Happy to share the Biodiversity Cell Atlas white paper, out today in @nature.com. We look at the possibilities, challenges, and potential impacts of molecularly mapping cells across the tree of life. www.nature.com/articles/s41...

Important read. Refugees caught in a bureaucratic nightmare. Nothing to do for months or years. Cooking in the bathroom instead of eating constant chips and chicken nuggets. Forced to take taxis no matter the length of the journey, long or short.

Ar-tooth-ficial general intelligence

Terminally online world phobia

We have developed a new workflow to map whole human organs at single-cell resolution, while integrating spatial transcriptomics, proteomics, and metabolomics. We applied this workflow to map precancerous lesions of the fallopian tubes. More here: www.biorxiv.org/content/10.1...

Baffling size comparison of the day

Somehow, somehow the knowledge of where to go and when to leave is encoded in the genes of the green darner dragonfly. I found this one, a male judging from his neon blue abdomen, sitting on the concrete outside a store in a strip mall in Atlanta. He likely hatched in a pond in Quebec or NY 🧵...

Are digits modified fins, or evolutionary innovations? Read how we tackled this old question from a new angle🧪 A story with @chasebolt.bsky.social, @homeobox.bsky.social and myself, coordinated by @denisduboule.bsky.social from @college-de-france.fr and published in @nature.com today! #InHoxWeTrust

New research shows the kidney’s “plumbing system” – its lymphatic vessels – undergoes dramatic changes during transplant rejection. These findings challenge long-held assumptions and could open the door to new treatments. Read more here ⤵️ sanger.ac.uk/news_item/ki...

Science: only when you write up the manuscript, you realize what you should have done.

Sad to hear that David Baltimore died. I am one of hundreds of scientists that David generously mentored, supported, and inspired. His influence on each of us was deep and lasting, and his impact on the world immeasurable. Arguably David Baltimore is one of the greatest scientists of any generation.

🧵How to write and manage your first research budgets The point of funding is to convert it into quality research. A well-spent research budget should fund the idea it was raised on, plus revision experiments, plus preliminary data for the next grant. So you need to spend, while avoiding waste.

It's seven years since we posted on Twitter about how kids kept coming into the library asking if we had any books about FORTNITE. We didn't back then, and we'd never heard of it so we tried asking what it was.

Great job for anyone looking to move into scientific communications from the lab!

Just removed the date label from an old book and discovered that someone has drawn a design for a teapot that can serve either tea or poison how's your day going?

#NIH is hanging by a thread. The #CDC has been decimated. #RFK Jr. and Russell #Vought are psychopaths--I don't say this frivolously--they are cold, calculating, inflicting violence on millions through public policy. It is where we are right now. These men are not normal. 1/

37) We want to thank the NIH for providing federal funding for this work. And we note here that this grant was illegally terminated by the federal administration causing future studies on the manner in which these changes influence human disease risk and birth process to be ended.

1) I am delighted to present this terrific tour de force research conducted by my post-doc Dr. Gayani Senevirathne @gayani.bsky.social and published today in Nature - www.nature.com/articles/s41...

Textbooks: “Enhancers are just a bunch of TFBSs” But how do they REALLY work? New paper with many contributors here @berkeleylab.lbl.gov, @anshulkundaje.bsky.social, @anusri.bsky.social A 🧵 (1/n) Free access link: rdcu.be/erD22

I've reached 100 British springtail species! This was helped by a recent glasshouse sampling trip, where I added these 4 species. 3 are now in the pipeline to have reference-quality genomes sequenced for the first time, by the @sangerinstitute.bsky.social. More info in the thread below! 🧵1/7

Check out the graphical abstract for a paper recently published in Ecological Modelling. I have papers published in Ecological Modelling. Never again, I guess.

#OnThisDay in 1858, a seminal journal article comprised of papers by Alfred Russel Wallace FRS and Charles Darwin FRS on the theory of evolution by natural selection was published by the Linnean Society, the first public announcement of the theory of evolution. bit.ly/3k8fq4u

In my small corner of biology, I’m constantly reassured by how frequently we confirm main findings. And then when differences do show up, they very rarely end up being fraud, but instead tell us something important about differences in experimental design.

i think it is hard for some people to really their heads around the reality that kennedy is staunchly anti-vaccine and thinks that people should suffer through disease and that those who die deserved it and that those who survive are a better order of human being

1/ - Trade Policy in 2025 - Step 1. Donald Trump invents threatened new tariff rates on your country based on some combination of the trade balance, vibes, personal grievance, vibes, how much he likes you, vibes, or a Peter Navarro formula so stupid it made Lesotho enemy #1. Also vibes.

