Alexander V. Veselov 😷🎮 (@alexxxmd.bsky.social)

Comparison of different colistin sulfate regimens for carbapenem-resistant gram-negative bacteria pneumonia in neurocritical care patients: a retrospective cohort study Qian Zeng, et al. Antimicrobial Agents and Chemotherapy, 2025 doi.org/10.1128/aac....

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Comparison of different colistin sulfate regimens for carbapenem-resistant gram-negative bacteria pneumonia in neurocritical care patients: a retrospective cohort study | Antimicrobial Agents and Chemotherapy Hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP) are the main nosocomial infections with high rates of morbidity and mortality (1). Owing to the severity of HAP and VAP in the intensive care unit (ICU), early appropriate antimicrobial therapy significantly improves the survival of patients (2). In recent years, the overuse and misuse of broad-spectrum antibiotics have accelerated the spread of antibiotic-resistant bacteria. The dramatic increase in multidrug-resistant (MDR) bacteria represented by gram-negative bacteria (GNB) has complicated the management, therapy, and outcome of nosocomial infections. Among these pathogens, carbapenem-resistant GNB (CR-GNB), especially CR-Acinetobacter baumannii (CRAB), CR-Enterobacteriaceae (CRE), and CR-Pseudomonas aeruginosa (CRPA), have gained attention with growing public health challenges worldwide (1). https://doi.org/10.1128/aac.00644-25