⭐ ICMx 2025 Recap #VisualAbstract Haemoadsorption to remove inflammatory mediators in sepsis: past, present, and future doi.org/10.1186/s40635-025-00740-0

⭐ ICMx 2025 Recap #VisualAbstract Early sepsis recognition: a pilot study using a rapid high-multiplex host-response mRNA diagnostic test doi.org/10.1186/s40635-025-00735-x

⭐ ICMx 2025 Recap #VisualAbstract Machine learning-based identification of efficient and restrictive physiological subphenotypes in acute respiratory distress syndrome doi.org/10.1186/s40635-025-00737-9

Happy New Year from ICMx! 🥂 Wishing you health, peace, and a year of scientific excellence in 2026. We are excited to continue sharing the latest experimental medicine insights with you. 👉 Join our growing community on Bluesky: @icmexperimental.bsky.social

⭐ ICMx 2025 Recap #VisualAbstract Wearable devices for patient monitoring in the intensive care unit doi.org/10.1186/s40635-025-00738-8

⭐ ICMx 2025 Recap #VisualAbstract Unlocking opportunities to transform patient care: an expert insight on limitations and opportunities in patient monitoring doi.org/10.1186/s40635-025-00733-z

⭐ ICMx 2025 Recap #VisualAbstract Patient–ventilator synchrony under non-invasive ventilation is improved by an automated real time waveform analysis algorithm: a bench study doi.org/10.1186/s40635-025-00726-y

⭐ ICMx 2025 Recap #VisualAbstract Renal mitochondria response to sepsis: a sequential biopsy evaluation of experimental porcine model doi.org/10.1186/s40635-025-00732-0

⭐ ICMx 2025 Recap #VisualAbstract Using weak signals to predict spontaneous breathing trial success: a machine learning approach doi.org/10.1186/s40635-025-00724-0

⭐ ICMx 2025 Recap #VisualAbstract Regional cerebral oxygen saturation during initial mobilization of critically ill patients is associated with clinical outcomes: a prospective observational study doi.org/10.1186/s40635-025-00722-2

⭐ ICMx 2025 Recap #VisualAbstract From the best-of-the-year collection: a standout ICMx 2025 Visual Abstract you don’t want to miss. Exploring timely and safe discharge from ICU: a comparative study of machine learning predictions and clinical practices 🔗 doi.org/10.1186/s40635-025-00717-z

⭐ ICMx 2025 Recap #VisualAbstract Kicking off our ICMx 2025 Year-in-Review! Translational approach to assess brain injury after cardiac arrest in preclinical models: a narrative review 🔗 doi.org/10.1186/s40635-024-00710-y

Unravelling the complex inflammatory landscape of COVID-19 infection Delirium in COVID-19 ARDS associates with unique cytokine signatures and altered B/T-cell subsets. 🔗 doi.org/10.1186/s40635-025-00825-w #MedSky #FOAMed #ICU #Covid19 #ImmunoSky

Mitochondrial oxygen tension drops in acute sepsis and correlates with severity, yet recovers by follow-up, supporting reversible metabolic dysfunction rather than persistent failure. 🔗 doi.org/10.1186/s40635-025-00808-x #MedSky #FOAMed #ICU #Sepsis #ImmunoSky

Hepatic and intestinal microcirculation and pulmonary inflammation in VV ECMO in rats Microcirculatory injury varied with ECMO flow: gut hypoxia emerged only at low-flow, liver impairment at both. Lung inflammation fell across ECMO groups under protective MV. 🔗 doi.org/10.1186/s40635-025-00824-x

Low-bicarbonate substitution and CO₂ removal in combined ECCO₂R-CRRT A lower bicarbonate load may optimize ECCO₂R-CRRT performance, enhancing VCO₂ at low flows without compromising patient stability, suggesting a modifiable dialysate target. 👉 doi.org/10.1186/s40635-025-00827-8 #MedSky#ICU #ARDS

Recovering mice restored NKA with more activating NKRs and cytotoxic subsets, while lethal sepsis showed persistent NK suppression. 🔗 doi.org/10.1186/s40635-025-00829-6 #MedSky #FOAMed #ImmunoSky #Sepsis #ICU

🩸 Knowledge gaps in extracorporeal blood purification From cytokine adsorption to pathogen removal, EBP faces major mechanistic and clinical uncertainties. Precision phenotyping and real-time immune monitoring may unlock its potential. 🔗 doi.org/10.1186/s40635-025-00819-8 #MedSky #ICU #Sepsis

REVIEW 🌊 Venous congestion from a vascular waterfall perspective Venous waterfalls, organ-specific Pcrit, and why kidneys suffer while liver/intestine partly buffer pressure. Implications for PEEP, fluids, and Doppler assessment. 🔗 doi.org/10.1186/s40635-025-00828-7

