We have recently uploaded our revised manuscript “Evaluating the role of pre-training dataset size and diversity on single-cell foundation model performance”. TL;DR: More models, more tasks => same results.

How much shit will Ontario continue to eat?

The way all of these people convinced themselves that Mamdani is antisemitic is a subject far more worthy of media examination than any of the ‘groupthink on campuses!’ thinkpieces we’ve been subjected to

First submission as an AE of TMLR. I hope I can do it justice 😁

A study out today in @natgenet.nature.com from Core Investigator Luke Gilbert, Haolong Li, & others identifies PTGES3 as a critical regulator of androgen receptor (AR) protein levels in prostate cancer, revealing a potential new target for tumors that become treatment-resistant.

Prosecution rests, defence may rest too? All this loafing around won't bring us to a conclusion

The committee clerk email is [email protected] Messages there will be translated and circulated to the full committee.

If you don't think rando MPs (and whoever else they share it with) should have access to personal information of individual applicants, reviewers, and students, confidential data, & full applications and reviews in every Canadian research grant (funded or not), please sign.

Nestle Brunch

Go Jays!

I absolutely applaud this, bravo!!

What the heck @sportsnetpr.bsky.social , this is the very worst time for your app to flake out. Boooooooo

Hello! The Narwhal is looking to talk to people in Canada who regularly send money home to Jamaica, Cuba, Haiti or the Bahamas and might increase it in the wake of Melissa. I am at [email protected] 💚

This is a step back after public outcry, which this government has done before: they're singularly attuned to polling. Retreat from disastrously bad policy isn't the same as a step towards better policy. I have no hope this is a first step to better housing policy. Not gonna happen with this gov

Please share🔉 We’re #hiring #AI #Engineers @columbiaseas.bsky.social @cancerdynamics.bsky.social 🚀Join us to build foundation models that learn & reason about cancer systems, integrating #LLMs #causalAI and multi-modal #genomics. Shape the next-generation of cancer therapies! tinyurl.com/5n7wp8ck

Leaders “have failed to support the one sector that makes Canada, well, Canadian: culture.” @hertzbarry.bsky.social crushed it here: www.theglobeandmail.com/culture/film...

We're excited to share that Dr. Omar Abdel-Wahab, a leukemia specialist at MSK, has been elected to the @nam.edu. With Dr. Abdel-Wahab’s appointment, a total of 28 MSK faculty members have been conferred with this recognition. Congratulations, Dr. Abdel-Wahab! bit.ly/49ezKw0

I'm excited to share work on a research direction my team has been advancing: connecting machine learning derived genetic variant embeddings to downstream tasks in human genetics. This work was led by the amazing Divyanshi Srivastava! www.biorxiv.org/content/10.1...

We're excited to present LeaVS, a method to scale up learning for protein function models. It is based on the co-design of wet lab experiments and in silico training.

This whole thread is one sensible good idea after another for how we could return sports fandom to it's intended purpose, rather than a way for Ticketmaster to squeeze Canadians moreso.

"🇨🇦 is finally waking up to the risks of relying on the US for digital infrastructure, we mustn't lose this momentum." Great new piece from one of our policy research associates @canadianshieldinstitute.ca Emily Osborne that helps to set up some of the market + governance Qs re: sovereign cloud.

Absolutely fabulous, very envious of this setup. Wish we had the vision to bring it to a stop (any stop) in Toronto

Apply to join one of the top AI research 🤖 institutes in the world in the wonderful city of Montréal! I will be recruiting 1-2 students this year. Just mention my name in your application.

FC: Diagnose, prevent, treat, and cure disease. It is a noble calling. It is your calling. #ASHG25

As Transactions on Machine Learning Research (TMLR) grows in number of submissions, we are looking for more reviewers and action editors. Please sign up! Only one paper to review at a time and <= 6 per year, reviewers report greater satisfaction than reviewing for conferences!

For the weekend crowd. I'm hiring a postdoc! If you're interested in algorithms, data structures and high-dimensional inference, and if you want to invent new methods for genomics and implement them in high-performance, robust and easy-to-use software, do I have a lab for you; ours!

