Jerome Govin
@jeromegovin.bsky.social
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📥 131
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Epigenetics 🧬, fungal infections 🍄 and cancer 🦀. And outdoor adventures 🏔️
Genes are the code. Epigenetics is the choice. 💊 Great review ! 👏
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23 days ago
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Jerome Govin
Nature Reviews Microbiology
5 months ago
ICYMI: New online! Aspergillus fumigatus biology, immunopathogenicity and drug resistance
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Aspergillus fumigatus biology, immunopathogenicity and drug resistance
Nature Reviews Microbiology, Published online: 02 May 2025; doi:10.1038/s41579-025-01180-zIn this Review, van de Veerdonk and colleagues explore Aspergillus fumigatus biology, the host immune responses and the fungal mechanisms of immune evasion, as well as emerging challenges such as virus-associated pulmonary aspergillosis and azole resistance, and reflect on future directions for therapeutics and patient care improvement.
https://www.nature.com/articles/s41579-025-01180-z?utm_source=bluesky&utm_medium=social&utm_campaign=nrmicro
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BK. Titanji
5 months ago
Absolutely brilliant science communication by
@unbiasedscipod.bsky.social
and Marta Tufet of GAVI. Clear explanation of why placebo controlled trials are not required for vaccines already known to be efficacious. I had to share.
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Ilan Schwartz
5 months ago
What's this all about? A new study from
@normanvanrhijn.bsky.social
and co which suggests that warmer climates will be more hospitable for environmental growth of Aspergillus fumigatus, A. flavus, and A. niger
assets-eu.researchsquare.com/files/rs-654...
(preprint)
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It is time to fear fungi.
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5 months ago
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Aaron Vogan
7 months ago
We did it! We caught Starship
#transposons
moving between
#fungal
species in the lab, including between species separated by ~100my. We think Starships are a mediator of HGT in fungi, akin to conjugative elements in bacteria. Check out the preprint.
www.biorxiv.org/content/10.1...
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5 months ago
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@nature.com
just highlight the risk of fungal infections. It is time to fear fungi.🍄 "High time to tackle drug-resistant fungal infections"
www.nature.com/articles/d41...
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High time to tackle drug-resistant fungal infections
To combat long-overlooked fungal pathogens, researchers and regulators must embrace innovative science and policy.
https://www.nature.com/articles/d41586-025-01177-x
5 months ago
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The last of us, Season 2, is out. 🍿 Fungi infections aren't just fiction. 🎦 They kill millions of people. ☠️ It is time to fear fungi. 🍄
gaffi.org
5 months ago
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Superbe initiative de vulgarisation scientifique par
@inserm.fr
avec la bande dessinée InScience. A lire sans modération !
www.inserm.fr/culture-scie...
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Bande dessinée – InScience : cultive ta santé avec l’Inserm ! · Inserm, La science pour la santé
La bande dessinée InScience : cultive ta santé avec l’Inserm ! nous entraîne au cœur de la recherche biomédicale, avec pédagogie et humour. Ses deux tomes, écrits et dessinés par Maïté Robert, sont ac...
https://www.inserm.fr/culture-scientifique/bande-dessinee-inscience-cultive-ta-sante-avec-linserm/
6 months ago
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This is huge. Can't wait to see a talk on it. Any virtual presentation soon ? Would also love to see a similar analysis in fungi. 🍄
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6 months ago
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Jerome Govin
Nature Plants
6 months ago
New Article: "An Oryza-specific histone H4 variant predisposes H4 lysine 5 acetylation to modulate salt stress responses"
rdcu.be/eg0Zs
An Oryza-specific histone H4 variant (H4.V) forms condensed, less stable nucleosomes, regulating the salt stress transcriptome.
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Jerome Govin
Brendan Maher
6 months ago
OK. I don't need to explain the importance of 'blue-sky' research to people on here, but this story in
@nature.com
is so cool! The area of research that delivered CRISPR gene editing has exploded and is turning up all kinds of cool tools for molecular biology.
www.nature.com/articles/d41...
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Microbial warfare brought us CRISPR. What big breakthroughs could be next?
