New vignette on our Editorial published in Intensive Care Medicine, written by Dr Jean-Marc Cavaillon, Dr Hjalmar Bouma and myself! #IDsky link.springer.com/article/10.1...

A clinical decision tool including a decision tree, point-of-care testing of CRP, and safety-netting advice to guide antibiotic prescribing in acutely ill children in primary care in Belgium (ARON): a pragmatic, cluster-randomised, controlled trial #IDSky www.thelancet.com/journals/lan...

Our editorial on the clinical value and physiological meaning of HLA-DR in monocytes in septic shock is out. In this editorial we comment on an article from Dr. Monneret et al on a large cohort. It has been a honor to write it with Dr Cavaillon and Dr Bouma #IDsky link.springer.com/article/10.1...

🚨 The Interim Report of the Global Climate and Health Summit is out! Please, read, share and connect with us. The second phase is open Honoured to be a Vice-Chair of this Summit www.physoc.org/policy/clima...

The immune system is dangerous, usually more to pathogens than to you. But only because it’s so tightly controlled. Activating a T cell can have horrific consequences. You really don’t want to trigger one unless it’s absolutely necessary. You need to be sure. How? 1/10

Top speakers, new projects with our European Group on Immunology of Sepsis (EGIS)...the Sepsis Update meeting in Heilderberg finish but we are back home with much work ahead! Thanks for inviting me again to participate! Sepsis is not a single disease, but different ones... sepsis-update.de

For fifth consecutive year, I appear in the 'Stanford list' of the most cited researchers in the world...Thanks to my group and our collaborators.... elsevier.digitalcommonsdata.com/datasets/btc...

An honor to have participated in the International Board of the XXI Congress of the European Shock Society. Congratulations to Borna Relja for an excellent scientific program and the perfect organization.Top speakers & an intense scientific exchange. The abstracs are available in the journal Shock.

Fantastic meeting of the European Shock Society at Dubrovnick, where I presented our work on proteomics associated to AI to stratify infection severity europeanshocksociety.org/Welcome---21...

Importante resultado del primer ensayo clínico aleatorizado y doble ciego de tratamiento antiviral en pacientes inmunodeprimidos. En un subgrupo de 57 pacientes con inmunosupresión de alto riesgo (sigue)

Vaccines save lives and complications! Our new study evaluating the Dengue vaccine TAK-003 in adolescents in São Paulo, Brazil during the 2024 (massive) outbreak @thelancetinfdis.bsky.social ⬇️ Symptomatic disease (1st and 2nd dose) ⬇️ Hospitalization (1st dose) doi.org/10.1016/S147...

Already in Dubrovnik ready to participate in the 21st congress of the European Shock Society. Thanks to Borna Relja and the organizing committee for inviting me to talk on Proteomics to stratify infection severity! europeanshocksociety.org/Welcome---21...

It’s World #Sepsis Day Sepsis kills 11 million people each year. Symptoms incl.: 🔸Fever or shivering 🔸Confusion 🔸Shortness of breath 🔸Rash that does not fade when pressed 🔸Extreme discomfort 🔸Sweaty skin Seek medical care as soon as possible when an infection is not getting better.

Today is the World's Sepsis Day. From our research group at IBSAL / USAL / CIBERES we are working to improve early detection and personalised medicine in this deadly condition...#IDsky #sepsis

I deeply condemn the terrorist attack in Jerusalem today. Hopefuly violence could stop soon in Israel and Palestine.

"Study Shows SARS-CoV-2 Corrupts Some White Blood Cells to Suppress Immune System, Suggesting a Path to Severe COVID Federally funded Johns Hopkins team finds the virus ‘reprograms’ neutrophils to impair production of immune cells critical for fighting COVID" www.hopkinsmedicine.org/news/newsroo...

Influenza vaccination is now a well recognized and recommended intervention for cardiovascular prevention. But, are cardiologists prepared and ready to recommend it ? My letter on the topic published in Atherosclerosis. #IDSky #VaccineSky www.atherosclerosis-journal.com/article/S002...

I came here to talk on infectious diseases, the topic I research into, but I cannot stay silent when the Israel Gov is applying the 'Endlösung' to the Palestinian people with the absolute inaction from the European Union.Shame on the EU, shame on all of us for letting this occur in front of our eyes

La positividad de la serología frente al Virus de Epstein-Barr en niños se asocia a una mayor mortalidad en caso de sepsis, según este estudio de cohortes. (sigue) jamanetwork.com/journals/jam...

A new preprint from our consortium in colab with Dr Angel Estella in Jerez and Stefanie Deinhardt-Emmer lab in Jena evidencing that poorer control of SARS-CoV-2 at the lung was associated to earlier need of mechanical ventilation...#IDsky #COVID19 www.authorea.com/users/957017...

#Medsky🧪 #IDsky #pedsky #immunosky @jama.com This #cohortstudy of pediatric #sepsis found associations with EBV seropositivity, supporting growing evidence that latent EBV infection is a significant, underrecognised, and potentially remediable #globalpublichealth problem.

Our new issue is live. So it's time to dive in!

#Medsky🧪 #IDsky #immunosky #Episky #publichealth The study has demonstrated an association between the #SARSCoV2 rebound & #Longcovid mortality in 🏥 groups & across antiviral treatment groups.

Israel has lost its place between the civilized countries in the world. Those Israelis touched by this genocide should press their government to stop this madness!