Pres. Kornbluth articulates such moral clarity in this rejection of the proposed “compact”: “the premise of the document is inconsistent with our core belief that scientific funding should be based on scientific merit alone” orgchart.mit.edu/letters/rega...

The Qwen team isn't playing around; they scaling around. #COLM2025

Now that I'm settled in at @umasschan.bsky.social, I'm hiring at all levels: grad students, post-docs, and software engineers/bioinformaticians! The goal of my lab is to understand the regulatory role of every nucleotide in our genomes and how this changes across every cell in our bodies.

Some multi-human agent AV collaboration just prior to Jacob Eisenstein's talk about multi-agent collaboration 😁 #COLM2025

PSA for folks at #COLM2025 this morning. As of 8:25, Registration is moving smoothly, not a massive lineup. So take your time & roll on in 😁

I'm also en route to #COLM2025, and would be glad to meet up with people and chat about building small LMs for enterprise uses, as well as data engineering and data synthesis

This doesn't seem like the most consequential abdication of responsibility by the Ford government, but it's the simplest one to have avoided: just buy solar generation, coupled with battery storage. Cheapest, fastest twin solution to Ontario's energy and GHG reduction. www.tvo.org/article/anal...

really neat clear explainer for the new on “centralizing flows” to theoretically model learning dynamics

Ontario will continue to enable graft like this until more Ontarians get sufficiently upset about it. Apparently - the corrupt Greenbelt deal - the corrupt Ontario Place deal - the abuse of rights via the notwithstanding clause - this corruption aren't enough to sour people on this government 🤷‍♂️

Excited to share a new paper that aims to narrow the conceptual gap between the idealized notion of Kolmogorov complexity and practical complexity measures for neural networks.

"The grocery giants in this province would really, really like to keep making all the profit from alcohol sales without even the slightest bit of environmental or social reciprocity." — @jm-mcgrath.bsky.social

With September 30 marking National Day for Truth and Reconciliation, APTN News looks at how many of the 94 Calls to Action have been answered since the Truth and Reconciliation Commission delivered its final report in 2015.

Super excited to get this out. This collab started a few years ago and is the first paper from it. Here, with experimental and computational approaches we: 1. establish that cell villages can be just as accurate (one might argue more accurate!) than arrayed-based designs bsky.app/profile/bior...

I have been driving for 20 years and never once got a speeding ticket. Speed cameras work, they save lives, you can very easily avoid fines by driving like a normal person. Most people know this, too. That's why they're popular.

Or many people habitually speed, and occasionally those result in injuries and death from collisions. He isn't dumb, but he's presuming that *you* are dumb. Don't be dumb.

It feels classically dystopian to deliver an announcement in front of a lectern emblazoned with "Protect Ontario" where they're likely to announce legislation that will make Ontarians less safe. But here we are.

In another preprint from the @brianhie.bsky.social Lab and @synbiogaolab.bsky.social, they introduce Germinal, a generative AI system for de novo antibody design. Germinal produces functional nanobodies in just dozens of tests, making custom antibody design more accessible than ever before.

This is great news!!!

Wow

As scientists and educators, we can help our students and their families wrestle with complex issues. I just send this message to my Genetics class, and the relevant link to the study jamanetwork.com/journals/jam...

I really worry about how it's simultaneously true that the building industry is in trouble, yet there's no visible discussion as to the obvious: very few of the vacant condos are suitable for the market. People don't want to live in them even amidst a housing crisis. Is BILD talking about this?

We are excited to share GPN-Star, a cost-effective, biologically grounded genomic language modeling framework that achieves state-of-the-art performance across a wide range of variant effect prediction tasks relevant to human genetics. www.biorxiv.org/content/10.1... (1/n)

Steve Silberman is not here to shout it — so it’s up to all of us. Vaccines don’t cause autism. Neither does Tylenol. (I mean seriously WTF?!?!) The “epidemic” of autism is the result of increased testing, broader definitions, and raised awareness. LOUDER.

The best days of Toronto are certainly ahead of us. Honestly the biggest impediment to Toronto realizing it's potential is an adversarial provincial government. It's bizarre that it's politically beneficial for the ONPC to hate on Toronto, yet economically terrible for the province.