My quote of the day It might seem unfair to reward a person for having so much pleasure over the years, asking the maize plant to solve specific problems and then watching its responses. Barbara McClintock

Just to ensure the message gets through: this decision is not supported by scientific evidence (the phase 3 trial data looks pretty good); it's a case of mRNA derangement syndrome from administration in the FDA

I tried to take a photo of a grasshopper on my windshield, but now it looks like a gigantic bug destroying the town.

No joke: I got angry hate mail today for writing an obituary of a Black woman scientist—because the person felt she did didn’t deserve the recognition. Which just makes me want to share it again: www.nature.com/articles/d41...

Finally published! “Shared PRAME epitopes are T-­ cell targets in NUT carcinoma” We stumbled into working on a rare deadly cancer without effective treatments and found that some existing TCR therapies might be worth trying (at least work in vitro) Link: jitc.bmj.com/content/14/2...

*30 officers*!?!

@mattdoyle.bsky.social How crazy on a scale of (1) Galaxy brain - (10) Cocoa-puffs is the idea that TFC try to buy low on Chuky Lozano? - he plays in an area of need - he's productive in the league - SD is very motivated to sell - he'll cost much less than Sargent In how many ways is this wrong?

Try it out, it's a much-enhanced experience

Yes! So much more attention to "pre-training" (I'd really appreciate if we could drop this term) is warranted.

❤️

Now with a bioinformatics/genomics label 🖥️🧬

"I would love to believe that cycling infrastructure is coddled by the City of Toronto. But the policies, the maintenance standards, and the lived experience on our streets suggest otherwise." - @spacing.bsky.social h/t @thebikinglawyer.bsky.social @jnyyz.bsky.social spacing.ca/toronto/2026...

Will be on @therundowntvo tonight at 8pm ET talking about Carney’s speech, Greenland and yeah, that other guy.

Anyone think Pierre Poilievre would have delivered a speech like that? Me neither.

How the hell did I not know about this essay by Sasha Hemon earlier?!?!? lithub.com/fascism-is-n...

pfff, tough start today. Thought everyone in the whole world.

Alright folks, it's live. Get the Canadian government off of X. www.ditchx.ca will give you a template letter for Treasury Board (which sets communication policy across GoC) or individual ministries for mailing (no stamp!), emailing, or quick talking points for phoning.

CBC News is opening 11 new local bureaus across Canada — in BC, YK, SK, MB, ON, and QC — expanding coverage in communities from Richmond to Dawson City to Sept-Îles. www.cbc.ca/news/editors... #CBCNews

The world dedicates a Poland-sized area of land to producing liquid biofuels such as bioethanol & biodiesel. Is there a more efficient way to generate energy? Putting solar panels on the land used for biofuels, e.g., would produce enough electricity for all cars and trucks worldwide to go electric.

Let's see how rad this is ```python import shutil def dont_do_this() -> None: shutil.rmtree('/') ```

1/ We found that deep sequence models memorize atomic facts "geometrically" -- not as an associative lookup table as often imagined. This opens up practical questions on reasoning/memory/discovery, and also poses a theoretical "memorization puzzle."

#MLCB2025 proceedings are up at proceedings.mlr.press/v311/ !

Best 2025 summary thread so far, take that to the bank.

We know you know it: quality journalism costs money. That’s why we’re always posting these appeals for your support — it’s not for fun! (For fun, we watch Heated Rivalry.) But how far does your dollar actually go toward funding our work? We crunched the numbers:

Genome-scale perturb-seq in primary human CD4+ T cells maps context-specific regulators of T cell programs and human immune traits https://www.biorxiv.org/content/10.64898/2025.12.23.696273v1

Amazing, better than forecast. It could happen here if we wanted it.

Please consider attending and RT. Great lineup of speakers!

My resolution this year was to be kinder to anyone I had a face to face interaction with. This was my small gesture to try and resist or counterbalance the insane vitriolic hate that the powerful carelessly spilled into the world. It's hard to be kind. But I'll stick to kindness next year too.

