🧠💥 Elevated APRI at admission predicts higher mortality in moderate–severe traumatic brain injury. A cutoff of 0.59 identified patients at risk, with AOR 1.67 for death. Simple labs, strong signal for prognosis. 🔗 doi.org/10.22514/sv.... #Trauma #CriticalCare #ICU #NeuroTrauma #EmergencyMedicine

🫀 Fatigue hits CPR performance 🌊After 100 m and 200 m beach rescues, lifeguards’ CPR quality dropped from ~90% at rest to ~78% — same decline regardless of distance 🫀Training under fatigue is essential to improve survival in drowning scenarios 🔗 doi.org/10.22514/sv.2025.159

🫀Low cardiac output syndrome remains a major driver of morbidity and mortality after adult cardiac surgery 🩺This review dissects its definitions, drivers, and the performance of inotropes and mechanical support. A must-read for anyone managing shock 🔗 doi.org/10.22514/sv....

🚨New horizons in resuscitation! ECMO is revolutionizing non-traumatic critical care From cardiac arrest to ARDS and poisoning, this review explores expanding indications, techniques, and outcomes 🔗 doi.org/10.22514/sv.... #ECMO #ECPR #CriticalCare #Resuscitation #SignaVitae

🩸🚑 Low pulse pressure sharply boosts mortality risk in trauma, especially at SBP extremes New model reveals a bimodal mortality pattern and a sharp risk rise with low PP in early trauma care 🔗 doi.org/10.22514/sv.... #Trauma #CriticalCare #EmergencyMedicine #Hemodynamics

Emergence delirium remains a challenge after pediatric tonsillectomy This RCT reports an 80% reduction with peritonsillar bupivacaine infiltration suggesting pain control may hold the key How would this influence your PACU practice? 🔗 doi.org/10.22514/sv.2025.144 #Anesthesia #PainMedicine #Delirium

🚨 New model to predict sepsis-associated DIC! Using MIMIC-IV data, researchers built a tool combining inflammation, coagulation & RBC markers (SOFA, INR, RDW…) 📈 AUC 0.78, better than single indicators Early detection saves lives 🔗 doi.org/10.22514/sv.... #Sepsis #LLM #AI #CriticalCare

🧠 Tormentic acid shows potent neuroprotection in stroke models reducing microglia-driven inflammation and blocking NF-κB activation A natural compound with therapeutic promise for ischemia-reperfusion injury 👉 doi.org/10.22514/sv.... #Neuroprotection #Stroke #criticalcare

🧬A new protocol for metabolomics and cytokine profiling could transform how we understand and treat #ARDS Standardized multi-omic analysis enables precise phenotyping and opens the door to truly personalized critical care doi.org/10.22514/sv.... #CriticalCare #Metabolomics #ICU #FOAMed #meded

🩺A year of impact in #CriticalCare! From groundbreaking sepsis insights to #AI saving lives in the #EmergencyDepartment explore the top Signa Vitae papers of 2024, redefining how we care for the critically ill 🔗 doi.org/10.22514/sv.... #ICU #Sepsis #Anesthesia #FOAMed #Meded

💨 Every breath in the OR has a climate cost 💤Anesthetic gasses can warm the planet up to 2,500× more than CO₂! 📚This new review calls for a green revolution in anesthesia low-flow, TIVA, and regional techniques can slash emissions by >80% 🔗 doi.org/10.22514/sv....

🧪Elevated LHR, SIRI, and SII values at ICU admission independently predict hyperactive delirium 🔥Simple inflammatory biomarkers may enable early risk stratification and improve patient outcomes 🔗 doi.org/10.22514/sv.2025.133 #CriticalCare #delirium #Biomarkers #inflammation #ICU #FOAMed #MedEd

🥑Can diet protect the heart? A multicenter study finds omega-3 intake cuts sudden cardiac arrest risk in men by 50%, but not in women ♂️♀️Sex-specific differences may guide tailored prevention. 🔗 doi.org/10.22514/sv.2025.128 #cardiacarrest #diet #cardiology #FOAMed

🧒In pediatric trauma, the lactate-to-albumin ratio (LAR) strongly predicts mortality 🧪Early measurement can identify high-risk patients and guide life saving decisions in the PICU 🔗 doi.org/10.22514/sv.... #Pediatrics #peds #TraumaCare #CriticalCare#ICU #FOAMed #Meded

👁️ New in Signa Vitae: CT-measured optic nerve sheath diameter (ONSD) helps spot methanol intoxication & predict outcomes Cut-off 5.57 mm → 85% sens., 80% spec. 🚑A potential game changer in the ED 🔗 doi.org/10.22514/sv.2025.129 #EmergencyMedicine #Toxicology #CriticalCare

💔 In intensive care, every line counts. 👶 1 in 3 central venous catheters in critically ill children are misplaced — risking complications when they’re most vulnerable. ✨ Smarter placement could save young lives. 🔗 doi.org/10.22514/sv.... #PICU #Pediatrics #PatientSafety

