ping @tscquizzato.com @filippodamico.bsky.social

Presented at #CCR25: In the ANH phase 3 trial involving adult patients undergoing elective cardiac surgery, acute normovolemic hemodilution did not reduce the number of patients receiving allogeneic red-cell transfusion. Full trial results: nej.md/3FxdMrW @criticalcarereviews.com

#ISICEM25 | Cardiac-Synchronized Mechanical Ventilation? 🫁❤️ 🔬 Markus Skrifvars explores its impact: ✅ Higher PaO₂ & lower PaCO₂ with no pressure differences ❓ Key question: Are pneumothorax findings relevant to humans, or is this an effect seen only in pigs? 🐷

#ISICEM25 | Key Questions in Advanced Airway Management 🫁❓ 🔥 Ari Moskowitz highlights ongoing debates: 🔹 Best device? ETI vs. SGA 🤔 🔹 Video vs. Direct Laryngoscopy 📹 🔹 When to intubate? Timing remains unclear ⏳ 🔹 Should strategy vary based on arrest etiology, rhythm, or location?

#ISICEM25 | Key Questions in Advanced Airway Management 🫁❓ 🔥 Ari Moskowitz highlights ongoing debates: 🔹 Best device? ETI vs. SGA 🤔 🔹 Video vs. Direct Laryngoscopy 📹 🔹 When to intubate? Timing remains unclear ⏳ 🔹 Should strategy vary based on arrest etiology, rhythm, or location?

#ISICEM25 | Ari Moskowitz on Controversies in Airway Management during CPR 🫁🚑 🔹 OHCA: RCTs suggest SGA may be as good or better than ETI, based on operator skill. 🔹 IHCA: Limited data—observational studies lean toward no intubation 🔹 Ongoing trials comparing SGA vs. ETI for IHCA.

#ISICEM25 | IV vs. IO Access—Key Takeaways 💉🦴 📢 Markus Skrifvars on why IV remains the first choice: ✅ Higher ROSC rate ✅ Standard method for non-cardiac arrest patients ✅ As fast as IO in most cases ✅ Less expensive

#ISICEM25 | IV vs. IO Access—What’s the Best Choice? 💉🦴 🔍 Markus Skrifvars explores the pros & cons: ✅ IO is as good as IV—but not better 💰 More expensive & should be second choice after IV 🚑 Useful in EMS for patients with difficult access (e.g., children) ⚡ No faster than IV

#ISICEM25 | 🏥 New Guidelines for Perioperative Cardiac Arrest 🔄❤️ 📢 Sharon Einav presents the methodology & PICO questions shaping the upcoming recommendations. 🔹 Evidence-based updates coming in the next few months! 🔹 Focus on best practices for managing cardiac arrest in surgical patients.

#ISICEM25 | 🚑 CPR Session Starting Now! 🚑 Moderated by Michel Slama & @fabio_taccone, this session dives into the latest advances in cardiopulmonary resuscitation

#ISICEM25 | 🏆 POSTER AWARDS 2025 🏆 👏 Xavier Monnet presents this year’s best research contributions! 📊 431 abstracts submitted ✅ 321 abstracts accepted 🏅 4 awards + 1 ISF (International Sepsis Forum) award A celebration of innovation and excellence in intensive care research!

#ISICEM25 | Lennie Derde asks: Why is nobody using SDD despite strong evidence? 🤔💊 📊 Thousands of patients, consistent data, and mortality reduction, yet SDD remains underutilized. 🔹 Open questions: •Availability •Optimal regimen •Impact on microbiome

#ISICEM25 | Paul Elbers on when to stop antibiotics—insights from data science 🔬💊 🔹 19% of patients had antibiotics reinitiated frequently Reinitiating antibiotics is linked to: 📈 Longer ICU stay (22.0 vs. 15.9 days) ⚠️ Higher 90-day mortality (40% vs. 25%)

#ISICEM25 | Antoni Torres on when to stop antibiotics in severe CAP 🦠💊 🔹 Outpatients: ≤5 days if stable 🔹 Non-severe inpatients: <5 days (minimum 3) 🔹 Severe CAP: ≥5 days if stable Key question: Can clinical stability criteria from CAP be applied to SCAP patients on mechanical ventilation?

