Autophagy-lysosome pathways are known targets of intracellular bacteria – Ivan Đikić @idikic.bsky.social et al find Legionella uses phosphoribosyl-ubiquitination via SidE to alter autophagic SNAREs & create a bacteria-containing vacuole unable to fuse with lysosomes www.embopress.org/doi/full/10....

Phosphoribosyl ubiquitination of SNARE proteins regulate autophagy in Legionella infection https://www.biorxiv.org/content/10.1101/2025.05.19.654886v1

#Autophagy and #mTOR papers and preprints from last week. As always a great selection, enjoy! 👌 biomed.news/bims-auttor/...

Excited to share our latest paper in Science Advances! We finally dissected a new pathway for mitochondrial quality control upon mtDNA replication stress! Let’s start a short thread! 🧵 www.science.org/doi/10.1126/...

#Autophagy and #mTOR papers from last week, lots of relevant stuff as always, enjoy! biomed.news/bims-auttor/...

RAB5c controls the assembly of non-canonical autophagy machinery to promote phagosome maturation and microbicidal function of macrophages https://www.biorxiv.org/content/10.1101/2025.03.25.645097v1

Happy to share the latest work from the lab @crick.ac.uk. Outstanding work from Di Chen and Tony Fearns showing the link between Mtb membrane damage, calcium leakage and ATG8/LC3 lipidation in macrophages. Congratulations Di and Tony! www.science.org/doi/10.1126/...

Exciting news from the lab out today in Science - the structure of human PINK1 on a TOM-VDAC complex! @wehi-research.bsky.social

🚀Our latest work reveals how RAB5c orchestrates LC3-associated phagocytosis (LAP) to boost macrophage defense against A. fumigatus! 🦠🔬 🧵 Dive into the mechanisms linking endosomal traffic to innate immunity! #Immunology #Autophagy #Phagocytosis #Macrophage #Preprint doi.org/10.1101/2025...