📊 Our retrospective study finds no difference in hemodynamic stability between low-flow sevoflurane and desflurane during laparoscopic sleeve gastrectomy Evidence supports low-flow anesthesia as safe & feasible in obese patients 🔗 www.signavitae.com/articles/10.22514/sv.2025

🌀 After the 2023 Türkiye earthquakes, cases of scabies & other itchy skin diseases surged in overcrowded shelters 🧼Better hygiene, clean water & safer housing are vital to protect survivors 🔗 doi.org/10.22514/sv.... #Earthquake #Health #dermatology #Turkiye #Hygiene

🤖Can AI help doctors read and interpret blood tests? A new study shows #ChatGPT can interpret arterial blood gases as well as physicians 💡This could lighten workloads and support faster, safer care in the ICU 🔗 doi.org/10.22514/sv.2025.138 #Healthcare #AI #FutureOfMedicine #MedEd

🌍💉 Should anesthetic gases like desflurane really be banned for their climate impact? This new editorial argues that their effect on global temperature is negligible & reversible raising questions about science vs policy in medicine 🔗 doi.org/10.22514/sv.... #Climatechange

🚑 Rapid sequence intubation is a lifesaving procedure but hypoxemia during intubation can be deadly ❓Can HFNC make intubation safer? A new review explores how this technique could help patients at risk of hypoxemia 🔗 doi.org/10.22514/sv.... #Criticalcare #anesthesia #icu #emergenymeddicine

😷 Feeling “just weak” or “tired” can land many older adults in the ER. But these non-specific complaints don’t always mean worse outcomes. Our study across 8 hospitals shows they often stay longer in the ED—but need ICU less often than those with clear symptoms. 🔗 doi.org/10.22514/sv.... #elderly

In the September issue of SIGNA VITAE there will be 4 articles on volatile anesthesia! Two of them on the global warming potentials debate Stay tuned on www.signavitae.com and on your favorite social media #climatechange #globalwarming #anesthesia #volatile #emergency

🧠 Pediatric stroke is rare but devastating This case links Epstein-Barr virus to focal cerebral arteriopathy, urging clinicians to consider viral triggers in acute pediatric neurologic events ⏱ Early imaging Full recovery www.signavitae.com/articles/10.22514/sv.2025.119 #Neurology #EmergencyMedicine

This study shows gastric ultrasound correlates well with residual volume even across different feeding protocols ✅ Less interruption ✅ More patient comfort Ultrasound might just be the new standard in ICU nutritional monitoring 🔗www.signavitae.com/articles/10.22514/sv.2025.111 #CriticalCare #ICU

🫁 Life after steroids? This real-world study shows rapid improvement in asthma control and quality of life after starting benralizumab — even in patients with comorbidities. The message is clear: the biologic era in severe asthma is here to stay 🔗 www.signavitae.com/articles/10....

🧠POD is a surgeon’s nightmare. But can better pain control help? 💊This RCT finds that while oxycodone didn’t reduce delirium compared to sufentanil, it did improve pain scores and reduced side effects 🔗www.signavitae.com/articles/10.22514/sv.2025.108 #Delirium #PostOpCare #Anesthesia #MedEd

🫁Too deep too shallow both dangerous 🧒Intubating a child is not just about skill it’s about precision This review maps the latest evidence on how to get it right, from formulas to ultrasound to palpation #pediatric #anesthesia #pedsanes 🔗 www.signavitae.com/articles/10.22514/sv.2025.120

🚑Korea’s BLS research is evolving: less focus on experience, more on standardized, tech-driven training 🫀The goal? Stronger skills, faster response, better survival in cardiac arrest 🔗https://doi.org/10.22514/sv.2025.117 #BLS #CPR #emergencymedicine #emergency #Paramedic #MedEd #FOAMed

🫘Is 80 mmHg really the magic number for kidney protection? Our review shows it’s not that simple, the real lower limit of renal autoregulation may be far lower, and disease-specific ❓Time to rethink blood pressure targets 🔗 doi.org/10.22514/sv.2025.001 #CriticalCare #Anesthesia

🫀In acute type A aortic dissection surgery, Rh-positive blood type is linked to better in-hospital survival 🩸Could your blood type influence surgical outcomes? 🔗 doi.org/10.22514/sv.... #AorticDissection #VascularSurgery #Blood #surgery #anesthesia #criticalcare

🧠New biomarker alert in TBI! Serum SIRT6 levels strongly predict neurological impairment and prognosis in early traumatic brain injury Strong correlations with GOS & NIHSS ❓Could SIRT6 be the key to early intervention? 🔗 doi.org/10.22514/sv.... #NeuroTrauma #CriticalCare #Brain #Trauma #FOAMed

💉 Regional anesthesia is revolutionizing cardiothoracic surgery! Reducing opioids speeds recovery and improves outcomes Paravertebral blocks, erector spinae blocks, and wound catheter anesthesia are becoming the go-to for pain management 💊Less opioid = less side effects!

