Vaults. They are cell biology's greatest puzzle! This preprint from Martin Beck's lab shows them docked on ER membranes with a ribosome inside. What on earth is going on there?? #CellBiology #WTFology www.biorxiv.org/content/10.6...

Oh! And happy St Lucy’s Day, one and all, may your eyes be healthy and free of infection

Lamb Koftas (before and after).

From the Rare Kidney Disease Centre

In London for the @lifearc.bsky.social annual meeting

Just a few weeks left to apply for our clinical PhD programme. We're looking for clinicians who are passionate about research to join the 3-year fully funded programme. Learn more and see what positions are available ⬇️ www.crick.ac.uk/careers-and-...

Are you a clinician who wants to do a PhD? Come to @crick.ac.uk (you can even come to my lab).

I don’t know who needs to hear this but the CDC is being eviscerated right now. America is not going to have any kind of outbreak response capacity after tonight. Americans’ health data is no longer secure. Say goodbye to federal public health in any capacity. It’s a disaster. We won’t recover.

Do you want to do a PhD with me and Mike Devine? Of course you do! Or if not, maybe you know someone who does? @devinelab.bsky.social www.crick.ac.uk/careers-stud...

Carbonara.

@southlondongirl.bsky.social right so I don’t recommend swimming with your iPhone in your pocket. Long story, also boring. But Sicily, excellent, @flossieteacake.bsky.social said I should share this pasta alla Norma with you. It’s got Ricotta Salata and everything. Aces. Shall we do dinner sometime?

The main thing - is it not already clear - RFKr Jr is uniquely unqualified to lead the HHS. All main agencies under his watch - NIH, FDA, CMS - are also headed by incompetent contrarian peddlers of disinformation, conspiracy theories, and pseudoscience. This will, and already does, cost lives.

If someone you know buys into claims about "genetic optimization" of embryos using polygenic scores of cognition, just send them our 2024 paper on Beethoven & musicality. We wrote it to help communicate limits of individual-level genetic predictions & complexity of links between DNA & behaviour. 🧪👇

I know we're supposed to reflexively dismiss the loss of any niche subject in the humanities, but this is a big part of why the university exists: so a student who wants to learn Basque can learn Basque. & the reason a school can offer that class is because THEY HAVE A ROMANCE LANGUAGES DEPARTMENT.

Surely you meant to write ‘formerly a world class institution’?

🎥 The Keystone Symposium on Autophagosomes & Endolysosomes is now on demand! Watch talks on lysosome‑mediated quality control, nutrient regulation & cell signaling—insights from leaders in the field . 👉 keysym.us/KSAutophagy2... #KSAutophagy25 #autophagosome #endolysosomes @bealelab.bsky.social

The Autophagosomes & Endolysosomes meeting wraps today in Whistler, capping days of deep insight into lysosomal biology & autophagy. 👏 Congrats to our Keystone scholarship awardees—your future in science is bright! 🔗 keysym.us/scholarships... #KSAutophagy25 @bealelab.bsky.social

Cheering myself up by reminding myself this is happening next week.

Chan Lee @harperlabhms.bsky.social reports CASM-driven V-ATPase recruitment to lysosomes for acidification upon TRPML1 activation via DMXL1-RAVE loader. With Magdalene Moran(Caraway), Sophie Helaine lab, Joao Paulo, & HarperLab teams(HMS). Funds: Warren Alpert FND/NIH www.nature.com/articles/s41...

Sharing this on the eve of tomorrow's vote. I am a palliative care doctor who is not opposed to AD. But enshrining in law a state-funded right to die, while not enshrine a similar right to the palliative care that might make life worth living, is so very wrong. www.theguardian.com/commentisfre...

Robert F Kennedy Jr said he is “retiring” all 17 members of a crucial government panel of vaccine advisors He is removing all members of the Advisory Committee on Immunization Practices, which advises the CDC and Prevention This could serious damage US health www.cnbc.com/2025/06/09/r...

We have raised concerns about existing deficiencies in the Terminally Ill Adults (End of Life) Bill. We believe the bill in its current form lacks adequate protections for patients and professionals. Full statement: ow.ly/EOhP50W692q

Well this wasn’t at all 100% predictable.

