I’m excited to catch up with the amazing ELMI community soon. See you there 😎

🎉 Congratulations to all authors on this brilliant paper and the well-deserved JCB cover feature! 👏 A beautiful study connecting cortical cytoskeleton organization, cell shape, signaling, and epidermal differentiation. We are truly excited to see our technology contribute to this outstanding work.

1/3 How does the cortical #cytoskeleton connect cell shape w/ cell fate? A recent @jcb.org @rupress.org paper by Soffer et al. uses the #epidermis to study how shape transitions are coordinated w/ differentiation. The study identifies #spectrin as an essential organizer of the #actomyosin cortex.

1/2 🧬 For #DNArepair studies, chemically-induced damage is often too blunt. 🎯 Local laser-induced #DNAdamage changes the experimental game. Instead of damaging the whole sample, one can target a selected nuclear region and follow the response over time with #LiveImaging. #Microscopy #Bioimaging

1/4 🔬 In many tissue samples, the region of interest is surrounded by material you do *not* want in your downstream analysis. #LCM helps isolate selected cells or tissue regions with higher specificity before DNA, RNA, or protein analysis. #Microscopy #Bioimaging #LaserCaptureMicrodissection

1/4 🌱 Biologists spend enormous effort keeping their favorite organisms happy. But to understand biology, one often needs to perturb it. 🎯 Precisely. 💡 That is where #photomanipulation comes in: focused light used to locally modify, stimulate, cut, or disrupt processes in a sample.

1/3 😬Every live-cell microscopist knows the feeling: the fluorescence signal looked perfect when the experiment started. 🔬In #FluorescenceMicroscopy, prolonged/intense excitation can permanently destroy fluorophores. ❌For #LiveCellImaging, that means fine details becoming harder to resolve.

1/2 🇩🇪 We are pleased to support the EMBL @events.embl.org Course “Advanced Fluorescence Imaging Techniques” in Heidelberg together with #Evident Microscopy. ✨ Anja Zimmermann will contribute to the course with a talk and hands-on workshops on RAPP #photomanipulation systems. #EMBLFluorImaging

1/3 🪄 What if you could move intracellular structures using only light? 🌀 FLUCS uses a rapidly scanned IR laser to generate thermoviscous flows inside the sample. ❌ No contact ❌ No labels ❌ No RI matching required ✅ Just your sample & IR light #Photomanipulation #Microscopy #Bioimaging #Biophysics

1/3 💡 What makes the @sutterinstrument.bsky.social MOM® stand out? It is built around a simple idea: move the objective, not the specimen. Its open, robust design makes it a flexible platform built to serve evolving workflows for years to come. #Microscopy #Bioimaging

1/3 🫀 Atherosclerotic lesions are #plaque buildups in the arterial wall that reduce blood flow. Foam cells, i.e., lipid-laden macrophages, are central to plaque progression. 💔 As lesions advance, the outcome can be severe: thrombosis, heart attack, or stroke. #LaserCaptureMicrodissection

1/2 ✨Mark and track only the molecules you choose. 🔦 #Photoactivation: Signal appears only after local illumination. 🎨 #Photoconversion: Contextual tracking, where you can mark a selected population but observe both the converted and unconverted populations. ➡️The real power of both? Spatial control.

1/3 UGA-42 is a scanner-based #photomanipulation series for microscopy and macroscopy. It places the laser virtually anywhere in the camera/scanner's field of view for sequential point illumination and ROI scanning. #Microscopy #Bioimaging

1/3 ❓What makes holographic #photomanipulation different from point stimulation? ✨With Holo4D, light is shaped differently. An SLM creates defined holographic patterns that can be projected simultaneously in 3D. 📌x⏱️That turns sequential targeting into spatially coordinated stimulation across time.

1/2 🤔 Single- or multi-photon #microscopy? 🔘 A #confocal pinhole rejects out-of-focus fluorescence at detection, but excitation still happens along the beam path. ✨ In #multiphoton, fluorescence is generated mainly at the focal volume, supporting deeper, gentler imaging in sensitive live specimens.

