this is a materpiece by the young and brilliant @filippodamico.bsky.social everything you know about blood pressure targets is from (old) animal studies and different animals have different thresholds! freely availbale on @signavitaejournal.bsky.social

Our latest issue contains a editorial by our Editor-in-Chief @giovannilandoni.bsky.social and @martinabaiardo.bsky.social about Prof. Rinaldo Bellomo, a great scientist and physician that inspired many, but sadly passed away this year www.signavitae.com/articles/10.22514/sv.2025.091

Published today! #MICROCLOTS in the lungs of #ARDS patients a well-recognized phenomenon among senior experts (unknown by the rest till #COVID19 ) important clinical implications link to the article pubmed.ncbi.nlm.nih.gov/40754474/

Reads the full article at: 🔗 www.signavitae.com/articles/10....

💉 Regional anesthesia is revolutionizing cardiothoracic surgery! Reducing opioids speeds recovery and improves outcomes Paravertebral blocks, erector spinae blocks, and wound catheter anesthesia are becoming the go-to for pain management 💊Less opioid = less side effects!

⏱️ Time is muscle in cardiac emergencies! In conditions like MI, arrhythmias, and heart failure, every minute counts Early recognition + rapid intervention = better outcomes Read more on timely interventions in our latest review: www.signavitae.com/articles/10.22514/sv.2025.093 #CardiacEmergency

We finally landed also on Instagram! We are a peer-reviewed, open access, journal about Anesthesia, Intensive care, Emergency and Pain Medicine. 👉 Follow us today and help shape the future of critical care! Find more about us at www.signavitae.com

STOP WASTING TIME YOU COULD USE DOING RESEARCH! Just upload your files when you are submitting the manuscript. Don't worry about typesetting rules or a specific reference style, you can submit your manuscript to Signa Vitae in any format of your choice

🚨Solid organ transplant patients in the ED? 🩺Don’t miss this comprehensive update on diagnosis, infection management, drug interactions & organ-specific pitfalls A must-read for emergency & acute care teams 🔗 www.signavitae.com/articles/10.22514/sv.2025.092 #TransplantMedicine #EmergencyMedicine

we identified a patient-specific pro-hemorrhagic phenotype link.springer.com/article/10.1...

💉 Safer sedation in obese patients! Remimazolam + Sufentanil outperforms Propofol in painless colonoscopy: 🔻 Less apnea (26% vs 50%) 🔻 Less hypoxemia (32% vs 66%) 🔻 Less injection pain (8% vs 34%) 🔗 www.signavitae.com/articles/10.22514/sv.2024.085 #Anesthesia #SignaVitae

Follow us on all other social media X: x.com/MRE_signavitae LinkedIn: www.linkedin.com/company/signa-vitae Facebook: www.facebook.com/profile.php?id=100064149758501

🫁 What really defines ventilator-associated pneumonia in critically ill children? 👉 This narrative review compares current clinical and epidemiological definitions, aiming to support more accurate diagnosis and surveillance 🔗 www.signavitae.com/articles/10.22514/sv.2023.050 #ICU #Ventilation

🫁Is Direct Laryngoscopy better than Direct+Video Larygoscopy? 🥼96 residents tried the different approaches with different results ‼️ You may find the results unexpected 🔗 signavitae.com/articles/10.22514/sv.2023.053 #AirwayManagement #SignaVitae #MedEd #FOAMed

🚨 #BackPain? There’s a smarter way to treat it 💊A new review shows how combining Dexketoprofen + Tramadol can relieve pain fast while reducing the need for strong opioids A smarter, safer approach to acute pain 🔗 www.signavitae.com/articles/10.22514/sv.2025.078 #PainManagement #SignaVitae #MedEd

Authors, editors, reviewers, and other potential users should use CONSORT 2025 when writing and evaluating manuscripts of randomized trials to ensure that trial reports are clear and transparent. Learn more in this Special Communication. https://ja.ma/3TlnKQe

Me as a kid reading Dune: I don’t get why their whole society is built around the eradication of A.I., seems like they’re wasting a lot of tech Me as an adult: oh that’s why

Today our Editor-in Chief, Professor Giovanni Landoni , had a lecture with @nejm.org Editor-in-Chief, Professor Eric Rubin, organised by Unisr in Milan, Italy

👑Live from #CCR25 the #Princetrial 🫀Does remote ischemic preconditioning reduce troponin levels after surgery? A preview on the matter is in #signavitae 🔗 www.signavitae.com/articles/10.22514/sv.2024.151 @giovannilandoni.bsky.social @mmarmiere.bsky.social

Spoiler alert: what you would expect #foamed #foamcc #meded #medsky #cccsky #emimcc www.nejm.org/doi/full/10....