Bank holiday Beef Wellington. And yes I am wearing cricketing whites.

So important.

@rcpsych.bsky.social cannot support the Terminally Ill Adults (End of Life) Bill for England and Wales in its current form and is once again urging MPs to look at our concerns ahead of the pivotal Commons Report stage debate and Third Reading. More here: www.rcpsych.ac.uk/news-and-fea...

1 in 5 of the UK’s care workforce have a non-British passport. Starmer would have us believe these carers are the “squalid” result of a “failed experiment”. I say they do vital, necessary, humane, skilled work and they are worth their weight in gold.

Also birth rate would need to go up. Currently very difficult economically for young couples to have kids.

Worth a follow!

Pie.

The White House has turned COVID.gov from a public health resource into a politically charged platform promoting the lab-leak theory and attacking specific scientists and the pandemic response in general. Let’s fact check its 5 headline claims… 🧵

Imagine asking an alien to guess which of these two politicians America’s overtly performative Christians lined up behind

Canapés before Easter Sunday lunch a highlight! Whipped feta, pomegranate and pea shoot croustades. Followed by lamb stuffed with pistachios and apricots, roasted vegetables, halloumi, salads, hummous, flatbreads. Champagnes; Chateau Musar, 20 year old Madeira.

Happy Easter everyone!

This why allowing people to hide their racism, misogyny and bigotry behind letters is a disservice to us all. When someone says they are "anti-DEI" always challenge them to own their hate. Do they oppose diversity? are they offended by equity? or is it the inclusion of others that offends them?

Are you a clinician looking for a fully-funded postdoctoral research opportunity? 🩺 Take a look at our postdoctoral career development fellowships for clinicians, and see how you can join our vibrant community of clinician scientists. Apply by 30 April ➡️ www.crick.ac.uk/careers-and-...

Yet again I beg you to read the ruling before commenting. Or reposting people who also clearly haven’t read the ruling. As with Cass, so much lazy outsourcing to others.

I don't want to live in a society where people with complicated lives and vulnerabilities are seen as expendable in easing the suffering of others. But that's exactly what this assisted dying bill would achieve. My Observer column. www.theguardian.com/commentisfre...

Great to welcome you here today!

A bit late, but never too late to spread the word on influenza M2 protein cleavage by caspase-6. Great PhD work by Carmen along with @bealelab.bsky.social @imperialinfect.bsky.social

Unbelievable. Richard Youle, winner of the Breakthrough Prize for Life Sciences, just got fired from the NIH. If you want to know what madness looks like, here it is, my friend.

NEW: The doctor behind breakthrough Parkinson’s research was among the scientists purged from the National Institutes of Health, the US’s leading medical research agency. www.wired.com/story/doctor...

This article is almost beyond belief Heartbroken for American medical science and concerned for the children

Could you submit an abstract by tomorrow (27 March)? Of course you could! See you there. #autophagy

Today I lost an NIH grant training clinicians to do research about intimate partner violence with perinatal women. More women are murdered in the perinatal period than die of obstetric complications. I didn't just lose a grant. We lost an entire cohort of people building careers to prevent that.

Gee, I wonder what that study on vaccines and autism will show www.washingtonpost.com/health/2025/... "Geier and his father, Mark Geier, have published papers claiming vaccines increase the risk of autism, a theory that has been studied for decades and scientifically debunked."

Cheers to fellow members of the "coterie of dead-enders"! www.theatlantic.com/ideas/archiv...

Submit your abstracts/scholarship applications by 3/27 (11:59pm MST) to present at the Autophagosomes and Endolysosomes meeting. Join Christina Towers & other leading experts! Dive in: keysym.us/KSAutophagy25. #KSAutophagy25 #autophagosome #endolysosomes youtu.be/zTfeKZSGF9Y @bealelab.bsky.social

💥 Voting for the new @rcphysicians.bsky.social President opens on Monday. 💥 Here's why I believe @drasifqasim.bsky.social would be such a superb new president: Decency. Integrity. Courage. Candour The deepest commitment to excellence in medicine. The true #VoiceOfPhysicans. #VoteAsifQasim