The political momentum is evolving from the axis 'left / right' to a new one: 'pro-democracy / pro-dictatorships'. I miss those times of healthy exchange of opinions between people thinking different...

I wonder what Auschwitz's survivors would say about what their grandsons are doing to the Palestinians...Stop this madness now! www.bbc.com/news/videos/...

Systemic corticosteroids for CAP 🟢For adult inpatients with non-severe CAP, we recommend NOT administering systemic corticosteroids (strong recommendation, low-quality evidence) 🟢For adult inpatients with severe CAP we suggest systemic corticosteroids #idsky

Closing USAID (which will kill thousands of people in Africa), dismantling the American scientific system and impairing vaccine access warrants the Peace Nobel Prize for Trump, I am sure.. Norwegians are preparing the invitation to Oslo already..

I bring here an old article from our group classifying the immunological alterations in sepsis into ten major immunophenotypes. Still useful in my view. #IDsky #immunoSky www.journalofinfection.com/article/S016... www.journalofinfection.com/article/S016...

Ischaemic endothelial necroptosis is the principal mechanism promoting RBC haemolysis. Why? It seems haemolysis of RBCs prevents bleeding. The RBC membranes act as a seal where endothelial cells have died via necroptosis. But their accumulation can cause a blockage. 6/8

Analysis of >1,000 COVID-19 patients vessels by researchers in Sydney: They found that endothelial necroptosis, NOT clotting, causes red blood cell rupture and microvascular blockage, revealing a platelet-independent bleeding control system www.nature.com/articles/s41...

Si quieres hacer la tesis sobre biomarcadores de sepsis en nuestro grupo en Salamanca tengo un contrato de 4 años para ti. Requisito: grado ± máster. Si te interesa escríbeme a [email protected]

Read here the new article from our European Group on Immunology of Sepsis #EGIS reviewing the hot topics in sepsis in immunosupressed patients.Thanks to Stefanie Deinhardt-Emmer & Hjalmar Bouma for leading us in this work published in Lancet Resp Med #IDsky www.sciencedirect.com/science/arti...

Many people stayed in silence when Nazis killed millions of Jews during WWII, and that was really bad... I cannot stay in silence today. 1) Hamas is a terrorist group that must release the hostages. 2) Israeli Goverment is committing genocide against Palestinians. They must stop killing innocents.

Machine-learning analysis identifies “elite” viral controllers with increased survival and homeostatic responses in critical COVID-19. I link here our new paper again since I forgot to include the hastag #IDsky onlinelibrary.wiley.com/doi/10.1002/...

New re-analysis of our data from the CIBERESUCICOVID project using machine learning approaches identifying a group of elite viral controllers in the ICU with homeostatic responses to SARS-CoV-2 with strong antibody and mild inflammatory responses and increased survival dx.doi.org/10.1002/ctm2...

I originally intended to write the sort of self-congratulatory piece that most would expect, but it didn't quite work out that way...

Europe should stop importing goods from El Salvador. Let me to say something in Spanish: El comportamiento del gobierno del El Salvador tratando así a los presos es una vergüenza para la humanidad...

We celebrate today that Amanda de la Fuente from our group is already PhD.. She has developed a superinteresting work evidencing that combining endothelial and innate immunity biomarkers outperforms individual biomarkers to detect organ failure during infection www.ijidonline.com/article/S120...

We should overcome these terrible times by enhancing international scientific collaboration. We must support our colleagues in the USA. Let's do what we do best, improving people's health by doing research!

Even if we have efficient antivirals in a future Coronavirus or Influenza pandemic, it is really important to have systems in place to early delivery them to patients at the highest risk of complications. Working on these systems in advance is mandatory to decrease mortality in this scenario.

What is happening in US sounds familiar to me. It already happened in my country 400 years ago.. It was called Inquisition, which prevented scientific development in Spain for 300 years... We are still paying the price...

One year ago, I started as professor at one of the best Universities in Spain, University of Salamanca. After more than 20 years working in clinical research in different hospitals, it is a privilege to have the opportunity to teach what I learnt on pneumonia, sepsis and emerging infections

¿Quieres hacer una Tesis sobre diagnóstico precoz de Sepsis? ¿Aprender sobre modelos predictivos de esta enfermedad combinado información clínica y biológica? Estamos buscando un candidato/a para solicitar un contrato predoctoral en Salamanca. Si te interesa escríbeme a [email protected]

2/ Born in Montana in 1919, Hilleman was raised on a farm with no electricity or plumbing. His twin sister died at birth. His mother died soon after. He grew up in poverty—but was brilliant, determined, and curious.

Girl 11 years old, frequent contact with a hamster: Itchy ring-shaped erythematous plaque, slightly raised on the edges with slight superficial flaking on the right forearm. 1-2 weeks of evolution 1/2 continuum.aeped.es continuum.aeped.es/screens/play... #pediatric #dermatology

In a few weeks, a Tesla car will cost like half a dozen eggs..

"significant survival benefit among patients hospitalized for SARS-CoV-2 infection receiving Remdesivir across all disease severity levels" Systematic review & meta-analysis of the effectiveness of remdesivir to treat SARS-CoV-2 infection in hospitalized patients: academic.oup.com/cid/article/...

Trump, RFK and Musk are imposing tariffs of 200% to intelligence, progress and compassion to other human beings..