness of the need for clinical trial reform by forwarding this review. pssjournal.biomedcentral.com/articles/10....

@primarycaretrials.bsky.social Help raise awareness of the need for clinical trial reform by forwarding this review. pssjournal.biomedcentral.com/articles/10....

@imperialctu.bsky.social Help raise awareness of the need for clinical trial reform by forwarding this review. pssjournal.biomedcentral.com/articles/10....

@southamptonctu.bsky.social Help raise awareness of the need for reform in clinical trials by forwarding this analysis of critical care clinical trial science., pssjournal.biomedcentral.com/articles/10....

@scharr-msg.bsky.social Help us reform critical care science and clinical trials. Forward to raise awareness pssjournal.biomedcentral.com/articles/10....

Quand beaucoup de d'etudes randomisees dans votre spécialité sont des échecs, il faut se poser des questions... @lawrencelynn.bsky.social l'a fait

@oxfordstatistics.bsky.social Help us reform critical care science and clinical trials. Forward to raise awareness pssjournal.biomedcentral.com/articles/10....

@clevelandclinicmls.bsky.social Help us reform critical care science and clinical trials. Forward to raise awareness pssjournal.biomedcentral.com/articles/10....

@medsci.ox.ac.uk Help us reform critical care science and clinical trials. Forward to raise awareness pssjournal.biomedcentral.com/articles/10....

@acmedsci.bsky.social Help us reform critical care science and clinical trials. Forward to raise awareness pssjournal.biomedcentral.com/articles/10....

@causalhuber.bsky.social Help us in critical care raise awareness of the need for CI. pssjournal.biomedcentral.com/articles/10....

@causalab.org Help is in critical care by forwarding and understanding the present state. pssjournal.biomedcentral.com/articles/10....

@causalscience.org Understand the need for causal science in clinical care. Forward to increase the focus on CI. pssjournal.biomedcentral.com/articles/10....

@berkeleyctml.bsky.social Don’t miss this review applying CI to evaluate clinical trials. Pass it on as we need reform. x.com/soboleffspac...

@statsmethods.bsky.social Don’t miss this CI evaluation of critical care syndrome trials. Send it along as we are seeking reform. x.com/soboleffspac...

@icmexperimental.bsky.social Don’t miss this paper x.com/soboleffspac...

@intenscaremed.bsky.social Dint miss this history of synthetic syndrome science. x.com/soboleffspac...

@scottishics.bsky.social Don’t miss this paper x.com/soboleffspac...

@esicm.bsky.social In the late 20th century Europeans were intellectually colonized by the US critical care idea of the streamlined, threshold triage gated disease/cause agnostic RCT. The consequence was pathological consensus and decades of stagnation. This is that story. x.com/soboleffspac...

@damienbarraudmd.bsky.social @load-dependent.bsky.social Most respectfully, & I genuinely mean that, show some intellectual spine! Retire safely colonized, or act & spare the next generation of critical-care mentees from repeating your fate, decades spent safely agonizing above the epistemic deck

Bone showed us that you could take many different diseases, pass them through a shared disease agnostic triage threshold, and study them as one population. That made large trials easier but it also disconnected them from causation. The world was intellectually colonized by US critical care science

@doced.bsky.social I know your grad paper is on sepsis. Don’t miss this highly popular review that published a couple weeks ago (note the views and retweets). See if your mentors will debate this. If they agree, bring on the disclosure so the LMICs researchers are informed x.com/soboleffspac...

@emswami.bsky.social Don’t miss this article related to critical care trials and funding. x.com/soboleffspac...

@beatrizgoulao.bsky.social Don’t miss this review relating to trials and funding x.com/soboleffspac...

@sherrirose.bsky.social Don’t miss this review relating to trial structure and funding. x.com/soboleffspac...

@lizstuart.bsky.social Don’t miss this popular paper relevant trial structure and funding. x.com/soboleffspac...

@kirstyro.bsky.social Don’t miss this popular article relation to trials and funding. x.com/soboleffspac...

@msafavi.bsky.social Don’t miss the popular article about trials and funding. x.com/soboleffspac...

@s-greenwood.bsky.social Don’t miss this very popular discussion of trials and the direction of funding. x.com/soboleffspac...

@marionkcampbell.bsky.social Dr. Campbell please take the time to read this highly popular review. I would welcome your feedback. x.com/soboleffspac...

1 “Evidence-based medicine” (EBM); valid evidence. eg RCT testing a drug for disease efficacy 2 “RCT mimics”: trials resembling RCTs but condition on syndromes or non-specific states 3 “False evidence based medicine” (FEBM) is evidence based on these RCT mimics pubmed.ncbi.nlm.nih.gov/41402862/

Follow this thread for a discussion of the present state of critical care science. The “carpet doctors” and the “carpet scientists”. Hopefully we will have an open discussion/debate.

If you are a young critical care scientist do not miss this critical care review. The landscape of critical care science is about to change. Be sure to stay ahead of the wave. @sccmcriticalcare.bsky.social @criticalcare.bsky.social @criticalcarereviews.com pubmed.ncbi.nlm.nih.gov/41402862/

Don’t miss the new discussion of RCT transportability at Vanderbilt’s datamethods site. What standards should be defined for RCT generalization to clinical guidelines.