Fluid removal improves muscle performance and weakness in critically ill patients Ultrafiltration during CRRT reduced muscle and tissue edema on US and was linked to improved strength scores within 36 h, suggesting fluid balance may influence muscle quality. 🔗 doi.org/10.1186/s40635-025-00830-z

Impaired serum neutralization and death in Omicron-infected critically ill patients: insights from the French SEVARVIR study Early strategies boosting neutralization may be key. 🔗 doi.org/10.1186/s40635-025-00831-y #MedSky #FOAMed #PulmSky #PulmCrit #IDSky #ImmunoSky

💪 MUScleNut study Muscle ultrasound revealed marked early SM decline in critical illness; nutritional risk predicted greater loss, underscoring the need for optimized strategies. 📎 doi.org/10.1186/s40635-025-00823-y #MedSky #FOAMed #RadSky #EchoSky #EchoFirst #POCUS

How much #lung water is too much?🌊 This study demonstrates that CT-based estimates of EVLW in COVID-19 patients correlate well with TPTD values—suggesting a non-invasive, cost-effective alternative for #ICU monitoring. 🔗 doi.org/10.1186/s40635-025-00752-w #MedSky

Can steroids reshape post-arrest metabolism? High-dose methylprednisolone after OHCA alters plasma metabolites for 48 h—lowering ω-6 fatty acids and boosting tryptophan, arginine, and C3. A metabolic shift with therapeutic potential? 🔗 doi.org/10.1186/s40635-025-00754-8 #MedSky #CardioSky

In a new ICU mouse model, age and sex drive divergent responses to LPS-induced lung injury. Old males benefit most from ventilation, but old females fare worst. A step forward for translational critical care research. 🔗 doi.org/10.1186/s40635-025-00756-6 #MedSky #PulmSky #PulmCrit #IDSky

Mixed reality in the ICU? 👓 The ArtekMed system blends AR/VR for teleconsultation—rated promising by most users but still lags behind standard video calls in usability. Real-time virtual care is coming… 🔗 doi.org/10.1186/s40635-025-00758-4 #MedSky

Can we control fever in acute brain injury without compromising brain oxygen? 🧠🌡️ Extended diclofenac infusions reduce temperature—but slightly lower PtO₂ too. What does this mean for neurocritical care? 🔗 doi.org/10.1186/s40635-025-00759-3 #MedSky #NeuroSky

📢 Call for #Abstracts #LIVES2025, the 38th Annual Congress of the @esicm.bsky.social , invites you to submit your original contributions in #IntensiveCare. ✨ Accepted abstracts will be published in a Supplement of #ICMx! 🗓️ Deadline: 10 April 2025, 23:59 CET 🔗

🔬 The ESICM #Research Awards recognize groundbreaking projects that advance the field of #IntensiveCare. 🔹 Showcase your expertise 🔹 Gain recognition within the #ICU community 🔹 Contribute to the progress of #CriticalCare 📅 Deadline: 10 April, 23:59 CEST www.esicm.org/research/awa... #MedSky

📢 New Visual Abstract! The effects of urine alkalinization on kidney function in critically ill patients with COVID-19: a proof-of-concept randomized clinical trial. 🔗 doi.org/10.1186/s40635-025-00739-7 #MedSky #ICMxVisualAbstract #FOAMcc #NephSky #Nephpearls

🩺 Exploring kidney protection in COVID-19 This trial assessed whether urine alkalinization could reduce #AKI risk. 👉 While pH targets were achieved, no significant clinical benefits emerged. A stepping stone for future research? 🔗 doi.org/10.1186/s40635-025-00739-7 #MedSky #NephSky #Nephpearls

📢 Mark your calendars for the #NEXTJamboree! 🎉 Join @esicm.bsky.social for the third edition of this free digital event, where young intensivists connect, share insights, and discuss the future of intensive care. 📅 April 29 – don’t miss it! More details 👉 www.esicm.org/events/next-...

Capnodynamics vs. pulmonary catheterization 🏥 A new study finds that the capnodynamic method accurately estimates mixed venous oxygen saturation in post-op cardiac patients, offering a less invasive alternative to traditional monitoring. 🔗 doi.org/10.1186/s40635-025-00741-z #MedSky #CardioSky

🔬 Stay up to date with the latest advances in intensive care medicine! At ICMx, we share groundbreaking research and key experimental studies. 🚑📚 Follow us not only here on Bluesky, but also on LinkedIn for more exclusive content! 🔗

Prehospital airway rescue: EVA vs. PCV 🩸 A hemorrhagic #trauma model shows that EVA via a 14F catheter provides sufficient oxygenation with lower intratracheal pressures and reduced lactate accumulation—could this be the future of field ventilation? 🌬️ 🔗 doi.org/10.1186/s40635-025-00742-y #MedSky