Gene editing and many other useful biotechnology tools came from studies of bacteria fighting off viral invaders. But scientists have only begun to unlock the secrets of this ancient arms race.
https://www.nature.com/articles/d41586-025-01065-4
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Ilan Schwartz
6 months ago
Cracks in the Curriculum: The Hidden Deficiencies in Fungal Disease Coverage in Medical Books Isabela Rost / Alessandro Pasqualotto and colleagues
academic.oup.com/ofid/article...
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Cracks in the Curriculum: The Hidden Deficiencies in Fungal Disease Coverage in Medical Books
Abstract. Textbooks remain a primary source of reference and education for many health care professionals and students. This study assessed the mycology co
https://academic.oup.com/ofid/article/12/4/ofaf145/8101540
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Great news. But unfortunately, pathogenic fungi not funded...
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6 months ago
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Jerome Govin
LabEx ParaFrap
7 months ago
📅 Save the Date! The EMBO Workshop "Host-Parasite Relationship: From Mechanisms to Control Strategies" organized by @ParaFrap will take place on October 5-8, 2025, at Les Embiez Island. Stay updated on registration opening —enter your email here:
coming-soon.embo.org/w25-83
#Science
#Parasite
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Jerome Govin
Daniel Gorelick
6 months ago
Built a peer review system that doesn’t take forever. Spoiler: scientists love it. Huge thanks to the amazing team at The Company of Biologists for making Fast & Fair happen. Read the preprint:
bit.ly/4iZ30st
#biologists100
@biologists.bsky.social
@biologyopen.bsky.social
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Fast & Fair peer review: a pilot study demonstrating feasibility of rapid, high-quality peer review in a biology journal
Traditional peer review is slow, often delayed by the time-consuming process of identifying reviewers and lengthy review turnaround times. This study tests the feasibility of the Fast & Fair peer revi...
https://bit.ly/4iZ30st
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🚨Our new prepint 🚨 ▶️ When a bromodomain goes rogue Rsc1 bromodomain 2 doesn’t bind acetyl-lysines. It grabs DNA instead — and yeast cells die 💀 without it. Plot twist? Read our preprint: 👉
www.biorxiv.org/content/10.1...
#chromatin
#bromodrama
#DNAlover
And a 🧵👇 1/5
6 months ago
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Todays was the 28th meeting of the Grenoble
#Epigenetics
Club, with enthusiastic talks from
@hakimi.bsky.social
, J. Timmins and Hana Petrzilkova. Kindly hosted by W. Galej at EMBL Grenoble. Thanks !
epigenetics.fr
6 months ago
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Jerome Govin
UMR Génomique Métabolique
6 months ago
📢
#PhD
and
#postdoctoral
positions available in Pedro Oliveira lab. We seek candidates for Microbial Genomic and Epigenetic teams to work on
#epigenomics
of
#bacteria
and
#microbiomes
. Start: Fall 2025. Please RT!
@cea.fr
@univparissaclay.bsky.social
@genopole.bsky.social
@upcite.bsky.social
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I've been waiting so long for this. Great !
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6 months ago
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Jerome Govin
Mara Duncan
6 months ago
A slight modification to the standard yeast lithium acetate transformation protocol increases transformation efficiency substantially. Basically, 2 fold increase if you resuspend in 2M sorbitol after heat shock, and an additive increase with some sorbitol during heat shock.
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Enhancing Yeast Transformation: Achieving up to a Tenfold Increase Through a Single Adjustment in the Lithium Acetate–Polyethylene Glycol Method
In red are the proposed improvements to the classical yeast transformation protocol.
https://onlinelibrary.wiley.com/doi/full/10.1002/yea.3999?campaign=wolearlyview
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🤩 Amazing interview of Edith Heard
www.lemonde.fr/sciences/art...
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Edith Heard, généticienne : « Il a fallu que je vienne en France pour planter des racines et m’épanouir »
« Je ne serais pas arrivée là si… » Chaque semaine, « Le Monde » interroge une personnalité sur un moment décisif de son existence. La chercheuse franco-britannique, professeure au Collège de France, ...
https://www.lemonde.fr/sciences/article/2025/03/16/edith-heard-geneticienne-il-a-fallu-que-je-vienne-en-france-pour-planter-des-racines-et-m-epanouir_6581797_1650684.html
6 months ago
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Jerome Govin
Di Jiang
7 months ago
@science.org
RNA polymerase II at histone genes predicts outcome in human cancer 🧬💊
@fredhutch.bsky.social
@hhmi.bsky.social
www.science.org/doi/10.1126/...
