Impaired serum neutralization and death in Omicron-infected critically ill patients: insights from the French SEVARVIR study Early strategies boosting neutralization may be key. 🔗 doi.org/10.1186/s40635-025-00831-y #MedSky #FOAMed #PulmSky #PulmCrit #IDSky #ImmunoSky

💪 MUScleNut study Muscle ultrasound revealed marked early SM decline in critical illness; nutritional risk predicted greater loss, underscoring the need for optimized strategies. 📎 doi.org/10.1186/s40635-025-00823-y #MedSky #FOAMed #RadSky #EchoSky #EchoFirst #POCUS

How much #lung water is too much?🌊 This study demonstrates that CT-based estimates of EVLW in COVID-19 patients correlate well with TPTD values—suggesting a non-invasive, cost-effective alternative for #ICU monitoring. 🔗 doi.org/10.1186/s40635-025-00752-w #MedSky

Can steroids reshape post-arrest metabolism? High-dose methylprednisolone after OHCA alters plasma metabolites for 48 h—lowering ω-6 fatty acids and boosting tryptophan, arginine, and C3. A metabolic shift with therapeutic potential? 🔗 doi.org/10.1186/s40635-025-00754-8 #MedSky #CardioSky

In a new ICU mouse model, age and sex drive divergent responses to LPS-induced lung injury. Old males benefit most from ventilation, but old females fare worst. A step forward for translational critical care research. 🔗 doi.org/10.1186/s40635-025-00756-6 #MedSky #PulmSky #PulmCrit #IDSky

Mixed reality in the ICU? 👓 The ArtekMed system blends AR/VR for teleconsultation—rated promising by most users but still lags behind standard video calls in usability. Real-time virtual care is coming… 🔗 doi.org/10.1186/s40635-025-00758-4 #MedSky

Can we control fever in acute brain injury without compromising brain oxygen? 🧠🌡️ Extended diclofenac infusions reduce temperature—but slightly lower PtO₂ too. What does this mean for neurocritical care? 🔗 doi.org/10.1186/s40635-025-00759-3 #MedSky #NeuroSky

📢 Call for #Abstracts #LIVES2025, the 38th Annual Congress of the @esicm.bsky.social , invites you to submit your original contributions in #IntensiveCare. ✨ Accepted abstracts will be published in a Supplement of #ICMx! 🗓️ Deadline: 10 April 2025, 23:59 CET 🔗

🔬 The ESICM #Research Awards recognize groundbreaking projects that advance the field of #IntensiveCare. 🔹 Showcase your expertise 🔹 Gain recognition within the #ICU community 🔹 Contribute to the progress of #CriticalCare 📅 Deadline: 10 April, 23:59 CEST www.esicm.org/research/awa... #MedSky

📢 New Visual Abstract! The effects of urine alkalinization on kidney function in critically ill patients with COVID-19: a proof-of-concept randomized clinical trial. 🔗 doi.org/10.1186/s40635-025-00739-7 #MedSky #ICMxVisualAbstract #FOAMcc #NephSky #Nephpearls

🩺 Exploring kidney protection in COVID-19 This trial assessed whether urine alkalinization could reduce #AKI risk. 👉 While pH targets were achieved, no significant clinical benefits emerged. A stepping stone for future research? 🔗 doi.org/10.1186/s40635-025-00739-7 #MedSky #NephSky #Nephpearls

📢 Mark your calendars for the #NEXTJamboree! 🎉 Join @esicm.bsky.social for the third edition of this free digital event, where young intensivists connect, share insights, and discuss the future of intensive care. 📅 April 29 – don’t miss it! More details 👉 www.esicm.org/events/next-...

