De novo design of protein nanoparticles with integrated functional motifs pubmed.ncbi.nlm.nih.gov/41509406/ #cryoem

Another fruitful collaboration with the Otzen group 🦠🧫🧬 We looked for curli and Fap operons across the bacterial tree of life (GTDB v226), and found that while Fap operon synteny and FapC repeat numbers are remarkably conserved, the opposite is true for curli operons and csgA!

New manuscript alert. Turns out that calcium ion coordination may be a more common mechanism than we initially expected to trigger polymerization of extracellular filaments. @mikesleutel.bsky.social @vikramalva.bsky.social www.biorxiv.org/content/10.6...

Distinct flagellins differentially fine tune biofilm initiation via flagellar stator-associated proteins www.biorxiv.org/content/10.64898/2025.12.30.697036v1 #cryoem

Alpha-synuclein fibril structures cluster into distinct classes pubmed.ncbi.nlm.nih.gov/41404791/ #cryoem

Capsid flexibility during Ty1 virus-like particle assembly www.biorxiv.org/content/10.64898/2025.12.17.694965v1 #cryoem

Happy to share that our work on HLp, a bacterial histone from Leptospira perolatii, is now published in Nature Communications 🎉 In this study, we show that HLp forms stable tetramers that wrap ~60 bp of DNA, revealing a distinct histone–DNA organization in bacteria. www.nature.com/articles/s41...

Type III secretion system effector evolved to be mechanically labile and initiate unfolding from the N-terminus. https://www.biorxiv.org/content/10.64898/2025.12.03.691928v1

Check out our latest paper on mirusviruses, one of the most remarkable new groups of protist viruses - extremely diverse, carry lots of spliceosomal introns (including new homing introns) and are at the evolutionary crossroads between tailed phages and herpesviruses! www.nature.com/articles/s41...

A Bundled Antiparallel Cytochrome Nanowire Structure Suggests Roles in Cell-Cell Electron Transfer and Biofilm Formation pubmed.ncbi.nlm.nih.gov/41279714/ #cryoem

The Inaugural Flatiron Institute Cryo-EM Conformational Heterogeneity Challenge pubmed.ncbi.nlm.nih.gov/41280101/ #cryoem

Latest work from the group looking at using our functionalised dipeptides for energy storage via a micellar analogue to MOST... www.nature.com/articles/s42...

How Sup35 monomer conformation and amyloid fibril polymorphism determine yeast strain phenotypes pubmed.ncbi.nlm.nih.gov/41282265/ #cryoem

Structural insights into the atypical filament assembly of pyrin domain-containing IFI16 pubmed.ncbi.nlm.nih.gov/41193640/ #cryoem

An Asgard archaeon with internal membrane compartments Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors! www.biorxiv.org/content/10.1...

Structures of the sheathed flagellum reveal mechanisms of assembly and rotation in Vibrio cholerae pubmed.ncbi.nlm.nih.gov/41174224/ #cryoem

We are looking for a computational postdoc to work with us on new optimisation algorithms to make #RELION even better. Join our bubbly team at the @mrclmb.bsky.social in Cambridge, UK. 🤗 RTs appreciated. mrc.tal.net/vx/appcentre...

Separation of halide oxidation and substrate halogenation chemistries rationalizes site-selective vanadium dependent haloperoxidase catalysis www.biorxiv.org/content/10.1101/2025.10.24.684477v1 #cryoem

Impurities in amyloid studies: The power of automated model building within a cautionary tale for structural biologists pubmed.ncbi.nlm.nih.gov/41123416/ #cryoem

This looks pretty cool and unexpected.... www.biorxiv.org/content/10.1...

A nice N&V article by Mike Dyall-Smith on our recent paper ( www.nature.com/articles/s41... ): www.nature.com/articles/s41...

Seed structure and phosphorylation in the fuzzy coat impact tau seeding competency pubmed.ncbi.nlm.nih.gov/41107248/ #cryoem

Donor strand complementation and calcium ion coordination drive the chaperone-free polymerization of archaeal cannulae pubmed.ncbi.nlm.nih.gov/41083437/ #cryoem

Cannulae paper published in final form. Thanks to the many collaborators and to the reviewers. @jerryknowsnothing.bsky.social @mikesleutel.bsky.social @vikramalva.bsky.social rdcu.be/eKVlI

Molecular Microbiology | Microbiology Journal | Wiley Online Library onlinelibrary.wiley.com/doi/10.1111/...

CryoSeek identification of glycofibrils with diverse compositions and structural assemblies www.biorxiv.org/content/10.1101/2025.09.30.679562v1 #cryoem

Absolute hand determination of glycofibrils from natural sources in cryo-EM www.biorxiv.org/content/10.1101/2025.09.30.679555v1 #cryoem

Look at this nice cover: beautiful archaella, image made by @sshamphavi.bsky.social ! Thanks also to Marta Rodeiguez for keeping the EM im shape in @ottlab.bsky.social lab! At @biologyunifreiburg.bsky.social at @uni-freiburg.de @sfb1381.bsky.social @cibss.bsky.social

I’m thrilled to share my latest published manuscript, which summarizes my work in the exciting fields of structural biology and amyloid research. A huge thank you to @meytallandau.bsky.social and the team at @landaulabcssb.bsky.social for their shared efforts doi.org/10.1002/advs...

Structural and Functional Versatility of the Amyloidogenic Non-Amidated Variant of the Antimicrobial Peptide Citropin 1.3 pubmed.ncbi.nlm.nih.gov/41016026/ #cryoem

Self‐Assembly of Off‐Target Peptide Sequences: Implications for the Design of Soft Materials - Wang - Small - Wiley Online Library onlinelibrary.wiley.com/doi/10.1002/...

Filamentous structure of the CotVW complex, the crust proteins of the Bacillus subtilis endospore - Journal of Biological Chemistry www.jbc.org/article/S002... Spore protein assemblies are pretty wild. Nice inspiration for biomaterials design.

Structural basis of Pseudomonas biofilm-forming functional amyloid FapC formation | Science Advances www.science.org/doi/10.1126/...

I missed the original share on this article since I was locked out of my Bluesky account due to algorithmic impotence. Hate when that happens. Really cool structure from @jerryknowsnothing.bsky.social and co-authors. rdcu.be/eHQ1N

Happy to share that our story on the bacterial archaellum was published today in @natmicrobiol.nature.com www.nature.com/articles/s41... Congrats to the authors: @sshamphavi.bsky.social @loumollat.bsky.social @mariejoest.bsky.social Najwa Taib and @sgribaldo.bsky.social