Our new, comprehensive review on all things CAR T cell persistence is officially published in @cellcellpress.bsky.social @cp-trendscancer.bsky.social. Fantastic work from lead authors Kat Mueller and Jeremy Grenier. Link to the full article: www.cell.com/trends/cance...

We are experiencing an assault on science unparalleled by anything I’ve seen in my life. It’s not one issue or another anymore, the entire institution is under attack by the most powerful individuals in the country. This Friday, where will you be? standupforscience2025.org

Any speculation why big pharma and biotech industries have been so quiet about the current defunding of biomedical research? (which also means the defunding of biomedical research training)

With an Ro of 12-18, a mortality rate of about 1-2/10,000 and an MMR vaccination rate in this area of Texas at 82% we should expect to see this expand to many 1000 cases quickly and, unfortunately, potential deaths.

Honored to have our recently published first-in-human phase 1 clinical trial of repeatedly dosed intracerebroventrocular B7-H3 #CARTcells for children with #DIPG highlighted in @theaacr.bsky.social and #CancerDiscovery Research Watch ❤️🔬

My weekend with immunologists devising new strategies to treat cancer, allergy, Alzheimer’s, autoimmunity and infection. The WH has just paused peer-reviewed NIH funding that pays for these studies. If you care about human life, write your representatives. Demand that NIH funding is restored asap.

Excited and grateful that our initial report on temperature-sensitive protein switches is now published @naturemethods.bsky.social Co-led by PhD students Will Benman and @dennishuang.bsky.social www.nature.com/articles/s41... Brief thread:

Starting off 2025 inspired by this fantastic interview with @geochurch.bsky.social Beyond George's intellect and scientific genius, he is so adept at communicating complex ideas about teamwork, creativity, discovery, and innovation. Thanks @nightsciencepod.bsky.social @itaiyanai.bsky.social!

I’m excited to be a co-organizer this year for the SITC Winter School, where we focus on the core principles of #TumorImmunology & #CancerImmunotherapy. We’ll also be discussing advancements in drug development, biomarkers, & clinical trials. More info here: go.sitcancer.org/3XOCoBh Please join us!

Calling all cell therapists! The SITC Spring Scientific on Cellular Therapy for Solid Tumors takes place March 12-14 2025 in sunny San Diego. Fantastic speaker lineup, and slots for abstract talks www.sitcancer.org/education/sp... Early registration deadline is THIS FRIDAY. Abstracts due Jan 8th.

Here is link to Shixin's new paper: www.science.org/doi/epdf/10....

Fascinating study where they label CAR T cells and follow their trafficking in patients! Immediate biodistribution is to the liver and spleen, and they can see whether the Car goes into extramedullary masses. What explains differences between patients?

EZH2 inhibition enhances T cell immunotherapies by inducing lymphoma immunogenicity and improving T cell function www.cell.com/cancer-cell/...

ICYMI - over the summer Maria Parkhurst from our branch published one of the first reports of clinical responses after adoptive cell transfer of TCR engineered private neoantigen (tumor mutation) targeting T cells in metastatic cancer patients 🧪🦠🔬🩺 1/3 #Immunosky www.nature.com/articles/s41...

🚨NEW🧪: TET2 regulates early and late transitions in exhausted CD8+ T cell differentiation and limits CAR T cell function - #CARTCell #immunotherapy #TCell #tcellrx #immunology www.science.org/doi/10.1126/...

Postdocs in Immuno-Oncology: consider this awesome career development opportunity! You get to network with accomplished faculty and rising start peers in preparation for running a research group! Info: irvingcancerimmunologysymposium.com Application link: docs.google.com/forms/d/e/1F...

In vivo CRISPR screens identify key modifiers of CAR T cell function in myeloma https://www.biorxiv.org/content/10.1101/2024.11.19.624352v1

I made a starter pack for those of us interested in or working on T cells. Let me know if you would like to be added or know somebody that should be added. Looking forward to scientific discussions and updates on our favorite immune cell type!

Inspired by the other amazing starter packs - here's one for cancer researchers! I tried to make this broad - from immunology to genomics to cell biology and so much more.. This list also includes organizations & institutes supporting cancer researchers 🧪🔬⚕️🩺 Hope its useful! go.bsky.app/FEoaJMc

🐦➡️🦋 Looking to rebuild your network on Bluesky by reconnecting with your existing X/Twitter contacts? The Skylink browser extension makes it easy! chromewebstore.google.com/detail/sky-f... Thanks @jmschreiber91.bsky.social! #scicomm #cancer #tumorimmunology