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ChatGPT just invented "histonic modifications". I kind of like it.
7 months ago
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Jerome Govin
Epigenome Technologies
7 months ago
Epigenetics Update - Lactate controls cancer stemness and plasticity through epigenetic regulation
bit.ly/3Qf3oqc
Maria J. Rodríguez Colman (University Medical Center Utrecht) reporting in Cell Metab
#Epigenetics
#Cancer
#Metabolism
--- Gain deeper insights into gene regulation with
epigenome.us
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Use microbiote to deliver drugs.💊 In the brain. 🧠 Through the nose. 👃 😍
www.cell.com/cell/fulltex...
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Engineered commensals for targeted nose-to-brain drug delivery
Shen et al. investigate the use of Lactobacillus plantarum, a commensal bacterial strain, as a chassis for targeting the olfactory mucosa to facilitate precise nose-to-brain delivery of therapeutic mo...
https://www.cell.com/cell/fulltext/S0092-8674%2825%2900046-7
8 months ago
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Jerome Govin
Cell Biology J-Club
8 months ago
Protein codes promote selective subcellular compartmentalization | Science
www.science.org/doi/10.1126/...
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Protein codes promote selective subcellular compartmentalization
Cells have evolved mechanisms to distribute ~10 billion protein molecules to subcellular compartments where diverse proteins involved in shared functions must assemble. Here, we demonstrate that proteins with shared functions share amino acid sequence ...
https://www.science.org/doi/10.1126/science.adq2634
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Amazing review from the Traven lab. "we also need to study the metabolic mechanisms that control tolerance of fungal pathogens" 🍄
journals.asm.org/doi/10.1128/...
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Metabolic homeostasis in fungal infections from the perspective of pathogens, immune cells, and whole-body systems | Microbiology and Molecular Biology Reviews
SUMMARYThe ability to overcome metabolic stress is a major determinant of outcomes during infections. Pathogens face nutrient and oxygen deprivation in host niches and during their encounter with immu...
https://journals.asm.org/doi/10.1128/mmbr.00171-22
8 months ago
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Amazing ressource in 🇫🇷 research. Don’t forget to use it with click & read plug in !
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8 months ago
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Just another day riding back home. Grenoble, French Alps !
8 months ago
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Heard today : ""Life is a bike, you need to keep moving so you don't fall"
8 months ago
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🚀 Excited to share our latest research on antifungal drug discovery! 🍄💊 We use humanized Candida models and NanoBiT assays to identify selective inhibitors of the Bdf1 bromodomain, a promising antifungal target.
doi.org/10.1002/advs...
#AntifungalResearch
#DrugDiscovery
A 🧵 1/6 👇
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Humanized Candida and NanoBiT Assays Expedite Discovery of Bdf1 Bromodomain Inhibitors With Antifungal Potential
The fungal BET protein Bdf1 is a potential antifungal target in pathogenic Candida species requiring the inhibition of both its bromodomains. Humanized Candida strains and NanoBiT complementation ass...
https://doi.org/10.1002/advs.202404260
8 months ago
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Jerome Govin
Springer Nature
8 months ago
Most all academics share something in common, passion for what they do. But this passion and drive can combine to create a situation where workloads weigh heavy. In this Nature Careers Podcast, researchers describe how they sought help and turned their working lives around:
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‘There is life after burnout in academia’
Researchers with lived experience of the chronic workplace stress that typifies burnout describe how they sought help and turned their working lives around.
http://spklr.io/63322FjSo
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ChatGPT (or equivalent) can't write my grants. But it saves me so much time in the writing process. Just mind-blowing... 🤯
8 months ago
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When academics migrate from ✖️ to 🦋
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8 months ago
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Fungal infections are also common among soldiers wounded in the field. 🍄🫡
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8 months ago
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Anything I could live-stream from my lab? 🤔🤪
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8 months ago
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Jerome Govin
Retraction Watch
8 months ago
“Until we acknowledge that publish or perish is the natural consequence of the rankings obsession, we’re not going to fix anything.” Our Ivan Oransky speaks with
@nature.com
.