#AI Unlocks #ARDS Subphenotypes 🔬 New #MachineLearning models classify ARDS into "Efficient" & "Restrictive" subphenotypes—each with unique clinical outcomes. Could this shift the way we approach #ventilation? 🔗 doi.org/10.1186/s40635-025-00737-9 #MedSky #FOAMed #PulmSky #ICU #IntensiveCare

🤔 No One-Size-Fits-All for Mechanical Power in Ventilation: A new study explores how MP affects ventilator outcomes & highlights the need for personalized thresholds. 🗝️ Key takeaway? Median MP matters—universal cutoffs don’t. 🔗 doi.org/10.1186/s40635-025-00736-w #MedSky #FOAMed #PulmSky #AI #ICU

🩸 Call for Submissions: Blood Purification in #Sepsis – From Bench to Bedside 🏥🔬 ICMx invites researchers to contribute to our new collection exploring the role of extracorporeal blood purification in sepsis. 🔗 Submit now: bit.ly/SubmitToICMx #MedSky #NephSky #IDSky #IntensiveCare #CriticalCare

📢 Stay connected with Intensive Care Medicine Experimental #ICMx on social media! Follow us for the latest research & updates in #IntensiveCare. 🔬🩺 🔹 BlueSky: bsky.app/profile/icme... 🔹 LinkedIn: www.linkedin.com/company/icm-... Join the conversation and be part of the ICMx community! 🚀 #MedSky

🧵 February 2025 #Reviews in #ICMx! Stay up to date with the latest in #CriticalCare & #IntensiveCare —from #AI in mortality prediction to the future of patient monitoring. Don’t forget to like & share to keep the conversation going! Check out our top reviews this month! ⬇️ #FOAMcc #Sepsis #ICU

Fighting macrolide-resistant pneumococcal #pneumonia 💊 A porcine model study shows that combining ceftriaxone, azithromycin & steroids enhances bacterial clearance & controls #inflammation. Could this be the optimal strategy? Read more 🔗 doi.org/10.1186/s40635-025-00731-1 #MedSky #IDSky #PulmSky

Can wearables revolutionize #ICU monitoring? 📊 These devices offer continuous, non-invasive tracking of vitals, bridging gaps between intensive & step-down care. Challenges remain, but the future is promising! Read more 👇 🔗 doi.org/10.1186/s40635-025-00738-8 #MedSky #FOAMed

Mitochondria & sepsis: a complex relationship? 🦠 🔬 New research in a porcine model shows how #sepsis severity drives renal mitochondrial dysfunction—offering insights into #AKI mechanisms beyond haemodynamic changes. Read more: 👉 doi.org/10.1186/s40635-025-00732-0 #MedSky #NephSky #Nephpearls

📢 Calling all researchers! 📝✨ ICMx is now accepting submissions! Share your groundbreaking work in #IntensiveCare with a global audience. Open-access publishing & high visibility—submit today! 👉 https://icm-experimental.springeropen.com/ #MedSky #CriticalCare #ICMx

Transforming patient monitoring for better care! 🚑 Experts discuss how to overcome alarm fatigue, data overload & integration issues to optimize healthcare technology. Future solutions await: 🔗 doi.org/10.1186/s40635-025-00733-z #MedSky #FOAMed

🚀 NIV & Automation: A Better Match? This study finds that IntelliSync+ improves synchronization, particularly with obstructive #lung mechanics & high leaks. Could this reshape #NIV delivery? 🔗 doi.org/10.1186/s40635-025-00726-y #MedSky #PulmSky #PulmCrit

🤖 AI vs. Logistic Regression: Who predicts #ARDS mortality better? A new meta-analysis finds AI models outperform LR models in sensitivity & accuracy, especially in moderate to severe ARDS. Could #AI enhance critical care decisions? 👉 doi.org/10.1186/s40635-024-00706-8 #MedSky #PulmSky #PulmCrit

🕰️ Circadian Rhythms & ICU Outcomes Disrupted biological clocks in #ICU patients may worsen #cardiovascular risks. This review explores how melatonin & clock genes interact with heart rate & BP—could restoring rhythm improve outcomes? 🔗 doi.org/10.1186/s40635-025-00730-2 #MedSky #FOAMed

👀 The Face of Acute Illness 🏥 Can subtle facial cues predict clinical deterioration? This systematic review identifies key features like paler skin tone & sad expressions. More research is needed, but could this aid rapid bedside assessments? 📖 doi.org/10.1186/s40635-025-00719-x #MedSky #FOAMed

🚨 #ECMO impacts teicoplanin pharmacokinetics! 📉 Most critically ill patients had insufficient drug levels, especially with #CRRT. Higher initial doses may be key for effective therapy. Learn more about these findings from a real-world #ICU study. 🔗 doi.org/10.1186/s40635-025-00729-9 #MedSky #IDSky