That's grand Doug, but if you hadn't cancelled over 800 projects back in 2018, we'd have more power, for less (😑😑😑), online by now. So, thanks for catching up to where the rest of us were back in 2015. www.thestar.com/politics/pro...

A lot of Canucks feel pride at a Canadian astronaut on a moon mission. The Carney government is milking this opportunity to associate itself with those good feelings while cutting nearly a third of all funding for Canada's space agency. www.canada.ca/en/treasury-...

Warms my heart to read science like this. So, so good.

Sequence Display generates large-scale protein sequence–activity datasets by simultaneously reading out the sequence of interest and a downstream editing efficiency - perfect for data hungry ML methods! Happy to have played a small part in this!

Apropos of nothing, if you set up a GitHub repo meant to support reproducing the results of your paper, yet withhold the data, you haven't done what you think you've done.

While politicians were fighting it out in public, scientists, technicians, and diplomats were working quietly on a cooperative project. Frankly, we could use a lot more international cooperation in space and other scientific endeavours. 6/8

My @thestar.com column: There’s lots of disagreement about Toronto transit projects, but damn near everyone can agree about one thing: electrifying and increasing GO Train service is a great idea. It’s a real shame Doug Ford’s government has screwed it up again. www.thestar.com/opinion/cont...

Loved this book from cover to cover, a really interesting read for even the most mildly curious urban transit nerd

Polarization isn't inherent, it's a decision

Excellent quote in this talk: "We can complain about X all day [...] But we should build things too." Super inspiring presentation by @mariaa.bsky.social happening now. The safety features built into Lea are brilliant; indiesky take note! #atmosphereconf

Ran on building housing. Balked at making four plexes legal across ontario. Ramming jets downtown so 1000s of new units may be cancelled. Ontario voter, tell me how you make it sense of it? Are you so comfortable it doesn't matter? Is the culture war stuff thrilling?

This is an epic Ford failure and he should lose the GTA over it., Over to you, Ontario voter.

How do survey papers provide value in this day and age? I can see one: survey but argue for the net benefits of one particular approach. Are there others? Seems like a question we should think about when composing a thorough survey paper is possible for anyone with access to a variety of models.

How much time & money will the Ontario voter allow the Ford govt to spend on a conservative culture war issue? Blank cheque?

Reminder: the airport claims it's very important to the economy, but zero independent studies demonstrate this, and their own "report" is deeply flawed bsky.app/profile/alex...

Bayesian Sensitivity of Causal Inference Estimators under Evidence-Based Priors Nikita Dhawan, Daniel Shen, Leonardo Cotta, Chris J. Maddison Action editor: Amit Sharma https://openreview.net/forum?id=0zqt85NUyK #causal #sensitivity #priors

Do any of you find that the older you get, the less patient you get? I'm seeing this in myself and I do not like it.

"Transportation Minister Prabmeet Sarkaria's office declined to comment." Everyone along Eglinton stands ready to welcome you all to the "WTF Metrolinx?" table. On Wednesdays, we wear pink.

He also thinks building a fantasy island off Toronto's shore, a tunnel under the 401, and ending transparency on his business/government dealings (are we still paying Elon Musk for Starlink?) are good. 55% of job losses were in Ontario, and none of these good things help that story.

New from me at TVO: the government's formal justification for gutting FOI law is nonsense and the only upside to all this is that legislative power can be a shield for this government and a sword for the next. www.tvo.org/article/anal...

I imagine there are bad but real reasons: - We probably don't have sufficient generation & distribution capacity for electricity (yet) - The government hasn't budgeted for this to be done in a reasonable time (they don't like trains, and def don't like ⚡ ones) In conclusion, voting matters.

This is kinda bonkers. In addition, 20 amino acids were found on Ryugu, along with uracil and vitamin B3. These have been found in other instances, but since the samples from Ryugu were collected directly from the asteroid and delivered in sealed capsules, contamination on Earth could be ruled out.