Capnodynamics vs. pulmonary catheterization 🏥 A new study finds that the capnodynamic method accurately estimates mixed venous oxygen saturation in post-op cardiac patients, offering a less invasive alternative to traditional monitoring. 🔗 doi.org/10.1186/s40635-025-00741-z #MedSky #CardioSky

🔬 Stay up to date with the latest advances in intensive care medicine! At ICMx, we share groundbreaking research and key experimental studies. 🚑📚 Follow us not only here on Bluesky, but also on LinkedIn for more exclusive content! 🔗

Prehospital airway rescue: EVA vs. PCV 🩸 A hemorrhagic #trauma model shows that EVA via a 14F catheter provides sufficient oxygenation with lower intratracheal pressures and reduced lactate accumulation—could this be the future of field ventilation? 🌬️ 🔗 doi.org/10.1186/s40635-025-00742-y #MedSky

#AI Unlocks #ARDS Subphenotypes 🔬 New #MachineLearning models classify ARDS into "Efficient" & "Restrictive" subphenotypes—each with unique clinical outcomes. Could this shift the way we approach #ventilation? 🔗 doi.org/10.1186/s40635-025-00737-9 #MedSky #FOAMed #PulmSky #ICU #IntensiveCare

🤔 No One-Size-Fits-All for Mechanical Power in Ventilation: A new study explores how MP affects ventilator outcomes & highlights the need for personalized thresholds. 🗝️ Key takeaway? Median MP matters—universal cutoffs don’t. 🔗 doi.org/10.1186/s40635-025-00736-w #MedSky #FOAMed #PulmSky #AI #ICU

🩸 Call for Submissions: Blood Purification in #Sepsis – From Bench to Bedside 🏥🔬 ICMx invites researchers to contribute to our new collection exploring the role of extracorporeal blood purification in sepsis. 🔗 Submit now: bit.ly/SubmitToICMx #MedSky #NephSky #IDSky #IntensiveCare #CriticalCare

📢 Stay connected with Intensive Care Medicine Experimental #ICMx on social media! Follow us for the latest research & updates in #IntensiveCare. 🔬🩺 🔹 BlueSky: bsky.app/profile/icme... 🔹 LinkedIn: www.linkedin.com/company/icm-... Join the conversation and be part of the ICMx community! 🚀 #MedSky

🧵 February 2025 #Reviews in #ICMx! Stay up to date with the latest in #CriticalCare & #IntensiveCare —from #AI in mortality prediction to the future of patient monitoring. Don’t forget to like & share to keep the conversation going! Check out our top reviews this month! ⬇️ #FOAMcc #Sepsis #ICU

Fighting macrolide-resistant pneumococcal #pneumonia 💊 A porcine model study shows that combining ceftriaxone, azithromycin & steroids enhances bacterial clearance & controls #inflammation. Could this be the optimal strategy? Read more 🔗 doi.org/10.1186/s40635-025-00731-1 #MedSky #IDSky #PulmSky

Can wearables revolutionize #ICU monitoring? 📊 These devices offer continuous, non-invasive tracking of vitals, bridging gaps between intensive & step-down care. Challenges remain, but the future is promising! Read more 👇 🔗 doi.org/10.1186/s40635-025-00738-8 #MedSky #FOAMed

Mitochondria & sepsis: a complex relationship? 🦠 🔬 New research in a porcine model shows how #sepsis severity drives renal mitochondrial dysfunction—offering insights into #AKI mechanisms beyond haemodynamic changes. Read more: 👉 doi.org/10.1186/s40635-025-00732-0 #MedSky #NephSky #Nephpearls

📢 Calling all researchers! 📝✨ ICMx is now accepting submissions! Share your groundbreaking work in #IntensiveCare with a global audience. Open-access publishing & high visibility—submit today! 👉 https://icm-experimental.springeropen.com/ #MedSky #CriticalCare #ICMx

Transforming patient monitoring for better care! 🚑 Experts discuss how to overcome alarm fatigue, data overload & integration issues to optimize healthcare technology. Future solutions await: 🔗 doi.org/10.1186/s40635-025-00733-z #MedSky #FOAMed

🚀 NIV & Automation: A Better Match? This study finds that IntelliSync+ improves synchronization, particularly with obstructive #lung mechanics & high leaks. Could this reshape #NIV delivery? 🔗 doi.org/10.1186/s40635-025-00726-y #MedSky #PulmSky #PulmCrit