🩸#ANHtrial results are live #CCR25 A survey from the authors: www.signavitae.com/articles/10.22514/sv.2025.076

ANH trial Results: In patients undergoing elective cardiac surgery, acute normovolaemic haemodilution, compared with usual care, did not reduce the number of patients requiring blood transfusion during their hospital stay. #CCR25

Presented at #CCR25: In the ANH phase 3 trial involving adult patients undergoing elective cardiac surgery, acute normovolemic hemodilution did not reduce the number of patients receiving allogeneic red-cell transfusion. Full trial results: nej.md/3FxdMrW @criticalcarereviews.com

O2O2O2O2O2O2O2O2 o2o2o2o2o2o2o2o2 oxygen is 21% of what you breath, wherever you are (underground or climbing an high mountain, crowded room or in a forest) with the notable exception of H (mainly ICU) and with a surprising ignorance of which % is the best @criticalcarereviews.com

🚨 Just 20 days to #CCR25! 12 major trial results in our unique long form format ➡️ Independent editorials & panel discussions ➡️ Clinical impact of these results explored ➡️ Join us in person or virtually (free livestream or paid if you want CPD/CME) criticalcarereviews.com/meetings/ccr25

🚨 FLUID Trial Results🚨 Balanced crystalloids vs saline in hospitalised patients 📍 16 Canadian hospitals 👥 >144,000 pts 😮 🏁 Cluster-crossover RCT 📊 90-day death or readmission ➡️ Big trial ! ➡️ Big numbers ! 🚩 The answer drops at #CCR25🚩

🚨 ENCOMPASS TRIAL Results at #CCR25🚨 📍 8 hospitals 👥 4032 patients 📊 Stepped-wedge cluster RCT 🎯 Tests STAR: nurse-led, telehealth care for high-risk sepsis survivors 🩺 Outcomes: 90-day readmission or death 📺 Free livestream — but it’s better in person!

🚨 RESCUE 3 TRIAL Results 🚨 📍 33 sites 🇺🇸🇫🇷🇩🇪 👥 n=223 📊 Open-label RCT 🎯 Lungpacer diaphragm pacing after ≥2 weaning attempts & ≥96h MV 🩺 Outcome: Successful weaning by D30 🤔 Is this the future of mechanical ventilation? 📺 Free livestream, but it's better in person

In memory of professor Rinaldo Bellomo: A giant of intensive care medicine CCR Journal Watch - tracking the critical care literature daily https://doi.org/10.1016/j.ccrj.2025.100110

🚨UK-ROX TRIAL Results at #CCR25🚨 📍 ~100 🇬🇧 ICUs 👥 ~16,500 pts 🎯 Conservative vs usual oxygen therapy in invasively ventilated adults 🩺 Outcome: Mortality day 90 🤔 Will less oxygen save lives? 📺 Free livestream — but it's better in person! 🔗 criticalcarereviews.com/ccr25

🩸 Our new meta-analysis on arterial line blood cultures Contamination rate with arterial catheter–drawn cultures was comparable to venipuncture & lower vs venous catheter–drawn cultures 📌 In critically ill adults, arterial line sampling may be a reasonable alternative. doi.org/10.1093/cid/...

wow this personalized approach by Fabio Guarracino (Pisa, Italy) is really attractive for ICU patients

What makes a successful RCT? Any idea on what to say here in Washington tomorrow? www.kdctmeeting.com

C-POPE or C-PAP? after Pope Francis used non invasive ventilation for days, we might start call C-PAP as C-POPE to improve dissemination among lay people and physicians who did not read our @bjajournals.bsky.social article presented in @criticalcarereviews.com pubmed.ncbi.nlm.nih.gov/39753402/

The initiation of vasopressin following recommendations by a reinforcement learning model was associated with decreased mortality in patients with septic shock already receiving norepinephrine. https://ja.ma/3FOK2WU #ISICEM25

Among patients with moderate to severe ARDS, inhaled sedation with sevoflurane resulted in fewer ventilator-free days at day 28 and lower 90-day survival than sedation with propofol. https://ja.ma/4kxDZGm #ISICEM25