Incredible! Scientists receive a rare standing ovation after announcing that a new treatment can double the survival time for pancreatic cancer, the deadliest cancer which was once considered “undruggable.” When we fund and support science, we can achieve anything! (Video: Dr. Wish Dhillon)

"One thing that actually propelled actual US greatness after World War II was tying large scientific investments to a non-partisan, merit-based process. But that is not the way of Trump, who wants to extend tools of control and retribution over science." Trump is wrecking everything. Illuminating:

Rec League Nelson White ~ Mi'kmaq c. 2026

Sonny Rollins was the last surviving musician from Art Kane’s famous photo “A Great Day In Harlem.” Image: Art Kane

The old centre was 568,000 ft.². The new one is 280,000 ft.² (The province is floating a misleading number of 400k but that reflects a math error, plus 120k is a parking garage.) The old building’s exhibition space was 134k. The new one has 120k. Not bigger. Smaller.

Discover BEstimate: a tool streamlining CRISPR base editing with precise gRNA design, targeting site analysis, and off-target predictions! 🧬✨ PMID:42045938, Genome Biol 2026 @OTSociety @NAR_Open https://doi.org/10.1186/s13059-026-04077-z #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Doug Ford balked on his home building promises / & reforms by giving in to his nimby base, people who are also afraid of people without homes. Good luck Ontario.

The Church Street pedestrianization project is APPROVED 20-4. Church between Wellesley Street East and Alexander Street will be made car-free between June 19 and August 21.

Councillors will propose literally any approach to pedestrian safety, as long as it does not include requiring drivers to pay attention and follow the law

"A SAFER ONTARIO MEANS FEWER STOLEN CARS so you can speed through school zones at 90km/hr with complete impunity & Doug Ford's blessing since he banned speed cameras to allow you to do that"

The form, revealed! If you go ahead through the hoops, you might as well send the same material to your MPP, MP, city rep, friends, family, neighbourhood association — the sky is the limit! I’d love to hear from anyone who is inspired to have their say! #NoJetsTO #TOpoli #ONpoli

From Safe Parkside: look what happened on Parkside Drive after Premier Doug Ford banned speed cameras.

Struggling desperately to get to the end of this dreadful paper I've been assigned to review. So, so boring.

Bhattacharya: "I don't see a bottleneck now.... My job is to make sure every single dollar goes out, and it will go out by the end of the year on excellent science. A lot of the concerns, it just seems like political noise to me. It's not reality." Reality... 🧵1/6 www.27unihted.org/jay-fact-che...

Today, we published 61 transcripts and excerpts of testimony heard by the Fulton County special purpose grand jury. The transcripts include the never-before-seen testimony of prominent Trump allies, including Rudy Giuliani, Lindsey Graham, and Cleta Mitchell. bsky.app/profile/anna...

Seems rude to point it all out sheesh

1/7 New paper accepted as ICML spotlight arxiv.org/abs/2605.03517! We unify self-supervised learning (SSL) algorithms (e.g., contrastive, VICReg, stopgrad) via latent distribution matching (LDM), which matches an induced latent distribution to an explicit latent model.

go.bsky.app/AJubGZF I made this starter pack with ML/AI companies on Bluesky. For now it's a bit short, but we hope to see it growing as more companies land on here. If you are interested, please follow them to encourage them staying on Bluesky. If I missed any, pls let me know to add them!

NEW: That didn’t take long. It looks like freedom of information requests relating to ministers and their offices are already being knocked back by some FOI departments really only hours after the budget received royal assent. #OnPoli

@tombogert.bsky.social any idea if Martino's son is coaching with him?

Why is it that when a driver nearly hits you with their car, in a situation where it's clearly their fault (not paying attention, looking at their phone, etc), they get *so mad* at you for shouting to get their attention to stop?

I’m not crying, you’re crying. ❤️ www.cbc.ca/news/world/b...

Share far and wide. 🧪🧬🔬🩺🛟

Jay Bhattacharya pulls a study because he doesn’t like the conclusions. I cannot explain how bad this is and how it reeks of the stench of ideological zealotry and has no basis in science. www.nytimes.com/2026/04/22/u...