🤖 AI vs. Logistic Regression: Who predicts #ARDS mortality better? A new meta-analysis finds AI models outperform LR models in sensitivity & accuracy, especially in moderate to severe ARDS. Could #AI enhance critical care decisions? 👉 doi.org/10.1186/s40635-024-00706-8 #MedSky #PulmSky #PulmCrit

🕰️ Circadian Rhythms & ICU Outcomes Disrupted biological clocks in #ICU patients may worsen #cardiovascular risks. This review explores how melatonin & clock genes interact with heart rate & BP—could restoring rhythm improve outcomes? 🔗 doi.org/10.1186/s40635-025-00730-2 #MedSky #FOAMed

👀 The Face of Acute Illness 🏥 Can subtle facial cues predict clinical deterioration? This systematic review identifies key features like paler skin tone & sad expressions. More research is needed, but could this aid rapid bedside assessments? 📖 doi.org/10.1186/s40635-025-00719-x #MedSky #FOAMed

🚨 #ECMO impacts teicoplanin pharmacokinetics! 📉 Most critically ill patients had insufficient drug levels, especially with #CRRT. Higher initial doses may be key for effective therapy. Learn more about these findings from a real-world #ICU study. 🔗 doi.org/10.1186/s40635-025-00729-9 #MedSky #IDSky

Early #sepsis recognition matters! 🏥🔬 A pilot study on the TriVerity Test shows promising results in rapidly identifying bacterial & viral infections in the #ED. Could this host-response mRNA test revolutionize sepsis diagnosis? 🤔 👉 doi.org/10.1186/s40635-025-00735-x #MedSky #IDSky

🦠 Septic Shock & Immune Modulation: A Game Changer? Therapeutic plasma exchange (TPE) shows promise in septic shock by removing harmful mediators & restoring balance. This study explores its effects on inflammation & biomarkers. 📖 doi.org/10.1186/s40635-025-00725-z #MedSky #IDSky #Sepsis

Sepsis & the Heart: A Deadly Energy Crisis ⚠️ Sepsis-induced myocardial dysfunction (SIMD) isn’t just about cell death—it’s about failing energy metabolism. This review explores how mitochondria hold the key to better therapies. 📖 Full article: doi.org/10.1186/s40635-025-00728-w #MedSky #CardioSky

🩺 Can nebulised heparin help #COVID-19 #ARDS patients? The CHARTER-Ireland trial found it was safe but didn’t reduce D-dimers and worsened oxygenation indices. Important findings for #CriticalCare! Read the full study: doi.org/10.1186/s40635-025-00727-x #IntensiveCare #MedSky #ICMx

🚨 New in #ICMx! 🔬 PET–CT imaging reveals dynamic neutrophil elastase distribution in early #sepsis. A porcine model shows a surprising shift from bone marrow (2h) to liver, spleen & lungs (4h). Could this reshape sepsis #diagnostics? 🧪 doi.org/10.1186/s406... #IntensiveCare #CriticalCare

🧪 How does #landiolol affect the metabolic and cytokine profile in #SepticShock? This STRESS-L sub-study found metabolic shifts in glucose, lactate & succinic acid, but no significant #cytokine changes. A step toward deeper insights! 👉 doi.org/10.1186/s40635-024-00708-6 #IntensiveCare #sepsis

🔨How can we minimize mechanical power during controlled #MechanicalVentilation? This study provides an analytical solution, revealing that elastic power is minimized at ~4.4 ml/kg of body weight. A key step in preventing #VILI. Read more: doi.org/10.1186/s40635-024-00699-4 #IntensiveCare #ICU

🤩 Intensive Care Medicine Experimental is now on Bluesky! Follow us on @icmexperimental.bsky.social and stay updated with new research and advancements in #CriticalCare. Let’s explore the #science driving the future of #IntensiveCare together! @esicm.bsky.social @icmjournal.bsky.social