1/4 🌱 Biologists spend enormous effort keeping their favorite organisms happy. But to understand biology, one often needs to perturb it. 🎯 Precisely. 💡 That is where #photomanipulation comes in: focused light used to locally modify, stimulate, cut, or disrupt processes in a sample.

3/3 🔬 Flexible by design: Holo4D can be added to existing or new single- and multi-photon microscopes and supports parallel multi-photon imaging with two-photon holographic stimulation. 📍 Not just light projection. Programmable 4D photomanipulation.

2/3 🧠 Especially useful when the biology is about cell clusters, circuit relationships, dendritic integration, or distributed cellular responses. ⚡ Applications range from #Optogenetics and uncaging to #Photoactivation, #Photoconversion, #Photoswitching, and neural mapping workflows.

1/3 ❓What makes holographic #photomanipulation different from point stimulation? ✨With Holo4D, light is shaped differently. An SLM creates defined holographic patterns that can be projected simultaneously in 3D. 📌x⏱️That turns sequential targeting into spatially coordinated stimulation across time.

📈or📉? Your downstream data is only as good as your starting material. Accuva Cellect offers IR capture & UV laser cutting in one #LCM system and a dedicated QC station for visual inspection. 👉 Or to put it simply: Cut. Capture. Verify. #LaserCaptureMicrodissection

1/5 🤔 What can you actually do with #FLUCS? 💡 FLUCS enables researchers to actively & flexibly control intracellular flows. Non-invasively & label-free. 📩 Get in contact with us to explore how FLUCS can add a new dimension to your research. #Photomanipulation #Bioimaging #Biophysics

3/3 🧠Multi-photon microscopy Custom Sutter microscopes with Photomanipulation/-stimulation, Optogenetics, FRAP, FLIM, & Holo4D add-ons. ✨Holo4D Complex, high-precision patterns in 3D. Study neural circuits, interactions & biological processes in new ways by stimulating individual cells/cell groups.

1/3 🇸🇪 We are excited to join #FOM2026 in Stockholm at a shared booth with Chroma as co-sponsors of the meeting. 📍 Stop by and discuss your workflow with Sven to explore which state-of-the-art imaging & photomanipulation solution best fits your needs. #Microscopy #Bioimaging #Photomanipulation

1/3 🇫🇷 We are excited to join the 2nd FBI Mechanobiology Meeting 2026 in Paris! Anja will present the “Latest Applications in Fast & Precise Photomanipulation” 🗓️ Thu 26/03 🕒 11:45–12:05 📍Come meet us & discuss your mechanobiological workflow. #Mechanobiology #Microscopy #Bioimaging #Photomanipulation

1/3 💡How do injured organs know it's time to regrow? 🎯UV-laser microsurgery was used to precisely injure zfish larval fins during live imaging, helping reveal how wound-adjacent cells initiate a tissue-scale Ca²⁺ wavefront & organ-wide repair response. #Bioimaging #Photomanipulation #ScienceAdvances

🇵🇹 Coimbra, here we come! ✨ We’re proud to support #ELMI2026 as a Gold Sponsor. We can't wait to hear what you're working on! 👏Huge thanks to @ppbioimaging.bsky.social for the incredible organization. 📆 See you in June! #Microscopy #ImagingScience #Bioimaging #ScientificInnovation #FLUCS

We’re excited to join the @dfg.de Final Symposium “Frontiers in Light Microscopy – Technologies Driving Discovery” @uniosnabrueck.bsky.social Looking forward to celebrating the discoveries emerging from the light microscopy community #LightMicroscopy #Bioimaging #CellBiology #ScienceInGermany

Welcome to #bps2026 We’re now represented by @Oxxius in the US. Find our CEO @swarnck.bsky.social together with Anna Fasoli at booth no. 428. As usual, get additional #photomanipulation info from the teams at Chroma Technology (Booth no. 413) and @sutterinstrument.bsky.social (booth no. 500).

⚡👩‍🔬Electrical signals are key for promoting organ regenerative growth, a new study! Out now in Science Advances, from the Mateus group @ritamateus.bsky.social at PoL and @mpi-cbg.de along with the lab of Frank Jülicher @mpipks.bsky.social Read the news here: tud.link/7jzptz Video:©️ Mateus group

short correction: page 18, obviously the beautiful neuron image by Ana Sanchez Moreno from @andrewplested.bsky.social lab, dendrites with spines are shown, not axons.