Guys. Isicem is on Bsky. And follow @filippodamico.bsky.social and @tscquizzato.bsky.social for isicem tweets !! 👏🏽👏🏽👏🏽👏🏽👏🏽

#ISICEM25 | Always fascinating to hear @MichardFrederic discuss the future of bedside screens 🖥️🔍 📊 Evolution to visual decision support tools 🔹 Turning data into knowledge ⚡ Faster & more accurate detection of abnormalities 🧠 Improving situation awareness & reducing cognitive workload

#ISICEM25 | Michard Frederic on the future of bedside monitoring! 🚀📊 🔹 New ways to display monitoring variables 🔹 Advanced tools to visualize data 🔹 Seamless data integration into a single monitor 🔹 Data fusion—combining variables into one visual tool

#ISICEM25 | Vitaly Herasevich on building smart alerts in critical care ⚡🔍 🔹 No perfect detection algorithm exists—manual confirmation is key 🔹 Visual decision support tools enhance clinician feedback 🔹 Real-time compliance reports enable reinforced learning

#ISICEM25 | Michael R. Pinsky on Autonomous Diagnosis & Treatment of Circulatory Shock 🚑💡 🔹 The key to precision resuscitation: •Is the patient in compensated shock? •Will cardiac output improve with fluids? •What is the arterial tone status? •Can the heart sustain output without filling pressures?

#ISICEM25 | Michael Pinsky presents an algorithm for precise personalized resuscitation in shock management 🔄📊 🔹 Stepwise decision-making: ✅ Is the patient hemodynamically stable? If yes, do nothing. ✅ If unstable, assess preload responsiveness. ✅ If preload-responsive, evaluate vasomotor tone

#ISICEM25 | Michael Pinsky on Functional Hemodynamic Monitoring & Closed-Loop Resuscitation 🔄📊 ✅ Guided resuscitation with clear decision rules ✅ Standardized yet personalized fluid & vasopressor strategies ✅ Adaptable across ICUs, remote care, and austere environments Looking at the future!

#ISICEM25 | Lennie Derde on the future of sepsis treatment 🔬🦠 🚀 Moving beyond syndromes to treatable traits 🔹 Reframing immunobiology for better-targeted therapies 🎯 Immune modulation: precision over generalization 🧬 Metabolic reprogramming—a new frontier?

#ISICEM25 | Patricia Rocco on the future of ARDS treatment 🫁🔬 ARDS is heterogeneous, requiring tailored management strategies

#ISICEM25 | @fabio_taccone delivers a brilliantly clear presentation on Automated Pupillometry 👁️💡 "The conclusion is quite simple: If you think measuring pupils makes sense, the pupillometer is better than you!" 🔹 Objective, reproducible, and precise 🔹 Eliminates subjectivity in pupil assessment

#ISICEM25 | Massimiliano Greco on wearable technologies and the future of ICU monitoring! 🚀📡 🔹 Increase mobility & physical therapy 🔹 Reduce invasive devices & sampling 🔹 Improve data visualization & reduce fatigue 🔹 Detect delirium earlier 🔹 Bridge monitoring gaps between ICU & wards

#ISICEM25 | 🚀 The session ‘HOW I IMAGINE THE FUTURE’ is now starting! Moderated by Zsolt Molnar & Christian Stoppe, this session explores bold visions for the future of intensive care.

#ISICEM25 | 🔥 Big debate in the room! After the first fluid challenge in septic shock, BP rises from 90/40 to 95/45. What’s the next move? More fluids 💧 or start vasopressors 💉

#ISICEM25 | 🔴 Live from the Arch Room! The Round Table on Early Hemodynamic Resuscitation of Septic Shock is underway. 🗣️ Moderator: Xavier Monnet 💡 Experts: Daniel De Backer, Emily J See, Jean-Louis Teboul, Michelle Chew

#ISICEM25 | Julie Helms explores the role of contact phase activation in bleeding 🩸🔬

#ISICEM25 | Matthieu Schmidt on Setting PEEP in ECMO 🫁🔍 🔹 PEEP helps maintain lung recruitment while reducing driving pressure. 🔹 Personalization is key—balancing overdistension & collapse. 🔹 EIT & transpulmonary pressure can guide adjustments

#ISICEM25 | Day 3 kicks off! 🚀 In the Gold Room, the focus is on ECMO. 🫀 Armand Mekontso Dessap explores the veno-pulmonary configuration—a strategy to support the right heart in critical scenarios

#ISICEM25 | Axel Nierhaus discusses when to consider immunoglobulins in sepsis 🧪🦠

#ISICEM25 | Massimo Girardis explores the immune effects of commonly used medications 💊🦠. Every drug impacts immunity—so how can we optimize treatment at the bedside?

