Best 2025 summary thread so far, take that to the bank.

We know you know it: quality journalism costs money. That’s why we’re always posting these appeals for your support — it’s not for fun! (For fun, we watch Heated Rivalry.) But how far does your dollar actually go toward funding our work? We crunched the numbers:

Genome-scale perturb-seq in primary human CD4+ T cells maps context-specific regulators of T cell programs and human immune traits https://www.biorxiv.org/content/10.64898/2025.12.23.696273v1

Amazing, better than forecast. It could happen here if we wanted it.

Please consider attending and RT. Great lineup of speakers!

My resolution this year was to be kinder to anyone I had a face to face interaction with. This was my small gesture to try and resist or counterbalance the insane vitriolic hate that the powerful carelessly spilled into the world. It's hard to be kind. But I'll stick to kindness next year too.

Oh look, big tough-guy talk from councillors Saxe and Bradford. Both of whom opposed bus priority lanes on Dufferin and Bathurst. They don't care about faster transit, and care nothing for Line 6 riders. Both must be bored. Are there no sensible housing policy items for them to vote against?

Nemotron 3 A new hybrid mamba2/attention LLM from NVIDIA that beats Qwen3-30B-A3B (same size & shape) Notes: * 1M context, with incredible recall past 256K * New open datasets * 10 open source RL environments Overall this is a huge win for neolabs huggingface.co/nvidia/NVIDI...

So @lchoshen.bsky.social posted a thread on X about how different training runs tend to converge, and I just had to argue with him. Training variation is fascinating, and I think we've kinda cracked it!

I did not imagine this was Charles Ebbets, but maybe I should have ? Also, was the person taking *this* photo also wearing jitterbug-ready footwear?

I guess it's fitting that it's a reimagined, worse version of someone else's artwork

What do we reveal about ourselves when we talk to AI? 🤔💭 In our new WiAIR – Women in AI Research episode, we speak with Maria Antoniak about personal disclosures in human–LLM conversations — and what they mean for ethical AI development. (1/8🧵)

There is no magic in transit policy, but this is as close as it gets. Congestion pricing works as intended, and the second order effects are amazing on their own. It's such a shame that because of the province's political cowardace we won't enjoy cleaner air and less congestion in Toronto.

Movie you've watched more than ~600~ six times with a gif. Hard mode: no Stars, LOTR, Pixar, Disney animation

Bullseye

Today's thought: if Wittgenstein had been alive to see the advent & use of LLMs, he would surely have died of exhaustion induced by continuously yelling at us all.

Guaranteed funding for five years and a 20% increase in a $39K base stipend if you haul in a fellowship. World class facilities and faculty in metabolism, structural biology, epigenetics, and beyond. Grand Rapids is half the cost of living of California or Boston. Apply by December 1st if interested

Look around. The case for more, not less, liberal arts education - actual, real education in reading, writing, thinking, arguing, analyzing, & synthesizing by doing the actual hard work for which there is no substitute - is stronger than it’s ever been at any point in human history.

Full slush fund. This should not be tolerated in a democracy.

If you discuss a "well-known" phenomenon in your paper, it should be a piece of cake to cite some works that support this assertion. A citation-free assertion that something is "well-known" makes me suspicious

Highly recommended. If you're looking for a sage voice for independent Canadian journalism with a focus on the environment, look no further

we released Olmo 3! lot of exciting stuff but wanna focus on: 🐟Olmo 3 32B Base, the best fully-open base model to-date, near Qwen 2.5 & Gemma 3 on diverse evals 🐠Olmo 3 32B Think, first fully-open reasoning model approaching Qwen 3 levels 🐡12 training datasets corresp to different staged training

In a new phase 3 trial, people randomly assigned to receive a flu shot made with modified mRNA were 34.5% less likely to be diagnosed with an influenza-like illness than people given a standard flu shot made with inactivated virus. We need to stop the anti-science attacks against mRNA vaccines!

Come do a PhD internship with me!