Curious how @rappopto.bsky.social can boost your biological research? Missed the webinar? Good news! You can still catch the 20-minute talk by @martinbrill.bsky.social on the @eurobioimaging.bsky.social #TechExchange YouTube channel 👇 ▶️ Watch here: youtu.be/pdRdvnvvh7I?...

Curious how @rappopto.bsky.social can support your biological research? Learn about advanced photomanipulation techniques in a webinar hosted by @eurobioimaging.bsky.social January 23, 2026 14:00–14:30 CET by @martinbrill.bsky.social Register here: www.eurobioimaging.eu/events/event...

There is still time to apply! See linked document for details. Our new 2p microscope got freshly installed and tested this week and is now waiting for you :)

Funding comes from the @dfg.de courtesy to the Emmy Noether programme. To learn more about the lab, check out www.haberkernlab.de!

📢 Join us, the Haberkern lab, @uni-wuerzburg.de for a postdoc studying neural circuit mechanisms of navigation. You’ll spearheading neurophysiology experiments on our brand new 2P! ⏳ Apply by 28th February 2026 Details: www.haberkernlab.de/docs/ENPostd... #neuroscience #academicjobs #postdoc

New reviewed preprint 📄 from Menno Winter's lab using the UGA-42 Geo #photomanipulation device: The study uncovers a new, highly organized way the medial and lateral entorhinal cortices communicate — offering clues about how the brain separates spatial and episodic memory. doi.org/10.7554/eLif...

2/2 As the year comes to a close and holidays approach – we want to express our sincere thanks for your confidence in us and the pleasant cooperation in the past year. Wishing you and your loved ones happy holidays and a successful New Year.

All set in Philadelphia at #CellBio The American Society for Cell Biology #ASCB conference has officially started and we are excited to meet you. Find @swarnck.bsky.social at our friends from @89-north.bsky.social & Chroma at their booth #1116 and talk #photomanipulation, #cellbiology

I really enjoyed the spirit and hospitality.

Day 4 #SFN2025 in ☀️ San Diego Still around? Last chance to chat #photomanipulation & #multiphoton with @martinbrill.bsky.social & @swarnck.bsky.social Find them with their friends from Chroma Technology + 89 North booth (2120)

Day 3 at #SfN2025: Our custom applications let you switch seamlessly between slice and in vivo imaging on @sutterinstrument.bsky.social microscopes. Paired with our Rapp Holo-4D holographic photostim, you’re equipped for precise all-optical stimulation. Q&A: visit Chroma and 89North booth 2120.

Day 2 at #SfN2025 in San Diego: You can also find our solutions for #photomanipulation at our friends @sutterinstrument.bsky.social booth, number 600. Just ask for Adam Goldring. He knows our stuff.

Day 1 #SfN2025 exhibition has opened its doors. You can find @martinbrill.bsky.social and @swarnck.bsky.social with our friends from 89North and Chroma Technology Corp. at their both no. 2021. Come by and let's talk about your experiments and #photomanipulation from @rappopto.bsky.social

‪ Outstanding work by the entire team - congratulations to all authors involved! It’s great to see the precision and performance of the @rappopto.bsky.social Caliburn ablation laser in action — the level of detail in those cuts is genuinely impressive.

Beautiful pictures—thanks for sharing, @kasiagrochowska.bsky.social Congratulations again on the new system. It's great to see that it's being put into action so quickly and successfully. We look forward to more great pictures in the future ;)

Grateful to have had the chance to connect to many old friends and to make new ones at the incredible "Bee and Fly Neuroethology Meeting" at the Harnack house of the @maxplanck.de in Berlin. The energy around new discoveries and brilliant scientists was infectious, and inspiring.

Amazing opportunity, join the Manzini Lab and become part of the Institute of Animal Physiology in Giessen!

