Grochowska lab (SynPro) (@kasiagrochowska.bsky.social)

doi.org/10.1007/s122... Lysosomes are much more than 'garbage dump', they are metabolic hub with really cool functions! If you are interested in this topic but would not like to go to deep in the molecular pathways (which are cool as well!), I hope you may find this contribution useful!

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How do neuronal lysosomes maintain functional synapses? - BIOspektrum The complex architecture of neurons poses unique challenges in maintaining proteome balance. Lysosomes, cellular metabolic hubs and main degradative organelles, play a central role in this process, thus supporting synaptic activity. Recent findings suggest that a specialized subpopulation of lysosomes in dendrites fuse with plasma membrane and release aggregation-prone proteins to the extracellular space. At the same time, they lead to structural changes in synapses, an intriguing link between the control of protein concentration and structural synaptic plasticity. https://doi.org/10.1007/s12268-025-2527-4