By studying a unique, light-activated protein in dragonflies, researchers may have unlocked new opportunities for deep-tissue optogenetics. Read the OPN story: https://bit.ly/4mzOB8T #optogenetics #proteins 💡 ⚛️ 🧪

📈or📉? Your downstream data is only as good as your starting material. Accuva Cellect offers IR capture & UV laser cutting in one #LCM system and a dedicated QC station for visual inspection. 👉 Or to put it simply: Cut. Capture. Verify. #LaserCaptureMicrodissection

2/2 🔗 One or multiple Rapp devices can be combined within one system & integrated alongside imaging workflows such as lattice light-sheet, spinning disk, confocal, widefield, and multi-photon microscopy. ✅ Expand your microscopy from simple observation to full interactive control.

1/2 🌈x🛠️ Light can become a versatile tool in your experiments. Photomanipulation is the controlled use of focused light to locally modify/stimulate/disrupt biological & physical processes in a sample. ❓Which photomanipulation approach could unlock the most interesting possibilities for your biology?

www.nature.com/articles/s41... Two-author papers are always special. Using optogenetic stimulation of hippocampal synapses in awake mice and tracking them over approx. 2 weeks, we link synaptic strength, spine volume and their stability. It's confirmed: bigger spines are stronger and more stable 😅

1/5 🤔 What can you actually do with #FLUCS? 💡 FLUCS enables researchers to actively & flexibly control intracellular flows. Non-invasively & label-free. 📩 Get in contact with us to explore how FLUCS can add a new dimension to your research. #Photomanipulation #Bioimaging #Biophysics

🇸🇪 Thank you to everyone who visited us at #FOM2026 in Stockholm. 💡Sven came away with many useful discussions on #photomanipulation & advanced #bioimaging. 👋 We appreciated the strong interest throughout the meeting & look forward to seeing you again next year! #Microscopy #Multiphoton #FLUCS

1/3 🇸🇪 We are excited to join #FOM2026 in Stockholm at a shared booth with Chroma as co-sponsors of the meeting. 📍 Stop by and discuss your workflow with Sven to explore which state-of-the-art imaging & photomanipulation solution best fits your needs. #Microscopy #Bioimaging #Photomanipulation

3/3 🎯 UGA-42 Series: Three devices, one modular platform ⚡ Caliburn for ablation & microdissection 🔷 Geo for shaped illumination of larger areas ✨ Firefly for general photomanipulation

2/3 🔄 FLUCS Contact- and label-free flow manipulation using scanned IR laser-induced thermoviscous flows, in parallel with imaging.

1/3 🇫🇷 We are excited to join the 2nd FBI Mechanobiology Meeting 2026 in Paris! Anja will present the “Latest Applications in Fast & Precise Photomanipulation” 🗓️ Thu 26/03 🕒 11:45–12:05 📍Come meet us & discuss your mechanobiological workflow. #Mechanobiology #Microscopy #Bioimaging #Photomanipulation

2/3 🔬 At Rapp, we are proud to see our technologies enabling discoveries like this, where precision photomanipulation becomes a key step in uncovering complex biological mechanisms.

3/3 👏 Congratulations again to the Mateus Group @ritamateus.bsky.social, the lab of Frank Jülicher @mpipks.bsky.social & all other authors on this exciting work published in Science Advances. 📄Read the open access publication here: www.science.org/doi/10.1126/...

1/3 💡How do injured organs know it's time to regrow? 🎯UV-laser microsurgery was used to precisely injure zfish larval fins during live imaging, helping reveal how wound-adjacent cells initiate a tissue-scale Ca²⁺ wavefront & organ-wide repair response. #Bioimaging #Photomanipulation #ScienceAdvances

📢 We are happy to share our booth with our good friends from Chroma Technology Corp. & TOPTICA Photonics.