It was a splendid time with @kasiagrochowska.bsky.social and Long Yan from Florida Lifetime Imaging. It’s been a great pleasure working together - thank you @kasiagrochowska.bsky.social and the team for the fruitful collaboration! All the best for terrific data and exciting endeavors to come 🙌

New insights: Muscles grow by splitting sarcomeres! 💥 Using our UGA-42 #photomanipulation, the authors showed sarcomeres divide under tension to stay functional during development. Congrats to all authors on a beautiful scientific paper!

Wonderful work by @viji-draviam.bsky.social and team. Congratulations on the publication! We're honored to be cited in your work—exciting to see our contributions supporting cutting-edge research. Looking forward to following your continued discoveries!

A beautiful new paper about IP3 Uncaging with the UGA-42 system: Endothelial cells pass signals by triggering receptors on neighbors—not through gap junctions. A new way vessels stay in sync! by Buckley, Zhang, Lee, Wilson & McCarron 2025 FASEB faseb.onlinelibrary.wiley.com/doi/10.1096/...

Come say hello at our joint booth at #ELMI2025 There's some great coffee and beer to celebrate 25 years of @eurobioimaging.bsky.social Just walk up the helix and grab yours. We're happy to chat Toptica Chroma @microscopy.confocalnl.com @ultimeyes.bsky.social by CAIRN & @rappopto.bsky.social

ELMI @eulimi.bsky.social turns 25 next week – and we’re bringing cake (if the mouse leaves us any)... See you at the 25th European Light Microscopy Initiative meeting at @embl.org w/ our friends Toptica, @microscopy.confocalnl.com, @ultimeyes.bsky.social by CAIRN GmbH, and Chroma Technology Corp.

1/2 A stunning new paper from Deqing Kong & the Jörg Großhans lab dives deep into how cells change shape and reorganize during development. Their toolkit? Precision light from @rappopto.bsky.social And we’re thrilled our lasers played a key role. www.cell.com/current-biol...

2/2 The study explores how localized Ca²⁺ signaling influences cellular dynamics using @rappopto.bsky.social 375 nm laser, and the Caliburn laser for microsurgical ablation of cell junctions - offering high spatial and temporal control. Congrats to all authors involved. www.cell.com/current-biol...

Our CEO @swarnck.bsky.social is experiencing the Chinese Cell Biology Community at #CSCB2025 in Zhuai. He made new friends & e.g. saw the new Zeiss LSM Lightfield 4D. Special thanks are due to our local partners & hosts Echo Li from Chroma Technologies and Siyuan Feng from Evident Scientific.

Today, we were part of the Girls' and Boys' Day, the “Girls' and Boys' Future Day” A program to support stereotype-free career and study choices for all. The pupils successfully completed the day with happiness and full of motivation, thanks to a great team @rappopto.bsky.social

Our Applications Specialist Anja Zimmermann is on a tour with Jan Dolzer from our US-Partner Sutter Instrument @sutterinstrument.bsky.social. On tour, Jan is giving a talk about "What is hidden under the noise" today at @biodip.bsky.social @crtd-tud.bsky.social @cmcb-tud.bsky.social 👍👍

#NWG2025 @neurowissg.bsky.social in Göttingen has started! We are looking forward to talking to you. Come by and take a look at our booth 39.

The countdown is on! Just one day left until #TiM2025 @gerbi-gmb.de Thanks to our great partners in the workshops, you have the chance to dive deeper into the #FLUCS universe #photomanipulation and experience the latest functionality to make your samples move as you want to.

Great preview of of our #FLUCS workshop next week #TIM2025 from @gerbi-gmb.de Our CEO @swarnck.bsky.social and founder Gert Rapp as well as Simona Stelea are looking forward to meeting you there

WOW absolutely stunning movies and excellent ablation approaches! Congratulations to @micromotility.bsky.social and group as well as @jekely.biologists.social.ap.brid.gy for an amazing showcase of the precision ablation using the caliburn system from @rappopto.bsky.social.

Congrats to @theajacobs.bsky.social, @luschnig.bsky.social and others for a wonderful paper using #photomanipulation with precision ablation from @rappopto.bsky.social

Amazing technique of On-Demand Photoactivation of DNA-Based Motor Motion shown by the group of Khalid Salaita from @emoryuniversity.bsky.social Congrats to all authors involved! Great work using UV laser and #Photomanipulation from @rappopto.bsky.social