Oh look, big tough-guy talk from councillors Saxe and Bradford. Both of whom opposed bus priority lanes on Dufferin and Bathurst. They don't care about faster transit, and care nothing for Line 6 riders. Both must be bored. Are there no sensible housing policy items for them to vote against?

Nemotron 3 A new hybrid mamba2/attention LLM from NVIDIA that beats Qwen3-30B-A3B (same size & shape) Notes: * 1M context, with incredible recall past 256K * New open datasets * 10 open source RL environments Overall this is a huge win for neolabs huggingface.co/nvidia/NVIDI...

So @lchoshen.bsky.social posted a thread on X about how different training runs tend to converge, and I just had to argue with him. Training variation is fascinating, and I think we've kinda cracked it!

I did not imagine this was Charles Ebbets, but maybe I should have ? Also, was the person taking *this* photo also wearing jitterbug-ready footwear?

I guess it's fitting that it's a reimagined, worse version of someone else's artwork

What do we reveal about ourselves when we talk to AI? 🤔💭 In our new WiAIR – Women in AI Research episode, we speak with Maria Antoniak about personal disclosures in human–LLM conversations — and what they mean for ethical AI development. (1/8🧵)

There is no magic in transit policy, but this is as close as it gets. Congestion pricing works as intended, and the second order effects are amazing on their own. It's such a shame that because of the province's political cowardace we won't enjoy cleaner air and less congestion in Toronto.

Movie you've watched more than ~600~ six times with a gif. Hard mode: no Stars, LOTR, Pixar, Disney animation

Bullseye

Today's thought: if Wittgenstein had been alive to see the advent & use of LLMs, he would surely have died of exhaustion induced by continuously yelling at us all.

Guaranteed funding for five years and a 20% increase in a $39K base stipend if you haul in a fellowship. World class facilities and faculty in metabolism, structural biology, epigenetics, and beyond. Grand Rapids is half the cost of living of California or Boston. Apply by December 1st if interested

Look around. The case for more, not less, liberal arts education - actual, real education in reading, writing, thinking, arguing, analyzing, & synthesizing by doing the actual hard work for which there is no substitute - is stronger than it’s ever been at any point in human history.

Full slush fund. This should not be tolerated in a democracy.

If you discuss a "well-known" phenomenon in your paper, it should be a piece of cake to cite some works that support this assertion. A citation-free assertion that something is "well-known" makes me suspicious

Highly recommended. If you're looking for a sage voice for independent Canadian journalism with a focus on the environment, look no further

we released Olmo 3! lot of exciting stuff but wanna focus on: 🐟Olmo 3 32B Base, the best fully-open base model to-date, near Qwen 2.5 & Gemma 3 on diverse evals 🐠Olmo 3 32B Think, first fully-open reasoning model approaching Qwen 3 levels 🐡12 training datasets corresp to different staged training

In a new phase 3 trial, people randomly assigned to receive a flu shot made with modified mRNA were 34.5% less likely to be diagnosed with an influenza-like illness than people given a standard flu shot made with inactivated virus. We need to stop the anti-science attacks against mRNA vaccines!

Come do a PhD internship with me!

My first @umasschan.bsky.social/@impvienna.bsky.social affiliated paper is up! tomtom-lite is a re-implementation of tomtom targeting the ML age of genomics. Fast annotations ("what is this motif?") and simple large-scale discovery of motifs. Check it out! academic.oup.com/bioinformati...

Creating a caricature of your critics in order to dodge responsibility for the negative consequences of your votes is the real immaturity here. If you don't want to be held accountable for the way your votes affect Toronto, maybe councillor isn't the right job for you.

This is as close as I want to get to the trashful profile in the Times. This take is true, not only supported by how many of them have shamefully acquiesced to Trump this past year, but also by who is corruptly profiting in plain sight from it. Much shame to go around.

the aws cli is utter trash, a total disgrace to the fine lineage of shell tools.