Has anyone have experience with data versioning tools? I'm looking at lake FS or DVC, but there are others surely that people have opinions about? 📈🤖 #ml #datascience

SCOOP: Two weeks ago, the head of the CDC delayed publication of a report showing covid vaccine cut likelihood of ER visits and hospitalizations by half. Now that report is no longer allowed to be published in CDC’s flagship scientific journal. My latest. 1/2 www.washingtonpost.com/health/2026/...

This remains the greatest piece of persuasive advertising ever made about electrification. It's insane to me that Nissan dropped it & it's insane that no one on the green left has picked it up to make it a national PSA.

THREAD: The IEA global energy review 2026 * CO2 record high, but growth nearly ground to halt * Clean energy shaved 3bn tonnes off CO2 * Fossil-fuel power pushed into reverse * Age of Electricity "confirmed" * "Extraordinary" solar growth * Batteries up 40% * EVs up 20% 1/10

It's hard to overstate how much of an advance that result is. Mean survival for pancreatic is very low (owing to lateness of stage at discovery & other factors). A true breakthrough

There needs to be a giant billboard in every major American city that touts this. In any other era except this suicidal science administration, this would be a miraculous, wondrous thing.

At what point do people in Ontario rise up and say, we have no hospitals or schools, and you are buying jets so you can fly from the Toronto islands to Muskoka, and this is too fucking much? You can only buy so many ads and buy off so many drivers, before it is too fucking much

New paper: Back into Plato’s Cave Are vision and language models converging to the same representation of reality? The Platonic Representation Hypothesis says yes. BUT we find the evidence for this is more fragile than it looks. Project page: akoepke.github.io/cave_umwelten/ 1/9

It's a gift, and if opposition parties can't do anything with it, and if the Ontario voter eats it, well, I dunno.

Large study of the effects of mRNA COVID vaccination impacts in France. jamanetwork.com/journals/jam... 1/3

We are so excited to see our work out in @nature.com! We present a multi-omic single-cell atlas of 12 organs in human fetal development, explore the enhancer landscape, use deep learning to infer rules of transcription factor activity, and interpret non-coding variants in complex traits: #GeneReg 🧬🖥️

This is great journalism. Also, this is why access to information about who provincial officials are being lobbied by is *absolutely essential* for the public to know.

I travelled 27 hrs, fought endless visa issues to give this talk for our award-winning paper at #CHI2026. Your turn to show up 📍 P1, Room 112, Apr 15 (Wed), 12 noon. But why? I wish the didn't impact every knowledge worker. Sadly, it does, and we need to talk about it. 1/n

I'm noticing the gradual accretion of errors in datasets based on the sloppy application of LMs to extract questions and process answers. One example: prompt applied to GPT4 to extract questions, supporting material, answers from a text. Error-prone, collating info from all over, no error checking.

Ok, you've gotta give us *some indication* of what's going on. Please do better @ttcalerts.bsky.social

Enbridge is making a solid effort to be the worst large company in Canada, which is a high bar to clear.

Tl;dr: two preprints on contrastive PCA w/ Maria Carilli and Kayla Jackson solve the non-spatial setting, spatial contrastive PCA, and contrastive functional PCA. www.biorxiv.org/content/10.1... www.biorxiv.org/content/10.6... 17/17

Precisely. Get it together @mark-carney.bsky.social

One of thew few senior scientists who is willing to take a stand and speak up--I'm thankful for Jack and wish more of his colleagues would follow him

Man, how many divers does it take to inflate and tie up a raft?

That's grand Doug, but if you hadn't cancelled over 800 projects back in 2018, we'd have more power, for less (😑😑😑), online by now. So, thanks for catching up to where the rest of us were back in 2015. www.thestar.com/politics/pro...

A lot of Canucks feel pride at a Canadian astronaut on a moon mission. The Carney government is milking this opportunity to associate itself with those good feelings while cutting nearly a third of all funding for Canada's space agency. www.canada.ca/en/treasury-...

Warms my heart to read science like this. So, so good.

Sequence Display generates large-scale protein sequence–activity datasets by simultaneously reading out the sequence of interest and a downstream editing efficiency - perfect for data hungry ML methods! Happy to have played a small part in this!

Apropos of nothing, if you set up a GitHub repo meant to support reproducing the results of your paper, yet withhold the data, you haven't done what you think you've done.

While politicians were fighting it out in public, scientists, technicians, and diplomats were working quietly on a cooperative project. Frankly, we could use a lot more international cooperation in space and other scientific endeavours. 6/8