Breast cancer mortality dropped 58% from 1975 to 2019. Localized, early detected breast cancer has a 99% 5 year survival rate. Modern mammogram tech was developed by NASA for telescopes. Last year, RFK Jr. cancelled 87 research grants on breast cancer. www.nytimes.com/2026/03/16/u...

Simple truths

The Ontario government wants to rewrite the law that compelled it to disclose documents revealing the Greenbelt land scandal, the Skills Development Fund controversy and others. For @nationalobserver.com 🧵

This demonstrates why ministerial actions and paperwork should remain, rightly, within the public's realm of access to information.

This is a nuclear bomb to Ontario's democracy. The Ford government wants to obfuscate absolutely everything it does.

Please consider writing your MP and MPP about this. Doug Ford's obsession with re-litigating old Toronto city government grievances is getting in the way of responsible government. Not all Ontarians approve of his nonsense, and frankly more elected officials, and the public, should hear about it.

Both Sides 2 Joni Mitchell 1999

When you ask Claude Code to refactor a script, it turns into Martin Fowler

How in the hell would these geniuses think it was at all sensible to allow a private vendor to own vehicle location and arrival prediction data for this public transit?!? Metrolinx is rotten.

In a scathing review, the top US medical journal's editorial board warned that the "destruction that Kennedy has wrought in 1 in office might take generations to repair."

Don't build stupid artificial islands that nobody wants or needs, don't propose insane tunnel highways nobody think are feasible, do fund education adequately. Governing ON is hard, but not that hard.

This *is* insane. His ignorance knows no bounds, nor does his contempt for the city. The sooner we're rid of him and back to saner governance, the better.

Goes without saying that Orwell did not say the thing she attributed to him.

A new preprint with Matthew Schmitt, @kiseokmicro.bsky.social and Vincenzo Vitelli makes a huge step forward in learning functional groups of components in complex biological systems. It's dimension reduction that speaks to biological function. www.biorxiv.org/content/10.6...

Recognizing this pattern is one of the most important things in thinking about what principles and values ought to guide urban planning.

Winter Road, Night Illingworth Kerr 1985

For anyone under this misconception: the "good times" vibes had *nothing* to do with Tory. That was the feds & province plus previous council's work. Tory's legacy was gradual starvation of the city by a refusal to fund it via taxation, and boondogles like SmartTrack. He had no vision. Bye Felicia.

FC Dallas have three shots on goal, and three goals. Not a great night for Luka Gavran, and not a great start defensively for TFC 😔

@mattdoyle.bsky.social does the Salloi & Sargent signings (Tommy Scoops served up a double cone this AM) bump TFC up a tier (albeit to 'unconvincing')? Or would you still say the team is rebuilding? Or maybe we should see them play football first?

I had my first new good idea today since I fell ill with a cold, about 12 days ago. Thank goodness.

Wow

So much of our present crisis is coddled, ignorant, and short sighted people tearing down the institutions that protect them because they don’t understand that bad things can happen.

My quote of the day It might seem unfair to reward a person for having so much pleasure over the years, asking the maize plant to solve specific problems and then watching its responses. Barbara McClintock

Just to ensure the message gets through: this decision is not supported by scientific evidence (the phase 3 trial data looks pretty good); it's a case of mRNA derangement syndrome from administration in the FDA

I tried to take a photo of a grasshopper on my windshield, but now it looks like a gigantic bug destroying the town.

No joke: I got angry hate mail today for writing an obituary of a Black woman scientist—because the person felt she did didn’t deserve the recognition. Which just makes me want to share it again: www.nature.com/articles/d41...

Finally published! “Shared PRAME epitopes are T-­ cell targets in NUT carcinoma” We stumbled into working on a rare deadly cancer without effective treatments and found that some existing TCR therapies might be worth trying (at least work in vitro) Link: jitc.bmj.com/content/14/2...