Thrilled to bits to see our latest work online in Dev Cell! 🥳 We wanted to know how cells build functional organs with precision🫀🫁📏 Here we show how coupling of cell shape and organ function fine tunes the form and contractile power of the developing #zebrafish heart 1/n tinyurl.com/cell-stretch

Dev biologists! 3-yr postdoc position at King's, collaboration with Trizzino lab @marcotrizzino.bsky.social modelling CHD3 neural crest. We are looking for postdocs with mad embryology skills @the-node.bsky.social #developmental @ccrb27.bsky.social thenode.biologists.com/jobs/postdoc...

I think this quote is both unsustainable and unsupported by the analysis in the piece. First and foremost, it portrays fraud as *consuming* science rather than merely growing alongside it. Much of the “fraud” in the paper is just metric gaming whackamole that doesn’t get read, cited or used.

At his confirmation hearing, RFK Jr claimed he wouldn’t take away vaccines. So far he has: Removed COVID vaccine recommendations Fired the CDC’s vaccine committee Replaced scientists with antivaxxers Cancelled vaccine hesitancy research Pulled $500m in mRNA vaccine research

The mRNA vaccine platform has already been assessed across diverse clinical indications, many with remarkable progress: —cancer neoantigen vaccines [in patients with refractory disease (e.g. pancreatic)] —more than 15 infectious diseases —autoimmune diseases —rare disease for genome editing

To say that "the data show these vaccines fail" in regards to the mRNA plaform is unforgivable. For those of you that don't remember - this is the data from a SINGLE dose. In December 2020. So good I cried in grateful tears.

Release from HHS: HHS will wind down its development of the mRNA vaccine development activities under the Biomedical Advanced Research and Development Authority (BARDA).

🎨 FREE GUIDE: Create Science Visuals with Impact! Science is complex, but your visuals don’t have to be. A well-designed graphic can make all the difference in how research is understood, shared, and remembered. 1/2

With our own Sam Behjati, paediatric oncologist and scientist extraordinaire @sangerinstitute.bsky.social, on the speaker list!

I'm excited to announce our new biorxiv preprint, wherein we investigate the evolution of the weirdest genetic locus I've ever seen! Behold the tgr genes of the social amoeba, which mediate self/non-self discrimination during facultative multicellularity 🐅 🧵 1/ www.biorxiv.org/content/10.1...

Sophisticated Anglo-Saxon metalwork from ancient ship burial, probably of king, at Sutton Hoo in Suffolk, dating from 7C and first unearthed in 1939 ~ purse lid ■ gold belt buckle ■ shoulder clasps

Former soldier + TV personality Ant Middleton (who wants to run for Mayor of London - was hoping to go for the Reform nomination) wants to ban Kemi Badenoch, Priti Patel, Rishi Sunak and Suella Braverman, as well as Sadiq Khan, and Boris, Churchill and King Charles III from government roles

Happy to share our publication - Comparative connectomics of two distantly related nematode species reveals patterns of nervous system evolution www.science.org/doi/10.1126/...

An artist's enthusiasm for other art can be a good tonic in news-saturated dumb times www.youtube.com/watch?v=-dIw...

Group leader positions in @sangerinstitute.bsky.social Cellular Genomics, led by @mhaniffa.bsky.social, to decode and recode human tissues. Broad net - clinical research, in vitro models, single cell, AI. Vibrant, supportive community. Please share! sanger.wd103.myworkdayjobs.com/en-GB/Wellco...

amazing things are happening in the shrimp rodeo community www.reddit.com/r/ShrimpsIsB...

If the implied threat of violence here were coming from literally anyone but Bum Flare Man and the Lads the debate wouldn't be about how best to appease them, but whether the response should be giving the police Challenger battle tanks or Apache Longbow attack helicopters.

Biologist folk (especially in evolutionary biology and/or ecology, but it don’t matter): Can you give me your favorite examples of trade offs in biology? Organism or system don’t matter. Primary literature or reviews preferred.

🐌💫 Snail embryos never looked so fabulous! Tubulin (white), phospho-histone H3 (pink), and F-Actin (cyan) light up this early stage like a cytoskeletal disco ball. Image from Clemens Cabernard & Adam von Barnau Sythoff 🪩🧬 #FluorescenceFriday

🎲 Our paper on the genetics, energetics, and allostery in proteins with randomized cores and surfaces is out today @science.org! 🧬 By charting a protein’s sequence universe, we could rationalize which versions were kept through evolution – and why many stable ones were not.

Inverse Tragedy of the Commons: Biscuit box brought to the office. But no one wants to eat the last one, for reasons of etiquette (real or imagined). The biscuit sits overnight and goes stale - loses its essence. Everyone loses. We must be brave enough to take the (last) biscuit

Good grief, the US National Cancer Institute projects it will fund only one in 25 RO1 grant applications in 2026. This is massively defunding cancer research. Despicable vandalism. www.cancer.gov/grants-train...

UK is not close to societal collapse, nor anywhere near boiling point. It’s more that a load of commentators have pickled their brains from being submerged in the brine of their social media bubbles.

Better version of the meme.