Today I share a visual abstract of one of the articles I like the most from our group, deciphering key immunopathological events in severe pandemic influenza. This was a colaboration with my former boss, Dr. David Kelvin, and it was published in Critical Care in 2010: doi: 10.1186/cc9259 #IDsky

In this visual abstract of our article in In IJID we highlight the importance of of combining innate immunity and endothelial dysfunction biomarkers to predict increases in the magnitude of organ failure in patients with infection and sepsis (10.1016/j.ijid.2024.107142)

Another visual abstract of a previous work from our group evidencing the benefit of implementing programms to detect sepsis in preventing mortality derived from nosocomial sepsis (J Hosp Infec DOI: 10.1016/j.jhin.2017.08.022) #IDsky #sepsis

I share here the visual abstract of an important article from our group in colab with the groups of Dr Toni Torres (Hospital Clinic) and Rosario Menendez (Hosp La Fe) identifying Lymphopenic Community Acquired Pneumonia as a phenotype associated with mortality doi: 10.1016/j.ebiom.2017.09.023 #IDsky

This article from our group summarised the main immunological alterations in sepsis (Journal of Infection doi: 10.1016/j.jinf.2016.01.010) www.journalofinfection.com/article/S016...

A new summary of an old article from our group published in Journal of Infection (doi: 10.1016/j.jinf.2014.12.010) #sepsis #IDsky #infection

With the support of AI, I am starting to summarise some of our more important articles (summary 1: Quantification of Immune Dysregulation by Next-generation Polymerase Chain Reaction to Improve Sepsis Diagnosis in Surgical Patients", Annals of Surgery, DOI: 10.1097/SLA.0000000000002406)

In the pandemics, a mainstream theory proposed that in critical status, viral replication was over. Here we show that 60% of ventilated patients had replicative virus in the lungs, with 20% in high levels, mainly those with early resp. failure. #IDsky #COVID19 www.sciencedirect.com/science/arti...

Do critically ill COVID-19 patients still carry live virus in the lungs? In our new study we show that patients who develop rapid respiratory failure still have replicating virus. Important finding for guiding antivirals in future pandemics #IDsky #COVID19 www.sciencedirect.com/science/arti...

💥🆕“Sepsis”.The Lancet Seminar Our new article 👇Free Access bit.ly/4aJIiKo @unmc.bsky.social @unmc-id.bsky.social @unmccom.bsky.social @critcaremed.bsky.social @criticalcarereviews.com @thelancet.com @thelancetinfdis.bsky.social@lancetrespirmed.bsky.social#IDSky #MedSky #PCCSky #ICUSky #Ansky #EMSky

In immunocompromised patients, persistent COVID often fails single-drug treatment. Madrid study shows combination therapy (Remdesivir + Paxlovid ± Sotrovimab) clears infection and overcomes resistance. buff.ly/tqlmc0I Personalized antiviral strategies matter. #medsky #IDsky #publichealth #oncsky

A new paper from WHO-ISARIC that confirms lymphopenia as a marker of severity and poor prognosis in COVID-19, reinforcing our description of lymphopenic CAP (L-CAP) in 2017 In EbioMedine (I link our paper as a response to this one) link.springer.com/article/10.1...

This paper identifies transcriptomic signatures associated to mortality in sepsis similar to those we found ten years ago: neutrophil dysregulation + adaptive immunity depression, and evidences the relevance of combining host and microbial info. academic.oup.com/ajrccm/artic...

Microbes Meet Host: The Next Frontier in Sepsis Classification @atscommunity.bsky.social #medsky 🔓 Open Access 🔗 tinyurl.com/bdes2e5s

After more than eight years serving as coordinator of the European Group on Immunology of Sepsis (EGIS) along with Prof. Ignacio Rubio, it is time for me to step back. The steering committee has designed Dr. Martin Winkler as my sucessor. I am sure he will do an excellent job. www.egis-online.eu

News are so terrible these days, that I need to concentrate in something constructive: let's do science, teach and cure people working together! In the world we are more people willing to improve things than those willing to destroy it...!

@biosepsis.bsky.social Help raise awareness of the patient safety need for critical care clinical trial reform by forwarding this review. pssjournal.biomedcentral.com/articles/10....

Excellent piece that explains why Denmark’s childhood vaccine schedule isn’t right for the United States. Every major publication should run a piece like this. @jakescottmd.bsky.social: www.statnews.com/2025/12/19/d...

Terrible attacks against the Jewish community in Australia and against the University community in the USA this week. My sincere condolences to the victims and their families.

This (just published) paper confirms what we described in 2021: critically ill COVID-19 patients lacking of antibodies against the virus have poorer outcomes. I link the two papers below.. link.springer.com/article/10.1...

With 450 million people, some of the best Universities in the world, the more advanced democratic systems and the best social protection in the world, we should believe in our own future...we the European Union countries must stay together to keep on representing a model to the world! #EuropeanUnion

New vignette on our Editorial published in Intensive Care Medicine, written by Dr Jean-Marc Cavaillon, Dr Hjalmar Bouma and myself! #IDsky link.springer.com/article/10.1...

A clinical decision tool including a decision tree, point-of-care testing of CRP, and safety-netting advice to guide antibiotic prescribing in acutely ill children in primary care in Belgium (ARON): a pragmatic, cluster-randomised, controlled trial #IDSky www.thelancet.com/journals/lan...

Our editorial on the clinical value and physiological meaning of HLA-DR in monocytes in septic shock is out. In this editorial we comment on an article from Dr. Monneret et al on a large cohort. It has been a honor to write it with Dr Cavaillon and Dr Bouma #IDsky link.springer.com/article/10.1...