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‘Publish or perish’ culture blamed for reproducibility crisis
Survey of more than 1,600 biomedical researchers also flagged small sample sizes and cherry-picking of data as leading causes of reproducibility problems.
https://www.nature.com/articles/d41586-024-04253-w
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Linking epigenetics and metabolism. Beautiful work by Snyder lab!😍
www.nature.com/articles/s42...
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Short-chain fatty acid metabolites propionate and butyrate are unique epigenetic regulatory elements linking diet, metabolism and gene expression - Nature Metabolism
Nshanian et al. investigate the differential effects of the short-chain fatty acids propionate and butyrate on chromatin remodelling and gain insight into the mechanisms that drive selective histone a...
https://www.nature.com/articles/s42255-024-01191-9
8 months ago
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Jerome Govin
Rebecca Drummond 🍄
9 months ago
Nice overview of the problems we face when tackling fungal infections and how climate change might exacerbate them. With quotes from myself and
@martinhoenigl.bsky.social
#immunosky
#microsky
🧪
www.dailymail.co.uk/sciencetech/...
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California wildfires could make 'The Last of Us' a REALITY
As HBO finally confirms the release date of The Last of Us season two, scientists say the show's premise could soon be a reality - and disasters like the California wildfires could be to blame.
https://www.dailymail.co.uk/sciencetech/article-14270537/california-wildfire-deadly-fungus.html
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Jerome Govin
8 months ago
Our
#Paramecium
artwork is featured on the cover of
#NAR
!
doi.org/10.1093/nar/...
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Jerome Govin
HHMI
9 months ago
HHMI Investigators Bonnie Bassler, Jennifer Doudna, and Feng Zhang, & HHMI Professors Keivan Stassun and David Walt were recognized by President Joe Biden with the nation’s highest honors for exemplary achievements & leadership in science & technology. Read more:
www.whitehouse.gov/briefing-roo...
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Jerome Govin
Wolfgang Huber
9 months ago
How to do differential expression with scRNAseq data? State of the art is "pseudo-bulk" analysis with RNA-seq methods like edgeR or DESeq2, where "cell type" is encoded as discrete categories. Biologically, discrete categories are not always the most appropriate concept.(1/3)
doi.org/10.1038/s415...
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Analysis of multi-condition single-cell data with latent embedding multivariate regression - Nature Genetics
Latent embedding multivariate regression models multi-condition single-cell RNA-seq using a continuous latent space, enabling data integration, per-cell gene expression prediction and clustering-free ...
https://doi.org/10.1038/s41588-024-01996-0
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Dr Elodie Chabrol
9 months ago
5 tools to help you with science communication by Animate Your Science 👇 👨🏻🎨Canva - For graphic design 🎨Coolors - For colour palette generation 📊Flourish - For data visualisation 📑Tiny wow - For document conversion ✅Linguix - For grammar checks
www.animateyour.science/post/5-best-...
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5 Best FREE SciComm Tools
Looking for some handy tools to level-up your SciComm game? You have come to the right place. Check out our 5 favourite FREE SciComm tools!
https://www.animateyour.science/post/5-best-free-scicomm-tools
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I want to use AI to write the minutes of my meetings. Does anyone have any experience / recommendation with a specific tool? Thanks !
9 months ago
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There numbers are the introduction of all my fungal grants. It is time to fear fungi. 🍄
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9 months ago
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Jerome Govin
Oded Rechavi
9 months ago
When someone says epigenetics but means gene expression
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Jerome Govin
1000WomeninSTEM
9 months ago
#womeninSTEM
trading cards
#1000portraits
1️⃣-6️⃣0️⃣ portraits are now available as collectible cards including
@valmasdel.bsky.social
@docteur-drey.bsky.social
@tanialouis.fr
@elisabethbik.bsky.social
@nucleosomepolice.bsky.social
(link
aninfinityofhypotheses.wordpress.com/wp-content/u...
)
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Jerome Govin
Norman van Rhijn
10 months ago
With more
#MycoSky
arriving here by the day, lets gather everyone and rebuild. Please let me know if I’ve missed out on you or anyone relevant 🍄🟫😎
go.bsky.app/FYRJn6M
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