My first @umasschan.bsky.social/@impvienna.bsky.social affiliated paper is up! tomtom-lite is a re-implementation of tomtom targeting the ML age of genomics. Fast annotations ("what is this motif?") and simple large-scale discovery of motifs. Check it out! academic.oup.com/bioinformati...

Creating a caricature of your critics in order to dodge responsibility for the negative consequences of your votes is the real immaturity here. If you don't want to be held accountable for the way your votes affect Toronto, maybe councillor isn't the right job for you.

This is as close as I want to get to the trashful profile in the Times. This take is true, not only supported by how many of them have shamefully acquiesced to Trump this past year, but also by who is corruptly profiting in plain sight from it. Much shame to go around.

the aws cli is utter trash, a total disgrace to the fine lineage of shell tools.

you should quit social media if you can. if you can't, you should use apps that give you and old-school reverse chronological feed of posts from people you follow. yes, like bluesky. www.gelliottmorris.com/p/you-should...

Great piece by Zadie Smith. When the right talks about classics or "Western" culture, these works are only important to the extent that it demonstrates their superiority, they have no interest in art in and of itself beyond that www.theguardian.com/commentisfre...

That warm fuzzy feeling when you rediscover a bug in cpython that's been closed as `not planned` 🤪

Are you an early-stage graduate student (2nd or 3rd year) or early-stage postdoc based in the US or Canada, working primarily in Drosophila? Would you like to help improve the experience of all trainees working in Drosophila research? If so, read on. (Please repost to reach a broad audience.)

*Urgently* looking for emergency reviewers for the ARR October Interpretability track 🙏🙏 ReSkies much appreciated

We have recently uploaded our revised manuscript “Evaluating the role of pre-training dataset size and diversity on single-cell foundation model performance”. TL;DR: More models, more tasks => same results.

How much shit will Ontario continue to eat?

The way all of these people convinced themselves that Mamdani is antisemitic is a subject far more worthy of media examination than any of the ‘groupthink on campuses!’ thinkpieces we’ve been subjected to

First submission as an AE of TMLR. I hope I can do it justice 😁

A study out today in @natgenet.nature.com from Core Investigator Luke Gilbert, Haolong Li, & others identifies PTGES3 as a critical regulator of androgen receptor (AR) protein levels in prostate cancer, revealing a potential new target for tumors that become treatment-resistant.

Prosecution rests, defence may rest too? All this loafing around won't bring us to a conclusion

The committee clerk email is [email protected] Messages there will be translated and circulated to the full committee.

If you don't think rando MPs (and whoever else they share it with) should have access to personal information of individual applicants, reviewers, and students, confidential data, & full applications and reviews in every Canadian research grant (funded or not), please sign.

Nestle Brunch

Go Jays!

I absolutely applaud this, bravo!!

What the heck @sportsnetpr.bsky.social , this is the very worst time for your app to flake out. Boooooooo

Hello! The Narwhal is looking to talk to people in Canada who regularly send money home to Jamaica, Cuba, Haiti or the Bahamas and might increase it in the wake of Melissa. I am at [email protected] 💚

This is a step back after public outcry, which this government has done before: they're singularly attuned to polling. Retreat from disastrously bad policy isn't the same as a step towards better policy. I have no hope this is a first step to better housing policy. Not gonna happen with this gov

Please share🔉 We’re #hiring #AI #Engineers @columbiaseas.bsky.social @cancerdynamics.bsky.social 🚀Join us to build foundation models that learn & reason about cancer systems, integrating #LLMs #causalAI and multi-modal #genomics. Shape the next-generation of cancer therapies! tinyurl.com/5n7wp8ck

Leaders “have failed to support the one sector that makes Canada, well, Canadian: culture.” @hertzbarry.bsky.social crushed it here: www.theglobeandmail.com/culture/film...

We're excited to share that Dr. Omar Abdel-Wahab, a leukemia specialist at MSK, has been elected to the @nam.edu. With Dr. Abdel-Wahab’s appointment, a total of 28 MSK faculty members have been conferred with this recognition. Congratulations, Dr. Abdel-Wahab! bit.ly/49ezKw0