🇵🇹 Coimbra, here we come! ✨ We’re proud to support #ELMI2026 as a Gold Sponsor. We can't wait to hear what you're working on! 👏Huge thanks to @ppbioimaging.bsky.social for the incredible organization. 📆 See you in June! #Microscopy #ImagingScience #Bioimaging #ScientificInnovation #FLUCS

We’re excited to join the @dfg.de Final Symposium “Frontiers in Light Microscopy – Technologies Driving Discovery” @uniosnabrueck.bsky.social Looking forward to celebrating the discoveries emerging from the light microscopy community #LightMicroscopy #Bioimaging #CellBiology #ScienceInGermany

Welcome to #bps2026 We’re now represented by @Oxxius in the US. Find our CEO @swarnck.bsky.social together with Anna Fasoli at booth no. 428. As usual, get additional #photomanipulation info from the teams at Chroma Technology (Booth no. 413) and @sutterinstrument.bsky.social (booth no. 500).

@visitech.bsky.social Thanks for the mention! Excited to keep pushing things forward together with this fantastic group of partners.

Beautiful ablations! Congrats to all people involved for very convincing experiments and results!

Curious how @rappopto.bsky.social can boost your biological research? Missed the webinar? Good news! You can still catch the 20-minute talk by @martinbrill.bsky.social on the @eurobioimaging.bsky.social #TechExchange YouTube channel 👇 ▶️ Watch here: youtu.be/pdRdvnvvh7I?...

Curious how @rappopto.bsky.social can support your biological research? Learn about advanced photomanipulation techniques in a webinar hosted by @eurobioimaging.bsky.social January 23, 2026 14:00–14:30 CET by @martinbrill.bsky.social Register here: www.eurobioimaging.eu/events/event...

New reviewed preprint 📄 from Menno Winter's lab using the UGA-42 Geo #photomanipulation device: The study uncovers a new, highly organized way the medial and lateral entorhinal cortices communicate — offering clues about how the brain separates spatial and episodic memory. doi.org/10.7554/eLif...

2/2 As the year comes to a close and holidays approach – we want to express our sincere thanks for your confidence in us and the pleasant cooperation in the past year. Wishing you and your loved ones happy holidays and a successful New Year.

1/2 We strongly believe in science and technology for the good of humankind - and in protecting our forests. This year, we are donating the planting of 1,000 trees on our doorstep in mixed forests in Schleswig-Holstein, Germany to support biodiversity and climate protection.

All set in Philadelphia at #CellBio The American Society for Cell Biology #ASCB conference has officially started and we are excited to meet you. Find @swarnck.bsky.social at our friends from @89-north.bsky.social & Chroma at their booth #1116 and talk #photomanipulation, #cellbiology

Huge thanks to the @sutterinstrument.bsky.social team for a great visit after #SfN2025 We enjoyed diving into discussions about future projects #photomanipulation, #holographic stimulation, flexible in-vivo/in-vitro setups, & #FLIM on Sutter #multiphoton systems. Exciting times for #neuroscience!

Day 4 #SFN2025 in ☀️ San Diego Still around? Last chance to chat #photomanipulation & #multiphoton with @martinbrill.bsky.social & @swarnck.bsky.social Find them with their friends from Chroma Technology + 89 North booth (2120)

Day 3 at #SfN2025: Our custom applications let you switch seamlessly between slice and in vivo imaging on @sutterinstrument.bsky.social microscopes. Paired with our Rapp Holo-4D holographic photostim, you’re equipped for precise all-optical stimulation. Q&A: visit Chroma and 89North booth 2120.

Day 2 at #SfN2025 in San Diego: You can also find our solutions for #photomanipulation at our friends @sutterinstrument.bsky.social booth, number 600. Just ask for Adam Goldring. He knows our stuff.

Day 1 #SfN2025 exhibition has opened its doors. You can find @martinbrill.bsky.social and @swarnck.bsky.social with our friends from 89North and Chroma Technology Corp. at their both no. 2021. Come by and let's talk about your experiments and #photomanipulation from @rappopto.bsky.social

‪ Outstanding work by the entire team - congratulations to all authors involved! It’s great to see the precision and performance of the @rappopto.bsky.social Caliburn ablation laser in action — the level of detail in those cuts is genuinely impressive.

Absolutely beautiful work, congrats!

Application is open! Come join us and our fantastic line-up of speakers next year in March in Bonn!

Beautiful pictures—thanks for sharing, @kasiagrochowska.bsky.social Congratulations again on the new system. It's great to see that it's being put into action so quickly and successfully. We look forward to more great pictures in the future ;)