⏱️ Time is muscle in cardiac emergencies! In conditions like MI, arrhythmias, and heart failure, every minute counts Early recognition + rapid intervention = better outcomes Read more on timely interventions in our latest review: www.signavitae.com/articles/10.22514/sv.2025.093 #CardiacEmergency

🧪 Can presepsin guide sepsis diagnosis in patients with organ failure, even with kidney dysfunction? 🫘This study shows it can, with tailored cutoff values for hypercreatinemia 💡 Prognostic power beats CRP & rivals PCT 🔗 www.signavitae.com/articles/10.22514/sv.2023.044 #Sepsis #EmergencyMedicine

❓Which biomarkers best predict survival after in-hospital cardiac arrest? This study highlights GPR, lactate, NLR & PLR as independent predictors 📈 GPR >57.8 = higher mortality risk 🥇 Lactate had the strongest predictive value 🔗 www.signavitae.com/articles/10.22514/sv.2025.097 #cardiacarrest

🚨Solid organ transplant patients in the ED? 🩺Don’t miss this comprehensive update on diagnosis, infection management, drug interactions & organ-specific pitfalls A must-read for emergency & acute care teams 🔗 www.signavitae.com/articles/10.22514/sv.2025.092 #TransplantMedicine #EmergencyMedicine

STOP WASTING TIME YOU COULD USE DOING RESEARCH! Just upload your files when you are submitting the manuscript. Don't worry about typesetting rules or a specific reference style, you can submit your manuscript to Signa Vitae in any format of your choice

We finally landed also on Instagram! We are a peer-reviewed, open access, journal about Anesthesia, Intensive care, Emergency and Pain Medicine. 👉 Follow us today and help shape the future of critical care! Find more about us at www.signavitae.com

🚨 Only 35% of pediatric patients survive after CPR! Are there any predictors of poorer outcomes? You can find them in this article: www.signavitae.com/articles/10.22514/sv.2025.101 #Pediatrics #CPR #Cardiacarrest #MedEd #FOAMed

🔌What is the role of TENS in minimizing acute postoperative pain? This review highlights how TENS complements analgesia to facilitate mobilization, improve pain control and potentially shorten hospital stay. ⚡️Can TENS become a standard adjunct in multimodal #painmanagement?

Our latest issue contains a editorial by our Editor-in-Chief @giovannilandoni.bsky.social and @martinabaiardo.bsky.social about Prof. Rinaldo Bellomo, a great scientist and physician that inspired many, but sadly passed away this year www.signavitae.com/articles/10.22514/sv.2025.091

🩸 Why do we bleed? How can we stop it? From DOAC to recents breakthroughs, this comprehensive review unveils novel strategies for managing bleeding risks in high-stakes surgery 🔬 Read, cite and apply: www.signavitae.com/articles/10.22514/sv.2025.094 #anesthesia #criticalcare #signavitae

💧Early diuretics after cardiac surgery? No gain, potential pain In this post-hoc analysis of the #BROTHERstudy early IV diuresis didn’t prevent #AKI and prolonged hospitalization 🔗 www.signavitae.com/articles/10.22514/sv.2023.112 #Anesthesia #CardiacSurgery #ICU #MedEd @yukikotani.bsky.social

🚨Can we predict in-hospital cardiac arrest before it happens? 🤖A new #deeplearning model (Deep-ICU CMS) outperforms conventional scores with predictions 24h in advance using just 4 parameters Is this going to be implemented in future? Full article: www.signavitae.com/articles/10.22514/sv.2024.045

In ED patients with sepsis, a positive SIC score predicts in-hospital death, DIC, organ injury, bleeding, thrombosis & transfusion needs Sepsis-induced coagulopathy is not just a lab value, it’s a warning sign! 🔗 www.signavitae.com/articles/10.22514/sv.2024.069 #MedEd #Sepsis #SignaVitae

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💉 Safer sedation in obese patients! Remimazolam + Sufentanil outperforms Propofol in painless colonoscopy: 🔻 Less apnea (26% vs 50%) 🔻 Less hypoxemia (32% vs 66%) 🔻 Less injection pain (8% vs 34%) 🔗 www.signavitae.com/articles/10.22514/sv.2024.085 #Anesthesia #SignaVitae

🧓 Anesthesia & Arrhythmias in the Elderly 💉Sevoflurane may prolong QTc post-op while spinal doesn’t 🫀For patients at high arrhythmic risk, spinal may be the safer bet 🔗 www.signavitae.com/articles/10.22514/sv.2025.079 #SignaVitae #MedEd #Cardiology #anesthesia

🚨 #BackPain? There’s a smarter way to treat it 💊A new review shows how combining Dexketoprofen + Tramadol can relieve pain fast while reducing the need for strong opioids A smarter, safer approach to acute pain 🔗 www.signavitae.com/articles/10.22514/sv.2025.078 #PainManagement #SignaVitae #MedEd