🚨 The Interim Report of the Global Climate and Health Summit is out! Please, read, share and connect with us. The second phase is open Honoured to be a Vice-Chair of this Summit www.physoc.org/policy/clima...

The immune system is dangerous, usually more to pathogens than to you. But only because it’s so tightly controlled. Activating a T cell can have horrific consequences. You really don’t want to trigger one unless it’s absolutely necessary. You need to be sure. How? 1/10

Top speakers, new projects with our European Group on Immunology of Sepsis (EGIS)...the Sepsis Update meeting in Heilderberg finish but we are back home with much work ahead! Thanks for inviting me again to participate! Sepsis is not a single disease, but different ones... sepsis-update.de

For fifth consecutive year, I appear in the 'Stanford list' of the most cited researchers in the world...Thanks to my group and our collaborators.... elsevier.digitalcommonsdata.com/datasets/btc...

An honor to have participated in the International Board of the XXI Congress of the European Shock Society. Congratulations to Borna Relja for an excellent scientific program and the perfect organization.Top speakers & an intense scientific exchange. The abstracs are available in the journal Shock.

Fantastic meeting of the European Shock Society at Dubrovnick, where I presented our work on proteomics associated to AI to stratify infection severity europeanshocksociety.org/Welcome---21...

Importante resultado del primer ensayo clínico aleatorizado y doble ciego de tratamiento antiviral en pacientes inmunodeprimidos. En un subgrupo de 57 pacientes con inmunosupresión de alto riesgo (sigue)

Vaccines save lives and complications! Our new study evaluating the Dengue vaccine TAK-003 in adolescents in São Paulo, Brazil during the 2024 (massive) outbreak @thelancetinfdis.bsky.social ⬇️ Symptomatic disease (1st and 2nd dose) ⬇️ Hospitalization (1st dose) doi.org/10.1016/S147...

Already in Dubrovnik ready to participate in the 21st congress of the European Shock Society. Thanks to Borna Relja and the organizing committee for inviting me to talk on Proteomics to stratify infection severity! europeanshocksociety.org/Welcome---21...

It’s World #Sepsis Day Sepsis kills 11 million people each year. Symptoms incl.: 🔸Fever or shivering 🔸Confusion 🔸Shortness of breath 🔸Rash that does not fade when pressed 🔸Extreme discomfort 🔸Sweaty skin Seek medical care as soon as possible when an infection is not getting better.

Today is the World's Sepsis Day. From our research group at IBSAL / USAL / CIBERES we are working to improve early detection and personalised medicine in this deadly condition...#IDsky #sepsis

I deeply condemn the terrorist attack in Jerusalem today. Hopefuly violence could stop soon in Israel and Palestine.

"Study Shows SARS-CoV-2 Corrupts Some White Blood Cells to Suppress Immune System, Suggesting a Path to Severe COVID Federally funded Johns Hopkins team finds the virus ‘reprograms’ neutrophils to impair production of immune cells critical for fighting COVID" www.hopkinsmedicine.org/news/newsroo...

Influenza vaccination is now a well recognized and recommended intervention for cardiovascular prevention. But, are cardiologists prepared and ready to recommend it ? My letter on the topic published in Atherosclerosis. #IDSky #VaccineSky www.atherosclerosis-journal.com/article/S002...

I came here to talk on infectious diseases, the topic I research into, but I cannot stay silent when the Israel Gov is applying the 'Endlösung' to the Palestinian people with the absolute inaction from the European Union.Shame on the EU, shame on all of us for letting this occur in front of our eyes

La positividad de la serología frente al Virus de Epstein-Barr en niños se asocia a una mayor mortalidad en caso de sepsis, según este estudio de cohortes. (sigue) jamanetwork.com/journals/jam...

A new preprint from our consortium in colab with Dr Angel Estella in Jerez and Stefanie Deinhardt-Emmer lab in Jena evidencing that poorer control of SARS-CoV-2 at the lung was associated to earlier need of mechanical ventilation...#IDsky #COVID19 www.authorea.com/users/957017...

#Medsky🧪 #IDsky #pedsky #immunosky @jama.com This #cohortstudy of pediatric #sepsis found associations with EBV seropositivity, supporting growing evidence that latent EBV infection is a significant, underrecognised, and potentially remediable #globalpublichealth problem.

Our new issue is live. So it's time to dive in!

#Medsky🧪 #IDsky #immunosky #Episky #publichealth The study has demonstrated an association between the #SARSCoV2 rebound & #Longcovid mortality in 🏥 groups & across antiviral treatment groups.

Israel has lost its place between the civilized countries in the world. Those Israelis touched by this genocide should press their government to stop this madness!

The political momentum is evolving from the axis 'left / right' to a new one: 'pro-democracy / pro-dictatorships'. I miss those times of healthy exchange of opinions between people thinking different...

I wonder what Auschwitz's survivors would say about what their grandsons are doing to the Palestinians...Stop this madness now! www.bbc.com/news/videos/...

Systemic corticosteroids for CAP 🟢For adult inpatients with non-severe CAP, we recommend NOT administering systemic corticosteroids (strong recommendation, low-quality evidence) 🟢For adult inpatients with severe CAP we suggest systemic corticosteroids #idsky

Closing USAID (which will kill thousands of people in Africa), dismantling the American scientific system and impairing vaccine access warrants the Peace Nobel Prize for Trump, I am sure.. Norwegians are preparing the invitation to Oslo already..

I bring here an old article from our group classifying the immunological alterations in sepsis into ten major immunophenotypes. Still useful in my view. #IDsky #immunoSky www.journalofinfection.com/article/S016... www.journalofinfection.com/article/S016...