#ISICEM25 | Christopher Seymour presents a fascinating model of sepsis based on tolerance, damage, and resistance 🦠⚖️. Sepsis isn’t just about fighting infection—it’s about how the body tolerates, resists, or is damaged by it. Rethinking host response could reshape treatment strategies!

#ISICEM25 | Michael Bauer explores the dual role of neutrophils in host response and organ dysfunction 🔬🦠. Friend or foe? The challenge lies in distinguishing protective immune responses from harmful inflammation. Understanding this balance is key to improving outcomes in critical illness.

#ISICEM25 | Jan Bakker reminds us: Venous congestion can be present even in fluid-responsive patients 💧

#ISICEM25 | Paul H. Mayo dives into venous congestion, volume intolerance, and the VExUS score 🔍💧.

#ISICEM25 | Endotypes & Mortality – A key framework for personalizing sepsis management. Understanding distinct biological profiles could shape targeted therapies and improve outcomes with Prof Evangelos Giamarellos–Bourboulis

#ISICEM25 | Over 300 posters showcased in 4 days, highlighting the latest breakthroughs in intensive care and emergency medicine. A deep dive into innovation, research, and future clinical practice! Don’t miss it!

#ISICEM25 | Sheila Myatra asks: Should we predict fluid responsiveness in everyone? 💧🔍 Outstanding lectures! 🔥

#ISICEM25 | Michelle Chew explores how echocardiography can guide fluid challenges 📡💧. Not all shocks are the same!

#ISICEM25 | Tomoko Fujii addresses the question: Arterial PaO₂ or SpO₂? ✅ They correlate well, but SpO₂ is not a perfect replacement for PaO₂. 🔬 Key insights into oxygen monitoring in critically ill patients!

#ISICEM25 | Yelena Bodien & @Dr_Cit take the stage to discuss knowledge gaps in Disorders of Consciousness (DoC) and what can be done to bridge them. @isicem.bsky.social

Excitement is building for the start of the International Symposium on Intensive Care & Emergency Medicine! A packed program awaits, featuring cutting-edge research, expert insights, and key discussions. Stay tuned! #ISICEM25 @isicem.bsky.social

🫀Exciting breakthrough in #intraoperative hemodynamic management! Our #meta-analysis of #randomized trials reveals a game-changing perspective on intraoperative hypotension. Contrary to previous beliefs, intraoperative #hypotension may not be as harmful sciencedirect.com/science/articl…

Our letter published in #NEJM!📓 It shedding light on a critical issue in the #ECLS #Shock trial 🫀 Authors promptly respond, are you satisfied with their answer? doi: 10.1056/NEJMc2312854. @nejm.org

Our new meta-analysis revolutionizes blood pressure management in #critical and #perioperative patients. Discover how our findings can change clinical practice. 🔗 journals.lww.com/ccmjournal/abs…

The C.L.E.A.R. approach of protective #hemodynamics in #critically ill patients is a step forward in embracing complexity, moving beyond simple pressure targets. 🩺🔄 Read our full review for more insights! 📄💡 journals.lww.com/co-criticalcar…

The Observational Interpretation Fallacy Did you know? Observational studies often confuse association with causation, leading to misguided clinical practices. Our new review explores the “Observational Fallacy” and its impact on #medicine. 🩺 onlinelibrary.wiley.com/doi/10.1111/je…

📢 Our second review on protective hemodynamics now published in JCVA “Protective haemodynamics: C.L.E.A.R.!” The C.L.E.A.R. approach It is CLEAR! jcvaonline.com/article/S1053-…