Improved Therapeutic Antibody Reformatting through Multimodal Machine Learning arxiv.org/abs/2509.196...

Cell-free recombinase-integrated Boolean output system: Cell Systems www.cell.com/cell-systems...

Hollow-fibre biomanufacturing and cell-free engineering of HEK293 extracellular vesicles https://www.biorxiv.org/content/10.1101/2025.09.20.677537v1

Generative design of novel bacteriophages with genome language models www.biorxiv.org/content/10.1...

Microsystem technologies for accelerating the discovery and translation of immunotherapies www.nature.com/articles/s41...

Characterizing Cell-Free Transcription and Translation Dynamics with Nucleic Acid-Based Assays https://www.biorxiv.org/content/10.1101/2025.09.10.675373v1

Development of a nonreplicative phage-based DNA delivery system and its application to antimicrobial therapies: academic.oup.com/pnasnexus/ar...

How safe is your mind in a world flooded with junk information? Yuval Noah Harari warns that unlike past media, AI-driven networks never rest, blurring the boundaries between us and digital reality. He calls to preserve your autonomy as AI becomes more unpredictable  www.youtube.com/watch?v=K1Ov...

Cryo-EM structure of a cell-free synthesized full-length human β1-adrenergic receptor in complex with Gs: Structure www.cell.com/structure/fu...

Online monitoring of the mitochondrial respiration activity and protein formation in the Almost Living Cell-free Expression (ALiCE) system bmcbiotechnol.biomedcentral.com/articles/10....

Refinement of OnePot PURE and Crude Ribosome Production for Reproducible Cell-free Protein Synthesis app.jove.com/t/68826/refi...

Leveraging cell-free gene expression for RNA-based biopesticides production: mechanisms and applications scijournals.onlinelibrary.wiley.com/doi/abs/10.1...

Phage-based delivery of CRISPR-associated transposases for targeted bacterial editing | PNAS www.pnas.org/doi/10.1073/...

Chan Cao, University of Geneva, Cees Dekker, Delft University of Technology. And here is the link to the story www.nature.com/articles/s41... And an openly accessible link: rdcu.be/ezCRE

A novel tool for predicting the impact of mutations on protein solubility www.nature.com/articles/s41...

High‐Throughput Pipeline for Protein Expression and Solubility Profiling Using Synthetically Generated Plasmids currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...

Great talk by @sami-c.bsky.social about the proper use and caveats of AlphaFold2/3 predictions, highly recommended to watch www.youtube.com/watch?v=z7vy...

Optimization of Malonyl Coenzyme A Biosensors in a Reconstituted Cell-Free System for Detecting Acetyl-CoA Carboxylase Activity pubs.acs.org/doi/10.1021/...

DNA-Programmable Protein Degradation: Dynamic Control of Proteolysis-Targeting Chimera Activity via DNA Hybridization and Strand Displacement | JACS Au pubs.acs.org/doi/10.1021/...

Real-Time Affinity Measurements of Proteins Synthesized in Cell-Free Lysate Using Fluorescence Correlation Spectroscopy | Analytical Chemistry pubs.acs.org/doi/10.1021/...

Machine learning-guided evolution of pyrrolysyl-tRNA synthetase for improved incorporation efficiency of diverse noncanonical amino acids www.nature.com/articles/s41...

CF2H: a Cell-Free Two-Hybrid platform for rapid protein binder screening www.biorxiv.org/content/10.1...

🚀🤖 Our latest work, published in Digital Discovery, introduces a simple yet effective benchmark for testing how well self-driving laboratories can search for experimental conditions, especially when not every setup is guaranteed to work. Link: pubs.rsc.org/en/content/a... [1/4]

A Lactose-Based Kluyveromyces lactis Cell-Free Protein Synthesis System | Chem & Bio Engineering It's interesting to note that the yield of different proteins depends on the specific formulation of the cell-free reaction pubs.acs.org/doi/10.1021/...

Antimicrobial peptides: structure, functions and translational applications www.nature.com/articles/s41...

Continuous in situ synthesis of a complete set of tRNAs sustains steady-state translation in a recombinant cell-free system www.nature.com/articles/s41...

Cell-Free Protein Synthesis Reactor Formats: A Brief History and Analysis www.mdpi.com/2674-0583/3/...

Expanded ribosomal synthesis of non-standard cyclic backbones in vitro www.nature.com/articles/s41...

Rapid Cell-Free Combinatorial Mutagenesis Workflow Using Small Oligos Suitable for High-Iteration, Active Learning-Guided Protein Engineering doi.org/10.1101/2025...

This is wild! Engineering E. coli bacteria to turn plastic waste into paracetamol (Tylenol) www.nature.com/articles/s41... www.nature.com/articles/s41...

Lipid Modification and Membrane Localization of Proteins in Cell-Free System pubs.acs.org/doi/10.1021/...

A T7 RNAP regulatory toolbox for cell-free network engineering and biosensing applications www.biorxiv.org/content/10.1...

A synthetic cell phage cycle doi.org/10.1101/2025...

Mathematical Model of Cell-Free Transcription-Translation with Plasmid Crosstalk academic.oup.com/synbio/artic...

Cell-free genome-wide transcriptomics through machine learning optimization Using an active learning workflow to screen over 1,000,000 buffer conditions, a buffer was identified that increased mRNA yield 20-fold, enabling cell-free transcriptomics www.biorxiv.org/content/10.1...

Glycosylation of Structured Protein Domains in Cell-Free Reaction Environments | ACS Synthetic Biology pubs.acs.org/doi/10.1021/...

Optimization and Application of the Purified Cell-Free System chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...

Happy to share the peer-reviewed and updated version of our work on OrthoRep-driven evolution of aaRSs for genetic code expansion with unnatural amino acids. Congrats to Yuichi Furuhata, a true master bioengineer, on leading this excellent work! www.nature.com/articles/s41...

Residue-Specific Incorporation of Noncanonical Amino Acids in Auxotrophic Hosts: Quo Vadis? | Chemical Reviews pubs.acs.org/doi/full/10....

🎉 Congrats to Nate for his awesome preprint! We used deep learning to design phages with complex infectivity and specificity profiles. Big shifts in host targeting come from just a few mutations! Training on multifunctional data enables precise control over protein properties 🧬 tinyurl.com/yc4wtn8h

Next London Cell-free Biological Product Meeting: 🗓️ Monday, 16th June 2025 (1-5 pm) 📍 Imperial College London, South Kensington ✨ Keynote: Prof. Keith Pardee (Toronto) Limited talk slots available 📝 Register: forms.office.com/e/dbW6hJacmS #Cell-free #Biotech #ImperialCollege #UCL

Wow www.biorxiv.org/content/10.1... A cellular entity retaining only its replicative core: Hidden archaeal lineage with an ultra-reduced genome

What are the most-cited research papers of all time? https://go.nature.com/3Y4OMOD

Development of Lyophilized Eukaryotic Cell-Free Protein Expression System Based on Leishmania tarentolae | ACS Synthetic Biology pubs.acs.org/doi/10.1021/...

On-demand insulin manufacturing using cell-free systems with an “on-column” conversion approach www.biorxiv.org/content/10.1...

Optimizing Protein Production in the One-Pot PURE System: Insights into Reaction Composition and Expression Efficiency | ACS Synthetic Biology pubs.acs.org/doi/10.1021/...

SGH successfully uses phage therapy to treat antibiotic-resistant infection, a first in South-east Asia www.theonlinecitizen.com/2025/03/27/s...